Cuprizone (BioDeep_00001871907)
代谢物信息卡片
oxalic bis(cyclohexylidenehydrazide)
化学式: C14H22N4O2 (278.1742672)
中文名称: 双环己酮草酰二腙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(=NNC(=O)C(=O)NN=C2CCCCC2)CC1
InChI: InChI=1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
描述信息
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
D064449 - Sequestering Agents > D002614 - Chelating Agents
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(3)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vanesa Mattera, Federico Occhiuzzi, Jorge Correale, Juana M Pasquini. Remyelinating effect driven by transferrin-loaded extracellular vesicles.
Glia.
2024 Feb; 72(2):338-361. doi:
10.1002/glia.24478. [PMID: 37860913] - Li-Juan Song, Qing-Xian Han, Zhi-Bin Ding, Kexin Liu, Xiao-Xu Zhang, Min-Fang Guo, Dong Ma, Qing Wang, Bao-Guo Xiao, Cun-Gen Ma. Icariin ameliorates the cuprizone-induced demyelination associated with antioxidation and anti-inflammation.
Inflammopharmacology.
2024 Jan; ?(?):. doi:
10.1007/s10787-023-01388-6. [PMID: 38177566] - Ksenija Martinović, Jan Bauer, Markus Kunze, Johannes Berger, Sonja Forss-Petter. Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy.
Acta neuropathologica communications.
2023 Jun; 11(1):98. doi:
10.1186/s40478-023-01595-w. [PMID: 37331971] - Tingting Zhang, Tuancheng Feng, Kenton Wu, Jennifer Guo, Alissa L Nana, Guang Yang, William W Seeley, Fenghua Hu. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.
Acta neuropathologica.
2023 Apr; ?(?):. doi:
10.1007/s00401-023-02578-w. [PMID: 37120788] - Jing-Xian Sun, Ke-Ying Zhu, Yu-Meng Wang, Dan-Jie Wang, Mi-Zhen Zhang, Heela Sarlus, Irene Benito-Cuesta, Xiao-Qiang Zhao, Zao-Feng Zou, Qing-Yang Zhong, Yi Feng, Shuai Wu, Yan-Qing Wang, Robert A Harris, Jun Wang. Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function.
Acta pharmacologica Sinica.
2023 Apr; 44(4):766-779. doi:
10.1038/s41401-022-01000-7. [PMID: 36229601] - Mahalakshmi Shankaran, Hussein Mohammed, Ellen Tsang, Po-Yin Anne Wong, Joan Protasio, Elizabeth J Murphy, Frederic Bernard, Rui Chang, Tammy Dellovade, Scott Turner, Marc K Hellerstein. 24-hydroxycholesterol replacement rate measured in blood is a non-invasive biomarker of brain demyelination and remyelination in cuprizone-treated mice.
Experimental neurology.
2023 Mar; ?(?):114395. doi:
10.1016/j.expneurol.2023.114395. [PMID: 37003487] - Ghadha Ibrahim Fouad, Mostafa Mabrouk, Sara A M El-Sayed, Maha Z Rizk, Hanan H Beherei. Neurotherapeutic efficacy of loaded sulforaphane on iron oxide nanoparticles against cuprizone-induced neurotoxicity: role of MMP-9 and S100β.
Toxicology mechanisms and methods.
2023 Feb; ?(?):1-17. doi:
10.1080/15376516.2023.2177219. [PMID: 36775846] - Ghadha Ibrahim Fouad. Sulforaphane, an Nrf-2 Agonist, Modulates Oxidative Stress and Inflammation in a Rat Model of Cuprizone-Induced Cardiotoxicity and Hepatotoxicity.
Cardiovascular toxicology.
2023 01; 23(1):46-60. doi:
10.1007/s12012-022-09776-0. [PMID: 36650404] - Antoinette G Naeem, Reem N El-Naga, Haidy E Michel. Nebivolol elicits a neuroprotective effect in the cuprizone model of multiple sclerosis in mice: emphasis on M1/M2 polarization and inhibition of NLRP3 inflammasome activation.
Inflammopharmacology.
2022 Dec; 30(6):2197-2209. doi:
10.1007/s10787-022-01045-4. [PMID: 35948811] - Jennifer Enrich-Bengoa, Gemma Manich, Irene R Dégano, Alex Perálvarez-Marín. Deciphering the Genetic Crosstalk between Microglia and Oligodendrocyte Precursor Cells during Demyelination and Remyelination Using Transcriptomic Data.
International journal of molecular sciences.
2022 Nov; 23(23):. doi:
10.3390/ijms232314868. [PMID: 36499195] - Na Wang, Minghui Wang, Suren Jeevaratnam, Cassandra Rosenberg, Tadafumi C Ikezu, Francis Shue, Sydney V Doss, Alla Alnobani, Yuka A Martens, Melissa Wren, Yan W Asmann, Bin Zhang, Guojun Bu, Chia-Chen Liu. Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination.
Molecular neurodegeneration.
2022 11; 17(1):75. doi:
10.1186/s13024-022-00577-1. [PMID: 36419137] - Jinfeng Yuan, Nuo Xu, Yanlin Tao, Xinyan Han, Liu Yang, Jinglei Liang, Haojieyin Jin, Xiaoxia Zhang, Hui Wu, Hailin Shi, Fei Huang, Xiaojun Wu. Total astragalosides promote oligodendrocyte precursor cell differentiation and enhance remyelination in cuprizone-induced mice through suppression of Wnt/β-catenin signaling pathway.
Journal of ethnopharmacology.
2022 Nov; 298(?):115622. doi:
10.1016/j.jep.2022.115622. [PMID: 35964820] - Fatemeh Namazi, Elnaz Bordbar, Farnoosh Bakhshaei, Saeed Nazifi. The effect of Urtica dioica extract on oxidative stress, heat shock proteins, and brain histopathology in multiple sclerosis model.
Physiological reports.
2022 08; 10(15):e15404. doi:
10.14814/phy2.15404. [PMID: 35924324] - Yi-Xiao Dong, Shi-Feng Chu, Sha-Sha Wang, Ya-Juan Tian, Wen-Bin He, Yu-Sheng Du, Zhen-Zhen Wang, Xu Yan, Zhao Zhang, Nai-Hong Chen. Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response.
Acta pharmacologica Sinica.
2022 Mar; 43(3):563-576. doi:
10.1038/s41401-021-00696-3. [PMID: 34103690] - Damien Marechal, David K Dansu, Kamilah Castro, Julia Patzig, Laura Magri, Benjamin Inbar, Mar Gacias, Sarah Moyon, Patrizia Casaccia. N-myc downstream regulated family member 1 (NDRG1) is enriched in myelinating oligodendrocytes and impacts myelin degradation in response to demyelination.
Glia.
2022 02; 70(2):321-336. doi:
10.1002/glia.24108. [PMID: 34687571] - Zixuan Gao, Chu Zhang, Zhaowei Feng, Ziqi Liu, Yaru Yang, Kexin Yang, Lei Chen, Ruiqin Yao. C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis.
Experimental neurology.
2022 02; 348(?):113947. doi:
10.1016/j.expneurol.2021.113947. [PMID: 34902359] - Kota Yamashina, Shinji Yamamoto, Masako Matsumoto, Kensuke Iwasa, Nonoka Takeda, Chikara Haruta, Kei Maruyama, Kuniyoshi Shimizu, Keisuke Yoshikawa. Suppressive Effect of Fruiting Bodies of Medicinal Mushrooms on Demyelination and Motor Dysfunction in a Cuprizone-Induced Multiple Sclerosis Mouse Model.
International journal of medicinal mushrooms.
2022; 24(9):15-24. doi:
10.1615/intjmedmushrooms.2022044840. [PMID: 36004706] - Zhao Meng-Ru, Sui Ruo-Xuan, Yu Ming-Yang, Tian Tong, Zhang Lei, Yang Ying-Bo, Xiao Bao-Guo. Antagonizing astrocytic platelet activating factor receptor-neuroinflammation for total flavone of epimedium in response to cuprizone demyelination.
International immunopharmacology.
2021 Dec; 101(Pt A):108181. doi:
10.1016/j.intimp.2021.108181. [PMID: 34607229] - Huitong Song, Holly P McEwen, Thomas Duncan, Jun Yup Lee, Jonathan D Teo, Anthony S Don. Sphingosine kinase 2 is essential for remyelination following cuprizone intoxication.
Glia.
2021 12; 69(12):2863-2881. doi:
10.1002/glia.24074. [PMID: 34399014] - Jun An, Yan He, Jun-Jun Yin, Zhi-Bin Ding, Qing-Xian Han, Yang-Yang Chen, Qing Wang, Zhi Chai, Jie-Zhong Yu, Li-Juan Song, Bao-Guo Xiao, Cun-Gen Ma. Temporal and spatial evolution of various functional neurons during demyelination induced by cuprizone.
Journal of neurophysiology.
2021 11; 126(5):1756-1771. doi:
10.1152/jn.00224.2021. [PMID: 34669500] - Ni Ye, Jennifer Cruz, Xiaoyan Peng, Jinyun Ma, Aiming Zhang, Xiaodong Cheng. Remyelination is enhanced by Astragalus polysaccharides through inducing the differentiation of oligodendrocytes from neural stem cells in cuprizone model of demyelination.
Brain research.
2021 07; 1763(?):147459. doi:
10.1016/j.brainres.2021.147459. [PMID: 33794147] - Saeideh Gharekhani Digehsara, Niloofar Name, Nasrin Sartipnia, Elahe Karim, Saba Taheri, Maryam Tajabadi Ebrahimi, Javad Arasteh. Analysis of inflammasomes and CYP27B1 genes in cuprizone demyelinated C57BL/6 mice and evaluation of Th1 and Th2 patterns after oral administration of Lactobacillus casei strain T2 (IBRC-M10783).
Microbial pathogenesis.
2021 Jun; 155(?):104931. doi:
10.1016/j.micpath.2021.104931. [PMID: 33930419] - Zhi-Bin Ding, Qing-Xian Han, Qing Wang, Li-Juan Song, Guo-Guo Chu, Min-Fang Guo, Zhi Chai, Jie-Zhong Yu, Bao-Guo Xiao, Xin-Yi Li, Cun-Gen Ma. Fasudil enhances the phagocytosis of myelin debris and the expression of neurotrophic factors in cuprizone-induced demyelinating mice.
Neuroscience letters.
2021 05; 753(?):135880. doi:
10.1016/j.neulet.2021.135880. [PMID: 33838256] - Laetitia Pouzol, Nadège Baumlin, Anna Sassi, Mélanie Tunis, Julia Marrie, Enrico Vezzali, Hervé Farine, Ulrich Mentzel, Marianne M Martinic. ACT-1004-1239, a first-in-class CXCR7 antagonist with both immunomodulatory and promyelinating effects for the treatment of inflammatory demyelinating diseases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 03; 35(3):e21431. doi:
10.1096/fj.202002465r. [PMID: 33595155] - Behnam Khalilian, Soheila Madadi, Nima Fattahi, Beheshteh Abouhamzeh. Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis.
Journal of molecular histology.
2021 Feb; 52(1):125-134. doi:
10.1007/s10735-020-09929-x. [PMID: 33245472] - Yan He, Jun An, Jun-Jun Yin, Qiang Miao, Ruo-Xuan Sui, Qing-Xian Han, Zhi-Bin Ding, Jian-Jun Huang, Cun-Gen Ma, Bao-Guo Xiao. Ethyl Pyruvate-Derived Transdifferentiation of Astrocytes to Oligodendrogenesis in Cuprizone-Induced Demyelinating Model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2021 01; 18(1):488-502. doi:
10.1007/s13311-020-00947-x. [PMID: 33140235] - Priya Jhelum, Eva Santos-Nogueira, Wulin Teo, Alice Haumont, Isadora Lenoël, Peter K Stys, Samuel David. Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2020 11; 40(48):9327-9341. doi:
10.1523/jneurosci.1749-20.2020. [PMID: 33106352] - Cui-Hong Zhou, Shan-Shan Xue, Fen Xue, Ling Liu, Jun-Chang Liu, Quan-Rui Ma, Jun-Hui Qin, Qing-Rong Tan, Hua-Ning Wang, Zheng-Wu Peng. The impact of quetiapine on the brain lipidome in a cuprizone-induced mouse model of schizophrenia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Nov; 131(?):110707. doi:
10.1016/j.biopha.2020.110707. [PMID: 32905942] - Sha-Sha Wang, Hao-Zhi Bi, Shi-Feng Chu, Yi-Xiao Dong, Wen-Bin He, Ya-Juan Tian, Ying-Da Zang, Dong-Ming Zhang, Zhao Zhang, Nai-Hong Chen. CZ-7, a new derivative of Claulansine F, promotes remyelination induced by cuprizone by enhancing myelin debris clearance.
Brain research bulletin.
2020 06; 159(?):67-78. doi:
10.1016/j.brainresbull.2020.03.017. [PMID: 32289743] - Fang Xu, Xiaojuan Zhang, Xiaoqin Liu, Wei Zhang, Xiaolan She, Xiuhua Xue, Jiang Bian, Minfang Guo, Jiezhong Yu, Cungen Ma, Yanhua Li. [Dihydrotanshinone I (DHTS1) attenuates cuprizone-induced demyelination via regulating microglia polarization].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2020 May; 36(5):404-412. doi:
". [PMID: 32696752] - Jun An, Jun-Jun Yin, Yan He, Ruo-Xuan Sui, Qiang Miao, Qing Wang, Jie-Zhong Yu, Jing-Wen Yu, Fu-Dong Shi, Cun-Gen Ma, Bao-Guo Xiao. Temporal and Spatial Dynamics of Astroglial Reaction and Immune Response in Cuprizone-Induced Demyelination.
Neurotoxicity research.
2020 Mar; 37(3):587-601. doi:
10.1007/s12640-019-00129-4. [PMID: 31721051] - Yan He, Jun An, Jun-Jun Yin, Ruo-Xuan Sui, Qiang Miao, Zhi-Bin Ding, Qing-Xian Han, Qing Wang, Cun-Gen Ma, Bao-Guo Xiao. Ethyl pyruvate enhances spontaneous remyelination by targeting microglia phagocytosis.
International immunopharmacology.
2019 Dec; 77(?):105929. doi:
10.1016/j.intimp.2019.105929. [PMID: 31677497] - Qin-Ying Li, Qiang Miao, Ruo-Xuan Sui, Liang Cao, Cun-Gen Ma, Bao-Guo Xiao, Wei Xiao, Wen-Bo Yu. Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis.
International immunopharmacology.
2019 Oct; 75(?):105819. doi:
10.1016/j.intimp.2019.105819. [PMID: 31421546] - Qing Wang, Jing Wang, Zhichao Yang, Ruoxuan Sui, Qiang Miao, Yanhua Li, Jiezhong Yu, Chunyun Liu, Guangxian Zhang, Baoguo Xiao, Cungen Ma. Therapeutic effect of oligomeric proanthocyanidin in cuprizone-induced demyelination.
Experimental physiology.
2019 06; 104(6):876-886. doi:
10.1113/ep087480. [PMID: 30811744] - Edina Pandur, Ramóna Pap, Edit Varga, Gergely Jánosa, Sámuel Komoly, Judit Fórizs, Katalin Sipos. Relationship of Iron Metabolism and Short-Term Cuprizone Treatment of C57BL/6 Mice.
International journal of molecular sciences.
2019 May; 20(9):. doi:
10.3390/ijms20092257. [PMID: 31067791] - Dnyandev G Gadhave, Chandrakant R Kokare. Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies.
Drug development and industrial pharmacy.
2019 May; 45(5):839-851. doi:
10.1080/03639045.2019.1576724. [PMID: 30702966] - Marina Y Khodanovich, Anna O Pishchelko, Valentina Y Glazacheva, Edgar S Pan, Elena P Krutenkova, Vladimir B Trusov, Vasily L Yarnykh. Plant polyprenols reduce demyelination and recover impaired oligodendrogenesis and neurogenesis in the cuprizone murine model of multiple sclerosis.
Phytotherapy research : PTR.
2019 May; 33(5):1363-1373. doi:
10.1002/ptr.6327. [PMID: 30864249] - Jing Wang, Ruo-Xuan Sui, Qiang Miao, Qing Wang, Li-Juan Song, Jie-Zhong Yu, Yan-Hua Li, Bao-Guo Xiao, Cun-Gen Ma. Hydroxyfasudil alleviates demyelination through the inhibition of MOG antibody and microglia activation in cuprizone mouse model.
Clinical immunology (Orlando, Fla.).
2019 04; 201(?):35-47. doi:
10.1016/j.clim.2019.01.006. [PMID: 30660624] - Rajanikanth J Maganti, Xiaoping L Hronowski, Robert W Dunstan, Brian T Wipke, Xueli Zhang, Luke Jandreski, Stefan Hamann, Peter Juhasz. Defining Changes in the Spatial Distribution and Composition of Brain Lipids in the Shiverer and Cuprizone Mouse Models of Myelin Disease.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2019 03; 67(3):203-219. doi:
10.1369/0022155418815860. [PMID: 30501365] - Ruo-Xuan Sui, Qiang Miao, Jing Wang, Qing Wang, Li-Juan Song, Jing-Wen Yu, Liang Cao, Wei Xiao, Bao-Guo Xiao, Cun-Gen Ma. Protective and therapeutic role of Bilobalide in cuprizone-induced demyelination.
International immunopharmacology.
2019 Jan; 66(?):69-81. doi:
10.1016/j.intimp.2018.09.041. [PMID: 30445309] - Hamid Zahednasab, Masoumeh Firouzi, Sussan Kaboudanian-Ardestani, Zahra Mojallal-Tabatabaei, Sajad Karampour, Hossein Keyvani. The protective effect of rifampicin on behavioral deficits, biochemical, and neuropathological changes in a cuprizone model of demyelination.
Cytokine.
2019 01; 113(?):417-426. doi:
10.1016/j.cyto.2018.10.016. [PMID: 30539784] - E Varga, E Pandur, H Abrahám, A Horváth, P Ács, S Komoly, A Miseta, K Sipos. Cuprizone Administration Alters the Iron Metabolism in the Mouse Model of Multiple Sclerosis.
Cellular and molecular neurobiology.
2018 Jul; 38(5):1081-1097. doi:
10.1007/s10571-018-0578-5. [PMID: 29464444] - G O Omotoso, R M Kolo, T Afolabi, R Jaji-Sulaimon, I T Gbadamosi. Moringa oleifera Ameliorates Histomorphological Changes Associated with Cuprizone Neurotoxicity in the Hippocampal Cornu ammonis (CA) 3 Region.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2018 Jun; 33(1):95-99. doi:
". [PMID: 30091739] - Marc-Olivier Trépanier, Kayla D Hildebrand, Stella D Nyamoya, Sandra Amor, Richard P Bazinet, Markus Kipp. Phosphatidylcholine 36:1 concentration decreases along with demyelination in the cuprizone animal model and in post-mortem multiple sclerosis brain tissue.
Journal of neurochemistry.
2018 06; 145(6):504-515. doi:
10.1111/jnc.14335. [PMID: 29574981] - Attila Ozsvár, Róbert Szipőcs, Zoltán Ozsvár, Judith Baka, Pál Barzó, Gábor Tamás, Gábor Molnár. Quantitative analysis of lipid debris accumulation caused by cuprizone induced myelin degradation in different CNS areas.
Brain research bulletin.
2018 03; 137(?):277-284. doi:
10.1016/j.brainresbull.2018.01.003. [PMID: 29325992] - Yoshibumi Shimizu, Masaki Ishikawa, Mari Gotoh, Keiko Fukasawa, Shinji Yamamoto, Kensuke Iwasa, Keisuke Yoshikawa, Kimiko Murakami-Murofushi. Quantitative determination of cyclic phosphatidic acid and its carba analog in mouse organs and plasma using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Feb; 1076(?):15-21. doi:
10.1016/j.jchromb.2018.01.002. [PMID: 29353671] - Nellie A Martin, Arkadiusz Nawrocki, Viktor Molnar, Maria L Elkjaer, Eva K Thygesen, Miklos Palkovits, Peter Acs, Tobias Sejbaek, Helle H Nielsen, Zoltan Hegedus, Finn Sellebjerg, Tihamer Molnar, Eudes G V Barbosa, Nicolas Alcaraz, Ferenc Gallyas, Asa F Svenningsen, Jan Baumbach, Hans Lassmann, Martin R Larsen, Zsolt Illes. Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes.
PloS one.
2018; 13(8):e0202530. doi:
10.1371/journal.pone.0202530. [PMID: 30114292] - Reiji Yamazaki, Hiroko Baba, Yoshihide Yamaguchi. Unconventional Myosin ID is Involved in Remyelination After Cuprizone-Induced Demyelination.
Neurochemical research.
2018 Jan; 43(1):195-204. doi:
10.1007/s11064-017-2413-7. [PMID: 28986688] - Hao Yu, Mingfeng Wu, Geng Lu, Tingting Cao, Nan Chen, Yijia Zhang, Zhiguo Jiang, Hongbin Fan, Ruiqin Yao. Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination.
Brain research.
2018 Jan; 1678(?):75-84. doi:
10.1016/j.brainres.2017.09.034. [PMID: 29038005] - Taichi Nomura, Yoshio Bando, Hua You, Tatsuhide Tanaka, Shigetaka Yoshida. Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia.
Neurochemical research.
2017 Dec; 42(12):3525-3536. doi:
10.1007/s11064-017-2400-z. [PMID: 28929408] - Jian Zheng, Weijun Ding, Baoming Li, Youjun Yang. RETRACTED: Enriched environment promotes remyelination and motor function recovery through modulation of HDAC1/2 in mice.
Neuroscience letters.
2017 08; 655(?):121-130. doi:
10.1016/j.neulet.2017.06.039. [PMID: 28648457] - Heba R Ghaiad, Mohammed M Nooh, Maha M El-Sawalhi, Amira A Shaheen. Resveratrol Promotes Remyelination in Cuprizone Model of Multiple Sclerosis: Biochemical and Histological Study.
Molecular neurobiology.
2017 07; 54(5):3219-3229. doi:
10.1007/s12035-016-9891-5. [PMID: 27067589] - Elise Siegert, Friedemann Paul, Michael Rothe, Karsten H Weylandt. The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice.
BMC neuroscience.
2017 01; 18(1):19. doi:
10.1186/s12868-016-0312-5. [PMID: 28114887] - Ana Karolina Santana Nunes, Catarina Rapôso, Sura Wanessa Santos Rocha, Karla Patrícia de Sousa Barbosa, Rayana Leal de Almeida Luna, Maria Alice da Cruz-Höfling, Christina Alves Peixoto. Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model.
Brain research.
2015 Nov; 1627(?):119-33. doi:
10.1016/j.brainres.2015.09.008. [PMID: 26404052] - Sofia Anastasiadou, Sophie Liebenehm, Daniela Sinske, Christopher Meyer zu Reckendorf, Barbara Moepps, Alfred Nordheim, Bernd Knöll. Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model.
Glia.
2015 Jun; 63(6):958-76. doi:
10.1002/glia.22794. [PMID: 25639799] - Pietro Luigi Poliani, Yaming Wang, Elena Fontana, Michelle L Robinette, Yoshinori Yamanishi, Susan Gilfillan, Marco Colonna. TREM2 sustains microglial expansion during aging and response to demyelination.
The Journal of clinical investigation.
2015 May; 125(5):2161-70. doi:
10.1172/jci77983. [PMID: 25893602] - Mengru Liang, Yongyan Chen, Li Zhang, Lin Li, Guangliang Chen, Linlin Yin. Epimedium flavonoids ameliorate neuropathological changes and increases IGF-1 expression in C57BL/6 mice exposed to cuprizone.
Neurochemical research.
2015 Mar; 40(3):492-500. doi:
10.1007/s11064-014-1490-0. [PMID: 25663299] - Izabella Solti, Krisztian Kvell, Gergely Talaber, Sara Veto, Peter Acs, Ferenc Gallyas, Zsolt Illes, Katalin Fekete, Petra Zalan, Arpad Szanto, Zita Bognar. Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis.
PloS one.
2015; 10(6):e0129217. doi:
10.1371/journal.pone.0129217. [PMID: 26053248] - Iraj Ragerdi Kashani, Zahra Rajabi, Mohammad Akbari, Gholamreza Hassanzadeh, Alireza Mohseni, Mohammadtaha Kouchakinejad Eramsadati, Kheirollah Rafiee, Cordian Beyer, Markus Kipp, Adib Zendedel. Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis.
Experimental brain research.
2014 Sep; 232(9):2835-46. doi:
10.1007/s00221-014-3946-5. [PMID: 24798398] - Yinghua Xuan, Gen Yan, Hui Peng, Renhua Wu, Haiyun Xu. Concurrent changes in ¹H MRS metabolites and antioxidant enzymes in the brain of C57BL/6 mouse short-termly exposed to cuprizone: possible implications for schizophrenia.
Neurochemistry international.
2014 Apr; 69(?):20-7. doi:
10.1016/j.neuint.2014.02.004. [PMID: 24613425] - Haiyun Xu, Hong-Ju Yang, Xin-Min Li. Differential effects of antipsychotics on the development of rat oligodendrocyte precursor cells exposed to cuprizone.
European archives of psychiatry and clinical neuroscience.
2014 Mar; 264(2):121-9. doi:
10.1007/s00406-013-0414-3. [PMID: 23728937] - Johannes Goldberg, Moritz Daniel, Yasemin van Heuvel, Marion Victor, Cordian Beyer, Tim Clarner, Markus Kipp. Short-term cuprizone feeding induces selective amino acid deprivation with concomitant activation of an integrated stress response in oligodendrocytes.
Cellular and molecular neurobiology.
2013 Nov; 33(8):1087-98. doi:
10.1007/s10571-013-9975-y. [PMID: 23979168] - L P Chen, Z F Li, M Ping, R Li, J Liu, X H Xie, X J Song, L Guo. Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model.
Neuroscience.
2012 Sep; 221(?):96-107. doi:
10.1016/j.neuroscience.2012.06.063. [PMID: 22771621] - V Millet, M Marder, L A Pasquini. Adult CNP::EGFP transgenic mouse shows pronounced hypomyelination and an increased vulnerability to cuprizone-induced demyelination.
Experimental neurology.
2012 Jan; 233(1):490-504. doi:
10.1016/j.expneurol.2011.11.028. [PMID: 22155618] - M Kipp, S Gingele, F Pott, T Clarner, P van der Valk, B Denecke, L Gan, V Siffrin, F Zipp, W Dreher, W Baumgartner, S Pfeifenbring, R Godbout, S Amor, C Beyer. BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions.
Brain, behavior, and immunity.
2011 Nov; 25(8):1554-68. doi:
10.1016/j.bbi.2011.05.003. [PMID: 21620951] - M Kipp, T Clarner, S Gingele, F Pott, S Amor, P van der Valk, C Beyer. Brain lipid binding protein (FABP7) as modulator of astrocyte function.
Physiological research.
2011; 60(Suppl 1):S49-60. doi:
10.33549/physiolres.932168. [PMID: 21777034] - Vladislav Tsiperson, Xiaosong Li, Gary J Schwartz, Cedric S Raine, Bridget Shafit-Zagardo. GAS6 enhances repair following cuprizone-induced demyelination.
PloS one.
2010 Dec; 5(12):e15748. doi:
10.1371/journal.pone.0015748. [PMID: 21203420] - Lorelei C Taylor, Kasturi Puranam, Wendy Gilmore, Jenny P-Y Ting, Glenn K Matsushima. 17beta-estradiol protects male mice from cuprizone-induced demyelination and oligodendrocyte loss.
Neurobiology of disease.
2010 Aug; 39(2):127-37. doi:
10.1016/j.nbd.2010.03.016. [PMID: 20347981] - Øivind Torkildsen, Linn Anne Brunborg, Frits Thorsen, Sverre Jarl Mørk, Martin Stangel, Kjell-Morten Myhr, Lars Bø. Effects of dietary intervention on MRI activity, de- and remyelination in the cuprizone model for demyelination.
Experimental neurology.
2009 Jan; 215(1):160-6. doi:
10.1016/j.expneurol.2008.09.026. [PMID: 19000674] - Heather A Iocca, Sheila R Plant, Ying Wang, Laura Runkel, Brian P O'Connor, Emma T Lundsmith, Kyungmin Hahm, Hendrik W van Deventer, Linda C Burkly, Jenny P-Y Ting. TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model.
Journal of neuroimmunology.
2008 Feb; 194(1-2):97-106. doi:
10.1016/j.jneuroim.2007.12.003. [PMID: 18207576] - Si-Young Song, Chieko Kato, Eijiro Adachi, Ayako Moriya-Sato, Masayo Inagawa-Ogashiwa, Rieko Umeda, Naohiro Hashimoto. Expression of an acyl-CoA synthetase, lipidosin, in astrocytes of the murine brain and its up-regulation during remyelination following cuprizone-induced demyelination.
Journal of neuroscience research.
2007 Dec; 85(16):3586-97. doi:
10.1002/jnr.21456. [PMID: 17722065] - Daniella Urbach-Ross, Alexander W Kusnecov. Effects of acute and repeated exposure to lipopolysaccharide on cytokine and corticosterone production during remyelination.
Brain, behavior, and immunity.
2007 Oct; 21(7):962-74. doi:
10.1016/j.bbi.2007.03.010. [PMID: 17490854] - Sheila R Plant, Heather A Iocca, Ying Wang, J Cameron Thrash, Brian P O'Connor, Heather A Arnett, Yang-Xin Fu, Monica J Carson, Jenny P-Y Ting. Lymphotoxin beta receptor (Lt betaR): dual roles in demyelination and remyelination and successful therapeutic intervention using Lt betaR-Ig protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007 Jul; 27(28):7429-37. doi:
10.1523/jneurosci.1307-07.2007. [PMID: 17626203] - Andréanne Bédard, Pierrot Tremblay, Ariel Chernomoretz, Luc Vallières. Identification of genes preferentially expressed by microglia and upregulated during cuprizone-induced inflammation.
Glia.
2007 Jun; 55(8):777-89. doi:
10.1002/glia.20477. [PMID: 17285589] - Sheila R Plant, Ying Wang, Sophie Vasseur, J Cameron Thrash, Eileen J McMahon, Daniel T Bergstralh, Heather A Arnett, Stephen D Miller, Monica J Carson, Juan L Iovanna, Jenny P-Y Ting. Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues.
Glia.
2006 Apr; 53(5):529-37. doi:
10.1002/glia.20297. [PMID: 16374777] - P Zatta, M Raso, P Zambenedetti, W Wittkowski, L Messori, F Piccioli, P L Mauri, M Beltramini. Copper and zinc dismetabolism in the mouse brain upon chronic cuprizone treatment.
Cellular and molecular life sciences : CMLS.
2005 Jul; 62(13):1502-13. doi:
10.1007/s00018-005-5073-8. [PMID: 15971002] - Sheila R Plant, Heather A Arnett, Jenny P-Y Ting. Astroglial-derived lymphotoxin-alpha exacerbates inflammation and demyelination, but not remyelination.
Glia.
2005 Jan; 49(1):1-14. doi:
10.1002/glia.20089. [PMID: 15382206] - Heather A Arnett, Stephen P J Fancy, John A Alberta, Chao Zhao, Sheila R Plant, Sovann Kaing, Cedric S Raine, David H Rowitch, Robin J M Franklin, Charles D Stiles. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.
Science (New York, N.Y.).
2004 Dec; 306(5704):2111-5. doi:
10.1126/science.1103709. [PMID: 15604411] - H Jurevics, J Hostettler, E D Muse, D W Sammond, G K Matsushima, A D Toews, P Morell. Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain.
Journal of neurochemistry.
2001 May; 77(4):1067-76. doi:
10.1046/j.1471-4159.2001.00310.x. [PMID: 11359872] - R M Hysmith, P J Boor. Purification of benzylamine oxidase from cultured porcine aortic smooth muscle cells.
Biochemistry and cell biology = Biochimie et biologie cellulaire.
1988 Aug; 66(8):821-9. doi:
10.1139/o88-094. [PMID: 2848544] - D A Bakker, S K Ludwin. Blood-brain barrier permeability during Cuprizone-induced demyelination. Implications for the pathogenesis of immune-mediated demyelinating diseases.
Journal of the neurological sciences.
1987 Apr; 78(2):125-37. doi:
10.1016/0022-510x(87)90055-4. [PMID: 3553434] - T Wakabayashi, M Asano, K Ishikawa, H Kishimoto. Mechanism of the formation of megamitochondria by copper-chelating agents. V. Further studies on isolated megamitochondria.
Acta pathologica japonica.
1978 Mar; 28(2):215-23. doi:
10.1111/j.1440-1827.1978.tb00533.x. [PMID: 209665] - T Wakabayashi, M Asano, C Kurono. Mechanism of the formation of megamitochondria induced by copper-chelating agents. II. Isolation and some properties of megamitochondria from the cuprizone-treated mouse liver.
Acta pathologica japonica.
1975 Jan; 25(1):39-49. doi:
10.1111/j.1440-1827.1975.tb00148.x. [PMID: 166553] - T Wakabayashi, M Asano, C Kurono. Mechanism of the formation of megamitochondria induced by copper-chelating agents. I. On the formation process of megamitochondria in cuprizone-treated mouse liver.
Acta pathologica japonica.
1975 Jan; 25(1):15-37. doi:
10.1111/j.1440-1827.1975.tb00147.x. [PMID: 1136774]