6-Azauracil (BioDeep_00001871889)

   


代谢物信息卡片


6-Azauracil

化学式: C3H3N3O2 (113.0225)
中文名称: 6-氮尿嘧啶, 6-氮杂尿嘧啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NNC(=O)NC1=O
InChI: InChI=1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)

描述信息

D009676 - Noxae > D000963 - Antimetabolites

同义名列表

3 个代谢物同义名

6-Azauracil; 6-Azauracil; 6-Azauracil



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Allen J Duplantier, Mark A Dombroski, Chakrapani Subramanyam, Aimee M Beaulieu, Shang-Poa Chang, Christopher A Gabel, Crystal Jordan, Amit S Kalgutkar, Kenneth G Kraus, Jeff M Labasi, Christopher Mussari, David G Perregaux, Rick Shepard, Timothy J Taylor, Kristen A Trevena, Carrie Whitney-Pickett, Kwansik Yoon. Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535. Bioorganic & medicinal chemistry letters. 2011 Jun; 21(12):3708-11. doi: 10.1016/j.bmcl.2011.04.077. [PMID: 21565499]
  • Yongxiu Liu, Regina Geyer, Martijn van Zanten, Annaick Carles, Yong Li, Anja Hörold, Steven van Nocker, Wim J J Soppe. Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a role for the polymerase associated factor 1 complex in seed dormancy. PloS one. 2011; 6(7):e22241. doi: 10.1371/journal.pone.0022241. [PMID: 21799800]
  • Ma Carmen García-López, Ma Carmen Mirón-García, Ana I Garrido-Godino, Carlos Mingorance, Francisco Navarro. Overexpression of SNG1 causes 6-azauracil resistance in Saccharomyces cerevisiae. Current genetics. 2010 Jun; 56(3):251-63. doi: 10.1007/s00294-010-0297-z. [PMID: 20424846]
  • Richard J Nowak, Gregory D Cuny, Sungwoon Choi, Peter T Lansbury, Soumya S Ray. Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods. Journal of medicinal chemistry. 2010 Apr; 53(7):2709-18. doi: 10.1021/jm901062p. [PMID: 20232802]
  • Jonathan M Palmer, Robyn M Perrin, Taylor R T Dagenais, Nancy P Keller. H3K9 methylation regulates growth and development in Aspergillus fumigatus. Eukaryotic cell. 2008 Dec; 7(12):2052-60. doi: 10.1128/ec.00224-08. [PMID: 18849468]
  • I S Karpova, N V Korets'ka, L H Pal'chykovs'ka, V V Nehruts'ka. [Lectins from Sambucus nigra L inflorescences: isolation and investigation of biological activity using procaryotic test-systems]. Ukrains'kyi biokhimichnyi zhurnal (1999 ). 2007 Sep; 79(5):145-52. doi: ". [PMID: 18357788]
  • J L Betz, M Chang, T M Washburn, S E Porter, C L Mueller, J A Jaehning. Phenotypic analysis of Paf1/RNA polymerase II complex mutations reveals connections to cell cycle regulation, protein synthesis, and lipid and nucleic acid metabolism. Molecular genetics and genomics : MGG. 2002 Oct; 268(2):272-85. doi: 10.1007/s00438-002-0752-8. [PMID: 12395202]
  • N Kobayashi, F Hariguchi, T Okamoto, Y Okada, T Hayashi, T Matsuno. Characteristics of the anticoccidial activity of 6-azauracil. The Journal of veterinary medical science. 1996 Feb; 58(2):115-20. doi: 10.1292/jvms.58.115. [PMID: 8672580]
  • N Kobayashi, F Hariguchi, T Okamoto, Y Okada, T Hayashi, T Matsuno. Antagonistic effect of nucleic acid precursors on the anticoccidial activity of 6-azauracil. The Journal of veterinary medical science. 1996 Feb; 58(2):121-7. doi: 10.1292/jvms.58.121. [PMID: 8672581]
  • N Tamaki, S Fujimoto, C Mizota, M Kaneko, M Kikugawa. Inhibitory effect of 6-azauracil on beta-alanine metabolism in rat. Journal of nutritional science and vitaminology. 1989 Oct; 35(5):451-61. doi: 10.3177/jnsv.35.451. [PMID: 2632679]
  • A el-Tarras, R Braun, E Stenz, G Schuster. Mutagenicity of antiviral substances of nucleobase analogue type in Salmonella typhimurium employing metabolic activation by mouse liver homogenate or cell-free plant extracts. Zentralblatt fur Mikrobiologie. 1989; 144(3):191-6. doi: ". [PMID: 2672681]
  • H Bräunlich. Postnatal development and inducibility of renal tubular transport processes in rats. The International journal of pediatric nephrology. 1985 Jul; 6(3):177-82. doi: NULL. [PMID: 3840464]
  • C Fleck, H Bräunlich. Influence of inhibitors of protein synthesis on restitution of tubular transport capacity after unilateral nephrectomy. Experimental pathology. 1983; 23(4):243-51. doi: 10.1016/s0232-1513(83)80064-4. [PMID: 6688223]
  • M W Miller, B L Mylari, H L Howes, S K Figdor, M J Lynch, J E Lynch, S K Gupta, L R Chappel, R C Koch. Anticoccidial derivatives of 6-azauracil. 4. A 1000-fold enhancement of potency by phenyl sulfide and phenyl sulfone side chains. Journal of medicinal chemistry. 1981 Nov; 24(11):1337-42. doi: 10.1021/jm00143a015. [PMID: 6895527]
  • H Bräunlich. Influence of protein biosynthesis inhibitors on stimulated renal p-aminohippurate excretion in rats. Acta physiologica Academiae Scientiarum Hungaricae. 1981; 58(4):321-6. doi: NULL. [PMID: 6897148]
  • M W Miller, B L Mylari, H L Howes, S K Figdor, M J Lynch, J E Lynch, R C Koch. Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents. Journal of medicinal chemistry. 1980 Oct; 23(10):1083-7. doi: 10.1021/jm00184a005. [PMID: 6893468]
  • M Hropot, F Sörgel, B von Kerékjártó, H J Lang, R Muschaweck. Pharmacological effects of 1,3,5-triazines and their excretion characteristics in the rat. Advances in experimental medicine and biology. 1980; 122A(?):269-76. doi: 10.1007/978-1-4615-9140-5_44. [PMID: 6893515]
  • M W Miller, B L Mylari, H L Howes, J E Lynch, M J Lynch, R C Koch. Anticoccidial derivatives of 6-azauracil. 2. High potency and long plasma life of N1-phenyl structures. Journal of medicinal chemistry. 1979 Dec; 22(12):1483-7. doi: 10.1021/jm00198a010. [PMID: 583429]
  • O SMAHEL, J GRAFNETTEROVA, O SCHUECK, K DVORACEK, J KOENIG. [RENAL EXCRETION OF 6-AZAURACILRIBOSIDES IN MAN]. Casopis lekaru ceskych. 1965 Mar; 104(?):308-11. doi: NULL. [PMID: 14339678]
  • J GRAFNETTEROVA, J KOENIG, O SMAHEL, K DVORACEK, O SCHUECK. [RENAL EXCRETION OF 6-AZAURACIL RIBOSIDE IN MAN]. Casopis lekaru ceskych. 1964 Mar; 103(?):278-9. doi: NULL. [PMID: 14138938]
  • W KLINGER. [STUDIES ON THE MECHANISM OF ENZYME INDUCTION IN RATS AND MICE. I. THE EFFECTS OF 6-MERCAPTOPURINE AND RIBOAZAURACIL ON THE INCREASE IN L-ASCORBIC ACID SECRETION AND THE REDUCTION OF HEXOBARBITAL SLEEPING TIME AFTER BARBITAL ADMINISTRATION]. Acta biologica et medica Germanica. 1964; 13(?):890-904. doi: NULL. [PMID: 14335767]
  • V HABERMANN. Elimination by the urine of orotic acid and orotidine in man after application of 6-azauracil. Biochimica et biophysica acta. 1960 Sep; 43(?):137-8. doi: 10.1016/0006-3002(60)90420-0. [PMID: 13710251]