2-Iodomelatonin (BioDeep_00001871584)

   


代谢物信息卡片


2-Iodomelatonin

化学式: C13H15IN2O2 (358.01782399999996)
中文名称: 2-碘褪黑激素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NCCC1=C(NC2=C1C=C(C=C2)OC)I
InChI: InChI=1S/C13H15IN2O2/c1-8(17)15-6-5-10-11-7-9(18-2)3-4-12(11)16-13(10)14/h3-4,7,16H,5-6H2,1-2H3,(H,15,17)

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

1 个代谢物同义名

2-Iodomelatonin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M A López Patiño, A I Guijarro, A L Alonso-Gómez, M J Delgado. Characterization of two different melatonin binding sites in peripheral tissues of the teleost Tinca tinca. General and comparative endocrinology. 2012 Jan; 175(1):180-7. doi: 10.1016/j.ygcen.2011.11.017. [PMID: 22134177]
  • Hirotaka Ishii, Nobuyuki Tanaka, Momoko Kobayashi, Masakatsu Kato, Yasuo Sakuma. Gene structures, biochemical characterization and distribution of rat melatonin receptors. The journal of physiological sciences : JPS. 2009 Jan; 59(1):37-47. doi: 10.1007/s12576-008-0003-9. [PMID: 19340560]
  • Angela M S Poon, Kenneth M C Cheung, D S Lu, John C Y Leong. Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens. Spine. 2006 Aug; 31(18):2043-7. doi: 10.1097/01.brs.0000231796.49827.39. [PMID: 16915086]
  • Chang-Long Hu, Zheng Liu, Zhen-Yu Gao, Zhi-Hong Zhang, Yan-Ai Mei. 2-iodomelatonin prevents apoptosis of cerebellar granule neurons via inhibition of A-type transient outward K+ currents. Journal of pineal research. 2005 Jan; 38(1):53-61. doi: 10.1111/j.1600-079x.2004.00174.x. [PMID: 15617537]
  • Ercument Olmez, Zehra Kurcer. Melatonin attenuates alpha-adrenergic-induced contractions by increasing the release of vasoactive intestinal peptide in isolated rat penile bulb. Urological research. 2003 Aug; 31(4):276-9. doi: 10.1007/s00240-003-0327-0. [PMID: 12844242]
  • Celia S Pang, Si C Xi, Gregory M Brown, Shiu F Pang, Stephen Y W Shiu. 2[125I]Iodomelatonin binding and interaction with beta-adrenergic signaling in chick heart/coronary artery physiology. Journal of pineal research. 2002 May; 32(4):243-52. doi: 10.1034/j.1600-079x.2002.01860.x. [PMID: 11982794]
  • A M Poon, E H Choy, S F Pang. Modulation of blood glucose by melatonin: a direct action on melatonin receptors in mouse hepatocytes. Biological signals and receptors. 2001 Nov; 10(6):367-79. doi: 10.1159/000046904. [PMID: 11721092]
  • O Nosjean, J P Nicolas, F Klupsch, P Delagrange, E Canet, J A Boutin. Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 . Biochemical pharmacology. 2001 Jun; 61(11):1369-79. doi: 10.1016/s0006-2952(01)00615-3. [PMID: 11331072]
  • H Y Guerrero, F Gauer, C Schuster, P Pévet, M Masson-Pévet. Melatonin regulates the mRNA expression of the mt(1) melatonin receptor in the rat Pars tuberalis. Neuroendocrinology. 2000 Mar; 71(3):163-9. doi: 10.1159/000054533. [PMID: 10729787]
  • S Conway, S J Canning, H E Howell, E S Mowat, P Barrett, J E Drew, P Delagrange, D Lesieur, P J Morgan. Characterisation of human melatonin mt(1) and MT(2) receptors by CRE-luciferase reporter assay. European journal of pharmacology. 2000 Feb; 390(1-2):15-24. doi: 10.1016/s0014-2999(99)00914-0. [PMID: 10708702]
  • F Roka, L Brydon, M Waldhoer, A D Strosberg, M Freissmuth, R Jockers, C Nanoff. Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity. Molecular pharmacology. 1999 Nov; 56(5):1014-24. doi: 10.1124/mol.56.5.1014. [PMID: 10531408]
  • D J Kennaway, A Voultsios. Circadian rhythm of free melatonin in human plasma. The Journal of clinical endocrinology and metabolism. 1998 Mar; 83(3):1013-5. doi: 10.1210/jcem.83.3.4636. [PMID: 9506765]
  • J E Drew, L M Williams, L T Hannah, P Barrett, D R Abramovich. Melatonin receptors in the human fetal kidney: 2-[125I]iodomelatonin binding sites correlated with expression of Mel1a and Mel1b receptor genes. The Journal of endocrinology. 1998 Feb; 156(2):261-7. doi: 10.1677/joe.0.1560261. [PMID: 9518871]
  • C S Pang, P L Tang, Y Song, S F Pang, K W Ng, B Guardiola-Lemaitre, P Delagrange, G M Brown. Differential inhibitory effects of melatonin analogs and three naphthalenic ligands on 2-[125I]iodomelatonin binding to chicken tissues. Journal of pineal research. 1997 Oct; 23(3):148-55. doi: 10.1111/j.1600-079x.1997.tb00348.x. [PMID: 9406986]
  • L Iacovitti, N D Stull, K Johnston. Melatonin rescues dopamine neurons from cell death in tissue culture models of oxidative stress. Brain research. 1997 Sep; 768(1-2):317-26. doi: 10.1016/s0006-8993(97)00668-9. [PMID: 9369331]
  • S Conway, J E Drew, S J Canning, P Barrett, R Jockers, A D Strosberg, B Guardiola-Lemaitre, P Delagrange, P J Morgan. Identification of Mel1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levels. FEBS letters. 1997 Apr; 407(1):121-6. doi: 10.1016/s0014-5793(97)00315-3. [PMID: 9141494]
  • Y Song, C W Chan, G M Brown, S F Pang, M Silverman. Studies of the renal action of melatonin: evidence that the effects are mediated by 37 kDa receptors of the Mel1a subtype localized primarily to the basolateral membrane of the proximal tubule. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1997 Jan; 11(1):93-100. doi: 10.1096/fasebj.11.1.9034171. [PMID: 9034171]
  • Y Song, C S Pang, E A Ayre, G M Brown, S F Pang. Melatonin receptors in the chicken kidney are up-regulated by pinealectomy and linked to adenylate cyclase. European journal of endocrinology. 1996 Jul; 135(1):128-33. doi: 10.1530/eje.0.1350128. [PMID: 8765984]
  • C S Pang, P L Tang, S F Pang, G M Brown. Comparison of the pharmacological characteristics of 2-[125I]iodomelatonin binding sites in the lung, spleen, brain and kidney of chicken. Biological signals. 1995 Nov; 4(6):311-24. doi: 10.1159/000109465. [PMID: 8688910]
  • F Liu, H Yuan, K S Sugamori, A Hamadanizadeh, F J Lee, S F Pang, G M Brown, Z B Pristupa, H B Niznik. Molecular and functional characterization of a partial cDNA encoding a novel chicken brain melatonin receptor. FEBS letters. 1995 Oct; 374(2):273-8. doi: 10.1016/0014-5793(95)01129-3. [PMID: 7589552]
  • M Iigo, K Furukawa, A Hattori, M Hara, R Ohtani-Kaneko, T Suzuki, M Tabata, K Aida. Effects of pinealectomy and constant light exposure on day-night changes of melatonin binding sites in the goldfish brain. Neuroscience letters. 1995 Sep; 197(1):61-4. doi: 10.1016/0304-3940(95)11903-a. [PMID: 8545057]
  • Y Song, P C Tam, A M Poon, G M Brown, S F Pang. 2-[125I]iodomelatonin-binding sites in the human kidney and the effect of guanosine 5'-O-(3-thiotriphosphate). The Journal of clinical endocrinology and metabolism. 1995 May; 80(5):1560-5. doi: 10.1210/jcem.80.5.7745000. [PMID: 7745000]
  • M Rafii-el-Idrissi, J R Calvo, D Pozo, A Harmouch, J M Guerrero. Specific binding of 2-[125I]iodomelatonin by rat splenocytes: characterization and its role on regulation of cyclic AMP production. Journal of neuroimmunology. 1995 Mar; 57(1-2):171-8. doi: 10.1016/0165-5728(94)00182-n. [PMID: 7706434]
  • E S Maywood, M H Hastings. Lesions of the iodomelatonin-binding sites of the mediobasal hypothalamus spare the lactotropic, but block the gonadotropic response of male Syrian hamsters to short photoperiod and to melatonin. Endocrinology. 1995 Jan; 136(1):144-53. doi: 10.1210/endo.136.1.7828525. [PMID: 7828525]
  • A M Poon, E A Ayre, Y Song, S F Pang. Melatonin implant decreases the density of 2[125I]iodomelatonin binding sites in the chicken spleen. Biological signals. 1994 Nov; 3(6):278-87. doi: 10.1159/000109555. [PMID: 7728190]
  • A M Poon, S F Pang. Modulation of 2[125I]iodomelatonin binding sites in the guinea pig spleen by melatonin injection is dependent on the dose and period but not the time. Life sciences. 1994; 54(19):1441-8. doi: 10.1016/0024-3205(94)00599-0. [PMID: 8190017]
  • Y Song, A M Poon, P P Lee, S F Pang. Putative melatonin receptors in the male guinea pig kidney. Journal of pineal research. 1993 Oct; 15(3):153-60. doi: 10.1111/j.1600-079x.1993.tb00523.x. [PMID: 8106962]
  • Y Song, E A Ayre, S F Pang. [125I]iodomelatonin binding sites in mammalian and avian kidneys. Biological signals. 1993 Jul; 2(4):207-20. doi: NULL. [PMID: 8205164]
  • S F Pang, M L Dubocovich, G M Brown. Melatonin receptors in peripheral tissues: a new area of melatonin research. Biological signals. 1993 Jul; 2(4):177-80. doi: 10.1159/000109490. [PMID: 8205160]
  • A M Poon, X L Wang, S F Pang. Characteristics of 2-[125I]iodomelatonin binding sites in the pigeon spleen and modulation of binding by guanine nucleotides. Journal of pineal research. 1993 May; 14(4):169-77. doi: 10.1111/j.1600-079x.1993.tb00499.x. [PMID: 8393924]
  • S F Pang, E A Ayre, A M Poon, C S Pang, H Yuan, Z P Wang, Y Song, G M Brown. Effects of guanosine 5'-O-(3-thiotriphosphate) on 2-[125I]iodomelatonin binding in the chicken lung, brain and kidney: hypothesis of different subtypes of high affinity melatonin receptors. Biological signals. 1993 Jan; 2(1):27-36. doi: 10.1159/000109475. [PMID: 8394768]
  • Z P Wang, K M Cheng, G M Brown, C S Pang, S F Pang. Characterization of 2-[125I]iodomelatonin-binding sites in quail testes at mid-light and mid-dark. Neuroscience letters. 1992 Nov; 146(2):195-8. doi: 10.1016/0304-3940(92)90076-j. [PMID: 1337195]
  • Y Song, E A Ayre, S F Pang. The identification and characterization of 125I-labelled iodomelatonin-binding sites in the duck kidney. The Journal of endocrinology. 1992 Nov; 135(2):353-9. doi: 10.1677/joe.0.1350353. [PMID: 1474342]
  • Y Song, S F Pang. [125I]iodomelatonin-binding sites in the chicken kidney: characterization and comparison to other avian species. Biological signals. 1992 Nov; 1(6):313-21. doi: 10.1159/000109336. [PMID: 1307931]
  • H Yuan, S F Pang. [125I]iodomelatonin binding sites in the chicken brain: diurnal variation and effect of melatonin injection or pinealectomy. Biological signals. 1992 Jul; 1(4):208-18. doi: 10.1159/000109326. [PMID: 1339177]
  • F J Ebling, E S Maywood, T Humby, M H Hastings. Circadian and photoperiodic time measurement in male Syrian hamsters following lesions of the melatonin-binding sites of the paraventricular thalamus. Journal of biological rhythms. 1992; 7(3):241-54. doi: 10.1177/074873049200700305. [PMID: 1330085]
  • N Zisapel, Y Anis. Impact of circulating testosterone on iodomelatonin binding sites in the male rat brain. Molecular and cellular endocrinology. 1988 Dec; 60(2-3):119-26. doi: 10.1016/0303-7207(88)90170-0. [PMID: 2850953]