2-methoxyphenamine hcl (BioDeep_00001871445)
代谢物信息卡片
2-methoxyphenamine hcl
化学式: C11H17NO (179.131)
中文名称: 甲氧那明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=CC=C1OC)NC
InChI: InChI=1S/C11H17NO/c1-9(12-2)8-10-6-4-5-7-11(10)13-3/h4-7,9,12H,8H2,1-3H3
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CB - Non-selective beta-adrenoreceptor agonists
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Atsushi Nitta, Noriaki Shima, Tooru Kamata, Keiko Sasaki, Shuntaro Matsuta, Akari Ishikawa, Ryutaro Asai, Misato Wada, Hidenao Kakehashi, Shihoko Fujii, Hiroe Kamata, Hiroshi Nishioka, Takako Sato, Hitoshi Tsuchihashi, Akihiro Miki, Munehiro Katagi. Incorporation of Methoxyphenamine into Hair in Early Stage after Intake.
Journal of analytical toxicology.
2021 Nov; 45(9):1006-1013. doi:
10.1093/jat/bkaa165. [PMID: 33068108] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.
Analytical and bioanalytical chemistry.
2010 Apr; 396(7):2583-98. doi:
10.1007/s00216-010-3484-3. [PMID: 20155493] - Mario Thevis, Gerd Sigmund, Hans Geyer, Wilhelm Schänzer. Stimulants and doping in sport.
Endocrinology and metabolism clinics of North America.
2010 Mar; 39(1):89-105, ix. doi:
10.1016/j.ecl.2009.10.011. [PMID: 20122452] - Michael Moawad, Cheang S Khoo, Samiuela Lee, James R Hennell. Simultaneous determination of eight sympathomimetic amines in urine by gas chromatography/mass spectrometry.
Journal of AOAC International.
2010 Jan; 93(1):116-22. doi:
. [PMID: 20334173] - Akira Namera, Akihiro Nakamoto, Manami Nishida, Takeshi Saito, Izumi Kishiyama, Shota Miyazaki, Midori Yahata, Mikio Yashiki, Masataka Nagao. Extraction of amphetamines and methylenedioxyamphetamines from urine using a monolithic silica disk-packed spin column and high-performance liquid chromatography-diode array detection.
Journal of chromatography. A.
2008 Oct; 1208(1-2):71-5. doi:
10.1016/j.chroma.2008.08.091. [PMID: 18790482] - Mario Thevis, Gerd Sigmund, Anja Koch, Sven Guddat, Hans H Maurer, Wilhelm Schänzer. Doping control analysis of methoxyphenamine using liquid chromatography-tandem mass spectrometry.
European journal of mass spectrometry (Chichester, England).
2008; 14(3):145-52. doi:
10.1255/ejms.926. [PMID: 18708694] - Hajime Miyaguchi, Manabu Tokeshi, Yoshikuni Kikutani, Akihide Hibara, Hiroyuki Inoue, Takehiko Kitamori. Microchip-based liquid-liquid extraction for gas-chromatography analysis of amphetamine-type stimulants in urine.
Journal of chromatography. A.
2006 Sep; 1129(1):105-10. doi:
10.1016/j.chroma.2006.06.107. [PMID: 16872620] - Yi-Chien Hsieh, Chen-Wen Whang. Analysis of ethambutol and methoxyphenamine by capillary electrophoresis with electrochemiluminescence detection.
Journal of chromatography. A.
2006 Jul; 1122(1-2):279-82. doi:
10.1016/j.chroma.2006.05.078. [PMID: 16797572] - Seung-Woon Myung, Sung-Ho Yoon, Myungsoo Kim. Analysis of benzene ethylamine derivatives in urine using the programmable dynamic liquid-phase microextraction (LPME) device.
The Analyst.
2003 Dec; 128(12):1443-6. doi:
10.1039/b312227c. [PMID: 14737229] - G A Jacobson, F V Chong, N W Davies. LC-MS method for the determination of albuterol enantiomers in human plasma using manual solid-phase extraction and a non-deuterated internal standard.
Journal of pharmaceutical and biomedical analysis.
2003 Apr; 31(6):1237-43. doi:
10.1016/s0731-7085(02)00734-3. [PMID: 12667940] - B C Foster, D L Wilson, T D Cyr, J Moffatt, H S Buttar. The influence of pregnancy on the biotransformation and urinary excretion of methoxyphenamine in mice.
Biopharmaceutics & drug disposition.
1995 Jan; 16(1):1-11. doi:
10.1002/bdd.2510160102. [PMID: 7711279] - Y Nakahara, K Takahashi, K Konuma. Hair analysis for drugs of abuse. VI. The excretion of methoxyphenamine and methamphetamine into beards of human subjects.
Forensic science international.
1993 Dec; 63(1-3):109-19. doi:
10.1016/0379-0738(93)90265-c. [PMID: 7908007] - G Muralidharan, E M Hawes, G McKay, K K Midha. Quinine is a more potent inhibitor than quinidine in rat of the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.
Xenobiotica; the fate of foreign compounds in biological systems.
1991 Nov; 21(11):1441-50. doi:
10.3109/00498259109044394. [PMID: 1763518] - G Muralidharan, E M Hawes, G McKay, E D Korchinski, K K Midha. Quinidine but not quinine inhibits in man the oxidative metabolic routes of methoxyphenamine which involve debrisoquine 4-hydroxylase.
European journal of clinical pharmacology.
1991; 41(5):471-4. doi:
10.1007/bf00626372. [PMID: 1761076] - G Muralidharan, K K Midha, G McKay, E M Hawes, T Inaba. Selective in vivo inhibition by quinidine of methoxyphenamine oxidation in rat models of human debrisoquine polymorphism.
Xenobiotica; the fate of foreign compounds in biological systems.
1989 Feb; 19(2):189-97. doi:
10.3109/00498258909034691. [PMID: 2786289] - N R Srinivas, J W Hubbard, E M Hawes, G McKay, K K Midha. Enantioselective gas chromatographic assays with electron-capture detection for methoxyphenamine and its three primary metabolites in human urine.
Journal of chromatography.
1989 Jan; 487(1):61-72. doi:
10.1016/s0378-4347(00)83007-8. [PMID: 2715275] - S D Roy, H K Lim. Separation of optical isomers of methoxyphenamine and its metabolites as N-heptafluorobutyryl-L-prolyl derivatives by fused-silica capillary gas chromatography.
Journal of chromatography.
1988 Sep; 431(1):210-5. doi:
10.1016/s0378-4347(00)83087-x. [PMID: 2906939] - S D Roy, E M Hawes, K K Midha. Influence of urinary pH on the disposition of methoxyphenamine and three metabolites in humans.
Journal of pharmaceutical sciences.
1987 Jun; 76(6):427-32. doi:
10.1002/jps.2600760603. [PMID: 3625484] - S D Roy, E M Hawes, G McKay, E D Korchinski, K K Midha. Metabolism of methoxyphenamine in extensive and poor metabolizers of debrisoquin.
Clinical pharmacology and therapeutics.
1985 Aug; 38(2):128-33. doi:
10.1038/clpt.1985.148. [PMID: 4017414] - S D Roy, E M Hawes, G McKay, J W Hubbard, K K Midha. Methoxyphenamine metabolism in rat models of human debrisoquine phenotypes.
Canadian journal of physiology and pharmacology.
1985 Jul; 63(7):778-81. doi:
10.1139/y85-129. [PMID: 3876145] - S D Roy, G McKay, E M Hawes, K K Midha. Gas chromatographic quantitation of methoxyphenamine and three of its metabolites in plasma.
Journal of chromatography.
1984 Oct; 310(2):307-17. doi:
10.1016/0378-4347(84)80095-x. [PMID: 6150940] - G McKay, J K Cooper, E M Hawes, S D Roy, K K Midha. Identification of new secondary metabolites of methoxyphenamine in man.
Xenobiotica; the fate of foreign compounds in biological systems.
1983 Apr; 13(4):257-64. doi:
10.3109/00498258309052262. [PMID: 6624141] - T Niwaguchi, T Inoue. Excretion of methoxyphenamine and its metabolites in rat urine.
Journal of chromatography.
1978 Nov; 161(?):223-9. doi:
10.1016/s0021-9673(01)85230-4. [PMID: 730795] - K K Midha, J K Cooper, I J Mcgilveray, R T Coutts, R Dawe. Metabolism of methoxyphenamine in man and in monkey.
Drug metabolism and disposition: the biological fate of chemicals.
1976 Nov; 4(6):568-76. doi:
NULL. [PMID: 11979]
