Amperozide (BioDeep_00001871566)

   


代谢物信息卡片


4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide

化学式: C23H29F2N3O (401.22785680000004)
中文名称: 安哌齐持
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCNC(=O)N1CCN(CC1)CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
InChI: InChI=1S/C23H29F2N3O/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h5-12,22H,2-4,13-17H2,1H3,(H,26,29)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a Ki value of 26 nM. Amperozide has a low affinity for D2 receptors[1].

同义名列表

2 个代谢物同义名

4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide; Amperozide



数据库引用编号

7 个数据库交叉引用编号

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代谢反应

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0 个相关的物种来源信息

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文献列表

  • L Rauser, J E Savage, H Y Meltzer, B L Roth. Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor. The Journal of pharmacology and experimental therapeutics. 2001 Oct; 299(1):83-9. doi: . [PMID: 11561066]
  • M Volonté, E Monferini, M Cerutti, F Fodritto, F Borsini. BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex. Journal of neurochemistry. 1997 Jul; 69(1):182-90. doi: 10.1046/j.1471-4159.1997.69010182.x. [PMID: 9202309]
  • A Albinsson, E Palazidou, J Stephenson, G Andersson. Involvement of the 5-HT2 receptor in the 5-HT receptor-mediated stimulation of prolactin release. European journal of pharmacology. 1994 Jan; 251(2-3):157-61. doi: 10.1016/0014-2999(94)90396-4. [PMID: 8149973]
  • K Uvnäs-Moberg, P Alster, T H Svensson. Amperozide and clozapine but not haloperidol or raclopride increase the secretion of oxytocin in rats. Psychopharmacology. 1992; 109(4):473-6. doi: 10.1007/bf02247726. [PMID: 1365865]
  • A Albinsson, G Andersson. The effect of amperozide, a new antipsychotic drug, on plasma corticosterone concentration in the rat. Life sciences. 1992; 51(19):1535-44. doi: 10.1016/0024-3205(92)90564-6. [PMID: 1359366]
  • R Axelsson, A Nilsson, E Christensson, A Björk. Effects of amperozide in schizophrenia. An open study of a potent 5-HT2 receptor antagonist. Psychopharmacology. 1991; 104(3):287-92. doi: 10.1007/bf02246025. [PMID: 1924636]
  • A R Albinsson, G K Andersson. Subclinical characteristics of the wasting pig syndrome. Research in veterinary science. 1990 Jul; 49(1):71-6. doi: 10.1016/s0034-5288(18)31049-x. [PMID: 2382058]
  • A Albinsson, E Eriksson, G Andersson. Amperozide--effect on prolactin release in the rat. Pharmacology & toxicology. 1990; 66 Suppl 1(?):49-51. doi: 10.1111/j.1600-0773.1990.tb01607.x. [PMID: 2304896]
  • P Höglund, M Eriksson, E G Christensson. Antiarrhythmic effect of amperozide, a novel psychotropic compound with class III antiarrhythmic properties, on digoxin-induced arrhythmias in the guinea-pig. The Journal of pharmacy and pharmacology. 1986 Nov; 38(11):861-3. doi: 10.1111/j.2042-7158.1986.tb04514.x. [PMID: 2879024]