PX-12 (BioDeep_00001871497)
代谢物信息卡片
2-(Sec-butyldisulfanyl)-1h-imidazole
化学式: C7H12N2S2 (188.0442)
中文名称: 2-(仲丁基二硫基)-1H-咪唑, 1H-咪唑，2-[（1-甲基丙基）二硫代]
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)SSC1=NC=CN1
InChI: InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:94291
- PubChem: 219104
- DrugBank: DB05448
- ChEMBL: CHEMBL406050
- CAS: 141400-58-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hongyan Yang, Libo Li, Yu Jiao, Yuanliang Zhang, Yuhua Wang, Kunjie Zhu, Chao Sun. Thioredoxin-1 mediates neuroprotection of Schisanhenol against MPP+-induced apoptosis via suppression of ASK1-P38-NF-κB pathway in SH-SY5Y cells.
Scientific reports.
2021 11; 11(1):21604. doi:
10.1038/s41598-021-01000-3. [PMID: 34732784] - Carmen Gil, Tiziana Ginex, Inés Maestro, Vanesa Nozal, Lucía Barrado-Gil, Miguel Ángel Cuesta-Geijo, Jesús Urquiza, David Ramírez, Covadonga Alonso, Nuria E Campillo, Ana Martinez. COVID-19: Drug Targets and Potential Treatments.
Journal of medicinal chemistry.
2020 11; 63(21):12359-12386. doi:
10.1021/acs.jmedchem.0c00606. [PMID: 32511912] - Yuping Liu, Yang Zhao, Zhonghong Wei, Li Tao, Xiaobo Sheng, Siliang Wang, Jiao Chen, Junshan Ruan, Zhaoguo Liu, Yuzhu Cao, Yunlong Shan, Aiyun Wang, Wenxing Chen, Yin Lu. Targeting Thioredoxin System with an Organosulfur Compound, Diallyl Trisulfide (DATS), Attenuates Progression and Metastasis of Triple-Negative Breast Cancer (TNBC).
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 50(5):1945-1963. doi:
10.1159/000494874. [PMID: 30396169] - Xiang Ren, Heyuan Lu, Nina Wang, Chenghong Zhang, Yunpeng Ji, Shiqi Cui, Yichen Dong, Kaiyuan Yang, Mengyi Du, Fengsheng Diao, Li Kong. Thioredoxin is implicated in the anti‑apoptotic effects of grape seed proanthocyanidin extract during hyperglycemia.
Molecular medicine reports.
2017 Nov; 16(5):7731-7737. doi:
10.3892/mmr.2017.7508. [PMID: 28944891] - Eduardo Reynoso, Hua Liu, Lin Li, Anthony L Yuan, She Chen, Zhigao Wang. Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.
The Journal of biological chemistry.
2017 10; 292(42):17514-17524. doi:
10.1074/jbc.m117.799353. [PMID: 28878015] - Gang Li, Kun Gao, Yuan Chi, Xiling Zhang, Takahiko Mitsui, Jian Yao, Masayuki Takeda. Upregulation of connexin43 contributes to PX-12-induced oxidative cell death.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2016 Jun; 37(6):7535-46. doi:
10.1007/s13277-015-4620-7. [PMID: 26684802] - Prahlad V Raninga, Giovanna Di Trapani, Slavica Vuckovic, Maneet Bhatia, Kathryn F Tonissen. Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma.
Oncotarget.
2015 Jun; 6(17):15410-24. doi:
10.18632/oncotarget.3795. [PMID: 25945832] - A F Baker, K N Adab, N Raghunand, Hhs Chow, S P Stratton, S W Squire, M Boice, L A Pestano, D L Kirkpatrick, T Dragovich. A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers.
Investigational new drugs.
2013 Jun; 31(3):631-641. doi:
10.1007/s10637-012-9846-2. [PMID: 22711542] - Ramesh K Ramanathan, Joe J Stephenson, Glen J Weiss, Linda A Pestano, Ann Lowe, Alton Hiscox, Rafael A Leos, Julie C Martin, Lynn Kirkpatrick, Donald A Richards. A phase I trial of PX-12, a small-molecule inhibitor of thioredoxin-1, administered as a 72-hour infusion every 21 days in patients with advanced cancers refractory to standard therapy.
Investigational new drugs.
2012 Aug; 30(4):1591-6. doi:
10.1007/s10637-011-9739-9. [PMID: 21863237] - Jennifer S Carew, Juan A Esquivel, Claudia M Espitia, Christoph M Schultes, Marcel Mülbaier, Joe D Lewis, Bernd Janssen, Francis J Giles, Steffan T Nawrocki. ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma.
PloS one.
2012; 7(1):e31120. doi:
10.1371/journal.pone.0031120. [PMID: 22295124] - Ramesh K Ramanathan, James Abbruzzese, Tomislav Dragovich, Lynn Kirkpatrick, Jose M Guillen, Amanda F Baker, Linda A Pestano, Sylvan Green, Daniel D Von Hoff. A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination.
Cancer chemotherapy and pharmacology.
2011 Mar; 67(3):503-9. doi:
10.1007/s00280-010-1343-8. [PMID: 20461382] - Ramesh K Ramanathan, D Lynn Kirkpatrick, Chandra P Belani, David Friedland, Sylvan B Green, H-H Sherry Chow, Catherine A Cordova, Steven P Stratton, Elizabeth R Sharlow, Amanda Baker, Tomislav Dragovich. A Phase I pharmacokinetic and pharmacodynamic study of PX-12, a novel inhibitor of thioredoxin-1, in patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2007 Apr; 13(7):2109-14. doi:
10.1158/1078-0432.ccr-06-2250. [PMID: 17404093] - Amanda F Baker, Tomislav Dragovich, Wendy R Tate, Ramesh K Ramanathan, Denise Roe, Chiu-Hsieh Hsu, D Lynn Kirkpatrick, Garth Powis. The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma.
The Journal of laboratory and clinical medicine.
2006 Feb; 147(2):83-90. doi:
10.1016/j.lab.2005.09.001. [PMID: 16459166] - Bénédicte F Jordan, Matthew Runquist, Natarajan Raghunand, Robert J Gillies, Wendy R Tate, Garth Powis, Amanda F Baker. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2005 Jan; 11(2 Pt 1):529-36. doi:
NULL. [PMID: 15701837] - Sarah J Welsh, Ryan R Williams, Anne Birmingham, David J Newman, D Lynn Kirkpatrick, Garth Powis. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
Molecular cancer therapeutics.
2003 Mar; 2(3):235-43. doi:
NULL. [PMID: 12657718]
