5-Benzylacyclouridine (BioDeep_00001871546)

   


代谢物信息卡片


5-Benzylacyclouridine

化学式: C14H16N2O4 (276.111)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CC2=CN(C(=O)NC2=O)COCCO
InChI: InChI=1S/C14H16N2O4/c17-6-7-20-10-16-9-12(13(18)15-14(16)19)8-11-4-2-1-3-5-11/h1-5,9,17H,6-8,10H2,(H,15,18,19)

描述信息

D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

5-Benzylacyclouridine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • G Pizzorno, L Yee, B A Burtness, J C Marsh, J W Darnowski, M Y Chu, S H Chu, E Chu, J J Leffert, R E Handschumacher, P Calabresi. Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor. Clinical cancer research : an official journal of the American Association for Cancer Research. 1998 May; 4(5):1165-75. doi: NULL. [PMID: 9607574]
  • G F Orr, D L Musso, G E Boswell, J L Kelley, S S Joyner, S T Davis, D P Baccanari. Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils. Journal of medicinal chemistry. 1995 Sep; 38(19):3850-6. doi: 10.1021/jm00019a015. [PMID: 7562916]
  • J P Sommadossi, E M Cretton, L B Kidd, H M McClure, D C Anderson, M H el Kouni. Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy. Cancer chemotherapy and pharmacology. 1995; 37(1-2):14-22. doi: 10.1007/bf00685624. [PMID: 7497584]
  • S T Davis, S S Joyner, P Chandrasurin, D P Baccanari. Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine. Biochemical pharmacology. 1993 Jan; 45(1):173-81. doi: 10.1016/0006-2952(93)90390-i. [PMID: 8424810]
  • J W Darnowski, R E Handschumacher, R A Wiegand, F A Goulette, P Calabresi. Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine. Biochemical pharmacology. 1991 Jun; 41(12):2031-6. doi: 10.1016/0006-2952(91)90146-v. [PMID: 2039551]
  • P Calabresi, A Falcone, M H St Clair, M C Wiemann, S H Chu, J W Darnowski. Benzylacyclouridine reverses azidothymidine-induced marrow suppression without impairment of anti-human immunodeficiency virus activity. Blood. 1990 Dec; 76(11):2210-5. doi: . [PMID: 2257294]
  • A Falcone, J W Darnowski, R M Ruprecht, S H Chu, I Brunetti, P Calabresi. Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice. Blood. 1990 Dec; 76(11):2216-21. doi: NULL. [PMID: 2257295]
  • S M Cha. Development of inhibitors of pyrimidine metabolism. Yonsei medical journal. 1989 Dec; 30(4):315-26. doi: 10.3349/ymj.1989.30.4.315. [PMID: 2697111]
  • D S Martin, R L Stolfi, R C Sawyer. Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine. Cancer chemotherapy and pharmacology. 1989; 24(1):9-14. doi: 10.1007/bf00254098. [PMID: 2720896]
  • J W Darnowski, R E Handschumacher. Benzylacyclouridine. Pharmacokinetics, metabolism and biochemical effects in mice. Biochemical pharmacology. 1988 Jul; 37(13):2613-8. doi: 10.1016/0006-2952(88)90254-7. [PMID: 3390221]
  • G J Peters, C J van Groeningen, E J Laurensse, J Lankelma, A Leyva, H M Pinedo. Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites. Cancer chemotherapy and pharmacology. 1987; 20(2):101-8. doi: 10.1007/bf00253962. [PMID: 3664929]
  • J W Darnowski, R E Handschumacher. Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine. Cancer research. 1985 Nov; 45(11 Pt 1):5364-8. doi: NULL. [PMID: 4053009]
  • M Y Chu, F N Naguib, M H Iltzsch, M H el Kouni, S H Chu, S Cha, P Calabresi. Potentiation of 5-fluoro-2'-deoxyuridine antineoplastic activity by the uridine phosphorylase inhibitors benzylacyclouridine and benzyloxybenzylacyclouridine. Cancer research. 1984 May; 44(5):1852-6. doi: . [PMID: 6231986]