2,4-Thiazolidinedione (BioDeep_00001871370)

   


代谢物信息卡片


2,4-Thiazolidinedione

化学式: C3H3NO2S (116.9884498)
中文名称: 2,4-噻唑烷二酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(=O)NC(=O)S1
InChI: InChI=1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)

描述信息

D007004 - Hypoglycemic Agents

同义名列表

1 个代谢物同义名

2,4-Thiazolidinedione



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Xinyi Zhang, Yuan Gao, Keyun Tang, Zongyu Li, Alexandra A Halberstam, Liqun Zhou, Rachel J Perry. Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma. American journal of physiology. Endocrinology and metabolism. 2024 Mar; 326(3):E341-E350. doi: 10.1152/ajpendo.00346.2023. [PMID: 38294697]
  • Lim Shern Kwok, Shim Siang Yian, Layla Qasim Ismael, Yvonne Tee Get Bee, Gam Lay Harn, Khoo Boon Yin. Vimentin protein is a factor for decreasing breast cancer cell proliferation co-culture with human bone marrow-derived mesenchymal stem cells pre-treated with thiazolidinedione solutions. Molecular biology reports. 2024 Feb; 51(1):317. doi: 10.1007/s11033-024-09269-z. [PMID: 38381204]
  • Rozh Q Ameen, Zahra A Amin, Hiwa O Ahmad, Diler D Ghafur, Melodya G Toma, Nyan Sabah, Muhammad Fakhir, Gardoon Abdulla. Gastroprotective effect of rhodanine and 2,4-thiazolidinediones scaffolds in rat stomachs by contribution of anti-apoptotic (BCL-2) and tumor suppressor (P53) proteins. Scientific reports. 2024 01; 14(1):1699. doi: 10.1038/s41598-024-51446-4. [PMID: 38242960]
  • Yuanbo Qi, Mingyao Hu, Yang Qiu, Luyu Zhang, Yongchuang Yan, Yi Feng, Chenghao Feng, Xinyue Hou, Zhigang Wang, Di Zhang, Jie Zhao. Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET. Toxicology and applied pharmacology. 2023 Mar; ?(?):116440. doi: 10.1016/j.taap.2023.116440. [PMID: 36870574]
  • Shashank R Joshi, Saibal Das, Suja Xaviar, Shambo Samrat Samajdar, Indranil Saha, Sougata Sarkar, Shatavisa Mukherjee, Santanu Kumar Tripathi, Jyotirmoy Pal, Nandini Chatterjee. Efficacy and safety of lobeglitazone, a new Thiazolidinedione, as compared to the standard of care in type 2 diabetes mellitus: A systematic review and meta-analysis. Diabetes & metabolic syndrome. 2023 Jan; 17(1):102703. doi: 10.1016/j.dsx.2022.102703. [PMID: 36634469]
  • Chris E Shannon, Mukundan Ragavan, Juan Pablo Palavicini, Marcel Fourcaudot, Terry M Bakewell, Ivan A Valdez, Iriscilla Ayala, Eunsook S Jin, Muniswamy Madesh, Xianlin Han, Matthew E Merritt, Luke Norton. Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease. Molecular metabolism. 2021 03; 45(?):101154. doi: 10.1016/j.molmet.2020.101154. [PMID: 33359401]
  • Chia-Yu Tsai, Fernanda Rosa, Massimo Bionaz, Pedram Rezamand. Effects of 2,4-thiazolidinedione (TZD) on milk fatty acid profile and serum vitamins in dairy goats challenged with intramammary infusion of Streptococcus uberis. The Journal of dairy research. 2020 Nov; 87(4):416-423. doi: 10.1017/s0022029920000941. [PMID: 33168108]
  • Marta Monge, Cristina Fornaguera, Carme Quero, Aurora Dols-Perez, Gabriela Calderó, Santiago Grijalvo, María José García-Celma, Carlos Rodríguez-Abreu, Conxita Solans. Functionalized PLGA nanoparticles prepared by nano-emulsion templating interact selectively with proteins involved in the transport through the blood-brain barrier. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2020 Nov; 156(?):155-164. doi: 10.1016/j.ejpb.2020.09.003. [PMID: 32927077]
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  • Shankar Sengottuvelan, Ritika Uppal, Suneetha Vuppu. Validation of a sensitive simultaneous LC-MS/MS method for the quantification of novel anti-cancer thiazolidinedione and quinazolin-4-one derivatives in rat plasma and its application in a rat pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Jul; 1121(?):18-27. doi: 10.1016/j.jchromb.2019.05.003. [PMID: 31082683]
  • Safikur Rahman, Md Tabish Rehman, Gulam Rabbani, Parvez Khan, Mohamed F AlAjmi, Md Imtaiyaz Hassan, Ghazala Muteeb, Jihoe Kim. Insight of the Interaction between 2,4-thiazolidinedione and Human Serum Albumin: A Spectroscopic, Thermodynamic and Molecular Docking Study. International journal of molecular sciences. 2019 Jun; 20(11):. doi: 10.3390/ijms20112727. [PMID: 31163649]
  • John M Dennis, Beverley M Shields, William E Henley, Angus G Jones, Andrew T Hattersley. Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared with models based on simple clinical features: an analysis using clinical trial data. The lancet. Diabetes & endocrinology. 2019 06; 7(6):442-451. doi: 10.1016/s2213-8587(19)30087-7. [PMID: 31047901]
  • Paul Crawford, Amanda J Crawford. Edema from Taking Cinnamon for Treatment of Diabetes: Similar Biochemistry and Pathophysiology to Thiazolidinedione Medications. Journal of the American Board of Family Medicine : JABFM. 2018 Sep; 31(5):809-811. doi: 10.3122/jabfm.2018.05.180024. [PMID: 30201678]
  • Tuyen N M Hua, Jun Namkung, Ai N H Phan, Vu T A Vo, Min-Kyu Kim, Yangsik Jeong, Jong-Whan Choi. PPARgamma-mediated ALDH1A3 suppression exerts anti-proliferative effects in lung cancer by inducing lipid peroxidation. Journal of receptor and signal transduction research. 2018 Jun; 38(3):191-197. doi: 10.1080/10799893.2018.1468781. [PMID: 29873276]
  • Jeong-Hwa Yoon, Se Hee Min, Chang Ho Ahn, Young Min Cho, Seokyung Hahn. Comparison of non-insulin antidiabetic agents as an add-on drug to insulin therapy in type 2 diabetes: a network meta-analysis. Scientific reports. 2018 03; 8(1):4095. doi: 10.1038/s41598-018-22443-1. [PMID: 29511288]
  • Sabbu Satish, Ankita Srivastava, Pragya Yadav, Salil Varshney, Rakhi Choudhary, Vishal M Balaramnavar, Tadigoppula Narender, Anil Nilkanth Gaikwad. Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells. European journal of medicinal chemistry. 2018 Jan; 143(?):780-791. doi: 10.1016/j.ejmech.2017.11.041. [PMID: 29220798]
  • Sabina Yasmin, Fabio Capone, Antonio Laghezza, Fabrizio Dal Piaz, Fulvio Loiodice, Viswanathan Vijayan, Velmurugan Devadasan, Susanta K Mondal, Özlem Atlı, Merve Baysal, Ashok K Pattnaik, Venkatesan Jayaprakash, Antonio Lavecchia. Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes. Scientific reports. 2017 10; 7(1):14453. doi: 10.1038/s41598-017-14776-0. [PMID: 29089569]
  • Pankaj Sharma, T Srinivasa Reddy, Niggula Praveen Kumar, Kishna Ram Senwar, Suresh K Bhargava, Nagula Shankaraiah. Conventional and microwave-assisted synthesis of new 1H-benzimidazole-thiazolidinedione derivatives: A potential anticancer scaffold. European journal of medicinal chemistry. 2017 Sep; 138(?):234-245. doi: 10.1016/j.ejmech.2017.06.035. [PMID: 28668476]
  • Sho Akai, Shingo Oda, Tsuyoshi Yokoi. Establishment of a novel mouse model for pioglitazone-induced skeletal muscle injury. Toxicology. 2017 05; 382(?):1-9. doi: 10.1016/j.tox.2017.03.001. [PMID: 28263783]
  • Tatjana Djakovic Sekulic, Adam Smolinski. RP-HPTLC Data in Correlation Studies of a 5-Arylidene-2,4-Thiazolidinedione Derivatives. Journal of chromatographic science. 2017 May; 55(5):564-570. doi: 10.1093/chromsci/bmx001. [PMID: 28158569]
  • Abbas Ahmadi, Mohsen Khalili, Lida Sohrabi, Nazanin Delzendeh, Babak Nahri-Niknafs, Fariba Ansari. Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione. Mini reviews in medicinal chemistry. 2017; 17(8):721-726. doi: 10.2174/1389557516666161130095407. [PMID: 27903228]
  • Simon K Wright, Beverly R Wuertz, George Harris, Raed Abu Ghazallah, Wendy A Miller, Patrick M Gaffney, Frank G Ondrey. Functional activation of PPARγ in human upper aerodigestive cancer cell lines. Molecular carcinogenesis. 2017 01; 56(1):149-162. doi: 10.1002/mc.22479. [PMID: 26999671]
  • Omorogieva Ojo. The Use of Exenatide in Managing Markers of Cardiovascular Risk in Patients with Type 2 Diabetes: A Systematic Review. International journal of environmental research and public health. 2016 09; 13(10):. doi: 10.3390/ijerph13100941. [PMID: 27669277]
  • Fátima O Martins, Teresa C Delgado, Joana Viegas, Joana M Gaspar, Donald K Scott, Robert M O'Doherty, M Paula Macedo, John G Jones. Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinaemia. British journal of pharmacology. 2016 Jan; 173(2):267-78. doi: 10.1111/bph.13362. [PMID: 26447327]
  • Yanan Bu, Jian Yu. [Rosiglitazone protects against endotoxin-induced acute liver injury in rats]. Zhonghua yi xue za zhi. 2015 Oct; 95(39):3180-3. doi: NULL. [PMID: 26814114]
  • Jong-Hwa Lee, Chi-Kyoung Noh, Chang-Soon Yim, Yoo-Seong Jeong, Sung Hoon Ahn, Wooin Lee, Dae-Duk Kim, Suk-Jae Chung. Kinetics of the Absorption, Distribution, Metabolism, and Excretion of Lobeglitazone, a Novel Activator of Peroxisome Proliferator-Activated Receptor Gamma in Rats. Journal of pharmaceutical sciences. 2015 Sep; 104(9):3049-59. doi: 10.1002/jps.24378. [PMID: 25648999]
  • Elena Flowers, Bradley E Aouizerat, Fahim Abbasi, Cynthia Lamendola, Kaylene M Grove, Yoshimi Fukuoka, Gerald M Reaven. Circulating microRNA-320a and microRNA-486 predict thiazolidinedione response: Moving towards precision health for diabetes prevention. Metabolism: clinical and experimental. 2015 Sep; 64(9):1051-9. doi: 10.1016/j.metabol.2015.05.013. [PMID: 26031505]
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  • Hsiu-Ting Tseng, Young Joo Park, Yoon Kwang Lee, David D Moore. The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice. Journal of biomedical science. 2015 May; 22(?):30. doi: 10.1186/s12929-015-0133-3. [PMID: 25951943]
  • R Grace Walton, Beibei Zhu, Resat Unal, Michael Spencer, Manjula Sunkara, Andrew J Morris, Richard Charnigo, Wendy S Katz, Alan Daugherty, Deborah A Howatt, Philip A Kern, Brian S Finlin. Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity. The Journal of biological chemistry. 2015 May; 290(18):11547-56. doi: 10.1074/jbc.m114.628487. [PMID: 25784555]
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