4-Aminobenzoate (BioDeep_00001871996)
代谢物信息卡片
4-Aminobenzoate
化学式: C7H6NO2- (136.0399)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C(=O)[O-])N
InChI: InChI=1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
描述信息
An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:17836
- PubChem: 4876
- ChEMBL: CHEMBL1762658
- MeSH: para-Aminobenzoates
- CAS: 2906-28-7
- MetaboLights: MTBLC17836
分类词条
相关代谢途径
Reactome(0)
BioCyc(8)
- superpathway of chorismate metabolism
- tetrahydrofolate biosynthesis
- superpathway of tetrahydrofolate biosynthesis
- superpathway of tetrahydrofolate biosynthesis and salvage
- 4-hydroxymandelate degradation
- superpathway of aromatic compound degradation via 2-hydroxypentadienoate
- superpathway of aromatic compound degradation via 3-oxoadipate
- tetrahydrofolate biosynthesis I
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Xiaokang Wang, Tiesong Wu, Hongyan Ma, Xiaoling Huang, Kaiyuan Huang, Chunxiao Ye, Shiping Zhu. VX-765 ameliorates inflammation and extracellular matrix accumulation by inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy.
The Journal of pharmacy and pharmacology.
2022 Mar; 74(3):377-386. doi:
10.1093/jpp/rgab112. [PMID: 34383065] - Kenichi Umehara, Yumi Cleary, Stephen Fowler, Neil Parrott, Dietrich Tuerck. Accelerating Clinical Development of Idasanutlin through a Physiologically Based Pharmacokinetic Modeling Risk Assessment for CYP450 Isoenzyme-Related Drug-Drug Interactions.
Drug metabolism and disposition: the biological fate of chemicals.
2022 03; 50(3):214-223. doi:
10.1124/dmd.121.000720. [PMID: 34937801] - Si Wen, Fei Deng, Lulu Li, Li Xu, Xin Li, Qiuling Fan. VX-765 ameliorates renal injury and fibrosis in diabetes by regulating caspase-1-mediated pyroptosis and inflammation.
Journal of diabetes investigation.
2022 Jan; 13(1):22-33. doi:
10.1111/jdi.13660. [PMID: 34494385] - Zafar Ali Khan, Namdeo Prabhu, Naseer Ahmed, Abhishek Lal, Rakhi Issrani, Afsheen Maqsood, Fahim Vohra, Mohammad Khursheed Alam. A Comparative Study on Alvogyl and a Mixture of Black Seed Oil and Powder for Alveolar Osteitis: A Randomized Double-Blind Controlled Clinical Trial.
International journal of clinical practice.
2022; 2022(?):7756226. doi:
10.1155/2022/7756226. [PMID: 35685605] - Zhengyuan Zhou, Michael R Zalutsky, Satish K Chitneni. Fluorine-18 Labeling of the MDM2 Inhibitor RG7388 for PET Imaging: Chemistry and Preliminary Evaluation.
Molecular pharmaceutics.
2021 10; 18(10):3871-3881. doi:
10.1021/acs.molpharmaceut.1c00531. [PMID: 34523337] - Karen Yee, Cristina Papayannidis, Norbert Vey, Michael J Dickinson, Kevin R Kelly, Sarit Assouline, Margaret Kasner, Karen Seiter, Mark W Drummond, Sung-Soo Yoon, Je-Hwan Lee, Steven Blotner, Lori Jukofsky, William E Pierceall, Jianguo Zhi, Silke Simon, Brian Higgins, Gwen Nichols, Annabelle Monnet, Susanne Muehlbauer, Marion Ott, Lin-Chi Chen, Giovanni Martinelli. Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study⋆.
Leukemia research.
2021 01; 100(?):106489. doi:
10.1016/j.leukres.2020.106489. [PMID: 33302031] - Maria José Martinez-Zapata, Robin Wm Vernooij, Daniel Simancas-Racines, Sonia Maria Uriona Tuma, Airton T Stein, Rosa Maria M Moreno Carriles, Emilio Vargas, Xavier Bonfill Cosp. Phlebotonics for venous insufficiency.
The Cochrane database of systematic reviews.
2020 11; 11(?):CD003229. doi:
10.1002/14651858.cd003229.pub4. [PMID: 33141449] - Ryuichi Noguchi, Kosuke Kaji, Tadashi Namisaki, Kei Moriya, Hideto Kawaratani, Mitsuteru Kitade, Hiroaki Takaya, Yosuke Aihara, Akitoshi Douhara, Kiyoshi Asada, Norihisa Nishimura, Toshio Miyata, Hitoshi Yoshiji. Novel oral plasminogen activator inhibitor‑1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats.
Molecular medicine reports.
2020 Oct; 22(4):2948-2956. doi:
10.3892/mmr.2020.11360. [PMID: 32945412] - Jia Li, Jia-Huan Hao, Di Yao, Rong Li, Xue-Fei Li, Zhi-Yuan Yu, Xiang Luo, Xing-Hua Liu, Ming-Huan Wang, Wei Wang. Caspase-1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia.
CNS neuroscience & therapeutics.
2020 09; 26(9):925-939. doi:
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Investigational new drugs.
2020 08; 38(4):1156-1165. doi:
10.1007/s10637-019-00869-2. [PMID: 31734832] - Yi-Hao Wang, Yan Li, Jun-Nan Wang, Qing-Xiang Zhao, Shuang Wen, Si-Cong Wang, Tao Sun. A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction with NLRP3 Inflammasome.
Neurochemical research.
2020 Aug; 45(8):1860-1869. doi:
10.1007/s11064-020-03050-x. [PMID: 32410045] - Brittany Woodby, Claudia Sticozzi, Erika Pambianchi, Gino Villetti, Maurizio Civelli, Giuseppe Valacchi, Fabrizio Facchinetti. The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways.
Archives of biochemistry and biophysics.
2020 05; 685(?):108355. doi:
10.1016/j.abb.2020.108355. [PMID: 32268137] - Radu-Liviu Sumalan, Lilia Croitor, Mihaela Petric, Isidora Radulov, Paulina Bourosh, Renata-Maria Sumalan, Manuela Crisan. p-Aminobenzoate Organic Salts as Potential Plant Growth Regulators for Tomatoes.
Molecules (Basel, Switzerland).
2020 Apr; 25(7):. doi:
10.3390/molecules25071635. [PMID: 32252303] - Yiyi Li, Xuan Niu, Haitao Xu, Qingwen Li, Lanxia Meng, Mingyang He, Jie Zhang, Zhentao Zhang, Zhaohui Zhang. VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis.
Experimental cell research.
2020 04; 389(1):111847. doi:
10.1016/j.yexcr.2020.111847. [PMID: 31972218] - Su-Qin Lang, Wen-Hua Lang, Hai-Yan Yu, Li Wang. Metabolic activation of TM5441 in vitro and in vivo: Formation of reactive metabolites and human enzymes involved.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Feb; 143(?):105195. doi:
10.1016/j.ejps.2019.105195. [PMID: 31852629] - Daohang Liu, Zhi Dong, Fei Xiang, Hailin Liu, Yuchun Wang, Qian Wang, Jiangyan Rao. Dendrobium Alkaloids Promote Neural Function After Cerebral Ischemia-Reperfusion Injury Through Inhibiting Pyroptosis Induced Neuronal Death in both In Vivo and In Vitro Models.
Neurochemical research.
2020 Feb; 45(2):437-454. doi:
10.1007/s11064-019-02935-w. [PMID: 31865520] - Jiayu Man, Feifei Jiao, Yiya Wang, Yueqing Gu, Li Ding, Chang Shu. Determination of benzonatate and its metabolite in human plasma by HPLC-MS/MS: A preliminary pharmacokinetic study in healthy Chinese volunteers after oral administration of benzonatate soft capsule.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 173(?):134-143. doi:
10.1016/j.jpba.2019.05.030. [PMID: 31129533] - Dave Singh, Kai Michael Beeh, Brendan Colgan, Oliver Kornmann, Brian Leaker, Henrik Watz, Germano Lucci, Silvia Geraci, Aida Emirova, Mirco Govoni, Marie Anna Nandeuil. Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD.
Respiratory research.
2019 Aug; 20(1):180. doi:
10.1186/s12931-019-1142-7. [PMID: 31399091] - Zsuzsanna Pápai, Lin-Chi Chen, Daniel Da Costa, Steven Blotner, Faye Vazvaei, Michelle Gleave, Russell Jones, Jianguo Zhi. A single-center, open-label study investigating the excretion balance, pharmacokinetics, metabolism, and absolute bioavailability of a single oral dose of [14C]-labeled idasanutlin and an intravenous tracer dose of [13C]-labeled idasanutlin in a single cohort of patients with solid tumors.
Cancer chemotherapy and pharmacology.
2019 07; 84(1):93-103. doi:
10.1007/s00280-019-03851-0. [PMID: 31062077] - Lindi Chen, Fabio Pastorino, Philip Berry, Jennifer Bonner, Calum Kirk, Katrina M Wood, Huw D Thomas, Yan Zhao, Antonio Daga, Gareth J Veal, John Lunec, David R Newell, Mirco Ponzoni, Deborah A Tweddle. Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma.
International journal of cancer.
2019 06; 144(12):3146-3159. doi:
10.1002/ijc.32058. [PMID: 30536898] - Joachim Michael Matz, Mutsumi Watanabe, Mofolusho Falade, Takayuki Tohge, Rainer Hoefgen, Kai Matuschewski. Plasmodium Para-Aminobenzoate Synthesis and Salvage Resolve Avoidance of Folate Competition and Adaptation to Host Diet.
Cell reports.
2019 01; 26(2):356-363.e4. doi:
10.1016/j.celrep.2018.12.062. [PMID: 30625318] - Guanghua Lu, Ranran Zhou, Sheng Li, Tianjian Dang, Jianchao Liu. Bioaccumulation and Biomagnification of 2-Ethylhexyl-4-dimethylaminobenzoate in Aquatic Animals.
International journal of environmental research and public health.
2018 10; 15(11):. doi:
10.3390/ijerph15112395. [PMID: 30380631] - Dongsheng Zhu, Haijun Guo, Yu Chang, Yun Ni, Lin Li, Zhi-Min Zhang, Piliang Hao, Yong Xu, Ke Ding, Zhengqiu Li. Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin.
Angewandte Chemie (International ed. in English).
2018 07; 57(30):9284-9289. doi:
10.1002/anie.201802003. [PMID: 29768700] - Elizabeth M King, Tanya L Cerajewska, Matthew Locke, Nicholas C A Claydon, Maria Davies, Nicola X West. The Efficacy of Plasma Rich in Growth Factors for the Treatment of Alveolar Osteitis: A Randomized Controlled Trial.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2018 Jun; 76(6):1150-1159. doi:
10.1016/j.joms.2017.12.025. [PMID: 29382467] - Steven Blotner, Lin-Chi Chen, Cristiano Ferlini, Jianguo Zhi. Phase 1 summary of plasma concentration-QTc analysis for idasanutlin, an MDM2 antagonist, in patients with advanced solid tumors and AML.
Cancer chemotherapy and pharmacology.
2018 03; 81(3):597-607. doi:
10.1007/s00280-018-3534-7. [PMID: 29392451] - Binni Ma, Guanghua Lu, Haohan Yang, Jianchao Liu, Zhenhua Yan, Matthew Nkoom. The effects of dissolved organic matter and feeding on bioconcentration and oxidative stress of ethylhexyl dimethyl p-aminobenzoate (OD-PABA) to crucian carp (Carassius auratus).
Environmental science and pollution research international.
2018 Mar; 25(7):6558-6569. doi:
10.1007/s11356-017-1002-2. [PMID: 29255981] - Hayato Miyake, Junichi Sakagami, Hiroaki Yasuda, Yoshio Sogame, Ryusuke Kato, Kanetoshi Suwa, Katsuyuki Dainaka, Tomoki Takata, Isao Yokota, Yoshito Itoh. Association of fatty pancreas with pancreatic endocrine and exocrine function.
PloS one.
2018; 13(12):e0209448. doi:
10.1371/journal.pone.0209448. [PMID: 30571730] - Hasina Akhter, Wen-Tan Huang, Thomas van Groen, Hui-Chien Kuo, Toshio Miyata, Rui-Ming Liu. A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2018; 64(2):447-457. doi:
10.3233/jad-180241. [PMID: 29914038] - Fabrizia Mariotti, Mirco Govoni, Germano Lucci, Debora Santoro, Marie Anna Nandeuil. Safety, tolerability, and pharmacokinetics of single and repeat ascending doses of CHF6001, a novel inhaled phosphodiesterase-4 inhibitor: two randomized trials in healthy volunteers.
International journal of chronic obstructive pulmonary disease.
2018 ; 13(?):3399-3410. doi:
10.2147/copd.s174156. [PMID: 30425469] - Meltem Erol, Ismet Çok, Özlem Bostan Gayret, Pembegül Günes, Özgül Yigit, Elif Sayman, Aysegül Günes, Duygu Sultan Çelik, Sahin Hamilçikan, Serdar Altinay, Oya Ercan. Evaluation of the endocrine-disrupting effects of homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) in rat pups during the prenatal, lactation, and early postnatal periods.
Toxicology and industrial health.
2017 Oct; 33(10):775-791. doi:
10.1177/0748233717718974. [PMID: 28879804] - Mesut Eren, Aaron T Place, Paul M Thomas, Panagiotis Flevaris, Toshio Miyata, Douglas E Vaughan. PAI-1 is a critical regulator of FGF23 homeostasis.
Science advances.
2017 09; 3(9):e1603259. doi:
10.1126/sciadv.1603259. [PMID: 28924605] - Binni Ma, Guanghua Lu, Jianchao Liu, Zhenhua Yan, Haohan Yang, Ting Pan. Bioconcentration and multi-biomarkers of organic UV filters (BM-DBM and OD-PABA) in crucian carp.
Ecotoxicology and environmental safety.
2017 Jul; 141(?):178-187. doi:
10.1016/j.ecoenv.2017.03.034. [PMID: 28343007] - Esraa M Zakaria, Nabila N El-Maraghy, Ahmed F Ahmed, Abdelmonim A Ali, Hany M El-Bassossy. PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Jun; 390(6):621-631. doi:
10.1007/s00210-017-1360-9. [PMID: 28224182] - Anthony T Cacek, Jogarao V S Gobburu, Mathangi Gopalakrishnan. Population Pharmacokinetics of an Intranasally Administered Combination of Oxymetazoline and Tetracaine in Healthy Volunteers.
Journal of clinical pharmacology.
2017 02; 57(2):247-254. doi:
10.1002/jcph.799. [PMID: 27436060] - Lingjuan Piao, Inji Jung, Joo Young Huh, Toshio Miyata, Hunjoo Ha. A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects against high-fat diet-induced obesity and adipocyte injury in mice.
British journal of pharmacology.
2016 09; 173(17):2622-32. doi:
10.1111/bph.13541. [PMID: 27339909] - Kelli J Glenn, Li J Yu, Micaela B Reddy, Adrian J Fretland, Neil Parrott, Sazzad Hussain, Mary Palacios, Faye Vazvaei, Jianguo Zhi, Dietrich Tuerck. Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans.
Xenobiotica; the fate of foreign compounds in biological systems.
2016 Aug; 46(8):667-76. doi:
10.3109/00498254.2015.1110761. [PMID: 26586447] - Maria José Martinez-Zapata, Robin W M Vernooij, Sonia Maria Uriona Tuma, Airton T Stein, Rosa M Moreno, Emilio Vargas, Dolors Capellà, Xavier Bonfill Cosp. Phlebotonics for venous insufficiency.
The Cochrane database of systematic reviews.
2016 Apr; 4(?):CD003229. doi:
10.1002/14651858.cd003229.pub3. [PMID: 27048768] - Yongfeng Zhang, Yi Zheng. Effects and mechanisms of potent caspase-1 inhibitor VX765 treatment on collagen-induced arthritis in mice.
Clinical and experimental rheumatology.
2016 Jan; 34(1):111-8. doi:
NULL. [PMID: 26742834] - Bo Yeong Jeong, Md Jamal Uddin, Jong Hee Park, Jung Hwa Lee, Hi Bahl Lee, Toshio Miyata, Hunjoo Ha. Novel Plasminogen Activator Inhibitor-1 Inhibitors Prevent Diabetic Kidney Injury in a Mouse Model.
PloS one.
2016; 11(6):e0157012. doi:
10.1371/journal.pone.0157012. [PMID: 27258009] - Yi Zhang, Lei Liu, Yun-Zi Liu, Xiao-Liang Shen, Teng-Yun Wu, Ting Zhang, Wei Wang, Yun-Xia Wang, Chun-Lei Jiang. NLRP3 Inflammasome Mediates Chronic Mild Stress-Induced Depression in Mice via Neuroinflammation.
The international journal of neuropsychopharmacology.
2015 Jan; 18(8):. doi:
10.1093/ijnp/pyv006. [PMID: 25603858] - Veronica R Placencio, Atsuhiko Ichimura, Toshio Miyata, Yves A DeClerck. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity.
PloS one.
2015; 10(7):e0133786. doi:
10.1371/journal.pone.0133786. [PMID: 26207899] - Yuling Chi, Jean-Francois Jasmin, Yoshinori Seki, Michael P Lisanti, Maureen J Charron, David J Lefer, Victor L Schuster. Inhibition of the Prostaglandin Transporter PGT Lowers Blood Pressure in Hypertensive Rats and Mice.
PloS one.
2015; 10(6):e0131735. doi:
10.1371/journal.pone.0131735. [PMID: 26121580] - Mingsheng Chen, Ying Zhang, Vladimir Dusevich, Yi Liu, Qingsong Yu, Yong Wang. Non-thermal atmospheric plasma brush induces HEMA grafting onto dentin collagen.
Dental materials : official publication of the Academy of Dental Materials.
2014 Dec; 30(12):1369-77. doi:
10.1016/j.dental.2014.10.004. [PMID: 25458523] - H A Spiller, J L Russell, M J Casavant, R Y Ho, R R Gerona. Identification of N-Hydroxy-para-aminobenzoic acid in a cyanotic child after benzocaine exposure.
Clinical toxicology (Philadelphia, Pa.).
2014 Nov; 52(9):976-9. doi:
10.3109/15563650.2014.958615. [PMID: 25211007] - Kanji Kubo, Kazuki Tsuji, Akira Mori, Seiji Ujiie. Synthesis and properties of cholesteryl 4-(Alkanoylamino)benzoates: liquid crystals and organogelators.
Journal of oleo science.
2014; 63(4):401-6. doi:
10.5650/jos.ess13160. [PMID: 24599108] - Dieter Blancquaert, Sergei Storozhenko, Jeroen Van Daele, Christophe Stove, Richard G F Visser, Willy Lambert, Dominique Van Der Straeten. Enhancing pterin and para-aminobenzoate content is not sufficient to successfully biofortify potato tubers and Arabidopsis thaliana plants with folate.
Journal of experimental botany.
2013 Sep; 64(12):3899-909. doi:
10.1093/jxb/ert224. [PMID: 23956417] - Hideki Yasui, Yuko Suzuki, Hideto Sano, Takafumi Suda, Kingo Chida, Takashi Dan, Toshio Miyata, Tetsumei Urano. TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells.
Thrombosis research.
2013 Jul; 132(1):100-5. doi:
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Neuroscience.
2013 Jun; 240(?):325-35. doi:
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Cancer chemotherapy and pharmacology.
2013 Jan; 71(1):73-83. doi:
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Dental materials : official publication of the Academy of Dental Materials.
2012 Dec; 28(12):1232-9. doi:
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International journal of andrology.
2012 Jun; 35(3):424-36. doi:
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The Journal of pharmacology and experimental therapeutics.
2011 Nov; 339(2):633-41. doi:
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Investigational new drugs.
2011 Oct; 29(5):719-29. doi:
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European journal of pharmacology.
2011 Sep; 667(1-3):287-91. doi:
10.1016/j.ejphar.2011.05.060. [PMID: 21641342] - Göksel Şimşek Kaya, Günay Yapici, Zeynep Savaş, Metin Güngörmüş. Comparison of alvogyl, SaliCept patch, and low-level laser therapy in the management of alveolar osteitis.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2011 Jun; 69(6):1571-7. doi:
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Journal of chromatography. A.
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Bioorganic & medicinal chemistry letters.
2011 Feb; 21(4):1134-40. doi:
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