PD184352(CI-1040) (BioDeep_00001871533)
代谢物信息卡片
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide
化学式: C17H14ClF2IN2O2 (477.97565879999996)
中文名称: 2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
InChI: InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
描述信息
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C69145 - Mitogen-Activated Protein Kinase Kinase Inhibitor
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91353
- PubChem: 6918454
- DrugBank: DB12429
- ChEMBL: CHEMBL105442
- CAS: 212631-79-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Christin Bruchhagen, Marcel Jarick, Carolin Mewis, Tobias Hertlein, Silke Niemann, Knut Ohlsen, Georg Peters, Oliver Planz, Stephan Ludwig, Christina Ehrhardt. Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound.
Scientific reports.
2018 06; 8(1):9114. doi:
10.1038/s41598-018-27445-7. [PMID: 29904167] - Cristina Pierro, Xuexin Zhang, Cynthia Kankeu, Mohamed Trebak, Martin D Bootman, H Llewelyn Roderick. Oncogenic KRAS suppresses store-operated Ca2+ entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines.
Cell calcium.
2018 06; 72(?):70-80. doi:
10.1016/j.ceca.2018.03.002. [PMID: 29748135] - Feixue Li, Huihui Ma, Jing Liu. Pyrethroid Insecticide Cypermethrin Modulates Gonadotropin Synthesis via Calcium Homeostasis and ERK1/2 Signaling in LβT2 Mouse Pituitary Cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 03; 162(1):43-52. doi:
10.1093/toxsci/kfx248. [PMID: 29149324] - Aby Joiakim, Patricia A Mathieu, Catherine Shelp, Julie Boerner, John J Reiners. Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells.
Drug metabolism and disposition: the biological fate of chemicals.
2016 May; 44(5):665-71. doi:
10.1124/dmd.115.066274. [PMID: 26953171] - Faith Hannah Nutter, John L Haylor, Arif Khwaja. Inhibiting ERK Activation with CI-1040 Leads to Compensatory Upregulation of Alternate MAPKs and Plasminogen Activator Inhibitor-1 following Subtotal Nephrectomy with No Impact on Kidney Fibrosis.
PloS one.
2015; 10(9):e0137321. doi:
10.1371/journal.pone.0137321. [PMID: 26415098] - Michelle Richter, Angelika F Winkel, Dietmar Schummer, Martin Gerlitz, Meltsje de Hoop, Bodo Brunner, Maike Glien, Dieter Schmoll. Pau d'arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway.
The Journal of toxicological sciences.
2014 Apr; 39(2):353-61. doi:
10.2131/jts.39.353. [PMID: 24646717] - Kathrin Rothe, Hans Jürgen Solinski, Ingrid Boekhoff, Thomas Gudermann, Andreas Breit. Morphine activates the E twenty six-like transcription factor-1/serum response factor pathway via extracellular signal-regulated kinases 1/2 in F11 cells derived from dorsal root ganglia neurons.
The Journal of pharmacology and experimental therapeutics.
2012 Jul; 342(1):41-52. doi:
10.1124/jpet.112.192757. [PMID: 22454534] - Rebecca E Schweppe, Anna A Kerege, Vibha Sharma, Joanna M Poczobutt, Arthur Gutierrez-Hartmann, Rachel L Grzywa, Bryan R Haugen. Distinct genetic alterations in the mitogen-activated protein kinase pathway dictate sensitivity of thyroid cancer cells to mitogen-activated protein kinase kinase 1/2 inhibition.
Thyroid : official journal of the American Thyroid Association.
2009 Aug; 19(8):825-35. doi:
10.1089/thy.2008.0362. [PMID: 19500021] - Shuang Wang, Jifu Jiang, Qiunong Guan, Hao Wang, Christopher Y C Nguan, Anthony M Jevnikar, Caigan Du. Reduction of chronic allograft nephropathy by inhibition of extracellular signal-regulated kinase 1 and 2 signaling.
American journal of physiology. Renal physiology.
2008 Sep; 295(3):F672-9. doi:
10.1152/ajprenal.90285.2008. [PMID: 18614619] - Z Wu, D Gioeli, M Conaway, M J Weber, D Theodorescu. Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors.
The Prostate.
2008 Jun; 68(9):935-44. doi:
10.1002/pros.20745. [PMID: 18386291] - Qi-Long Ying, Jason Wray, Jennifer Nichols, Laura Batlle-Morera, Bradley Doble, James Woodgett, Philip Cohen, Austin Smith. The ground state of embryonic stem cell self-renewal.
Nature.
2008 May; 453(7194):519-23. doi:
10.1038/nature06968. [PMID: 18497825] - Rita Sarközi, Bradley Miller, Verena Pollack, Elisabeth Feifel, Gert Mayer, Andrey Sorokin, Herbert Schramek. ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells.
Journal of cellular physiology.
2007 Apr; 211(1):88-100. doi:
10.1002/jcp.20909. [PMID: 17131384] - Luciano J Costa, Robert M Gemmill, Harry A Drabkin. Upstream signaling inhibition enhances rapamycin effect on growth of kidney cancer cells.
Urology.
2007 Mar; 69(3):596-602. doi:
10.1016/j.urology.2007.01.053. [PMID: 17382186] - Maria Isabel Cerezo-Guisado, Natalia García-Román, Luis Jesús García-Marín, Alberto Alvarez-Barrientos, Maria Julia Bragado, Maria Jesús Lorenzo. Lovastatin inhibits the extracellular-signal-regulated kinase pathway in immortalized rat brain neuroblasts.
The Biochemical journal.
2007 Jan; 401(1):175-83. doi:
10.1042/bj20060731. [PMID: 16952276] - Sayu Omori, Mariko Hida, Hisayo Fujita, Hisahide Takahashi, Susumu Tanimura, Michiaki Kohno, Midori Awazu. Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease.
Journal of the American Society of Nephrology : JASN.
2006 Jun; 17(6):1604-14. doi:
10.1681/asn.2004090800. [PMID: 16641154] - Patricia M Lorusso, Alex A Adjei, Mary Varterasian, Shirish Gadgeel, Joel Reid, David Y Mitchell, Lorelei Hanson, Pamela DeLuca, Laura Bruzek, Jill Piens, Peggy Asbury, Keri Van Becelaere, Roman Herrera, Judith Sebolt-Leopold, Mark B Meyer. Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2005 Aug; 23(23):5281-93. doi:
10.1200/jco.2005.14.415. [PMID: 16009947] - James T Murray, David G Campbell, Mark Peggie, Alfonso Mora, Mora Alfonso, Philip Cohen. Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.
The Biochemical journal.
2004 Dec; 384(Pt 3):489-94. doi:
10.1042/bj20041058. [PMID: 15461588] - Susanne Naegele, Simon J Morley. Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress.
The Journal of biological chemistry.
2004 Oct; 279(44):46023-34. doi:
10.1074/jbc.m404945200. [PMID: 15292274] - Paul A Wabnitz, David Mitchell, David A M Wabnitz. In vitro and in vivo metabolism of the anti-cancer agent CI-1040, a MEK inhibitor, in rat, monkey, and human.
Pharmaceutical research.
2004 Sep; 21(9):1670-9. doi:
10.1023/b:pham.0000041464.27579.d0. [PMID: 15497695] - Yao Yao, Wei Li, Junwei Wu, Ursula A Germann, Michael S S Su, Keisuke Kuida, Diane M Boucher. Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation.
Proceedings of the National Academy of Sciences of the United States of America.
2003 Oct; 100(22):12759-64. doi:
10.1073/pnas.2134254100. [PMID: 14566055] - Matthew S Squires, Paula M Nixon, Simon J Cook. Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.
The Biochemical journal.
2002 Sep; 366(Pt 2):673-80. doi:
10.1042/bj20020372. [PMID: 12069688] - M Guo, A Joiakim, D T Dudley, J J Reiners. Suppression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12-O-tetradecanoylphorbol-13-acetate: role of transforming growth factor beta and mitogen-activated protein kinases.
Biochemical pharmacology.
2001 Dec; 62(11):1449-57. doi:
10.1016/s0006-2952(01)00801-2. [PMID: 11728381] - S Patel, P A Lochhead, G Rena, C Sutherland. Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression.
The Biochemical journal.
2001 Nov; 359(Pt 3):611-9. doi:
10.1042/0264-6021:3590611. [PMID: 11672436]