10E,12Z-octadecadienoic acid (BioDeep_00001871421)

   

natural product


代谢物信息卡片


(10E,12Z)-octadeca-10,12-dienoic acid

化学式: C18H32O2 (280.2402)
中文名称: 共轭亚油酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCC/C=C\C=C\CCCCCCCCC(=O)O
InChI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-9H,2-5,10-17H2,1H3,(H,19,20)/b7-6-,9-8+

描述信息

(10E,12Z)-Octadeca-10,12-dienoic acidactivates PPAR α and inhibits adipocyte differentiation[1]. (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid is effective orally[2][3].

同义名列表

3 个代谢物同义名

(10E,12Z)-octadeca-10,12-dienoic acid; 10E,12Z-octadecadienoic acid; trans-10,cis-12 CLA2



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Luzia Renata Oliveira Dias, Ligiane Oliveira Leme, José Felipe Warmling Sprícigo, Ivo Pivato, Margot Alves Nunes Dode. Effect of delipidant agents during in vitro culture on the development, lipid content, gene expression and cryotolerance of bovine embryos. Reproduction in domestic animals = Zuchthygiene. 2020 Jan; 55(1):11-20. doi: 10.1111/rda.13579. [PMID: 31650647]
  • Jose Cordoba-Chacon, Dhavamani Sugasini, Poorna C R Yalagala, Apoorva Tummala, Zachary C White, Toshihiro Nagao, Rhonda D Kineman, Papasani V Subbaiah. Tissue-dependent effects of cis-9,trans-11- and trans-10,cis-12-CLA isomers on glucose and lipid metabolism in adult male mice. The Journal of nutritional biochemistry. 2019 05; 67(?):90-100. doi: 10.1016/j.jnutbio.2019.01.020. [PMID: 30856468]
  • Tianying Zhang, Yue Ma, Hui Wang, Juan J Loor, Huifen Xu, Huaiping Shi, Jun Luo. Trans10, cis12 conjugated linoleic acid increases triacylglycerol accumulation in goat mammary epithelial cells in vitro. Animal science journal = Nihon chikusan Gakkaiho. 2018 Feb; 89(2):432-440. doi: 10.1111/asj.12935. [PMID: 29114968]
  • Huaiping Shi, Tianying Zhang, Cong Li, Jianjue Wang, Jiangtao Huang, Zhongyang Li. trans-10,cis-12-Conjugated Linoleic Acid Affects Expression of Lipogenic Genes in Mammary Glands of Lactating Dairy Goats. Journal of agricultural and food chemistry. 2017 Nov; 65(43):9460-9467. doi: 10.1021/acs.jafc.7b02377. [PMID: 29019657]
  • Azadeh Yeganeh, Carla G Taylor, Jenna Poole, Leslee Tworek, Peter Zahradka. Trans10, cis12 conjugated linoleic acid inhibits 3T3-L1 adipocyte adipogenesis by elevating β-catenin levels. Biochimica et biophysica acta. 2016 Apr; 1861(4):363-70. doi: 10.1016/j.bbalip.2016.01.004. [PMID: 26780430]
  • Tatiana M Marques, Rebecca Wall, Orla O'Sullivan, Gerald F Fitzgerald, Fergus Shanahan, Eamonn M Quigley, Paul D Cotter, John F Cryan, Timothy G Dinan, R Paul Ross, Catherine Stanton. Dietary trans-10, cis-12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice. The British journal of nutrition. 2015 Mar; 113(5):728-38. doi: 10.1017/s0007114514004206. [PMID: 25697178]
  • M Petzold, U Meyer, S Kersten, J Spilke, G Breves, S Dänicke. Impacts of CLA and dietary concentrate proportion on blood metabolite concentration and proliferation of peripheral blood mononuclear cells of periparturient dairy cows. Animal : an international journal of animal bioscience. 2015 Mar; 9(3):481-9. doi: 10.1017/s175173111400264x. [PMID: 25382062]
  • Yang Zhan, Hong Shi, Stephanie P B Caligiuri, Yinghong Wu, Vanessa Declercq, Carla G Taylor, Peter Zahradka, Malcolm R Ogborn, Harold M Aukema. Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy. The Journal of nutritional biochemistry. 2015 Feb; 26(2):130-7. doi: 10.1016/j.jnutbio.2014.09.011. [PMID: 25458529]
  • Nathalie Nicod, Robert S Parker, Elena Giordano, Virginia Maestro, Alberto Davalos, Francesco Visioli. Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport. The Journal of nutritional biochemistry. 2015 Feb; 26(2):165-72. doi: 10.1016/j.jnutbio.2014.10.002. [PMID: 25468613]
  • Ming-Shyong Wang, Chia-Ling Chang, Chien-I Lee, Huey-Mei Shaw. trans-10,cis-12 conjugated linoleic acid specifically increases tissue α-tocopherol mediated by PPARγ inhibition in mice. International journal of food sciences and nutrition. 2014 Nov; 65(7):841-7. doi: 10.3109/09637486.2014.917150. [PMID: 24840024]
  • Tomaž Malovrh, Enver Melkić, Drago Kompan, Alenka Levart, Lidija Kompan. Incorporation of conjugated linoleic acid isomers into porcine erythrocytes. European journal of nutrition. 2014 Apr; 53(3):989-93. doi: 10.1007/s00394-013-0618-3. [PMID: 24240600]
  • Shane M Huebner, Jake M Olson, James P Campbell, Jeffrey W Bishop, Peter M Crump, Mark E Cook. Dietary trans-10,cis-12 CLA reduces murine collagen-induced arthritis in a dose-dependent manner. The Journal of nutrition. 2014 Feb; 144(2):177-84. doi: 10.3945/jn.113.182550. [PMID: 24285692]
  • G Khelashvili, N Johner, G Zhao, D Harries, H L Scott. Molecular origins of bending rigidity in lipids with isolated and conjugated double bonds: the effect of cholesterol. Chemistry and physics of lipids. 2014 Feb; 178(?):18-26. doi: 10.1016/j.chemphyslip.2013.12.012. [PMID: 24394210]
  • Hanna Stinshoff, Sandra Wilkening, Ana Hanstedt, Heinrich Bollwein, Christine Wrenzycki. Dimethylsulfoxide and conjugated linoleic acids affect bovine embryo development in vitro. Reproduction, fertility, and development. 2014; 26(4):502-10. doi: 10.1071/rd12372. [PMID: 23574633]
  • Laura J den Hartigh, Chang Yeop Han, Shari Wang, Mohamed Omer, Alan Chait. 10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species. Journal of lipid research. 2013 Nov; 54(11):2964-78. doi: 10.1194/jlr.m035188. [PMID: 23956445]
  • A K G Kadegowda, T A Burns, S L Pratt, S K Duckett. Inhibition of stearoyl-CoA desaturase 1 reduces lipogenesis in primary bovine adipocytes. Lipids. 2013 Oct; 48(10):967-76. doi: 10.1007/s11745-013-3823-1. [PMID: 23929455]
  • E G Prates, S P Alves, C C Marques, M C Baptista, A E M Horta, R J B Bessa, R M Pereira. Fatty acid composition of porcine cumulus oocyte complexes (COC) during maturation: effect of the lipid modulators trans-10, cis-12 conjugated linoleic acid (t10,c12 CLA) and forskolin. In vitro cellular & developmental biology. Animal. 2013 May; 49(5):335-45. doi: 10.1007/s11626-013-9624-2. [PMID: 23645468]
  • E G Prates, C C Marques, M C Baptista, M I Vasques, N Carolino, A E M Horta, R Charneca, J T Nunes, R M Pereira. Fat area and lipid droplet morphology of porcine oocytes during in vitro maturation with trans-10, cis-12 conjugated linoleic acid and forskolin. Animal : an international journal of animal bioscience. 2013 Apr; 7(4):602-9. doi: 10.1017/s1751731112001899. [PMID: 23098362]
  • Suresh K Mohankumar, Carla G Taylor, Linda Siemens, Peter Zahradka. Activation of phosphatidylinositol-3 kinase, AMP-activated kinase and Akt substrate-160 kDa by trans-10, cis-12 conjugated linoleic acid mediates skeletal muscle glucose uptake. The Journal of nutritional biochemistry. 2013 Feb; 24(2):445-56. doi: 10.1016/j.jnutbio.2012.01.006. [PMID: 22704782]
  • H-J Song, A A Sneddon, S D Heys, K W J Wahle. Regulation of fatty acid synthase (FAS) and apoptosis in estrogen-receptor positive and negative breast cancer cells by conjugated linoleic acids. Prostaglandins, leukotrienes, and essential fatty acids. 2012 Dec; 87(6):197-203. doi: 10.1016/j.plefa.2012.09.002. [PMID: 23142364]
  • Meaghan Reardon, Semone Gobern, Kristina Martinez, Wan Shen, Tanya Reid, Michael McIntosh. Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes. Lipids. 2012 Nov; 47(11):1043-51. doi: 10.1007/s11745-012-3711-0. [PMID: 22941440]
  • Benjamin J Belda, Jerry T Thompson, Raghu Sinha, K Sandeep Prabhu, John P Vanden Heuvel. The dietary fatty acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF(2α) synthesis in adipocytes. Prostaglandins & other lipid mediators. 2012 Oct; 99(1-2):30-7. doi: 10.1016/j.prostaglandins.2012.05.001. [PMID: 22583689]
  • Haiping Li, Yong Liu, Yan Bao, Xiaoming Liu, Heping Zhang. Conjugated linoleic acid conversion by six Lactobacillus plantarum strains cultured in MRS broth supplemented with sunflower oil and soymilk. Journal of food science. 2012 Jun; 77(6):M330-6. doi: 10.1111/j.1750-3841.2012.02723.x. [PMID: 22591404]
  • I A Hutchinson, A A Hennessy, R J Dewhurst, A C O Evans, P Lonergan, S T Butler. The effect of strategic supplementation with trans-10,cis-12 conjugated linoleic acid on the milk production, estrous cycle characteristics, and reproductive performance of lactating dairy cattle. Journal of dairy science. 2012 May; 95(5):2442-51. doi: 10.3168/jds.2011-4632. [PMID: 22541471]
  • Benjamin J Belda, Jerry T Thompson, Pinar O Eser, John P Vanden Heuvel. 10e12z CLA alters adipocyte differentiation and adipocyte cytokine expression and induces macrophage proliferation. The Journal of nutritional biochemistry. 2012 May; 23(5):510-8. doi: 10.1016/j.jnutbio.2011.02.009. [PMID: 21764284]
  • Jie Yu, Bing Yu, Honglin Jiang, Daiwen Chen. Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-α. The British journal of nutrition. 2012 Feb; 107(4):461-5. doi: 10.1017/s0007114511003205. [PMID: 21767451]
  • Xiaoran Liu, Shama V Joseph, Andrew P Wakefield, Harold M Aukema, Peter J H Jones. High dose trans-10,cis-12 CLA increases lean body mass in hamsters, but elevates levels of plasma lipids and liver enzyme biomarkers. Lipids. 2012 Jan; 47(1):39-46. doi: 10.1007/s11745-011-3616-3. [PMID: 22038709]
  • W M P B Weerasinghe, R G Wilkinson, A L Lock, M J de Veth, D E Bauman, L A Sinclair. Effect of a supplement containing trans-10,cis-12 conjugated linoleic acid on the performance of dairy ewes fed 2 levels of metabolizable protein and at a restricted energy intake. Journal of dairy science. 2012 Jan; 95(1):109-16. doi: 10.3168/jds.2011-4165. [PMID: 22192190]
  • Susana V Martins, Paula A Lopes, Susana P Alves, Cristina M Alfaia, Matilde F Castro, Rui J B Bessa, José A M Prates. Dietary CLA combined with palm oil or ovine fat differentially influences fatty acid deposition in tissues of obese Zucker rats. Lipids. 2012 Jan; 47(1):47-58. doi: 10.1007/s11745-011-3626-1. [PMID: 22090061]
  • K J Harvatine, D E Bauman. Characterization of the acute lactational response to trans-10, cis-12 conjugated linoleic acid. Journal of dairy science. 2011 Dec; 94(12):6047-56. doi: 10.3168/jds.2011-4657. [PMID: 22118092]
  • Yung-Chung Hsu, Margot M Ip. Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress. Cellular signalling. 2011 Dec; 23(12):2013-20. doi: 10.1016/j.cellsig.2011.07.015. [PMID: 21821121]
  • M Lapa, C C Marques, S P Alves, M I Vasques, M C Baptista, I Carvalhais, M Silva Pereira, A E M Horta, R J B Bessa, R M Pereira. Effect of trans-10 cis-12 conjugated linoleic acid on bovine oocyte competence and fatty acid composition. Reproduction in domestic animals = Zuchthygiene. 2011 Oct; 46(5):904-10. doi: 10.1111/j.1439-0531.2011.01762.x. [PMID: 21366717]
  • Md M Rahman, Ganesh V Halade, Paul J Williams, Gabriel Fernandes. t10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity. Journal of cellular physiology. 2011 Sep; 226(9):2406-14. doi: 10.1002/jcp.22578. [PMID: 21660964]
  • G Maxin, F Glasser, C Hurtaud, J L Peyraud, H Rulquin. Combined effects of trans-10,cis-12 conjugated linoleic acid, propionate, and acetate on milk fat yield and composition in dairy cows. Journal of dairy science. 2011 Apr; 94(4):2051-9. doi: 10.3168/jds.2010-3844. [PMID: 21426996]
  • Kenta Sato, Nahoko Shinohara, Taro Honma, Junya Ito, Tatsuya Arai, Naohisa Nosaka, Toshiaki Aoyama, Tsuyoshi Tsuduki, Ikuo Ikeda. The change in conjugated linoleic acid concentration in blood of Japanese fed a conjugated linoleic acid diet. Journal of nutritional science and vitaminology. 2011; 57(5):364-71. doi: 10.3177/jnsv.57.364. [PMID: 22293214]
  • M R Foote, S L Giesy, G Bernal-Santos, D E Bauman, Y R Boisclair. t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status, and metabolism. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 Dec; 299(6):R1521-8. doi: 10.1152/ajpregu.00445.2010. [PMID: 20844263]
  • Liam A Sinclair, Weerasinghe M P B Weerasinghe, Robert G Wilkinson, Michael J de Veth, Dale E Bauman. A supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat yield but does not alter organ weight or body fat deposition in lactating ewes. The Journal of nutrition. 2010 Nov; 140(11):1949-55. doi: 10.3945/jn.110.126490. [PMID: 20861215]
  • Jia-jie Zhai, Zhao-liang Liu, Jie-mei Li, Jian-ping Chen, Lin Jiang, Dong-mei Wang, Jin Yuan, Jian-Gang Shen, De-Po Yang, Jia-Qi Chen. Different mechanisms of cis-9,trans-11- and trans-10,cis-12- conjugated linoleic acid affecting lipid metabolism in 3T3-L1 cells. The Journal of nutritional biochemistry. 2010 Nov; 21(11):1099-105. doi: 10.1016/j.jnutbio.2009.09.007. [PMID: 20138494]
  • Melissa S Ashwell, Ryan P Ceddia, Ralph L House, Joseph P Cassady, Eugene J Eisen, Thomas E Eling, Jennifer B Collins, Sherry F Grissom, Jack Odle. Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis. The Journal of nutritional biochemistry. 2010 Sep; 21(9):848-55. doi: 10.1016/j.jnutbio.2009.06.013. [PMID: 19800780]
  • Satoru Tamura, Masafumi Kaneko, Atsushi Shiomi, Guang-Ming Yang, Toshiaki Yamaura, Nobutoshi Murakami. Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia. Bioorganic & medicinal chemistry letters. 2010 Mar; 20(6):1837-9. doi: 10.1016/j.bmcl.2010.01.165. [PMID: 20176483]
  • Susana V Martins, Paula A Lopes, Cristina M Alfaia, Pedro O Rodrigues, Susana P Alves, Rui M A Pinto, Matilde F Castro, Rui J B Bessa, José A M Prates. Serum adipokine profile and fatty acid composition of adipose tissues are affected by conjugated linoleic acid and saturated fat diets in obese Zucker rats. The British journal of nutrition. 2010 Mar; 103(6):869-78. doi: 10.1017/s000711450999256x. [PMID: 19878618]
  • Arturo Anadón, María R Martínez-Larrañaga, María A Martínez, Irma Ares, Eva Ramos, Pilar Gómez-Cortés, Manuela Juárez, Miguel A De la Fuente. Acute oral safety study of dairy fat rich in trans-10 C18:1 versus vaccenic plus conjugated linoleic acid in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Feb; 48(2):591-8. doi: 10.1016/j.fct.2009.11.037. [PMID: 19932730]
  • Anke Jaudszus, Peter Moeckel, Eckard Hamelmann, Gerhard Jahreis. Trans-10,cis-12-CLA-caused lipodystrophy is associated with profound changes of fatty acid profiles of liver, white adipose tissue and erythrocytes in mice: possible link to tissue-specific alterations of fatty acid desaturation. Annals of nutrition & metabolism. 2010; 57(2):103-11. doi: 10.1159/000319877. [PMID: 20924169]
  • Maria A Navarro, Lina Badimon, Cristina Rodriguez, Carmen Arnal, Enda J Noone, Helen M Roche, Jesus Osada, Jose Martinez-Gonzalez. Trans-10,cis-12-CLA dysregulate lipid and glucose metabolism and induce hepatic NR4A receptors. Frontiers in bioscience (Elite edition). 2010 01; 2(1):87-97. doi: 10.2741/e69. [PMID: 20036857]
  • I Gutowska, M Baśkiewicz, B Machaliński, D Chlubek, E Stachowska. Blood arachidonic acid and HDL cholesterol influence the phagocytic abilities of human monocytes/macrophages. Annals of nutrition & metabolism. 2010; 57(2):143-9. doi: 10.1159/000321546. [PMID: 21063085]
  • Tony Jourdan, Louiza Djaouti, Laurent Demizieux, Joseph Gresti, Bruno Vergès, Pascal Degrace. Liver carbohydrate and lipid metabolism of insulin-deficient mice is altered by trans-10, cis-12 conjugated linoleic acid. The Journal of nutrition. 2009 Oct; 139(10):1901-7. doi: 10.3945/jn.109.111062. [PMID: 19692528]
  • R Gervais, J W McFadden, A J Lengi, B A Corl, P Y Chouinard. Effects of intravenous infusion of trans-10, cis-12 18:2 on mammary lipid metabolism in lactating dairy cows. Journal of dairy science. 2009 Oct; 92(10):5167-77. doi: 10.3168/jds.2009-2281. [PMID: 19762835]
  • Oddrun A Gudbrandsen, Enrique Rodríguez, Hege Wergedahl, Sverre Mørk, Janne E Reseland, Jon Skorve, Andreu Palou, Rolf K Berge. Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats. The British journal of nutrition. 2009 Sep; 102(6):803-15. doi: 10.1017/s0007114509297200. [PMID: 19298684]
  • Virginia Navarro, María P Portillo, Alain Margotat, Jean-François Landrier, Maria T Macarulla, Denis Lairon, Jean-Charles Martin. A multi-gene analysis strategy identifies metabolic pathways targeted by trans-10, cis-12-conjugated linoleic acid in the liver of hamsters. The British journal of nutrition. 2009 Aug; 102(4):537-45. doi: 10.1017/s0007114509231734. [PMID: 19216830]
  • Yukiko K Nakamura, Stanley T Omaye. Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells. Nutrition (Burbank, Los Angeles County, Calif.). 2009 Jul; 25(7-8):800-11. doi: 10.1016/j.nut.2009.01.003. [PMID: 19299109]
  • Kevin J Harvatine, James W Perfield, Dale E Bauman. Expression of enzymes and key regulators of lipid synthesis is upregulated in adipose tissue during CLA-induced milk fat depression in dairy cows. The Journal of nutrition. 2009 May; 139(5):849-54. doi: 10.3945/jn.108.099994. [PMID: 19211829]
  • Darshan S Kelley, Madhuri Vemuri, Yuriko Adkins, Sher Himmat S Gill, Dawn Fedor, Bruce E Mackey. Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice. The British journal of nutrition. 2009 Mar; 101(5):701-8. doi: 10.1017/s0007114508027451. [PMID: 18710604]
  • Jonatan Miranda, Alfredo Fernández-Quintela, Itziar Churruca, Víctor M Rodríguez, Edurne Simón, María P Portillo. Hepatomegaly induced by trans-10,cis-12 conjugated linoleic acid in adult hamsters fed an atherogenic diet is not associated with steatosis. Journal of the American College of Nutrition. 2009 Feb; 28(1):43-9. doi: 10.1080/07315724.2009.10719760. [PMID: 19571159]
  • Sunjin Hur, Faith Whitcomb, Siyeon Rhee, Yooheon Park, Deborah J Good, Yeonhwa Park. Effects of trans-10,cis-12 conjugated linoleic acid on body composition in genetically obese mice. Journal of medicinal food. 2009 Feb; 12(1):56-63. doi: 10.1089/jmf.2008.0110. [PMID: 19298196]
  • Arrate Lasa, Itziar Churruca, Edurne Simón, Alfredo Fernández-Quintela, Victor Manuel Rodríguez, María Puy Portillo. Trans-10, cis-12-conjugated linoleic acid does not increase body fat loss induced by energy restriction. The British journal of nutrition. 2008 Dec; 100(6):1245-50. doi: 10.1017/s000711450800305x. [PMID: 18507880]
  • A L Lock, M Rovai, T A Gipson, M J de Veth, D E Bauman. A conjugated linoleic acid supplement containing trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats. Journal of dairy science. 2008 Sep; 91(9):3291-9. doi: 10.3168/jds.2008-1071. [PMID: 18765588]
  • Tine Tholstrup, Marianne Raff, Ellen M Straarup, Pia Lund, Samar Basu, Jens M Bruun. An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women. The Journal of nutrition. 2008 Aug; 138(8):1445-51. doi: 10.1093/jn/138.8.1445. [PMID: 18641189]
  • R M Pereira, I Carvalhais, J Pimenta, M C Baptista, M I Vasques, A E M Horta, I C Santos, M R Marques, A Reis, M Silva Pereira, C C Marques. Biopsied and vitrified bovine embryos viability is improved by trans10, cis12 conjugated linoleic acid supplementation during in vitro embryo culture. Animal reproduction science. 2008 Jul; 106(3-4):322-32. doi: 10.1016/j.anireprosci.2007.05.008. [PMID: 17580103]
  • Masao Yamasaki, Hirofumi Tachibana, Arisa Yamada, Yukari Ochi, Harishkumar Madhyastha, Kazuo Nishiyama, Koji Yamada. Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway. In vitro cellular & developmental biology. Animal. 2008 Jul; 44(7):290-4. doi: 10.1007/s11626-008-9120-2. [PMID: 18568373]
  • Lihui Ou, Yue Wu, Clement Ip, Xiaojing Meng, Yung-Chun Hsu, Margot M Ip. Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response. Journal of lipid research. 2008 May; 49(5):985-94. doi: 10.1194/jlr.m700465-jlr200. [PMID: 18263853]
  • A Lasa, E Simón, I Churruca, A Fernández-Quintela, V M Rodríguez, M P Portillo. Adiposity and serum parameters in hamsters fed energy restricted diets supplemented or not with trans-10,cis-12 conjugated linoleic acid. Journal of physiology and biochemistry. 2007 Dec; 63(4):297-304. doi: 10.1007/bf03165761. [PMID: 18457005]
  • K Lee, K Paek, H Y Lee, J H Park, Y Lee. Antiobesity effect of trans-10,cis-12-conjugated linoleic acid-producing Lactobacillus plantarum PL62 on diet-induced obese mice. Journal of applied microbiology. 2007 Oct; 103(4):1140-6. doi: 10.1111/j.1365-2672.2007.03336.x. [PMID: 17897219]
  • Yuren Wei, Dong Wang, Michael J Pagliassotti. Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells. Molecular and cellular biochemistry. 2007 Sep; 303(1-2):105-13. doi: 10.1007/s11010-007-9461-2. [PMID: 17426927]
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