Idarubicin hydrochloride (BioDeep_00001871650)
代谢物信息卡片
Idarubicin (hydrochloride)
化学式: C26H27NO9.HCl (533.1453)
中文名称: 盐酸依达比星
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl
InChI: /m0./s1
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D004791 - Enzyme Inhibitors
Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:31686
- KEGGdrug: D01747
- PubChem: 636362
- ChEMBL: CHEMBL1200976
- MeSH: Idarubicin
- CAS: 57852-57-0
- MetaboLights: MTBLC31686
- medchemexpress: HY-17381
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jie Ding, Yang Su, Yinglu Ruan, Nan Li, Qianchao Meng, Jiabang Yang, Li Chen, Chi Liu. Clinical features and outcomes of patients with acute myeloid leukemia: the single-center experience of 668 patients in China.
Hematology (Amsterdam, Netherlands).
2024 Dec; 29(1):2310960. doi:
10.1080/16078454.2024.2310960. [PMID: 38323781] - Mohammad Mehmandoust, Pouran Pourhakkak, Gizem Tiris, Hassan Karimi-Maleh, Nevin Erk. A reusable and sensitive electrochemical sensor for determination of idarubicin in environmental and biological samples based on NiFe2O4 nanospheres anchored N-doped graphene quantum dots composite; an electrochemical and molecular docking investigation.
Environmental research.
2022 Sep; 212(Pt B):113264. doi:
10.1016/j.envres.2022.113264. [PMID: 35427589] - Dorota Matyszewska, Ewa Nazaruk, Richard A Campbell. Interactions of anticancer drugs doxorubicin and idarubicin with lipid monolayers: New insight into the composition, structure and morphology.
Journal of colloid and interface science.
2021 Jan; 581(Pt A):403-416. doi:
10.1016/j.jcis.2020.07.092. [PMID: 32771749] - Colin P Bergstrom, Saurabh Dahiya, Weina Chen, Cheng Cheng Zhang, Hong Zhu, Jingsheng Yan, Yazan Madanat, Prapti Patel, Madhuri Vusirkala, Praveen Ramakrishnan, Syed Rizvi, Stephen Chung, Farrukh Awan, Larry D Anderson, Robert Collins, Ankit Kansagra. The association of leukocyte immunoglobulin-like receptor subfamily B-4 expression in acute myeloid leukemia and central nervous system involvement.
Leukemia research.
2021 01; 100(?):106480. doi:
10.1016/j.leukres.2020.106480. [PMID: 33285315] - Olga Maliszewska, Natalia Treder, IIona Olędzka, Piotr Kowalski, Natalia Miękus, Tomasz Bączek, Wojciech Rodzaj, Ewa Bień, Małgorzata Anna Krawczyk, Alina Plenis. Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: An Application in Drug Monitoring.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245799. [PMID: 33316898] - Balasubramani Gl, Rinky Rajput, Manish Gupta, Pradeep Dahiya, Jitendra K Thakur, Rakesh Bhatnagar, Abhinav Grover. Structure-based drug repurposing to inhibit the DNA gyrase of Mycobacterium tuberculosis.
The Biochemical journal.
2020 11; 477(21):4167-4190. doi:
10.1042/bcj20200462. [PMID: 33030198] - Xinping Zhou, Chen Mei, Jin Zhang, Ying Lu, Jianping Lan, Shengyun Lin, Yuefeng Zhang, Yuemin Kuang, Yanling Ren, Liya Ma, Juying Wei, Li Ye, Weilai Xu, Kongfei Li, Chenxi Lu, Jie Jin, Hongyan Tong. Epigenetic priming with decitabine followed by low dose idarubicin and cytarabine in acute myeloid leukemia evolving from myelodysplastic syndromes and higher-risk myelodysplastic syndromes: a prospective multicenter single-arm trial.
Hematological oncology.
2020 Oct; 38(4):531-540. doi:
10.1002/hon.2755. [PMID: 32469434] - Brendan O'Kelly, Padraig McGettrick, Daniel Angelov, Michael Fay, Tara McGinty, Aoife G Cotter, Gerard Sheehan, John S Lambert. Outcome of a patient with refractory Hodgkin lymphoma on pembrolizumab, infected with SARS-CoV-2.
British journal of haematology.
2020 Jul; 190(1):e1-e3. doi:
10.1111/bjh.16798. [PMID: 32379903] - Pengfei She, Shijia Li, Linying Zhou, Zhen Luo, Jinfeng Liao, Lanlan Xu, Xianghai Zeng, Ti Chen, Yaqian Liu, Yong Wu. Insights into idarubicin antimicrobial activity against methicillin-resistant Staphylococcus aureus.
Virulence.
2020 01; 11(1):636-651. doi:
10.1080/21505594.2020.1770493. [PMID: 32423280] - D Amicizia, R T Micale, B M Pennati, F Zangrillo, M Iovine, E Lecini, F Marchini, P L Lai, D Panatto. Burden of typhoid fever and cholera: similarities and differences. Prevention strategies for European travelers to endemic/epidemic areas.
Journal of preventive medicine and hygiene.
2019 Dec; 60(4):E271-E285. doi:
10.15167/2421-4248/jpmh2019.60.4.1333. [PMID: 31967084] - Bin Liang, Na Li, Shuofei Zhang, Aihua Qi, Jianhua Feng, Weiwei Jing, Changcan Shi, Zhaipu Ma, Shenmeng Gao. Idarubicin-loaded methoxy poly(ethylene glycol)-b-poly(l-lactide-co-glycolide) nanoparticles for enhancing cellular uptake and promoting antileukemia activity.
International journal of nanomedicine.
2019; 14(?):543-556. doi:
10.2147/ijn.s190027. [PMID: 30666113] - Sabry M Attia, Ali Y Alshahrani, Mohammed A Al-Hamamah, Mohammed M Attia, Quaiser Saquib, Sheikh F Ahmad, Mushtaq A Ansari, Ahmed Nadeem, Saleh A Bakheet. Dexrazoxane Averts Idarubicin-Evoked Genomic Damage by Regulating Gene Expression Profiling Associated With the DNA Damage-Signaling Pathway in BALB/c Mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 Nov; 160(1):161-172. doi:
10.1093/toxsci/kfx161. [PMID: 28973540] - Madita Uffmann, Mareike Rasche, Martin Zimmermann, Christine von Neuhoff, Ursula Creutzig, Michael Dworzak, Lenie Scheffers, Henrik Hasle, C Michel Zwaan, Dirk Reinhardt, Jan-Henning Klusmann. Therapy reduction in patients with Down syndrome and myeloid leukemia: the international ML-DS 2006 trial.
Blood.
2017 06; 129(25):3314-3321. doi:
10.1182/blood-2017-01-765057. [PMID: 28400376] - Charlotte K Brierley, Toby A Eyre. Acute monoblastic leukemia presenting with striking periorbital and periauricular infiltration.
Blood.
2017 06; 129(25):3396. doi:
10.1182/blood-2017-03-765776. [PMID: 28642361] - Kim Timmermans, Guus P Leijte, Matthijs Kox, Gert Jan Scheffer, Nicole M A Blijlevens, Peter P Pickkers. Release of Danger-Associated Molecular Patterns following Chemotherapy Does Not Induce Immunoparalysis in Leukemia Patients.
Acta haematologica.
2017; 138(1):39-43. doi:
10.1159/000477530. [PMID: 28723682] - Joanna Laskowska, Joanna Lewandowska-Bieniek, Joanna Szczepanek, Jan Styczyński, Andrzej Tretyn. Genomic and transcriptomic profiles and in vitro resistance to mitoxantrone and idarubicin in pediatric acute leukemias.
The journal of gene medicine.
2016 Aug; 18(8):165-79. doi:
10.1002/jgm.2889. [PMID: 27280600] - Linda Koutova, Monika Sterbova, Eva Pazourkova, Sarka Pospisilova, Iveta Svobodova, Ales Horinek, Daniel Lysak, Marie Korabecna. The impact of standard chemotherapy on miRNA signature in plasma in AML patients.
Leukemia research.
2015 Dec; 39(12):1389-95. doi:
10.1016/j.leukres.2015.08.009. [PMID: 26340914] - José Carlos Jaime-Pérez, Xitlaly Judith González-Leal, Mónica Andrea Pinzón-Uresti, Andrés Gómez-De León, Olga G Cantú-Rodríguez, Homero Gutiérrez-Aguirre, David Gómez-Almaguer. Is There Still a Role for Low-Dose All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia in the Arsenic Trioxide Era?.
Clinical lymphoma, myeloma & leukemia.
2015 Dec; 15(12):816-9. doi:
10.1016/j.clml.2015.09.002. [PMID: 26500134] - Trinity Vera, Ralph B D'Agostino, Jennifer H Jordan, Matthew C Whitlock, Giselle C Meléndez, Zanetta S Lamar, Mercedes Porosnicu, Herbert L Bonkovsky, Leslie B Poole, W Gregory Hundley. Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy.
The American journal of cardiology.
2015 Dec; 116(11):1752-5. doi:
10.1016/j.amjcard.2015.08.042. [PMID: 26433273] - Y Z Su, C B Wang, Y Zhou, N T Sun. Effects of changes in serum endostatin and fibroblast growth factor 19 on the chemotherapeutic sensitivity in acute myeloid leukemia patients.
Genetics and molecular research : GMR.
2015 May; 14(2):5181-7. doi:
10.4238/2015.may.18.8. [PMID: 26125711] - A Estella-Hermoso de Mendoza, R Castello-Cros, E Imbuluzqueta, C Cirauqui, R Pippa, M D Odero, M J Blanco-Prieto. Lipid Nanosystems Enhance the Bioavailability and the Therapeutic Efficacy of FTY720 in Acute Myeloid Leukemia.
Journal of biomedical nanotechnology.
2015 Apr; 11(4):691-701. doi:
10.1166/jbn.2015.1944. [PMID: 26310075] - Julia Riganti, Mariana P Caviedes, Ana C Torre, Mariana Guzzi Maqueda, Maria C Baztan Piñero, Victoria I Volonteri, Ricardo L Galimberti. Lingual ulceration associated with retinoic acid syndrome during treatment of acute promyelocytic leukemia.
International journal of dermatology.
2014 Jul; 53(7):912-6. doi:
10.1111/ijd.12316. [PMID: 24602108] - Mathieu Boulin, Héloïse Adam, Boris Guiu, Ludwig Serge Aho, Jean-Pierre Cercueil, Cyrille Di Martino, Philippe Fagnoni, Anne Minello, Jean Louis Jouve, Patrick Hillon, Laurent Bedenne, Côme Lepage. Predictive factors of transarterial chemoembolisation toxicity in unresectable hepatocellular carcinoma.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2014 Apr; 46(4):358-62. doi:
10.1016/j.dld.2013.12.012. [PMID: 24462550] - Dean Smith, Jane Stevens, John Quinn, Jamie Cavenagh, Wendy Ingram, Kwee Yong. Myeloma presenting during pregnancy.
Hematological oncology.
2014 Mar; 32(1):52-5. doi:
10.1002/hon.2088. [PMID: 23996410] - Gianluca Villa, Jose J Zaragoza, Aashish Sharma, Cosimo Chelazzi, Claudio Ronco, A Raffaele De Gaudio. High cutoff membrane to reduce systemic inflammation due to differentiation syndrome: a case report.
Blood purification.
2014; 38(3-4):234-8. doi:
10.1159/000369379. [PMID: 25531172] - Manuel Polaina-Rusillo, Maria del Pilar Pérez-del Barrio, Ana Maria Carrillo-Colmenero, César Ramírez-Tortosa, Josefa Borrego-Hinojosa, Antonio Liébana-Cañada. Renal cortical necrosis secondary to thrombotic microangiopathy in the context of acute promyelocytic leukaemia blast crisis.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2013 Nov; 33(6):845-8. doi:
10.3265/nefrologia.pre2013.sep.12162. [PMID: 24241370] - Amir T Fathi, Hossein Sadrzadeh, Darrell R Borger, Karen K Ballen, Philip C Amrein, Eyal C Attar, Julia Foster, Meghan Burke, Hector U Lopez, Christina R Matulis, Katherine M Edmonds, A John Iafrate, Kimberly S Straley, Katharine E Yen, Samuel Agresta, David P Schenkein, Cedric Hill, Ashkan Emadi, Donna S Neuberg, Richard M Stone, Yi-Bin Chen. Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response.
Blood.
2012 Nov; 120(23):4649-52. doi:
10.1182/blood-2012-06-438267. [PMID: 23074281] - D M Vail, B D Husbands, S G Kamerling, H Simpson, I D Kurzman, A McDonnell. Phase I study to determine the maximal tolerated dose and dose-limiting toxicities of orally administered idarubicin in dogs with lymphoma.
Journal of veterinary internal medicine.
2012 May; 26(3):608-13. doi:
10.1111/j.1939-1676.2012.00896.x. [PMID: 22404399] - Saurabh Wadhwa, Russell J Mumper. Polypeptide conjugates of D-penicillamine and idarubicin for anticancer therapy.
Journal of controlled release : official journal of the Controlled Release Society.
2012 Mar; 158(2):215-23. doi:
10.1016/j.jconrel.2011.10.027. [PMID: 22063001] - Khairallah Alhareth, Christine Vauthier, Claire Gueutin, Gilles Ponchel, Fathi Moussa. HPLC quantification of doxorubicin in plasma and tissues of rats treated with doxorubicin loaded poly(alkylcyanoacrylate) nanoparticles.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Mar; 887-888(?):128-32. doi:
10.1016/j.jchromb.2012.01.025. [PMID: 22341684] - Yongzhong Wang, Li Chen, Yunfei Ding, Weili Yan. Oxidized phospholipid based pH sensitive micelles for delivery of anthracyclines to resistant leukemia cells in vitro.
International journal of pharmaceutics.
2012 Jan; 422(1-2):409-17. doi:
10.1016/j.ijpharm.2011.10.029. [PMID: 22037443] - Yoshiki Tsuchiya, Yoshifumi Ubara, Tatsuya Suwabe, Junichi Hoshino, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Yuji Marui, Naoki Sawa, Fumi Takemoto, Kenmei Takaichi. Successful treatment of acute promyelocytic leukemia in a patient on hemodialysis.
Clinical and experimental nephrology.
2011 Jun; 15(3):434-437. doi:
10.1007/s10157-011-0405-5. [PMID: 21298312] - Roula A Farah, Khalil S Jalkh, Hussein Z Farhat, Paul E Sayad, Adel M Kadri. Acquired protein C deficiency in a child with acute myelogenous leukemia, splenic, renal, and intestinal infarction.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2011 Mar; 22(2):140-3. doi:
10.1097/mbc.0b013e32834248e6. [PMID: 21178585] - Ritesh Parajuli, Jessica Altman, Timothy Kuzel, Maria Perdekamp, Martin Tallman. Renal cell carcinoma and acute promyelocytic leukemia: a nonrandom association?.
American journal of hematology.
2010 Oct; 85(10):829. doi:
10.1002/ajh.21813. [PMID: 20721888] - Jerzy Gubernator, Grzegorz Chwastek, Mariola Korycińska, Maria Stasiuk, Grzegorz Grynkiewicz, Felicitas Lewrick, Regine Süss, Arkadiusz Kozubek. The encapsulation of idarubicin within liposomes using the novel EDTA ion gradient method ensures improved drug retention in vitro and in vivo.
Journal of controlled release : official journal of the Controlled Release Society.
2010 Aug; 146(1):68-75. doi:
10.1016/j.jconrel.2010.05.021. [PMID: 20510316] - Tapan M Kadia, Hui Yang, Alessandra Ferrajoli, Sirisha Maddipotti, Claudia Schroeder, Timothy L Madden, Julianne L Holleran, Merrill J Egorin, Farhad Ravandi, Deborah A Thomas, Willie Newsome, Blanca Sanchez-Gonzalez, James A Zwiebel, Igor Espinoza-Delgado, Hagop M Kantarjian, Guillermo Garcia-Manero. A phase I study of vorinostat in combination with idarubicin in relapsed or refractory leukaemia.
British journal of haematology.
2010 Jul; 150(1):72-82. doi:
10.1111/j.1365-2141.2010.08211.x. [PMID: 20456355] - Andrew S Holpuch, Garrett J Hummel, Meng Tong, Garrett A Seghi, Ping Pei, Ping Ma, Russell J Mumper, Susan R Mallery. Nanoparticles for local drug delivery to the oral mucosa: proof of principle studies.
Pharmaceutical research.
2010 Jul; 27(7):1224-36. doi:
10.1007/s11095-010-0121-y. [PMID: 20354767] - Farhad Ravandi, Jorge E Cortes, Daniel Jones, Stefan Faderl, Guillermo Garcia-Manero, Marina Y Konopleva, Susan O'Brien, Zeev Estrov, Gautam Borthakur, Deborah Thomas, Sherry R Pierce, Mark Brandt, Anna Byrd, B Nebiyou Bekele, Keith Pratz, Rajyalakshmi Luthra, Mark Levis, Michael Andreeff, Hagop M Kantarjian. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2010 Apr; 28(11):1856-62. doi:
10.1200/jco.2009.25.4888. [PMID: 20212254] - Gülsüm Emel Pamuk, Murat Taşçi, Erman Oztürk, Muzaffer Demir. Successful treatment of severe gastrointestinal bleeding after chemotherapy in acute myeloblastic leukemia with recombinant activated factor VII : report on one case and review of other uses in acute leukemias.
Medical oncology (Northwood, London, England).
2010 Mar; 27(1):16-9. doi:
10.1007/s12032-008-9163-y. [PMID: 19137431] - Ping Ma, Xiaowei Dong, Courtney L Swadley, Anshul Gupte, Markos Leggas, Harry C Ledebur, Russell J Mumper. Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia.
Journal of biomedical nanotechnology.
2009 Apr; 5(2):151-61. doi:
10.1166/jbn.2009.1021. [PMID: 20055093] - Bradley A McGregor, Alexander W Brown, Michael B Osswald, Michael R Savona. The use of higher dose clofarabine in adults with relapsed acute lymphoblastic leukemia.
American journal of hematology.
2009 Apr; 84(4):228-30. doi:
10.1002/ajh.21365. [PMID: 19260120] - Agnieszka Marczak. Fluorescence anisotropy of membrane fluidity probes in human erythrocytes incubated with anthracyclines and glutaraldehyde.
Bioelectrochemistry (Amsterdam, Netherlands).
2009 Feb; 74(2):236-9. doi:
10.1016/j.bioelechem.2008.11.004. [PMID: 19064336] - J P M Derikx, N M A Blijlevens, J P Donnelly, H Fujii, T Kanda, A A van Bijnen, E Heineman, W A Buurman. Loss of enterocyte mass is accompanied by diminished turnover of enterocytes after myeloablative therapy in haematopoietic stem-cell transplant recipients.
Annals of oncology : official journal of the European Society for Medical Oncology.
2009 Feb; 20(2):337-42. doi:
10.1093/annonc/mdn579. [PMID: 18725393] - Reyad Dada, Stefan Wilop, Edgar Jost, Oliver Galm, Nikolaus Gassler, Rainhardt Osieka. Successful treatment of hepatic encephalopathy in a patient with acute lymphoblastic leukemia.
Acta haematologica.
2009; 122(4):216-20. doi:
10.1159/000253029. [PMID: 19887778] - Patrick Shenjere, Ashok Roy, Brian Eyden, Saumitra S Banerjee. Pseudo-Gaucher cells in multiple myeloma.
International journal of surgical pathology.
2008 Apr; 16(2):176-9. doi:
10.1177/1066896907311120. [PMID: 18417675] - Handan Ağirbasli, Hulya Bilgen, Sema Keceli Ozcan, Baris Otlu, Gulce Sinik, Nilgün Cerikçioğlu, Riza Durmaz, Emine Can, Nevin Yalman, Gunduz Gedikoğlu, Takashi Sugita. Two possible cases of Trichosporon infections in bone-marrow-transplanted children: the first case of T. japonicum isolated from clinical specimens.
Japanese journal of infectious diseases.
2008 Mar; 61(2):130-2. doi:
NULL. [PMID: 18362402] - Alessandra Tedeschi, Marco Montillo, Elena Strocchi, Anna Maria Cafro, Elisabetta Tresoldi, Liliana Intropido, Michele Nichelatti, Laura Marbello, Claudia Baratè, Carlo Maurizio Camaggi, Enrica Morra. High-dose idarubicin in combination with Ara-C in patients with relapsed or refractory acute lymphoblastic leukemia: a pharmacokinetic and clinical study.
Cancer chemotherapy and pharmacology.
2007 May; 59(6):771-9. doi:
10.1007/s00280-006-0332-4. [PMID: 17256136] - Steven M Kornblau, Deborah E Banker, Derek Stirewalt, Danny Shen, Elizabeth Lemker, Srdan Verstovsek, Zeev Estrov, Stefan Faderl, Jorge Cortes, Miloslav Beran, C Ellen Jackson, Wenjing Chen, Elihu Estey, Frederick R Appelbaum. Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study.
Blood.
2007 Apr; 109(7):2999-3006. doi:
10.1182/blood-2006-08-044446. [PMID: 17158228] - M Albitar, M Johnson, K A Do, A Day, I Jilani, S Pierce, E Estey, H Kantarjian, M Keating, S Verstovsek, S O'brien, F J Giles. Levels of soluble HLA-I and beta2M in patients with acute myeloid leukemia and advanced myelodysplastic syndrome: association with clinical behavior and outcome of induction therapy.
Leukemia.
2007 Mar; 21(3):480-8. doi:
10.1038/sj.leu.2404506. [PMID: 17215857] - Edit Bárdi, Ildikó Bobok, Anna V Oláh, János Kappelmayer, Csongor Kiss. Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer.
Pathology oncology research : POR.
2007; 13(3):249-53. doi:
10.1007/bf02893506. [PMID: 17922055] - Miguel López-Lázaro, Nuria Pastor, Sami S Azrak, Maria Jesús Ayuso, Felipe Cortés, Caroline A Austin. Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.
Leukemia research.
2006 Jul; 30(7):895-8. doi:
10.1016/j.leukres.2005.11.005. [PMID: 16387358] - D Crivellari, D Lombardi, G Corona, C Massacesi, R Talamini, R Sorio, M D Magri, C Lestuzzi, A Lucenti, A Veronesi, G Toffoli. Innovative schedule of oral idarubicin in elderly patients with metastatic breast cancer: comprehensive results of a phase II multi-institutional study with pharmacokinetic drug monitoring.
Annals of oncology : official journal of the European Society for Medical Oncology.
2006 May; 17(5):807-12. doi:
10.1093/annonc/mdl013. [PMID: 16497825] - Agnieszka Marczak, Aleksandra Kowalczyk, Agata Wrzesień-Kus, Tadeusz Robak, Zofia Jóźwiak. Interaction of doxorubicin and idarubicin with red blood cells from acute myeloid leukaemia patients.
Cell biology international.
2006 Feb; 30(2):127-32. doi:
10.1016/j.cellbi.2005.09.001. [PMID: 16271486] - Nancy Dos Santos, Dawn Waterhouse, Dana Masin, Paul G Tardi, Göran Karlsson, Katarina Edwards, Marcel B Bally. Substantial increases in idarubicin plasma concentration by liposome encapsulation mediates improved antitumor activity.
Journal of controlled release : official journal of the Controlled Release Society.
2005 Jun; 105(1-2):89-105. doi:
10.1016/j.jconrel.2005.03.007. [PMID: 15878792] - N M A Blijlevens, J P Donnelly, B E de Pauw. Prospective evaluation of gut mucosal barrier injury following various myeloablative regimens for haematopoietic stem cell transplant.
Bone marrow transplantation.
2005 Apr; 35(7):707-11. doi:
10.1038/sj.bmt.1704863. [PMID: 15785771] - J M Horácek, R Pudil, M Tichý, L Jebavý, A Strasová, R Praus, P Zák, J Malý. The use of biochemical markers in cardiotoxicity monitoring in patients treated for leukemia.
Neoplasma.
2005; 52(5):430-4. doi:
NULL. [PMID: 16151589] - F Verholen, M Stalder, C Helg, Y Chalandon. Resistant pure red cell aplasia after allogeneic stem cell transplantation with major ABO mismatch treated by escalating dose donor leukocyte infusion.
European journal of haematology.
2004 Dec; 73(6):441-6. doi:
10.1111/j.1600-0609.2004.00320.x. [PMID: 15522068] - Joachim Drevs, Julia Fakler, Silke Eisele, Michael Medinger, Gerlinde Bing, Norbert Esser, Dieter Marmé, Clemens Unger. Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy.
Anticancer research.
2004 May; 24(3a):1759-63. doi:
NULL. [PMID: 15274352] - G Toffoli, R Sorio, B Basso, P Aita, G Corona, M Rupolo, G Ruolo, M Boiocchi. Pharmacokinetic comparison of 120-hour infusion versus hyperfractionated oral administration of idarubicin.
Journal of chemotherapy (Florence, Italy).
2004 Apr; 16(2):193-200. doi:
10.1179/joc.2004.16.2.193. [PMID: 15216956] - Frank Kroschinsky, Eberhard Schleyer, Ulf Renner, Claudia Schimming, Christoph Schimmelpfennig, Martin Bornhäuser, Thomas Illmer, Lorenz Trümper, Gerhard Ehninger, Markus Schaich. Increased myelotoxicity of idarubicin: is there a pharmacological basis? Results of a pharmacokinetic and an in vitro cytotoxicity study.
Cancer chemotherapy and pharmacology.
2004 Jan; 53(1):61-7. doi:
10.1007/s00280-003-0700-2. [PMID: 12955471] - ZoAnn E Dreyer, Richard P Kadota, Clinton F Stewart, Henry S Friedman, Donald H Mahoney, Larry E Kun, Charles W McCluggage, Peter C Burger, James Kepner, Richard L Heideman. Phase 2 study of idarubicin in pediatric brain tumors: Pediatric Oncology Group study POG 9237.
Neuro-oncology.
2003 Oct; 5(4):261-7. doi:
10.1215/s115285170200056x. [PMID: 14565163] - Jiroh Yamasaki, Tomoko Hata, Kengo Fuchigami, Katsuhiro Togami, Miyuki Honda, Takuya Fukushima, Yasushi Miyazaki, Itsuro Jinnai, Kazutaka Kuriyama, Masao Tomonaga. [Intensive multi-drug chemotherapy for acute myeloid leukemia in a renal allograft recipient].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
2003 Oct; 44(10):1015-9. doi:
NULL. [PMID: 14639948] - D d'Angelo, S Florio, L Crispino, R Ciarcia, G Pagnini. Medroxyprogesterone acetate increases anthracycline-induced lipid peroxidation and membrane fluidity.
Veterinary research communications.
2003 Sep; 27 Suppl 1(?):385-9. doi:
10.1023/b:verc.0000014186.23849.de. [PMID: 14535436] - Takashi Shimamoto, Akihiro Nakajima, Tomoko Katagiri, Yoshikazu Ito, Kazuma Ohyashiki. Myeloid/natural killer cell precursor acute leukemia accompanied by homozygous protein C deficiency.
International journal of hematology.
2003 Aug; 78(2):149-53. doi:
10.1007/bf02983384. [PMID: 12953810] - B Myers, H Lachmann, N H Russell. Novel combination chemotherapy for primary (AL) amyloidosis myeloma: clinical, laboratory and serum amyloid-P protein scan improvement.
British journal of haematology.
2003 Jun; 121(5):816-7. doi:
10.1046/j.1365-2141.2003.04352.x. [PMID: 12780799] - H Schiller, T Bartscht, A Arlt, M O Zahn, A Seifert, T Bruhn, H D Bruhn, F Gieseler. Thrombin as a survival factor for cancer cells: thrombin activation in malignant effusions in vivo and inhibition of idarubicin-induced cell death in vitro.
International journal of clinical pharmacology and therapeutics.
2002 Aug; 40(8):329-35. doi:
10.5414/cpp40329. [PMID: 12467301] - Gian Paolo Zara, Alessandro Bargoni, Roberta Cavalli, Anna Fundarò, Daniela Vighetto, Maria Rosa Gasco. Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats.
Journal of pharmaceutical sciences.
2002 May; 91(5):1324-33. doi:
10.1002/jps.10129. [PMID: 11977108] - B Vincenzi, D Santini, S Spoto, E Finolezzi, R M D'Angelillo, A La Cesa, G Tonini. The antineoplastic treatment in the elderly.
La Clinica terapeutica.
2002 May; 153(3):207-15. doi:
NULL. [PMID: 12161983] - Nancy Dos Santos, Lawrence D Mayer, Sheela A Abraham, Ryan C Gallagher, Kelly A K Cox, Paul G Tardi, Marcel B Bally. Improved retention of idarubicin after intravenous injection obtained for cholesterol-free liposomes.
Biochimica et biophysica acta.
2002 Apr; 1561(2):188-201. doi:
10.1016/s0005-2736(02)00345-0. [PMID: 11997119] - T Fukushima, T Yamashita, N Goto, T Ueda, K I Okabe, Y Kuraishi, R Ohno, A Urabe, M Ogawa. A pharmacokinetic study of idarubicin in Japanese patients with malignant lymphoma: relationship with leukocytopenia and neutropenia.
International journal of hematology.
2001 Oct; 74(3):297-302. doi:
10.1007/bf02982064. [PMID: 11721966] - O Kuhlmann, S Hofmann, M Weiss. Pharmacokinetics and toxicity of idarubicin in the rat.
European journal of drug metabolism and pharmacokinetics.
2001 Oct; 26(4):215-9. doi:
10.1007/bf03226374. [PMID: 11808862] - J A Myburgh, J A Smit, G A Pieterz, S Ling, M S Sandrin, I F McKenzie. Tolerance in baboon kidney transplantation with total lymphoid irradiation (TLI) and anti-CD3/CD4-idarubicin conjugates.
Transplantation.
2001 Sep; 72(6):1150-2. doi:
10.1097/00007890-200109270-00028. [PMID: 11579315] - N Tomita, H Kanamori, H Fujita, A Maruta, A Naitoh, S Nakamura, Y Ota, N Nozue, M Kihara, Y Ishigatsubo. Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid.
Anti-cancer drugs.
2001 Sep; 12(8):677-80. doi:
10.1097/00001813-200109000-00005. [PMID: 11604554] - A Szwarocka, A Kowalczyk, D Łubgan, Z Józwiak. The combined effect of IDA and glutaraldehyde on the properties of human erythrocytes.
International journal of pharmaceutics.
2001 Jun; 220(1-2):43-51. doi:
10.1016/s0378-5173(01)00643-3. [PMID: 11376966] - G Specchia, C T Storlazzi, A Cuneo, C Surace, A Mestice, A Pannunzio, M Rocchi, V Liso. Acute promyelocytic leukemia with additional chromosome abnormalities in a renal transplant case.
Annals of hematology.
2001 Apr; 80(4):246-50. doi:
10.1007/s002770000273. [PMID: 11401094] - M Ellis, A Shamoon, W Gorka, F Zwaan, B al-Ramadi. Severe hepatic injury associated with lipid formulations of amphotericin B.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2001 Mar; 32(5):E87-9. doi:
10.1086/319201. [PMID: 11229863] - M Smeets, R Raymakers, P Muus, G Vierwinden, P Linssen, R Masereeuw, T de Witte. Cyclosporin increases cellular idarubicin and idarubicinol concentrations in relapsed or refractory AML mainly due to reduced systemic clearance.
Leukemia.
2001 Jan; 15(1):80-8. doi:
10.1038/sj.leu.2401996. [PMID: 11243404] - T Pérez-Ruiz, C Martínez-Lozano, A Sanz, E Bravo. Simultaneous determination of doxorubicin, daunorubicin, and idarubicin by capillary electrophoresis with laser-induced fluorescence detection.
Electrophoresis.
2001 Jan; 22(1):134-8. doi:
10.1002/1522-2683(200101)22:1<134::aid-elps134>3.0.co;2-x. [PMID: 11197162] - Q Hu, T Zhou, L Zhang, H Li, Y Fang. Determination of idarubicin in human urine by capillary zone electrophoresis with amperometric detection.
Fresenius' journal of analytical chemistry.
2000 Dec; 368(8):844-7. doi:
10.1007/s002160000571. [PMID: 11227574] - U Pagnini, S Florio, P Lombardi, D d'Angelo, L Avallone, M Galdiero, G Iovane, G Tortora, G Pagnini. Modulation of anthracycline activity in canine mammary tumour cells in vitro by medroxyprogesterone acetate.
Research in veterinary science.
2000 Dec; 69(3):255-62. doi:
10.1053/rvsc.2000.0421. [PMID: 11124097] - S S Joshi, C A Kuszynski, M Bagchi, D Bagchi. Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells.
Toxicology.
2000 Nov; 155(1-3):83-90. doi:
10.1016/s0300-483x(00)00280-8. [PMID: 11154800] - X Wang, C Clowes, R Duarte, Q Q Pu. Serum ICAM-1 concentrations following conventional dose consolidation chemotherapy for acute myeloid leukemia and after high dose chemotherapy with autologous haematopoietic stem cell rescue.
International journal of oncology.
2000 Sep; 17(3):591-5. doi:
10.3892/ijo.17.3.591. [PMID: 10938403] - P Anderlini, S Giralt, B Andersson, N T Ueno, I Khouri, S Acholonu, A Cohen, M J Körbling, J Manning, J Romaguera, A Sarris, Rodriguez, F Hagemeister, P Mclaughlin, F Cabanillas, R E Champlin. Allogeneic stem cell transplantation with fludarabine-based, less intensive conditioning regimens as adoptive immunotherapy in advanced Hodgkin's disease.
Bone marrow transplantation.
2000 Sep; 26(6):615-20. doi:
10.1038/sj.bmt.1702580. [PMID: 11041566] - F Gieseler, M Clark, K Stiebeling, M Puschmann, S Valsamas. Induction of apoptosis by idarubicin: how important is the plasma peak?.
International journal of clinical pharmacology and therapeutics.
2000 Apr; 38(4):217-21. doi:
10.5414/cpp38217. [PMID: 10783832] - J K Schröder, S Kasimir-Bauer, S Seeber, M E Scheulen. In vitro effect of multidrug resistance modifiers on idarubicinol efflux in blasts of acute myeloid leukemia.
Journal of cancer research and clinical oncology.
2000 Feb; 126(2):111-6. doi:
10.1007/s004320050019. [PMID: 10664252] - P R Wielinga, H V Westerhoff, J Lankelma. The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells.
European journal of biochemistry.
2000 Feb; 267(3):649-57. doi:
10.1046/j.1432-1327.2000.01030.x. [PMID: 10651800] - W H Hamoudi, L J Medeiros, G Townsend, A B Glassman, C E Bueso-Ramos. Acute myelomonocytic leukemia with histologic features resembling sarcomatoid carcinoma in bone marrow.
Archives of pathology & laboratory medicine.
2000 Feb; 124(2):315-8. doi:
10.5858/2000-124-0315-amlwhf. [PMID: 10656748] - U Pagnini, C Pacilio, S Florio, A Crispino, P P Claudio, A Giordano, G Pagnini. Medroxyprogesterone acetate increases anthracyclines uptake in chronic lymphatic leukemia cells: role of nitric oxide and lipid peroxidation.
Anticancer research.
2000 Jan; 20(1A):33-42. doi:
". [PMID: 10769632] - L Vellón, T Cuello, P Gargallo, I Larripa. [Antisense oligonucleotides increase the apoptotic effect of idarubicin in K-562 cell line].
Medicina.
2000; 60(1):143-5. doi:
". [PMID: 10835712] - P R Wielinga, E de Waal, H V Westerhoff, J Lankelma. In vitro transepithelial drug transport by on-line measurement: cellular control of paracellular and transcellular transport.
Journal of pharmaceutical sciences.
1999 Dec; 88(12):1340-7. doi:
10.1021/js980497z. [PMID: 10585232] - S Dunkley, J Gibson, H Iland, C Li, D Joshua. Acute promyelocytic leukaemia complicating multiple myeloma: evidence of different cell lineages.
Leukemia & lymphoma.
1999 Nov; 35(5-6):623-6. doi:
10.1080/10428199909169629. [PMID: 10609802] - K Sumpter, R L Powles, N Raje, V Ramiah, S Kulkarni, J Treleaven, P N Mainwaring. Oral idarubicin as a single agent therapy in patients with relapsed or resistant multiple myeloma.
Leukemia & lymphoma.
1999 Nov; 35(5-6):593-7. doi:
10.1080/10428199909169624. [PMID: 10609797] - E H Estey, F J Giles, H Kantarjian, S O'Brien, J Cortes, E J Freireich, G Lopez-Berestein, M Keating. Molecular remissions induced by liposomal-encapsulated all-trans retinoic acid in newly diagnosed acute promyelocytic leukemia.
Blood.
1999 Oct; 94(7):2230-5. doi:
10.1182/blood.v94.7.2230.419k05_2230_2235. [PMID: 10498593] - W Boogerd, I S Tjahja, M M van de Sandt, J H Beijnen. Penetration of idarubicin into malignant brain tumor tissue.
Journal of neuro-oncology.
1999 Aug; 44(1):65-9. doi:
10.1023/a:1006335517191. [PMID: 10582671] - F Patriarca, A Geromin, R Fanin, D Damiani, A Sperotto, M Baccarani. Improvement of amyloid-related symptoms after autologous stem cell transplantation in a patient with hepatomegaly, macroglossia and purpura.
Bone marrow transplantation.
1999 Aug; 24(4):433-5. doi:
10.1038/sj.bmt.1701925. [PMID: 10467336] - M Kessel, F Gieseler, B G Woodcock. Influence of serum protein binding on the uptake and retention of idarubicin by sensitive and multidrug resistant human leukemic cells.
European journal of clinical pharmacology.
1999 Jul; 55(5):369-73. doi:
10.1007/s002280050642. [PMID: 10456486] - S Fogli, R Danesi, F Innocenti, A Di Paolo, G Bocci, C Barbara, M Del Tacca. An improved HPLC method for therapeutic drug monitoring of daunorubicin, idarubicin, doxorubicin, epirubicin, and their 13-dihydro metabolites in human plasma.
Therapeutic drug monitoring.
1999 Jun; 21(3):367-75. doi:
10.1097/00007691-199906000-00022. [PMID: 10365655] - F Durrieu, M A Belaud-Rotureau, F Lacombe, P Dumain, J Reiffers, M R Boisseau, P Bernard, F Belloc. Synthesis of Bcl-2 in response to anthracycline treatment may contribute to an apoptosis-resistant phenotype in leukemic cell lines.
Cytometry.
1999 Jun; 36(2):140-9. doi:
10.1002/(sici)1097-0320(19990601)36:2<140::aid-cyto8>3.0.co;2-p. [PMID: 10554162] - O Kuhlmann, S Hofmann, M Weiss. Determination of idarubicin and idarubicinol in rat plasma using reversed-phase high-performance liquid chromatography and fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications.
1999 May; 728(2):279-82. doi:
10.1016/s0378-4347(99)00107-3. [PMID: 10406213]
