Oxonic Acid (BioDeep_00001871499)
代谢物信息卡片
Oxonic Acid
化学式: C4H3N3O4 (157.0123558)
中文名称: 2,4-二羟基-1,3,5-三嗪-6-羧酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=NC(=O)NC(=O)N1)C(=O)O
InChI: InChI=1S/C4H3N3O4/c8-2(9)1-5-3(10)7-4(11)6-1/h(H,8,9)(H2,5,6,7,10,11)
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:30863
- PubChem: 4604
- DrugBank: DB03209
- ChEMBL: CHEMBL181932
- MeSH: Oxonic Acid
- CAS: 937-13-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yan Zhang, Yao Li, Chang Li, Yani Zhao, Lu Xu, Shanbo Ma, Fen Lin, Yanhua Xie, Junming An, Siwang Wang. Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Sep; 118(?):154957. doi:
10.1016/j.phymed.2023.154957. [PMID: 37478683] - Xiaowei Luo, Lipeng Zhou, Shukai Wang, Jing Yuan, Zihao Chang, Qian Hu, Yinxin Chen, Yuqi Liu, Ya Huang, Baojin Wang, Ye Gao, Zhaohui Wang, Yitong Cui, Yue Liu, Lanzhen Zhang. The Therapeutic Effect and the Potential Mechanism of Flavonoids and Phenolics of Moringa oleifera Lam. Leaves against Hyperuricemia Mice.
Molecules (Basel, Switzerland).
2022 Nov; 27(23):. doi:
10.3390/molecules27238237. [PMID: 36500329] - Haochen Guan, Huagang Lin, Xiaojun Wang, Ying Xu, Yuqi Zheng, Xun Zhou, Xuehong Diao, Zhibin Ye, Jing Xiao. Autophagy-dependent Na+-K+-ATPase signalling and abnormal urate reabsorption in hyperuricaemia-induced renal tubular injury.
European journal of pharmacology.
2022 Oct; 932(?):175237. doi:
10.1016/j.ejphar.2022.175237. [PMID: 36063871] - Linyun Jiang, Yulin Wu, Chang Qu, Yinsi Lin, Xiaoqing Yi, Changjun Gao, Jian Cai, Ziren Su, Huifang Zeng. Hypouricemic effect of gallic acid, a bioactive compound from Sonneratia apetala leaves and branches, on hyperuricemic mice.
Food & function.
2022 Oct; 13(19):10275-10290. doi:
10.1039/d2fo02068h. [PMID: 36125096] - Barakat M ALRashdi, Hassan A Elgebaly, Mousa O Germoush, Moath M Qarmush, Mona S Azab, Reem S Alruhaimi, Ahmad F Ahmeda, Mohammad H Abukhalil, Emadeldin M Kamel, Hany H Arab, Mohammed A Alzoghaibi, Mohammed F Alotaibi, Ayman M Mahmoud. A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats.
Environmental science and pollution research international.
2022 Sep; 29(42):63520-63532. doi:
10.1007/s11356-022-20274-2. [PMID: 35461413] - Chih-Chiang Wang, You-Liang Li, Po-Yen Chiu, Chun Chen, Hung-Che Chen, Fu-An Chen. Protective effects of corni fructus extract in mice with potassium oxonate-induced hyperuricemia.
The Journal of veterinary medical science.
2022 Aug; 84(8):1134-1141. doi:
10.1292/jvms.21-0671. [PMID: 35781421] - Tianqiao Yong, Danling Liang, Shaodan Chen, Chun Xiao, Xiong Gao, Qingping Wu, Yizhen Xie, Longhua Huang, Huiping Hu, Xiangmin Li, Yuancao Liu, Manjun Cai. Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Aug; 103(?):154256. doi:
10.1016/j.phymed.2022.154256. [PMID: 35714456] - Eisuke Booka, Chiyo K Imamura, Masashi Takeuchi, Hirofumi Kawakubo, Hiroya Takeuchi, Yusuke Tanigawara, Yuko Kitagawa, Narikazu Boku. Evaluation of clinical validity of an S-1 dosage formula based on renal function using data of the SPIRITS and the G-SOX trials.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association.
2022 07; 25(4):770-782. doi:
10.1007/s10120-022-01291-z. [PMID: 35357635] - Bin-Yuan Hu, Yun-Li Zhao, Dan-Yu Ma, Mei-Ling Xiang, Li-Xing Zhao, Xiao-Dong Luo. Anti-hyperuricemic bioactivity of Alstonia scholaris and its bioactive triterpenoids in vivo and in vitro.
Journal of ethnopharmacology.
2022 May; 290(?):115049. doi:
10.1016/j.jep.2022.115049. [PMID: 35150817] - Jing Tian, Baichuan Wang, Bin Xie, Xinwei Liu, Dapeng Zhou, Xuening Hou, Liangbi Xiang. Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice.
Modern rheumatology.
2022 Jan; 32(1):221-230. doi:
10.1080/14397595.2021.1899569. [PMID: 33705241] - Yu-Zhi Wang, Cong Zhou, Li-Jie Zhu, Xing-Li-Shang He, Lin-Zi Li, Xiang Zheng, Wan-Feng Xu, Ying-Jie Dong, Bo Li, Qiao-Xian Yu, Gui-Yuan Lv, Su-Hong Chen. Effects of Macroporous Resin Extract of Dendrobium officinale Leaves in Rats with Hyperuricemia Induced by Fructose and Potassium Oxonate.
Combinatorial chemistry & high throughput screening.
2022; 25(8):1294-1303. doi:
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European journal of pharmacology.
2021 Dec; 912(?):174592. doi:
10.1016/j.ejphar.2021.174592. [PMID: 34699754] - Chun-Lei Zhang, Jin-Juan Zhang, Qin-Feng Zhu, Huan-Yu Guan, Ya-Xin Yang, Xun He, Yao Fu, Teng-Xiang Chen, Li Dong, Xiao-Sheng Yang, Kai-Fa Tang, Guo-Bo Xu, Shang-Gao Liao. Antihyperuricemia and antigouty arthritis effects of Persicaria capitata herba in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Dec; 93(?):153765. doi:
10.1016/j.phymed.2021.153765. [PMID: 34610527] - Xia Zhao, Jing Wang, Liying Tang, Pei Li, Jing Ru, Yuzhi Bai. Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Bioengineered.
2021 12; 12(1):589-600. doi:
10.1080/21655979.2021.1882761. [PMID: 33517833] - Yoshitaka Saito, Yoh Takekuma, Satoshi Takeuchi, Yoshito Komatsu, Mitsuru Sugawara. Severe hypertriglyceridemia induced by S-1: Subsequent case series of four patients and further review of the literature.
International journal of clinical pharmacology and therapeutics.
2021 Dec; 59(12):787-793. doi:
10.5414/cp204091. [PMID: 34503646] - Qingqian Zhang, Yue Qian, Ying Yin. Comparison of S-1-based vs. capecitabine-based adjuvant chemotherapy for patients with gastric cancer: a systematic review and meta-analysis.
European journal of clinical pharmacology.
2021 Dec; 77(12):1791-1804. doi:
10.1007/s00228-021-03187-w. [PMID: 34275019] - Xiaoqing Li, Xiaoxiang Gao, Hui Zhang, Yuanyuan Liu, Md Moklesur Rahman Sarker, Yijing Wu, Xinhua Chen, Chao Zhao. The anti-hyperuricemic effects of green alga Enteromorpha prolifera polysaccharide via regulation of the uric acid transporters in vivo.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Dec; 158(?):112630. doi:
10.1016/j.fct.2021.112630. [PMID: 34687833] - Jiangchao Zhuang, Xie Zhou, Ting Liu, Shuai Zhang, Falei Yuan, Leifang Zhang, Zuisu Yang, Yan Chen. Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Die Pharmazie.
2021 11; 76(11):551-558. doi:
10.1691/ph.2021.1731. [PMID: 34782040] - Jinfen Chen, Lieqiang Xu, Linyun Jiang, Yulin Wu, Long Wei, Xiaoli Wu, Shihong Xiao, Yuhong Liu, Changjun Gao, Jian Cai, Ziren Su. Sonneratia apetala seed oil attenuates potassium oxonate/hypoxanthine-induced hyperuricemia and renal injury in mice.
Food & function.
2021 Oct; 12(19):9416-9431. doi:
10.1039/d1fo01830b. [PMID: 34606558] - Yoon-Young Sung, Dong-Seon Kim. Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats.
Nutrients.
2021 Sep; 13(10):. doi:
10.3390/nu13103323. [PMID: 34684325] - Xiaofen Qi, Haoran Chen, Kaifang Guan, Rongchun Wang, Ying Ma. Anti-hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats.
Journal of the science of food and agriculture.
2021 Sep; 101(12):4916-4924. doi:
10.1002/jsfa.11135. [PMID: 33543494] - Satoshi Kobayashi, Makoto Ueno, Gakuto Ogawa, Akira Fukutomi, Masafumi Ikeda, Takuji Okusaka, Tosiya Sato, Yoshinori Ito, Tomohiro Kadota, Tatsuya Ioka, Kazuya Sugimori, Naohiro Sata, Shoji Nakamori, Kyoko Shimizu, Nobumasa Mizuno, Hiroshi Ishii, Junji Furuse. Impact of Renal Function on S-1 + Radiotherapy for Locally Advanced Pancreatic Cancer: An Integrated Analysis of Data From 2 Clinical Trials.
Pancreas.
2021 08; 50(7):965-971. doi:
10.1097/mpa.0000000000001879. [PMID: 34629456] - Yuanyuan Xu, Xirong Cao, Haoan Zhao, Erlin Yang, Yue Wang, Ni Cheng, Wei Cao. Impact of Camellia japonica Bee Pollen Polyphenols on Hyperuricemia and Gut Microbiota in Potassium Oxonate-Induced Mice.
Nutrients.
2021 Jul; 13(8):. doi:
10.3390/nu13082665. [PMID: 34444825] - Chih-Chieh Yen, Yan-Shen Shan, Ying-Jui Chao, Ting-Kai Liao, I-Shu Chen, Hsuan-Yi Huang, I-Ting Liu, Chia-Jui Yen. Surgery alone, adjuvant tegafur/gimeracil/octeracil (S-1), or platinum-based chemotherapies for resectable gastric cancer: real-world experience and a propensity score matching analysis.
BMC cancer.
2021 Jul; 21(1):796. doi:
10.1186/s12885-021-08487-z. [PMID: 34243732] - Hongling Li, Xuejiao Liu, Mee-Hyun Lee, Haitao Li. Vitamin C alleviates hyperuricemia nephropathy by reducing inflammation and fibrosis.
Journal of food science.
2021 Jul; 86(7):3265-3276. doi:
10.1111/1750-3841.15803. [PMID: 34160066] - Yongmei Li, Zean Zhao, Jian Luo, Yanqing Jiang, Lu Li, Yanyu Chen, Leqi Zhang, Qinghua Huang, Ying Cao, Pingzheng Zhou, Ting Wu, Jianxin Pang. Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jul; 87(?):153585. doi:
10.1016/j.phymed.2021.153585. [PMID: 34044255] - Fei Yang, Wenjun Shi, Liting Wang, Nankun Qin, Chengxiang Wang, Yuying Guo, Guang Xu, Jie Fang, Xue Yu, Qun Ma. Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat.
BMC complementary medicine and therapies.
2021 Jun; 21(1):175. doi:
10.1186/s12906-021-03350-x. [PMID: 34172058] - Xiaofei Zhou, Bowei Zhang, Xiuli Zhao, Yongxi Lin, Jin Wang, Xiaowen Wang, Nan Hu, Shuo Wang. Chlorogenic acid supplementation ameliorates hyperuricemia, relieves renal inflammation, and modulates intestinal homeostasis.
Food & function.
2021 Jun; 12(12):5637-5649. doi:
10.1039/d0fo03199b. [PMID: 34018499] - Yoshitaka Saito, Yoh Takekuma, Yoshito Komatsu, Mitsuru Sugawara. Hypertriglyceridemia induced by S-1: A novel case report and review of the literature.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2021 Jun; 27(4):1020-1025. doi:
10.1177/1078155220956691. [PMID: 32936722] - Shozo Mori, Taku Aoki, Yuhki Sakuraoka, Takayuki Shimizu, Takamune Yamaguchi, Kyung-Hwa Park, Takatsugu Matsumoto, Takayuki Shiraki, Yukihiro Iso, Keiichi Kubota. Predictors of Poor Pathological Response to Neoadjuvant Gemcitabine Plus S-1 Chemotherapy in Patients With Pancreatic Ductal Adenocarcinoma.
Pancreas.
2021 May; 50(5):744-750. doi:
10.1097/mpa.0000000000001826. [PMID: 34016892] - Hui Chen, Liangjun Xue, Lihong Liu, Pengfei Li. Efficacy of apatinib combined with tegafur gimeracil and oteracil potassium in the second-line treatment of advanced gastric cancer.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 May; 26(3):917-923. doi:
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Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2021 May; 26(3):932-939. doi:
. [PMID: 34268956] - Yuchen Tian, Lianzhu Lin, Mouming Zhao, An Peng, Kun Zhao. Xanthine oxidase inhibitory activity and antihyperuricemic effect of Moringa oleifera Lam. leaf hydrolysate rich in phenolics and peptides.
Journal of ethnopharmacology.
2021 Apr; 270(?):113808. doi:
10.1016/j.jep.2021.113808. [PMID: 33450289] - Raouia Dhouibi, Hanen Affes, Maryem Ben Salem, Dorsaf Moalla, Rim Marekchi, Slim Charfi, Serria Hammami, Zouheir Sahnoun, Kamel Jamoussi, Khaled Mounir Zeghal, Kamilia Ksouda. Creation of an adequate animal model of hyperuricemia (acute and chronic hyperuricemia); study of its reversibility and its maintenance.
Life sciences.
2021 Mar; 268(?):118998. doi:
10.1016/j.lfs.2020.118998. [PMID: 33417953] - B W Xie, L Zang, J J Ma, J Sun, X Yang, M L Wang, A G Lu, W G Hu, M H Zheng. [Safety and effectiveness of oxaliplatin combined with capecitabine or oxaliplatin combined with S-1 neoadjuvant chemotherapy in the treatment of advanced gastric cancer].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery.
2021 Feb; 24(2):138-144. doi:
10.3760/cma.j.cn.441530-20200721-00433. [PMID: 33508919] - Yanyu Chen, Zean Zhao, Yongmei Li, Yang Yang, Lu Li, Yu Jiang, Cuiting Lin, Ying Cao, Pingzheng Zhou, Yuanxin Tian, Ting Wu, Jianxin Pang. Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jan; 80(?):153374. doi:
10.1016/j.phymed.2020.153374. [PMID: 33075645] - Peiyu Wen, Haibo Wang, Tengyang Ni, Xiaojun Dai, Zewen Chu, Shuang Ma, Liangliang Xiang, Zhen Zhou, Yayun Qian, Masataka Sunagawa, Yanqing Liu. A Study on the Effect and Mechanism of Xiaoaiping (XAP) Injection and S-1 Combination Therapy in Inhibiting the Invasion and Metastasis of Human GC Cells.
Anti-cancer agents in medicinal chemistry.
2021; 21(8):1037-1046. doi:
10.2174/1871520620666200918100422. [PMID: 32951585] - Hidenori Ando, Kiyoshi Eshima, Tatsuhiro Ishida. Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model.
Biological & pharmaceutical bulletin.
2021; 44(2):266-270. doi:
10.1248/bpb.b20-00825. [PMID: 33518679] - Jianfeng Yang, Jing Wang, Haibin Zhou, Yucheng Wang, Haitao Huang, Hangbin Jin, Qifeng Lou, Raj J Shah, Xiaofeng Zhang. Endoscopic radiofrequency ablation plus a novel oral 5-fluorouracil compound versus radiofrequency ablation alone for unresectable extrahepatic cholangiocarcinoma.
Gastrointestinal endoscopy.
2020 12; 92(6):1204-1212.e1. doi:
10.1016/j.gie.2020.04.075. [PMID: 32437711] - Min Shi, Fan Guo, Dan Liao, Rongshuang Huang, Yuying Feng, Xiaoxi Zeng, Liang Ma, Ping Fu. Pharmacological inhibition of fatty acid-binding protein 4 alleviated kidney inflammation and fibrosis in hyperuricemic nephropathy.
European journal of pharmacology.
2020 Nov; 887(?):173570. doi:
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CEN case reports.
2020 11; 9(4):347-353. doi:
10.1007/s13730-020-00485-7. [PMID: 32378178] - Yingchun Zeng, Yu Ma, Zhengyu Yang, Jiamin Mao, Yaxin Zheng. Antihyperuricemic efficacy of Scopoletin-loaded Soluplus micelles in yeast extract/potassium oxonate-induced hyperuricemic mice.
Drug development and industrial pharmacy.
2020 Sep; 46(9):1550-1557. doi:
10.1080/03639045.2020.1811302. [PMID: 32811191] - Shaoshi Wen, Dan Wang, Haiyang Yu, Mengyang Liu, Qian Chen, Ruixia Bao, Lin Liu, Yi Zhang, Tao Wang. The Time-Feature of Uric Acid Excretion in Hyperuricemia Mice Induced by Potassium Oxonate and Adenine.
International journal of molecular sciences.
2020 Jul; 21(15):. doi:
10.3390/ijms21155178. [PMID: 32707836] - Arshad Mehmood, Liang Zhao, Muhammad Ishaq, Muhammad Usman, Oumeddour Dounya Zad, Imam Hossain, Rifat Nowshin Raka, Muhammad Naveed, Lei Zhao, Chengtao Wang, Muhammad Nadeem. Uricostatic and uricosuric effect of grapefruit juice in potassium oxonate-induced hyperuricemic mice.
Journal of food biochemistry.
2020 07; 44(7):e13213. doi:
10.1111/jfbc.13213. [PMID: 32347580] - Hiroki Omizo, Yoshifuru Tamura, Chikayuki Morimoto, Masaki Ueno, Yuto Hayama, Emiko Kuribayashi-Okuma, Shunya Uchida, Shigeru Shibata. Cardio-renal protective effect of the xanthine oxidase inhibitor febuxostat in the 5/6 nephrectomy model with hyperuricemia.
Scientific reports.
2020 06; 10(1):9326. doi:
10.1038/s41598-020-65706-6. [PMID: 32518351] - Xiao-Cui Hong, Qi-Lian Liang, Xing-Bo Luo, Ke-Hui Hu, Hai-Xia Yang, Wen-Ting Ou, Hui-Jie Zhang. Clinical study of XiangShaLiuJunZi decoction combined with S-1 as maintenance therapy for stage III or IV gastric carcinoma and colorectal carcinoma.
Medicine.
2020 May; 99(19):e20081. doi:
10.1097/md.0000000000020081. [PMID: 32384478] - Po-Chih Yang, Kai-Wen Huang, Uei Pua, Man-Deuk Kim, Sheng-Ping Li, Xiao-Yong Li, Po-Chin Liang. Prognostic factor analysis of irreversible electroporation for locally advanced pancreatic cancer - A multi-institutional clinical study in Asia.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
2020 05; 46(5):811-817. doi:
10.1016/j.ejso.2019.12.006. [PMID: 31839436] - Hui Shi, Xiao Shan Liang, Li Wen Huang, Zhi Gang Luo, Long Tan. [The optimization and assessment of the method for inducing hyperuricemia in rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2020 May; 36(3):223-227. doi:
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The Journal of pharmacy and pharmacology.
2020 Apr; 72(4):551-560. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
2020 Mar; 47(3):548-550. doi:
NULL. [PMID: 32381945] - Ayed A Dera, Prasanna Rajagopalan, Mohammad A Alfhili, Irfan Ahmed, Harish C Chandramoorthy. Thymoquinone attenuates oxidative stress of kidney mitochondria and exerts nephroprotective effects in oxonic acid-induced hyperuricemia rats.
BioFactors (Oxford, England).
2020 Mar; 46(2):292-300. doi:
10.1002/biof.1590. [PMID: 31758843] - Muhammad Bilal, Saeed Ahmad, Tayyeba Rehman, Waheed Mumtaz Abbasi, Aymen Owais Ghauri, Muhammad Adeel Arshad, Sultan Ayaz, Allah Nawaz. Development of herbal formulation of medicinal plants and determination of its antihyperuricemic potential in vitro and in vivo rat's model.
Pakistan journal of pharmaceutical sciences.
2020 Mar; 33(2):641-649. doi:
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Scientific reports.
2020 02; 10(1):3161. doi:
10.1038/s41598-020-59939-8. [PMID: 32081926] - Ami Ota-Kontani, Hiroshi Hirata, Masatsune Ogura, Youichi Tsuchiya, Mariko Harada-Shiba. Comprehensive analysis of mechanism underlying hypouricemic effect of glucosyl hesperidin.
Biochemical and biophysical research communications.
2020 01; 521(4):861-867. doi:
10.1016/j.bbrc.2019.10.199. [PMID: 31711647] - Bin Han, Mengjuan Gong, Zhong Li, Yuqin Qiu, Zhongjie Zou. NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats.
Oxidative medicine and cellular longevity.
2020; 2020(?):6943860. doi:
10.1155/2020/6943860. [PMID: 32695259] - Tsuyoshi Hasegawa, Hitoshi Teraoka, Takuya Mori, Haruhito Kinoshita, Kentaro Nakamoto, Eiji Noda, Kosei Hirakawa, Masaichi Ohira. [Analysis of Renal Toxicity of S-1 plus CDDP Regimen with Short Hydration for Outpatients with Gastric Cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
2019 Dec; 46(13):2407-2409. doi:
NULL. [PMID: 32156947] - Gurpreet Kandav, D C Bhatt, Deepak Kumar Jindal. Targeting kidneys by superparamagnetic allopurinol loaded chitosan coated nanoparticles for the treatment of hyperuricemic nephrolithiasis.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2019 Dec; 27(2):661-671. doi:
10.1007/s40199-019-00300-4. [PMID: 31686374] - Yonger Chen, Cantao Li, Shuni Duan, Xin Yuan, Jian Liang, Shaozhen Hou. Curcumin attenuates potassium oxonate-induced hyperuricemia and kidney inflammation in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109195. doi:
10.1016/j.biopha.2019.109195. [PMID: 31362244] - Zhichao Zhou, Ya Dong, Hanchi Zhou, Jia Liu, Wei Zhao. MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
Biochemical and biophysical research communications.
2019 09; 517(3):413-420. doi:
10.1016/j.bbrc.2019.07.114. [PMID: 31378369] - Young-Sil Lee, Yoon-Young Sung, Heung Joo Yuk, Eunjung Son, SeonJoo Lee, Jin Soo Kim, Dong-Seon Kim. Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Sep; 62(?):152975. doi:
10.1016/j.phymed.2019.152975. [PMID: 31181404] - Tong-Hua Yang, De-Xiu Yan, Xiao-Yan Huang, Bo Hou, Yun-Bao Ma, Hua Peng, Xue-Mei Zhang, Ji-Jun Chen, Chang-An Geng. Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis.
Phytochemistry.
2019 Aug; 164(?):228-235. doi:
10.1016/j.phytochem.2019.05.019. [PMID: 31181354] - Akimitsu Iizuka, Mitsuro Kanda, Seiji Ito, Yoshinari Mochizuki, Hitoshi Teramoto, Kiyoshi Ishigure, Toshifumi Murai, Takahiro Asada, Akiharu Ishiyama, Hidenobu Matsushita, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara, Kenta Murotani, Yasuhiro Kodera. Proposal of a Scoring Scale to Estimate Risk of the Discontinuation of S-1 Adjuvant Monotherapy in Patients with Stage II to III Gastric Cancer: A Multi-Institutional Dataset Analysis.
World journal of surgery.
2019 08; 43(8):2016-2024. doi:
10.1007/s00268-019-04942-y. [PMID: 30737551] - Yung-Tsung Chau, Hsin-Yuan Chen, Po-Han Lin, Shih-Min Hsia. Preventive Effects of Fucoidan and Fucoxanthin on Hyperuricemic Rats Induced by Potassium Oxonate.
Marine drugs.
2019 06; 17(6):. doi:
10.3390/md17060343. [PMID: 31185695] - Hirofumi Yasui, Takeshi Kawakami, Hiroya Kashiwagi, Keita Mori, Katsuhiro Omae, Jun Kasai, Kunihiro Yoshisue, Masahiro Kawahira, Takahiro Tsushima, Nozomu Machida, Akira Fukutomi, Ken Yamaguchi. Pharmacokinetics of S-1 monotherapy in plasma and in tears for gastric cancer patients.
International journal of clinical oncology.
2019 Jun; 24(6):660-665. doi:
10.1007/s10147-018-01387-6. [PMID: 31011915] - Guoyan Liang, Yichu Nie, Yunbing Chang, Shixing Zeng, Changxiang Liang, Xiaoqing Zheng, Dan Xiao, Shiqiang Zhan, Qiujian Zheng. Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Jun; 59(?):152772. doi:
10.1016/j.phymed.2018.11.032. [PMID: 31005813] - Fei Yang, Mingyu Liu, Nankun Qin, Shuangshuang Li, Mengqi Yu, Chengxiang Wang, Qun Ma. Lipidomics coupled with pathway analysis characterizes serum metabolic changes in response to potassium oxonate induced hyperuricemic rats.
Lipids in health and disease.
2019 May; 18(1):112. doi:
10.1186/s12944-019-1054-z. [PMID: 31077208] - Wenjun You, Jie Wang, Yaowu Zou, Kui Che, Xu Hou, Honghua Fei, Yangang Wang. Modified Chuanhu anti-gout mixture, a traditional Chinese medicine, protects against potassium oxonate-induced hyperuricemia and renal dysfunction in mice.
The Journal of international medical research.
2019 May; 47(5):1927-1935. doi:
10.1177/0300060519831182. [PMID: 30832523] - Jun-Bao Liu, Tunyu Jian, Chao Yue, Dan Chen, Wei Chen, Ting-Ting Bao, Hai-Xia Liu, Yun Cao, Wei-Bing Li, Zhijian Yang, Robert M Hoffman, Chen Yu. Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus.
Anticancer research.
2019 Apr; 39(4):1689-1698. doi:
10.21873/anticanres.13274. [PMID: 30952707] - Jianbiao Yao, Houhong He, Jin Xue, Jianfang Wang, Huihui Jin, Jian Wu, Jiangning Hu, Ruwei Wang, Kenny Kuchta. Mori Ramulus (Chin.Ph.)-the Dried Twigs of Morus alba L./Part 1: Discovery of Two Novel Coumarin Glycosides from the Anti-Hyperuricemic Ethanol Extract.
Molecules (Basel, Switzerland).
2019 Feb; 24(3):. doi:
10.3390/molecules24030629. [PMID: 30754654] - Akio Nakashima, Atsushi Yamauchi, Junichi Matsumoto, Shinya Dohgu, Fuyuko Takata, Mitsuhisa Koga, Jiro Fukae, Yoshio Tsuboi, Yasufumi Kataoka. Feeding-produced subchronic high plasma levels of uric acid improve behavioral dysfunction in 6-hydroxydopamine-induced mouse model of Parkinson's disease.
Behavioural pharmacology.
2019 02; 30(1):89-94. doi:
10.1097/fbp.0000000000000413. [PMID: 29847340] - Naixin Liu, Ying Wang, Meifeng Yang, Wenxin Bian, Lin Zeng, Saige Yin, Ziqian Xiong, Yan Hu, Siyuan Wang, Buliang Meng, Jun Sun, Xinwang Yang. New Rice-Derived Short Peptide Potently Alleviated Hyperuricemia Induced by Potassium Oxonate in Rats.
Journal of agricultural and food chemistry.
2019 Jan; 67(1):220-228. doi:
10.1021/acs.jafc.8b05879. [PMID: 30562028] - Dool-Ri Oh, Jong Ro Kim, Chul Yung Choi, Chan-Hun Choi, Chang-Su Na, Bok Yun Kang, Seon-Jong Kim, Young Ran Kim. Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1.
BMC complementary and alternative medicine.
2019 Jan; 19(1):10. doi:
10.1186/s12906-018-2415-2. [PMID: 30621705] - Guoqiang Zhang, Yanrong Ma, Dali Xi, Zhi Rao, Xiaohan Sun, Xin'an Wu. Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies.
Biopharmaceutics & drug disposition.
2019 Jan; 40(1):3-11. doi:
10.1002/bdd.2164. [PMID: 30488476] - Kei Nishizawa, Noriaki Yoda, Fumi Morokado, Hisakazu Komori, Takeo Nakanishi, Ikumi Tamai. Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
PloS one.
2019; 14(4):e0214862. doi:
10.1371/journal.pone.0214862. [PMID: 30951542] - Hae Won Lee, Sook Jin Seong, Woo Youl Kang, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Seungil Cho, Kyunghee Cho, Yong Kyung Sung, Young-Ran Yoon, Jong Gwang Kim. Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients.
Drug design, development and therapy.
2019; 13(?):3127-3136. doi:
10.2147/dddt.s219822. [PMID: 31564829] - Heung Joo Yuk, Young-Sil Lee, Hyung Won Ryu, Seung-Hyung Kim, Dong-Seon Kim. Effects of Toona sinensis Leaf Extract and Its Chemical Constituents on Xanthine Oxidase Activity and Serum Uric Acid Levels in Potassium Oxonate-Induced Hyperuricemic Rats.
Molecules (Basel, Switzerland).
2018 Dec; 23(12):. doi:
10.3390/molecules23123254. [PMID: 30544886] - Rui Zhang, Shaoying Zhan, Shuyi Li, Zhenzhou Zhu, Jingren He, Jose M Lorenzo, Francisco J Barba. Anti-hyperuricemic and nephroprotective effects of extracts from Chaenomeles sinensis (Thouin) Koehne in hyperuricemic mice.
Food & function.
2018 Nov; 9(11):5778-5790. doi:
10.1039/c8fo01480a. [PMID: 30327809] - Tianqiao Yong, Dan Li, Muxia Li, Danling Liang, Xue Diao, Chenling Deng, Shaodan Chen, Yizhen Xie, Diling Chen, Dan Zuo. Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD.
Molecules (Basel, Switzerland).
2018 Oct; 23(10):. doi:
10.3390/molecules23102671. [PMID: 30336599] - Yoko Akune, Masakazu Yamada, Chika Shigeyasu. Determination of 5-fluorouracil and tegafur in tear fluid of patients treated with oral fluoropyrimidine anticancer agent, S-1.
Japanese journal of ophthalmology.
2018 Jul; 62(4):432-437. doi:
10.1007/s10384-018-0603-8. [PMID: 29931401] - Dejun Zhao, Jun-Fei Feng, Xue-Hui Wang. A retrospective study of concurrent radiotherapy plus S-1 for treating advanced non-small cell lung cancer.
Medicine.
2018 Jun; 97(22):e10740. doi:
10.1097/md.0000000000010740. [PMID: 29851779] - Yaolin Xu, Xi Guo, Yue Fan, Dansong Wang, Wenchuan Wu, Lili Wu, Tianshu Liu, Bei Xu, Yi Feng, Yan Wang, Wenhui Lou, Yuhong Zhou. Efficacy and safety comparison of nabpaclitaxel plus S-1 and gemcitabine plus S-1 as first-line chemotherapy for metastatic pancreatic cancer.
Japanese journal of clinical oncology.
2018 Jun; 48(6):535-541. doi:
10.1093/jjco/hyy063. [PMID: 29718363] - Xiaoran Liu, Ya Li, Zhixin Li, Xiaomin Wei, Yanjie Ma, Peng Cheng, Rui Jiao, Jinzhi Fang, Yun Xing, Jiali Tang, Min Wang, Taiming Li. A novel IgG1 monoclonal antibody against xanthine oxidase alleviates inflammation induced by potassium oxonate in mice.
International journal of biological macromolecules.
2018 Jun; 112(?):537-547. doi:
10.1016/j.ijbiomac.2018.01.171. [PMID: 29382583] - Hua Yang, Wenwei Bai, Lihui Gao, Jun Jiang, Yingxi Tang, Yanfen Niu, Hua Lin, Ling Li. Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases.
Journal of pharmacological sciences.
2018 Jun; 137(2):154-161. doi:
10.1016/j.jphs.2018.05.008. [PMID: 29934052] - Kei Saito, Hiroyuki Isayama, Yoshihiro Sakamoto, Yousuke Nakai, Kazunaga Ishigaki, Mariko Tanaka, Takeyuki Watadani, Junichi Arita, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Hideaki Ijichi, Keisuke Tateishi, Minoru Tada, Kiyoshi Hasegawa, Masashi Fukayama, Norihiro Kokudo, Kazuhiko Koike. A phase II trial of gemcitabine, S-1 and LV combination (GSL) neoadjuvant chemotherapy for patients with borderline resectable and locally advanced pancreatic cancer.
Medical oncology (Northwood, London, England).
2018 May; 35(7):100. doi:
10.1007/s12032-018-1158-8. [PMID: 29846849] - Kang Wang, Lei Hu, Jian-Kang Chen. RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and kidney injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 May; 101(?):617-626. doi:
10.1016/j.biopha.2018.02.010. [PMID: 29518608] - Yi Zhang, Lijun Jin, Jinchang Liu, Wei Wang, Haiyang Yu, Jian Li, Qian Chen, Tao Wang. Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia.
Journal of ethnopharmacology.
2018 Mar; 214(?):29-36. doi:
10.1016/j.jep.2017.12.004. [PMID: 29233733] - Naohiro Okano, Akiyoshi Kasuga, Kirio Kawai, Yoshiya Yamauchi, Takaaki Kobayashi, Daisuke Naruge, Fumio Nagashima, Junji Furuse. The Modified Glasgow Prognostic Score in Patients with Gemcitabine-refractory Biliary Tract Cancer.
Anticancer research.
2018 03; 38(3):1755-1761. doi:
10.21873/anticanres.12412. [PMID: 29491113] - Siti Sarwani Putri Mohamed Isa, Abdulwali Ablat, Jamaludin Mohamad. The Antioxidant and Xanthine Oxidase Inhibitory Activity of Plumeria rubra Flowers.
Molecules (Basel, Switzerland).
2018 Feb; 23(2):. doi:
10.3390/molecules23020400. [PMID: 29438299] - Laura-Gabriela Sánchez-Lozada, Fernando E García-Arroyo, Guillermo Gonzaga, Octaviano Silverio, Mónica G Blas-Marron, Itzel Muñoz-Jimenez, Edilia Tapia, Horacio Osorio-Alonso, Magdalena Madero, Carlos A Roncal-Jiménez, Ilana Weiss, Jason Glaser, Richard J Johnson. Kidney Injury from Recurrent Heat Stress and Rhabdomyolysis: Protective Role of Allopurinol and Sodium Bicarbonate.
American journal of nephrology.
2018; 48(5):339-348. doi:
10.1159/000494663. [PMID: 30391956] - Yuji Miura, Yasutaka Sukawa, Shuichi Hironaka, Misuzu Mori, Kazuhiro Nishikawa, Shinya Tokunaga, Hiroyuki Okuda, Takeshi Sakamoto, Keisei Taku, Kazuo Nishikawa, Toshikazu Moriwaki, Yuji Negoro, Yutaka Kimura, Keita Uchino, Katsunori Shinozaki, Hiroharu Shinozaki, Nobuyuki Musha, Hirotsugu Yoshiyama, Takashi Tsuda, Yoshinori Miyata, Naotoshi Sugimoto, Tsuyoshi Shirakawa, Miki Ito, Kimio Yonesaka, Kenichi Yoshimura, Narikazu Boku, Katsuhiko Nosho, Toshimi Takano, Ichinosuke Hyodo. Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G).
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association.
2018 Jan; 21(1):84-95. doi:
10.1007/s10120-017-0725-6. [PMID: 28497176] - Fernando E García-Arroyo, Guillermo Gonzaga, Itzel Muñoz-Jiménez, Mónica G Blas-Marron, Octaviano Silverio, Edilia Tapia, Virgilia Soto, Natarajan Ranganathan, Pari Ranganathan, Usha Vyas, Anthony Irvin, Diana Ir, Charles E Robertson, Daniel N Frank, Richard J Johnson, L Gabriela Sánchez-Lozada. Probiotic supplements prevented oxonic acid-induced hyperuricemia and renal damage.
PloS one.
2018; 13(8):e0202901. doi:
10.1371/journal.pone.0202901. [PMID: 30142173] - Qibiao Su, Hua Su, Zhihuan Nong, Dongmei Li, Laiyou Wang, Shifeng Chu, Lizhen Liao, Jie Zhao, Xianbiao Zeng, Qikang Ya, Fei He, Wenjie Lu, Baowei Wei, Guining Wei, Naihong Chen. Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats.
Kidney & blood pressure research.
2018; 43(1):220-233. doi:
10.1159/000487675. [PMID: 29490297] - Namju Kim, Jin Won Kim, Je-Hyun Baek, Jin-Soo Kim, Ho-Kyung Choung, Tae-Yong Kim, Kyung-Hun Lee, Yung-Jue Bang, Sang In Khwarg, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Jae-Yong Chung, Soyeon Ahn, Keun-Wook Lee. S-1-Induced Lacrimal Drainage Obstruction and Its Association with Ingredients/Metabolites of S-1 in Tears and Plasma: A Prospective Multi-institutional Study.
Cancer research and treatment.
2018 Jan; 50(1):30-39. doi:
10.4143/crt.2016.569. [PMID: 28253565] - Maria Fátima de Paula Ramos, Alceni do Carmo Morais Monteiro de Barros, Clara Versolato Razvickas, Fernanda T Borges, Nestor Schor. Xanthine oxidase inhibitors and sepsis.
International journal of immunopathology and pharmacology.
2018 Jan; 32(?):2058738418772210. doi:
10.1177/2058738418772210. [PMID: 29786457] - Miriam Martínez-Ramírez, Cristóbal Flores-Castillo, L Gabriela Sánchez-Lozada, Rocío Bautista-Pérez, Elizabeth Carreón-Torres, José Manuel Fragoso, José Manuel Rodriguez-Pérez, Fernando E García-Arroyo, Victoria López-Olmos, María Luna-Luna, Gilberto Vargas-Alarcón, Martha Franco, Oscar Pérez-Méndez. Hyperuricemia is Associated with Increased Apo AI Fractional Catabolic Rates and Dysfunctional HDL in New Zealand Rabbits.
Lipids.
2017 Dec; 52(12):999-1006. doi:
10.1007/s11745-017-4301-y. [PMID: 28940111] - Hui Wang, Ying Peng, Tingjian Zhang, Qunsheng Lan, Huimin Zhao, Wenbao Wang, Yufei Zhao, Xu Wang, Jianxin Pang, Shaojie Wang, Jiang Zheng. Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity.
Drug metabolism and disposition: the biological fate of chemicals.
2017 12; 45(12):1354-1363. doi:
10.1124/dmd.117.077818. [PMID: 29021351] - Yuichi Yasutake, Kengo Tomita, Masaaki Higashiyama, Hirotaka Furuhashi, Kazuhiko Shirakabe, Takeshi Takajo, Koji Maruta, Hirokazu Sato, Kazuyuki Narimatsu, Kenichi Yoshikawa, Yoshikiyo Okada, Chie Kurihara, Chikako Watanabe, Shunsuke Komoto, Shigeaki Nagao, Hirotaka Matsuo, Soichiro Miura, Ryota Hokari. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity.
Journal of gastroenterology and hepatology.
2017 Nov; 32(11):1839-1845. doi:
10.1111/jgh.13785. [PMID: 28295549] - Tae Hwan Kim, Soyoung Shin, Jeong Cheol Shin, Jürgen B Bulitta, Kwon-Yeon Weon, Sun Dong Yoo, Gi-Young Park, Seok Won Jeong, Dong Rak Kwon, Byung Sun Min, Mi Hee Woo, Beom Soo Shin. Effect of Sipjeondaebo-Tang on the Pharmacokinetics of S-1, an Anticancer Agent, in Rats Evaluated by Population Pharmacokinetic Modeling.
Molecules (Basel, Switzerland).
2017 Sep; 22(9):. doi:
10.3390/molecules22091488. [PMID: 28880240] - Dong-Hong Tang, You-Song Ye, Chen-Yun Wang, Zhe-Li Li, Hong Zheng, Kai-Li Ma. Potassium oxonate induces acute hyperuricemia in the tree shrew (tupaia belangeri chinensis).
Experimental animals.
2017 Aug; 66(3):209-216. doi:
10.1538/expanim.16-0096. [PMID: 28302963]