Methyl ecgonine (BioDeep_00001871548)

Main id: BioDeep_00000001463

 


代谢物信息卡片


ecgonine methyl ester

化学式: C10H17NO3 (199.1208372)
中文名称: 芽子碱甲酯
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CN1C2CCC1C(C(C2)O)C(=O)OC
InChI: InChI=1S/C10H17NO3/c1-11-6-3-4-7(11)9(8(12)5-6)10(13)14-2/h6-9,12H,3-5H2,1-2H3/t6-,7+,8-,9+/m0/s1

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
The O-debenzoyl analogue of cocaine.

同义名列表

2 个代谢物同义名

ecgonine methyl ester; Methyl ecgonine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Teresa Huertas, Carmen Jurado, Manuel Salguero, Teresa Soriano, Joaquin Gamero. Stability of Cocaine Compounds in Biological Fluids During Post-Analytical Sample Storage. Journal of analytical toxicology. 2020 Dec; 44(8):864-870. doi: 10.1093/jat/bkaa044. [PMID: 33313886]
  • Stephen H Curry, Matthew Marler. Effects of ecgonine methyl ester on cognition in scopolamine-impaired and aged rats. Psychopharmacology. 2020 May; 237(5):1331-1342. doi: 10.1007/s00213-020-05460-9. [PMID: 32034448]
  • Roberto Mandrioli, Laura Mercolini, Michele Protti. Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption. Molecules (Basel, Switzerland). 2020 Feb; 25(5):. doi: 10.3390/molecules25051046. [PMID: 32110941]
  • Lilian de Lima Feltraco Lizot, Anne Caroline Cezimbra da Silva, Marcos Frank Bastiani, Tales Fernando Maurer, Roberta Zilles Hahn, Magda Susana Perassolo, Marina Venzon Antunes, Rafael Linden. Simultaneous Determination of Cocaine and Metabolites in Human Plasma Using Solid Phase Micro-Extraction Fiber Tips C18 and UPLC-MS/MS. Journal of analytical toxicology. 2020 Jan; 44(1):49-56. doi: 10.1093/jat/bkz042. [PMID: 31095712]
  • Eleanor L Menzies, John R H Archer, Paul I Dargan, Mark C Parkin, Takahiro Yamamoto, David M Wood, Robin A Braithwaite, Simon P Elliott, Andrew T Kicman. Detection of cocaine and its metabolites in whole blood and plasma following a single dose, controlled administration of intranasal cocaine. Drug testing and analysis. 2019 Sep; 11(9):1419-1430. doi: 10.1002/dta.2657. [PMID: 31150569]
  • N C Rubio, F Krumbiegel, F Pragst, D Thurmann, A Nagel, E Zytowski, M Aranguren, J C Gorlelo, N Poliansky. Discrimination between chewing of coca leaves or drinking of coca tea and smoking of "paco" (coca paste) by hair analysis. A preliminary study of possibilities and limitations. Forensic science international. 2019 Apr; 297(?):171-176. doi: 10.1016/j.forsciint.2019.01.040. [PMID: 30798102]
  • Jordan A Marckel, Hanna N Wetzel, Sihame Amlal, Hassane Amlal, Andrew B Norman. A Recombinant Humanized Anticocaine Monoclonal Antibody Alters the Urinary Clearance of Cocaine and Its Metabolites in Rats. Drug metabolism and disposition: the biological fate of chemicals. 2019 03; 47(3):184-188. doi: 10.1124/dmd.118.083857. [PMID: 30578276]
  • Liron Shemesh-Darvish, Doron Shinar, Hussein Hallak, Aviva Gross, Moti Rosenstock. TV-1380 attenuates cocaine-induced changes in cardiodynamic parameters in monkeys and reduces the formation of cocaethylene. Drug and alcohol dependence. 2018 07; 188(?):295-303. doi: 10.1016/j.drugalcdep.2018.01.033. [PMID: 29807217]
  • Marion A Coe, Rebecca A Jufer Phipps, Edward J Cone, Sharon L Walsh. Bioavailability and Pharmacokinetics of Oral Cocaine in Humans. Journal of analytical toxicology. 2018 Jun; 42(5):285-292. doi: 10.1093/jat/bky007. [PMID: 29462364]
  • Marco Parolini, Luca Bini, Stefano Magni, Alessandro Rizzo, Anna Ghilardi, Claudia Landi, Alessandro Armini, Luca Del Giacco, Andrea Binelli. Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 2018 Jan; 232(?):603-614. doi: 10.1016/j.envpol.2017.09.097. [PMID: 28993024]
  • Nelida Cristina Rubio, Denise Thurmann, Franziska Krumbiegel, Fritz Pragst. Behaviour of hygrine and cuscohygrine in illicit cocaine production establishes their use as markers for chewing coca leaves in contrast with cocaine abuse. Drug testing and analysis. 2017 Feb; 9(2):323-326. doi: 10.1002/dta.1972. [PMID: 27004438]
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  • María Pilar Chantada-Vázquez, Juan Sánchez-González, Elena Peña-Vázquez, María Jesús Tabernero, Ana María Bermejo, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro. Simple and Sensitive Molecularly Imprinted Polymer - Mn-Doped ZnS Quantum Dots Based Fluorescence Probe for Cocaine and Metabolites Determination in Urine. Analytical chemistry. 2016 Mar; 88(5):2734-41. doi: 10.1021/acs.analchem.5b04250. [PMID: 26857857]
  • Juan Sánchez-González, María Jesús Tabernero, Ana María Bermejo, Pilar Bermejo-Barrera, Antonio Moreda-Piñeiro. Development of magnetic molecularly imprinted polymers for solid phase extraction of cocaine and metabolites in urine before high performance liquid chromatography - tandem mass spectrometry. Talanta. 2016 Jan; 147(?):641-9. doi: 10.1016/j.talanta.2015.10.034. [PMID: 26592657]
  • Vishakantha Murthy, Liyi Geng, Yang Gao, Bin Zhang, Jordan D Miller, Santiago Reyes, Stephen Brimijoin. Reward and Toxicity of Cocaine Metabolites Generated by Cocaine Hydrolase. Cellular and molecular neurobiology. 2015 Aug; 35(6):819-26. doi: 10.1007/s10571-015-0175-9. [PMID: 25814464]
  • Nelida Cristina Rubio, Martin Hastedt, Jorge Gonzalez, Fritz Pragst. Possibilities for discrimination between chewing of coca leaves and abuse of cocaine by hair analysis including hygrine, cuscohygrine, cinnamoylcocaine and cocaine metabolite/cocaine ratios. International journal of legal medicine. 2015 Jan; 129(1):69-84. doi: 10.1007/s00414-014-1061-6. [PMID: 25138383]
  • Yongzhen Liu, Bo Zheng, Stephanie Strafford, Ravi Orugunty, Michael Sullivan, Jeffrey Gus, Christian Heidbreder, Paul J Fudala, Azmi Nasser. Liquid chromatography/tandem mass spectrometry method for simultaneous determination of cocaine and its metabolite (-)ecgonine methyl ester in human acidified stabilized plasma samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jun; 961(?):77-85. doi: 10.1016/j.jchromb.2014.04.052. [PMID: 24861875]
  • Martin J Hicks, Stephen M Kaminsky, Bishnu P De, Jonathan B Rosenberg, Suzette M Evans, Richard W Foltin, David M Andrenyak, David E Moody, George F Koob, Kim D Janda, Rodolfo J Ricart Arbona, Michelle L Lepherd, Ronald G Crystal. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Human gene therapy. Clinical development. 2014 Mar; 25(1):40-9. doi: 10.1089/humc.2013.231. [PMID: 24649839]
  • Nicola S Vos, Eric A F Haak, Onno C Leeksma. [Recurrent neutropenia due to adulterated cocaine]. Nederlands tijdschrift voor geneeskunde. 2014; 158(?):A7430. doi: NULL. [PMID: 24988161]
  • Marco Parolini, Andrea Binelli. Adverse effects induced by ecgonine methyl ester to the zebra mussel: a comparison with the benzoylecgonine. Environmental pollution (Barking, Essex : 1987). 2013 Nov; 182(?):371-8. doi: 10.1016/j.envpol.2013.07.038. [PMID: 23974167]
  • Benedek Gy Plósz, Malcolm J Reid, Morten Borup, Katherine H Langford, Kevin V Thomas. Biotransformation kinetics and sorption of cocaine and its metabolites and the factors influencing their estimation in wastewater. Water research. 2013 May; 47(7):2129-40. doi: 10.1016/j.watres.2012.12.034. [PMID: 23453589]
  • Marcello Mascini, Camilla Montesano, Manuel Sergi, German Perez, Maristella De Cicco, Roberta Curini, Dario Compagnone. Peptides trapping cocaine: docking simulation and experimental screening by solid phase extraction followed by liquid chromatography mass spectrometry in plasma samples. Analytica chimica acta. 2013 Apr; 772(?):40-6. doi: 10.1016/j.aca.2013.02.027. [PMID: 23540246]
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  • Justin J Anker, Stephen Brimijoin, Yang Gao, Liyi Geng, Natalie E Zlebnik, Robin J Parks, Marilyn E Carroll. Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months. Biological psychiatry. 2012 Apr; 71(8):700-5. doi: 10.1016/j.biopsych.2011.11.014. [PMID: 22209637]
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  • Věra Hezinová, Zeineb Aturki, Karel Klepárník, Giovanni D'Orazio, František Foret, Salvatore Fanali. Simultaneous analysis of cocaine and its metabolites in urine by capillary electrophoresis-electrospray mass spectrometry using a pressurized liquid junction nanoflow interface. Electrophoresis. 2012 Feb; 33(4):653-60. doi: 10.1002/elps.201100410. [PMID: 22451058]
  • Philippe Hantson, Arnaud Capron, Pierre Wallemacq. Toxicokinetics of cocaine and metabolites in a body-packer becoming symptomatic. Journal of forensic and legal medicine. 2011 Nov; 18(8):385-7. doi: 10.1016/j.jflm.2011.07.004. [PMID: 22018173]
  • Sara Castiglioni, Renzo Bagnati, Manuela Melis, Deepika Panawennage, Paul Chiarelli, Roberto Fanelli, Ettore Zuccato. Identification of cocaine and its metabolites in urban wastewater and comparison with the human excretion profile in urine. Water research. 2011 Oct; 45(16):5141-50. doi: 10.1016/j.watres.2011.07.017. [PMID: 21824638]
  • Ellen G Duysen, Oksana Lockridge. Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans. Drug metabolism and disposition: the biological fate of chemicals. 2011 Aug; 39(8):1321-3. doi: 10.1124/dmd.111.039917. [PMID: 21540357]
  • Alexander L N van Nuijs, Jean-François Mougel, Isabela Tarcomnicu, Lieven Bervoets, Ronny Blust, Philippe G Jorens, Hugo Neels, Adrian Covaci. A one year investigation of the occurrence of illicit drugs in wastewater from Brussels, Belgium. Journal of environmental monitoring : JEM. 2011 Apr; 13(4):1008-16. doi: 10.1039/c0em00686f. [PMID: 21331424]
  • Cláudia Margalho, João Franco, Francisco Corte-Real, Duarte Nuno Vieira. Illicit drugs in alternative biological specimens: a case report. Journal of forensic and legal medicine. 2011 Apr; 18(3):132-5. doi: 10.1016/j.jflm.2010.12.006. [PMID: 21420652]
  • Maria João Valente, Félix Carvalho, M Lourdes Bastos, Márcia Carvalho, Paula Guedes de Pinho. Development and validation of a gas chromatography/ion trap-mass spectrometry method for simultaneous quantification of cocaine and its metabolites benzoylecgonine and norcocaine: application to the study of cocaine metabolism in human primary cultured renal cells. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Nov; 878(30):3083-8. doi: 10.1016/j.jchromb.2010.09.010. [PMID: 20965795]
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  • Michael L Smith, Eric Shimomura, Buddha D Paul, Edward J Cone, W David Darwin, Marilyn A Huestis. Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine. Journal of analytical toxicology. 2010 Mar; 34(2):57-63. doi: 10.1093/jat/34.2.57. [PMID: 20223096]
  • Robert B Parker, S Casey Laizure. The effect of ethanol on oral cocaine pharmacokinetics reveals an unrecognized class of ethanol-mediated drug interactions. Drug metabolism and disposition: the biological fate of chemicals. 2010 Feb; 38(2):317-22. doi: 10.1124/dmd.109.030056. [PMID: 19920055]
  • Diaa M Shakleya, Riet Dams, Robin E Choo, Hendree Jones, Marilyn A Huestis. Simultaneous liquid chromatography-mass spectrometry quantification of urinary opiates, cocaine, and metabolites in opiate-dependent pregnant women in methadone-maintenance treatment. Journal of analytical toxicology. 2010 Jan; 34(1):17-25. doi: 10.1093/jat/34.1.17. [PMID: 20109298]
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  • José Luiz da Costa, Fernando Gustavo Tonin, Luiz Antonio Zanolli, Alice Aparecida da Matta Chasin, Marina Franco Maggi Tavares. Simple method for determination of cocaine and main metabolites in urine by CE coupled to MS. Electrophoresis. 2009 Jun; 30(12):2238-44. doi: 10.1002/elps.200900032. [PMID: 19582724]
  • Eshwar Jagerdeo, Mohamed Abdel-Rehim. Screening of cocaine and its metabolites in human urine samples by direct analysis in real-time source coupled to time-of-flight mass spectrometry after online preconcentration utilizing microextraction by packed sorbent. Journal of the American Society for Mass Spectrometry. 2009 May; 20(5):891-9. doi: 10.1016/j.jasms.2009.01.010. [PMID: 19264505]
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