GMX1778 (BioDeep_00001871542)

   


代谢物信息卡片


2-[6-(4-Chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine

化学式: C19H22ClN5O (371.15127920000003)
中文名称: N-[6-(4-氯苯氧基)己基]-N-氰基-N-4-吡啶基胍
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1OCCCCCCN=C(NC#N)NC2=CC=NC=C2)Cl
InChI: InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor

同义名列表

2 个代谢物同义名

2-[6-(4-Chlorophenoxy)hexyl]-1-cyano-3-pyridin-4-ylguanidine; GMX1778



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Cristina Travelli, Silvio Aprile, Daiana Mattoteia, Giorgia Colombo, Nausicaa Clemente, Eugenio Scanziani, Salvatore Terrazzino, Maria Alessandra Alisi, Lorenzo Polenzani, Giorgio Grosa, Armando A Genazzani, Gian Cesare Tron, Ubaldina Galli. Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group. European journal of medicinal chemistry. 2019 Nov; 181(?):111576. doi: 10.1016/j.ejmech.2019.111576. [PMID: 31400709]
  • Xiaozhang Zheng, Paul Bauer, Timm Baumeister, Alexandre J Buckmelter, Maureen Caligiuri, Karl H Clodfelter, Bingsong Han, Yen-Ching Ho, Nikolai Kley, Jian Lin, Dominic J Reynolds, Geeta Sharma, Chase C Smith, Zhongguo Wang, Peter S Dragovich, Janet Gunzner-Toste, Bianca M Liederer, Justin Ly, Thomas O'Brien, Angela Oh, Leslie Wang, Weiru Wang, Yang Xiao, Mark Zak, Guiling Zhao, Po-Wai Yuen, Kenneth W Bair. Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. Journal of medicinal chemistry. 2013 Aug; 56(16):6413-33. doi: 10.1021/jm4008664. [PMID: 23859118]
  • Pierre Beauparlant, Dominique Bédard, Cynthia Bernier, Helen Chan, Karine Gilbert, Daniel Goulet, Michel-Olivier Gratton, Manon Lavoie, Anne Roulston, Emilie Turcotte, Mark Watson. Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777. Anti-cancer drugs. 2009 Jun; 20(5):346-54. doi: 10.1097/cad.0b013e3283287c20. [PMID: 19369827]
  • Dieter Fuchs, Rolf Christofferson, Mats Stridsberg, Elin Lindhagen, Faranak Azarbayjani. Regression of orthotopic neuroblastoma in mice by targeting the endothelial and tumor cell compartments. Journal of translational medicine. 2009 Mar; 7(?):16. doi: 10.1186/1479-5876-7-16. [PMID: 19284605]
  • Peter Hovstadius, Rolf Larsson, Elin Jonsson, Torsten Skov, Anne-Marie Kissmeyer, Klaus Krasilnikoff, Jonas Bergh, Mats O Karlsson, Anna Lönnebo, Johan Ahlgren. A Phase I study of CHS 828 in patients with solid tumor malignancy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 Sep; 8(9):2843-50. doi: NULL. [PMID: 12231525]