6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine (BioDeep_00001871481)

   


代谢物信息卡片


6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine

化学式: C14H15ClN6O (318.099581)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
InChI: InChI=1S/C14H15ClN6O/c1-7-4-17-9(8(2)11(7)22-3)5-21-6-18-10-12(15)19-14(16)20-13(10)21/h4,6H,5H2,1-3H3,(H2,16,19,20)

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor

同义名列表

1 个代谢物同义名

6-Chloro-9-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-9H-purin-2-amine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

PlantCyc(0)

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文献列表

  • Silviu Sbiera, Sabine Kendl, Isabel Weigand, Iuliu Sbiera, Martin Fassnacht, Matthias Kroiss. Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane. Molecular and cellular endocrinology. 2019 01; 480(?):36-41. doi: 10.1016/j.mce.2018.10.009. [PMID: 30315857]
  • Muhammad Wasif Saif, Chris Takimoto, Monica Mita, Udai Banerji, Nicole Lamanna, Januario Castro, Susan O'Brien, Christopher Stogard, Daniel Von Hoff. A phase 1, dose-escalation, pharmacokinetic and pharmacodynamic study of BIIB021 administered orally in patients with advanced solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Jan; 20(2):445-55. doi: 10.1158/1078-0432.ccr-13-1257. [PMID: 24097863]
  • Lin Xu, Caroline Woodward, Jing Dai, Chandra Prakash. Metabolism and excretion of 6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 inhibitor, in rats and dogs and assessment of its metabolic profile in plasma of humans. Drug metabolism and disposition: the biological fate of chemicals. 2013 Dec; 41(12):2133-47. doi: 10.1124/dmd.113.054023. [PMID: 24046333]
  • Naveen Dakappagari, Laura Neely, Shabnam Tangri, Karen Lundgren, Lori Hipolito, Annalee Estrellado, Francis Burrows, Hong Zhang. An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2010 Feb; 15(1):31-8. doi: 10.3109/13547500903261347. [PMID: 19747088]
  • Karen Lundgren, Hong Zhang, John Brekken, Nanni Huser, Rachel E Powell, Noel Timple, David J Busch, Laura Neely, John L Sensintaffar, Yong-ching Yang, Andres McKenzie, Jessica Friedman, Robert Scannevin, Adeela Kamal, Kevin Hong, Srinivas R Kasibhatla, Marcus F Boehm, Francis J Burrows. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Molecular cancer therapeutics. 2009 Apr; 8(4):921-9. doi: 10.1158/1535-7163.mct-08-0758. [PMID: 19372565]