Laquinimod (BioDeep_00001871396)
代谢物信息卡片
Laquinimod
化学式: C19H17ClN2O3 (356.09276420000003)
中文名称: 拉喹莫德
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(C1=CC=CC=C1)C(=O)C2=C(C3=C(C=CC=C3Cl)N(C2=O)C)O
InChI: InChI=1S/C19H17ClN2O3/c1-3-22(12-8-5-4-6-9-12)19(25)16-17(23)15-13(20)10-7-11-14(15)21(2)18(16)24/h4-11,23H,3H2,1-2H3
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:134738
- PubChem: 54677946
- DrugBank: DB06685
- ChEMBL: CHEMBL66092
- CAS: 248281-84-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ye Xiong, Yanqiong Fu, Zhuoli Li, Yu Zheng, Maiyin Cui, Chan Zhang, Xin Yi Huang, Yong Jian, Bai Hui Chen. Laquinimod Inhibits Microglial Activation, Astrogliosis, BBB Damage, and Infarction and Improves Neurological Damage after Ischemic Stroke.
ACS chemical neuroscience.
2023 06; 14(11):1992-2007. doi:
10.1021/acschemneuro.2c00740. [PMID: 37161270] - Anna Elgart, David J Greenblatt, Pippa S Loupe, Arik A Zur, Sivan Weiss, Dorit Mimrod, Ofer Spiegelstein. The Effect of CYP3A Induction and Inhibition on the Pharmacokinetics of Laquinimod, a Novel Neuroimmunomodulator.
Clinical pharmacology in drug development.
2020 11; 9(8):1015-1024. doi:
10.1002/cpdd.785. [PMID: 32237115] - Tiechao Jiang, Wenhao Zhang, Zhongyu Wang. Laquinimod Protects Against TNF-α-Induced Attachment of Monocytes to Human Aortic Endothelial Cells (HAECs) by Increasing the Expression of KLF2.
Drug design, development and therapy.
2020; 14(?):1683-1691. doi:
10.2147/dddt.s243666. [PMID: 32440094] - Ofer Spiegelstein, Dorit Mimrod, Laura Rabinovich, Eli Eyal, Craig Sprenger, Anna Elgart, Emil Samara, Joel Morganroth. A Thorough QT/QTc Study With Laquinimod, a Novel Immunomodulator in Development for Multiple Sclerosis and Huntington Disease.
Clinical pharmacology in drug development.
2019 01; 8(1):49-59. doi:
10.1002/cpdd.442. [PMID: 29786964] - Selma Mahiout, Jere Lindén, Javier Esteban, Ismael Sánchez-Pérez, Satu Sankari, Lars Pettersson, Helen Håkansson, Raimo Pohjanvirta. Toxicological characterisation of two novel selective aryl hydrocarbon receptor modulators in Sprague-Dawley rats.
Toxicology and applied pharmacology.
2017 07; 326(?):54-65. doi:
10.1016/j.taap.2017.04.020. [PMID: 28433708] - Sonali Narain, Richard Furie. Update on clinical trials in systemic lupus erythematosus.
Current opinion in rheumatology.
2016 09; 28(5):477-87. doi:
10.1097/bor.0000000000000311. [PMID: 27314466] - Kimberly Trotter, Marcus R Clark, Vladimir M Liarski. Overview of pathophysiology and treatment of human lupus nephritis.
Current opinion in rheumatology.
2016 09; 28(5):460-7. doi:
10.1097/bor.0000000000000319. [PMID: 27341623] - C C Mok. Towards new avenues in the management of lupus glomerulonephritis.
Nature reviews. Rheumatology.
2016 Apr; 12(4):221-34. doi:
10.1038/nrrheum.2015.174. [PMID: 26729459] - Brad H Rovin, Samir V Parikh. Lupus nephritis: the evolving role of novel therapeutics.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2014 Apr; 63(4):677-90. doi:
10.1053/j.ajkd.2013.11.023. [PMID: 24411715] - Elaine V Lourenço, Maida Wong, Bevra H Hahn, M Fernando Palma-Diaz, Brian J Skaggs. Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells.
Arthritis & rheumatology (Hoboken, N.J.).
2014 Mar; 66(3):674-85. doi:
10.1002/art.38259. [PMID: 24574228] - W Brück, C Wegner. Insight into the mechanism of laquinimod action.
Journal of the neurological sciences.
2011 Jul; 306(1-2):173-9. doi:
10.1016/j.jns.2011.02.019. [PMID: 21429524] - Shahram Lavasani, Balik Dzhambazov, Mehrnaz Nouri, Frida Fåk, Sophia Buske, Göran Molin, Henrik Thorlacius, Jan Alenfall, Bengt Jeppsson, Björn Weström. A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells.
PloS one.
2010 Feb; 5(2):e9009. doi:
10.1371/journal.pone.0009009. [PMID: 20126401] - Til Menge, Martin S Weber, Bernhard Hemmer, Bernd C Kieseier, Hans-Christian von Büdingen, Clemens Warnke, Scott S Zamvil, Aaron Boster, Omar Khan, Hans-Peter Hartung, Olaf Stüve. Disease-modifying agents for multiple sclerosis: recent advances and future prospects.
Drugs.
2008; 68(17):2445-68. doi:
10.2165/0003495-200868170-00004. [PMID: 19016573] - Carl Johan Sennbro, Magnus Olin, Karin Edman, Gunnar Hansson, Per Olov Gunnarsson, Leif D Svensson. Determination of the immunomodulator laquinimod in human plasma by liquid chromatography/tandem mass spectrometry; development, validation and application of two methods in clinical pharmacokinetic profiling.
Rapid communications in mass spectrometry : RCM.
2006; 20(22):3313-8. doi:
10.1002/rcm.2730. [PMID: 17044118] - Helén Tuvesson, Ingrid Hallin, Robert Persson, Birgitta Sparre, Per Olov Gunnarsson, Janeric Seidegård. Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Jun; 33(6):866-72. doi:
10.1124/dmd.104.002238. [PMID: 15764719] - Karin Edman, Birgitta Eriksson, Leif Svensson, Per Olov Gunnarsson. Determination of laquinimod in plasma by coupled-column liquid chromatography with ultraviolet absorbance detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Mar; 785(2):311-6. doi:
10.1016/s1570-0232(02)00926-1. [PMID: 12554144]