8-hydroxy-2-deoxyguanosine (BioDeep_00001871415)
Main id: BioDeep_00000027869
PANOMIX_OTCML-2023
代谢物信息卡片
8-hydroxy-2-deoxyguanosine
化学式: C10H13N5O5 (283.09166480000005)
中文名称: 2-脱氧-7,8-二氢-8-氧代鸟苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(OC1N2C3=C(C(=O)NC(=N3)N)NC2=O)CO)O
InChI: InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
描述信息
8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.
8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:40304
- PubChem: 135440064
- DrugBank: DB02502
- ChEMBL: CHEMBL1230628
- MeSH: 8-Hydroxy-2-Deoxyguanosine
- CAS: 88847-89-6
- medchemexpress: HY-W011540
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 669 - Vibrio harveyi: 10.1021/NP5009762
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shiming Song, Yanxia Gao, Shuai Feng, Zhipeng Cheng, Haibao Huang, Jingchuan Xue, Tao Zhang, Hongwen Sun. Widespread occurrence of two typical N, N'-substituted p-phenylenediamines and their quinones in humans: Association with oxidative stress and liver damage.
Journal of hazardous materials.
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Free radical biology & medicine.
2024 03; 213(?):266-273. doi:
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Scientific reports.
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PloS one.
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Journal of medical virology.
2024 01; 96(1):e29362. doi:
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Ecotoxicology and environmental safety.
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2023 Feb; 24(4):. doi:
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Nanotoxicology.
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Journal of environmental sciences (China).
2022 Oct; 120(?):30-40. doi:
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Molecules (Basel, Switzerland).
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Chemosphere.
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2022 Sep; 23(19):. doi:
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2022 Sep; 23(17):. doi:
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Chemosphere.
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Environmental geochemistry and health.
2022 Aug; 44(8):2649-2668. doi:
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Environmental research.
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Scandinavian journal of rheumatology.
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Environmental and molecular mutagenesis.
2022 07; 63(6):286-295. doi:
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Environment international.
2022 Jul; 165(?):107300. doi:
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Asian journal of andrology.
2022 Jul; 24(4):430-435. doi:
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Environmental research.
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International journal of molecular sciences.
2022 Apr; 23(9):. doi:
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BMC gastroenterology.
2022 Apr; 22(1):184. doi:
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Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
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Journal of hazardous materials.
2022 03; 425(?):127769. doi:
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Molecules (Basel, Switzerland).
2022 Mar; 27(5):. doi:
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Zeitschrift fur Naturforschung. C, Journal of biosciences.
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Lung.
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Mutation research. Genetic toxicology and environmental mutagenesis.
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Journal of immunology (Baltimore, Md. : 1950).
2022 01; 208(2):321-327. doi:
10.4049/jimmunol.2100711. [PMID: 34911771] - Larissa J Sanches, Poliana C Marinello, Walison A da Silva Brito, Natália M D Lopes, Rodrigo C Luiz, Rubens Cecchini, Alessandra L Cecchini. Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance.
Cell biology international.
2022 Jan; 46(1):73-82. doi:
10.1002/cbin.11700. [PMID: 34506671] - Cameron L McGlone, Lea Christian, Benjamin Schmeusser, Langni Liu, Charles E Chalfant, Daniel J Stephensen, Catherine M Sherwin, Christine M Rapp, Zafer Sattouf, Craig A Rohan, Connor Morris, Yanfang Chen, Jeffrey B Travers. Evidence for Systemic Reactive Oxygen Species in UVB-mediated Microvesicle Formation.
Photochemistry and photobiology.
2022 01; 98(1):242-247. doi:
10.1111/php.13494. [PMID: 34324712] - Elizaveta S Ershova, Galina V Shmarina, Andrey V Martynov, Natalia V Zakharova, Roman V Veiko, Pavel E Umriukhin, George P Kostyuk, Sergey I Kutsev, Natalia N Veiko, Svetlana V Kostyuk. NADPH-oxidase 4 gene over-expression in peripheral blood lymphocytes of the schizophrenia patients.
PloS one.
2022; 17(6):e0269130. doi:
10.1371/journal.pone.0269130. [PMID: 35696356] - Wenjing Song, Qing Han, Yanjian Wan, Xi Qian, Muhong Wei, Ying Jiang, Qi Wang. Repeated measurements of 21 urinary metabolites of volatile organic compounds and their associations with three selected oxidative stress biomarkers in 0-7-year-old healthy children from south and central China.
Chemosphere.
2022 Jan; 287(Pt 2):132065. doi:
10.1016/j.chemosphere.2021.132065. [PMID: 34496338] - Bensu Karahalil, Ece Miser Salihoğlu, Aylin Elkama, Gürdal Orhan, Evrim Saygın, Sevgi Yardim Akaydin. Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson's disease.
Basic & clinical pharmacology & toxicology.
2022 Jan; 130(1):158-170. doi:
10.1111/bcpt.13659. [PMID: 34582115] - Zhuan Feng, Yifei Qin, Fei Huo, Zhe Jian, Xiaomin Li, Jiejie Geng, Yong Li, Jiao Wu. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Biochimica et biophysica acta. Molecular basis of disease.
2022 01; 1868(1):166287. doi:
10.1016/j.bbadis.2021.166287. [PMID: 34626772] - Eman El-Sayed Khayal, Hanaa M Ibrahim, Amany Mohamed Shalaby, Mohamed Ali Alabiad, Arwa A El-Sheikh. Combined lead and zinc oxide-nanoparticles induced thyroid toxicity through 8-OHdG oxidative stress-mediated inflammation, apoptosis, and Nrf2 activation in rats.
Environmental toxicology.
2021 Dec; 36(12):2589-2604. doi:
10.1002/tox.23373. [PMID: 34553816] - Eman S El-Shetry, Amany Abdel-Rahman Mohamed, Safaa I Khater, Mohamed M M Metwally, Mohamed A Nassan, Shimaa Shalaby, Shefaa A M El-Mandrawy, Talha Bin Emran, Heba M Abdel-Ghany. Synergistically enhanced apoptotic and oxidative DNA damaging pathways in the rat brain with lead and/or aluminum metals toxicity: Expression pattern of genes OGG1 and P53.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2021 Dec; 68(?):126860. doi:
10.1016/j.jtemb.2021.126860. [PMID: 34583094] - Kiook Baek, Minho Kim, Kyeongmin Kwak. Exposure to diesel engine exhausts and increase of urinary 8-hydroxy-2'-deoxyguanosine among Male tank maintenance workers in the Republic of Korea Army.
Industrial health.
2021 Nov; 59(6):403-414. doi:
10.2486/indhealth.2021-0022. [PMID: 34588383] - Anders Jorgensen, Maria Bremholm Thygesen, Uffe Kristiansen, Henrik Enghusen Poulsen. An in silico kinetic model of 8-oxo-7,8-dihydro-2-deoxyguanosine and 8-oxo-7,8-dihydroguanosine metabolism from intracellular formation to urinary excretion.
Scandinavian journal of clinical and laboratory investigation.
2021 Nov; 81(7):540-545. doi:
10.1080/00365513.2021.1969682. [PMID: 34511003] - Ali Erdal Gunes, Ozgur Yılmaz, Celal Erbas, Seyda Nur Dagli, Hakim Celik. High serum 8-hydroxy-2'-deoxyguanosine levels predict DNA damage and aging in professional divers.
Revista da Associacao Medica Brasileira (1992).
2021 Nov; 67(11):1701-1705. doi:
10.1590/1806-9282.20210748. [PMID: 34909901] - Amelia Sancilio, Grazyna Jasienska, Catherine Panter-Brick, Anna Ziomkiewicz, Ilona Nenko, Richard G Bribiescas. Accelerated senescence as a cost of reproduction: Testing associations between oxidative stress and reproductive effort in rural and urban women.
American journal of human biology : the official journal of the Human Biology Council.
2021 11; 33(6):e23537. doi:
10.1002/ajhb.23537. [PMID: 33190335] - Ya-Chun Han, Shi-Qi Tang, Yu-Ting Liu, Ai-Mei Li, Ming Zhan, Ming Yang, Na Song, Wei Zhang, Xue-Qin Wu, Can-Hui Peng, Hao Zhang, Shikun Yang. AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice.
Cell death & disease.
2021 10; 12(10):925. doi:
10.1038/s41419-021-04184-8. [PMID: 34628484] - Fatma Yılmaz Coskun, Seyithan Taysı, Meral Kayıkçıoğlu. Can serum 8-hydroxy-2'-deoxyguanosine levels reflect the severity of pulmonary arterial hypertension?.
Revista da Associacao Medica Brasileira (1992).
2021 Oct; 67(10):1437-1442. doi:
10.1590/1806-9282.20210640. [PMID: 35018972] - Ajay Pratap Singh, Praveen Chandrasekharan, Sylvia Gugino, Sara Berkelhamer, Huamei Wang, Lori Nielsen, Vasantha H S Kumar. Effects of Neonatal Caffeine Administration on Vessel Reactivity in Adult Mice.
American journal of perinatology.
2021 10; 38(12):1320-1329. doi:
10.1055/s-0040-1712953. [PMID: 32485758] - Nihayet Bayraktar, İslim Güler, Mehmet Bayraktar, Ismail Koyuncu. Investigation the levels of endotoxin and 8-hydroxy-2'-deoxyguanosine in sera of patients with Helicobacter pylori-positive peptic ulcer.
International journal of clinical practice.
2021 Oct; 75(10):e14501. doi:
10.1111/ijcp.14501. [PMID: 34117680] - Yanfeng Sun, Yanjian Wan, Ying Jiang, Huaiji Wang. Urinary concentrations of acetaminophen in young children in central and south China: Repeated measurements and associations with 8-hydroxy-guanosine and 8-hydroxy-2'-deoxyguanosine.
The Science of the total environment.
2021 Sep; 787(?):147614. doi:
10.1016/j.scitotenv.2021.147614. [PMID: 33992949] - Takahiro Kataoka, Hina Shuto, Shota Naoe, Junki Yano, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Katsumi Hanamoto, Fumihiro Mitsunobu, Hiroaki Terato, Kiyonori Yamaoka. Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions.
Journal of radiation research.
2021 Sep; 62(5):861-867. doi:
10.1093/jrr/rrab069. [PMID: 34370027] - Selina F Darling-Reed, Yasmeen Nkrumah-Elie, Dominique T Ferguson, Hernan Flores-Rozas, Patricia Mendonca, Samia Messeha, Alicia Hudson, Ramesh B Badisa, Syreeta L Tilghman, Tracy Womble, Agnes Day, Marti Jett, Rasha Hammamieh, Karam F A Soliman. Diallyl Sulfide Attenuation of Carcinogenesis in Mammary Epithelial Cells through the Inhibition of ROS Formation, and DNA Strand Breaks.
Biomolecules.
2021 09; 11(9):. doi:
10.3390/biom11091313. [PMID: 34572526] - Heng-Da Wang, Zhi-Hao Zhong, Yu-Jie Weng, Zhen-Zhen Wei, Yu-Qing Zhang. Degraded Sericin Significantly Regulates Blood Glucose Levels and Improves Impaired Liver Function in T2D Rats by Reducing Oxidative Stress.
Biomolecules.
2021 08; 11(8):. doi:
10.3390/biom11081255. [PMID: 34439921] - Trine Henriksen, Allan Weimann, Emil List Larsen, Henrik Enghusen Poulsen. Quantification of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydro-guanosine concentrations in urine and plasma for estimating 24-h urinary output.
Free radical biology & medicine.
2021 08; 172(?):350-357. doi:
10.1016/j.freeradbiomed.2021.06.014. [PMID: 34166769] - Yu-Teng Chang, Mu-Chi Chung, Chang-Chi Hsieh, Jeng-Jer Shieh, Ming-Ju Wu. Evaluation of the Therapeutic Effects of Protocatechuic Aldehyde in Diabetic Nephropathy.
Toxins.
2021 08; 13(8):. doi:
10.3390/toxins13080560. [PMID: 34437430] - Soqrat Omari Shekaftik, Nafiseh Nasirzadeh. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review.
Nanotoxicology.
2021 08; 15(6):850-864. doi:
10.1080/17435390.2021.1936254. [PMID: 34171202] - Mehmet Oğuz Erbağcı, Gamze Tuna, Semir Köse, Nazlı Ecem Dal-Bekar, Merve Akış, Melis Kant, Sabahattin Altunyurt, Gül Hüray İşlekel. Association between early oxidative DNA damage and iron status in women with gestational diabetes mellitus.
Reproductive toxicology (Elmsford, N.Y.).
2021 08; 103(?):171-180. doi:
10.1016/j.reprotox.2021.05.009. [PMID: 34051274] - D Sürmelioğlu, H Gündoğar, S Taysi, Y H Bağiş. Effect of different bleaching techniques on DNA damage biomarkers in serum, saliva, and GCF.
Human & experimental toxicology.
2021 Aug; 40(8):1332-1341. doi:
10.1177/0960327121996030. [PMID: 33622079] - Tayfun Karatas, Sukru Onalan, Serkan Yildirim. Effects of prolonged fasting on levels of metabolites, oxidative stress, immune-related gene expression, histopathology, and DNA damage in the liver and muscle tissues of rainbow trout (Oncorhynchus mykiss).
Fish physiology and biochemistry.
2021 Aug; 47(4):1119-1132. doi:
10.1007/s10695-021-00949-2. [PMID: 34057672] - Benyang Wu, Xiaoyan Chai, Aiming He, Zhen Huang, Sheng Chen, Pingfan Rao, Lijing Ke, Leiwen Xiang. Inhibition of acrylamide toxicity in vivo by arginine-glucose maillard reaction products.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Aug; 154(?):112315. doi:
10.1016/j.fct.2021.112315. [PMID: 34082049] - Jinming Liu, Xi Chen, Xinghua Qiu, Hanxiyue Zhang, Xinchen Lu, Haonan Li, Wu Chen, Lina Zhang, Chengli Que, Tong Zhu. Association between exposure to polycyclic aromatic hydrocarbons and lipid peroxidation in patients with chronic obstructive pulmonary disease.
The Science of the total environment.
2021 Aug; 780(?):146660. doi:
10.1016/j.scitotenv.2021.146660. [PMID: 34030292] - Patricia Tomás-Simó, Luis D'Marco, María Romero-Parra, Mari Carmen Tormos-Muñoz, Guillermo Sáez, Isidro Torregrosa, Nuria Estañ-Capell, Alfonso Miguel, José Luis Gorriz, María Jesús Puchades. Oxidative Stress in Non-Dialysis-Dependent Chronic Kidney Disease Patients.
International journal of environmental research and public health.
2021 07; 18(15):. doi:
10.3390/ijerph18157806. [PMID: 34360098] - Daniela Martini, Raúl Domínguez-Perles, Alice Rosi, Michele Tassotti, Donato Angelino, Sonia Medina, Cristian Ricci, Alexandre Guy, Camille Oger, Letizia Gigliotti, Thierry Durand, Mirko Marino, Hans Gottfried-Genieser, Marisa Porrini, Monica Antonini, Alessandra Dei Cas, Riccardo C Bonadonna, Federico Ferreres, Francesca Scazzina, Furio Brighenti, Patrizia Riso, Cristian Del Bo', Pedro Mena, Angel Gil-Izquierdo, Daniele Del Rio. Effect of Coffee and Cocoa-Based Confectionery Containing Coffee on Markers of DNA Damage and Lipid Peroxidation Products: Results from a Human Intervention Study.
Nutrients.
2021 Jul; 13(7):. doi:
10.3390/nu13072399. [PMID: 34371907] - Tanmoy Mondal, Amit Nautiyal, Somiranjan Ghosh, Christopher A Loffredo, Deepanjan Mitra, Chabita Saha, Subrata Kumar Dey. An evaluation of DNA double strand break formation and excreted guanine species post whole body PET/CT procedure.
Journal of radiation research.
2021 Jul; 62(4):590-599. doi:
10.1093/jrr/rrab025. [PMID: 34037214] - Feizai Ha, Na Li, Changmao Long, Pai Zheng, Guiping Hu, Guang Jia, Tiancheng Wang. The Effect of Global DNA Methylation on PDCD5 Expression in the PBMC of Occupational Chromate Exposed Workers.
Journal of occupational and environmental medicine.
2021 07; 63(7):600-608. doi:
10.1097/jom.0000000000002192. [PMID: 34184653] - N V Semenova, I M Madaeva, A S Brichagina, S I Kolesnikov, L I Kolesnikova. 8-Hydroxy-2'-Deoxyguanosine as an Oxidative Stress Marker in Insomnia.
Bulletin of experimental biology and medicine.
2021 Jul; 171(3):384-387. doi:
10.1007/s10517-021-05233-0. [PMID: 34297292] - Peiwei Xu, Zhe Mo, Lizhi Wu, Weizhong Chen, Shengliang He, Yuan Chen, Dandan Xu, Jie Xiang, Zhijian Chen, Xiaoming Lou, Zhen Wang, Xiaofeng Wang. Elevated cadmium and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in residents living near electroplating industries.
Environmental science and pollution research international.
2021 Jul; 28(26):34427-34435. doi:
10.1007/s11356-021-13209-w. [PMID: 33651290] - Mohammad Iqbal, Muhammad Dawood Shah, Senty Vun-Sang, Yasumasa Okazaki, Shigeru Okada. The therapeutic potential of curcumin in alleviating N-diethylnitrosamine and iron nitrilotriacetate induced renal cell tumours in mice via inhibition of oxidative stress: Implications for cancer chemoprevention.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111636. doi:
10.1016/j.biopha.2021.111636. [PMID: 33957566] - Camilla B Larsen, Kamilla R Riis, Kristian H Winther, Emil L Larsen, Christina Ellervik, Laszlo Hegedüs, Thomas H Brix, Henrik E Poulsen, Steen J Bonnema. Treatment of Hyperthyroidism Reduces Systemic Oxidative Stress, as Measured by Markers of RNA and DNA Damage.
The Journal of clinical endocrinology and metabolism.
2021 06; 106(7):e2512-e2520. doi:
10.1210/clinem/dgab273. [PMID: 33901280] - Mu-Rong Chao, Mark D Evans, Chiung-Wen Hu, Yunhee Ji, Peter Møller, Pavel Rossner, Marcus S Cooke. Biomarkers of nucleic acid oxidation - A summary state-of-the-art.
Redox biology.
2021 06; 42(?):101872. doi:
10.1016/j.redox.2021.101872. [PMID: 33579665] - Enrica Rosato, Martina Bonelli, Marcello Locatelli, Ugo de Grazia, Angela Tartaglia, Fabio Savini, Cristian D'Ovidio. Forensic Biochemical Markers to Evaluate the Agonal Period: A Literature Review.
Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
10.3390/molecules26113259. [PMID: 34071519] - Suvanjaa Sivalingam, Emil List Larsen, Daniel H van Raalte, Marcel H A Muskiet, Mark M Smits, Lennart Tonneijck, Jaap A Joles, Bernt Johan von Scholten, Emilie Hein Zobel, Frederik Persson, Trine Henriksen, Lars Jorge Diaz, Tine W Hansen, Henrik Enghusen Poulsen, Peter Rossing. The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes.
Scientific reports.
2021 05; 11(1):10624. doi:
10.1038/s41598-021-90191-w. [PMID: 34012064] - Luis Pla, Félix Sancenón, M Carmen Martínez-Bisbal, Celia Bañuls, Nuria Estañ, Marina Botello-Marabotto, Elena Aznar, Guillermo Sáez, Sara Santiago-Felipe, Ramón Martínez-Máñez. A new 8-oxo-7,8-2'deoxyguanosine nanoporous anodic alumina aptasensor for colorectal cancer diagnosis in blood and urine.
Nanoscale.
2021 May; 13(18):8648-8657. doi:
10.1039/d0nr07948k. [PMID: 33942038] - Preeti Singh, Prasenjit Mitra, Taru Goyal, Shailja Sharma, Praveen Sharma. Evaluation of DNA Damage and Expressions of DNA Repair Gene in Occupationally Lead Exposed Workers (Jodhpur, India).
Biological trace element research.
2021 May; 199(5):1707-1714. doi:
10.1007/s12011-020-02298-2. [PMID: 32712906] - Mohammad Reza Masjedi, Sina Dobaradaran, Saeed Keshmiri, Farhad Taghizadeh, Hossein Arfaeinia, Farzad Fanaei, Mojtaba Behroozi, Farzaneh Nasrzadeh, Melika Joukar. Use of toenail-bounded heavy metals to characterize occupational exposure and oxidative stress in workers of waterpipe/cigarette cafés.
Environmental geochemistry and health.
2021 May; 43(5):1783-1797. doi:
10.1007/s10653-020-00751-8. [PMID: 33098497]