Dexibuprofen (BioDeep_00001871360)

   


代谢物信息卡片


(S)-(+)-Ibuprofen

化学式: C13H18O2 (206.1307)
中文名称: (S)-(+)-布洛芬
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
InChI: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic

同义名列表

2 个代谢物同义名

(S)-(+)-Ibuprofen; Dexibuprofen



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Gerard Esteruelas, Alba Ortiz, Josefina Prat, Estefania Vega, Montserrat Muñoz-Juncosa, Maria Luisa Garcia López, Miren Ettcheto, Antoni Camins, Elena Sánchez-López, Montserrat Pujol. Novel customized age-dependent corneal membranes and interactions with biodegradable nanoparticles loaded with dexibuprofen. Colloids and surfaces. B, Biointerfaces. 2023 Aug; 228(?):113394. doi: 10.1016/j.colsurfb.2023.113394. [PMID: 37301018]
  • Vaikunthavasan Thiruchenthooran, Marta Świtalska, Lorena Bonilla, Marta Espina, Maria Luisa García, Joanna Wietrzyk, Elena Sánchez-López, Anna Gliszczyńska. Novel Strategies against Cancer: Dexibuprofen-Loaded Nanostructured Lipid Carriers. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911310. [PMID: 36232614]
  • Miroslav Sisa, Marcela Dvorakova, Veronika Temml, Veronika Jarosova, Tomas Vanek, Premysl Landa. Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core. European journal of medicinal chemistry. 2020 Oct; 204(?):112620. doi: 10.1016/j.ejmech.2020.112620. [PMID: 32738413]
  • M Ahsan Shaker, Naveed Akhtar, Muhammad Usman Minhas, Kifayat Ullah Khan, Muhammad Imad-Ud-Din Zangi, Abubakar Munir. Effect of an Al/Mg Hydroxide Antacid and Food on the Pharmacokinetics of Dexibuprofen. Drug research. 2020 Apr; 70(4):158-164. doi: 10.1055/a-1114-5745. [PMID: 32110819]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yoonho Choi, Kyoung Ah Min, Chong-Kook Kim. Development and evaluation of dexibuprofen formulation with fast onset and prolonged effect. Drug development and industrial pharmacy. 2019 Jun; 45(6):895-904. doi: 10.1080/03639045.2019.1576720. [PMID: 30889990]
  • Zongwen Gao, Feng Cui, Xuemei Cao, Dejun Wang, Xiao Li, Tianzuo Li. Local infiltration of the surgical wounds with levobupivacaine, dexibuprofen, and norepinephrine to reduce postoperative pain: A randomized, vehicle-controlled, and preclinical study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Aug; 92(?):459-467. doi: 10.1016/j.biopha.2017.05.038. [PMID: 28570980]
  • Aisha Sana, Safila Naveed, Fatima Qamar, Sadia Shakeel. Simultaneous determination of ACE inhibitors and dexibuprofen in active pharmaceutical ingredient, formulations and human serum by RP-HPLC. Pakistan journal of pharmaceutical sciences. 2017 Mar; 30(2(Suppl.)):635-639. doi: NULL. [PMID: 28650333]
  • Zaman Ashraf, Alamgeer, Raqiqatur Rasool, Mubashir Hassan, Haseeb Ahsan, Samina Afzal, Khurram Afzal, Hongsik Cho, Song Ja Kim. Synthesis, Bioevaluation and Molecular Dynamic Simulation Studies of Dexibuprofen-Antioxidant Mutual Prodrugs. International journal of molecular sciences. 2016 Dec; 17(12):. doi: 10.3390/ijms17122151. [PMID: 28009827]
  • Xuan Zhang, Xing Liu, Tao Gong, Xun Sun, Zhi-rong Zhang. In vitro and in vivo investigation of dexibuprofen derivatives for CNS delivery. Acta pharmacologica Sinica. 2012 Feb; 33(2):279-88. doi: 10.1038/aps.2011.144. [PMID: 22301864]
  • Chunchao Han, Bo Cui. Improvement of the bioavailability and glycaemic metabolism of cinnamon oil in rats by liquid loadable tablets. TheScientificWorldJournal. 2012; 2012(?):681534. doi: 10.1100/2012/681534. [PMID: 22566775]
  • Brandy L Wilkinson, Paige E Cramer, Nicholas H Varvel, Erin Reed-Geaghan, Qingguang Jiang, Alison Szabo, Karl Herrup, Bruce T Lamb, Gary E Landreth. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiology of aging. 2012 Jan; 33(1):197.e21-32. doi: 10.1016/j.neurobiolaging.2010.06.014. [PMID: 20696495]
  • Selvadurai Muralidharan. Pharmacokinetic-pharmacodynamic model of newly developed dexibuprofen sustained release formulations. ISRN pharmaceutics. 2012; 2012(?):451481. doi: 10.5402/2012/451481. [PMID: 23316393]
  • Arun Rasheed, C K Ashok Kumar, Ashutosh Mishra. Synthesis, hydrolysis studies and phamacodynamic profiles of amide prodrugs of dexibuprofen with amino acids. Journal of enzyme inhibition and medicinal chemistry. 2011 Oct; 26(5):688-95. doi: 10.3109/14756366.2010.548327. [PMID: 21250819]
  • Clara Sciorati, Daniela Miglietta, Roberta Buono, Viviana Pisa, Dario Cattaneo, Emanuele Azzoni, Silvia Brunelli, Emilio Clementi. A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy. Pharmacological research. 2011 Sep; 64(3):210-7. doi: 10.1016/j.phrs.2011.05.003. [PMID: 21609764]
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  • C H Johnson, E Karlsson, S Sarda, L Iddon, M Iqbal, X Meng, J R Harding, A V Stachulski, J K Nicholson, I D Wilson, J C Lindon. Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides. Xenobiotica; the fate of foreign compounds in biological systems. 2010 Jan; 40(1):9-23. doi: 10.3109/00498250903348720. [PMID: 19919325]
  • Kwanghee Koh Park, Joon Woo Park, Andrew D Hamilton. Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin. Organic & biomolecular chemistry. 2009 Oct; 7(20):4225-32. doi: 10.1039/b911605b. [PMID: 19795061]
  • Kathleen M Knights, Leanne K Winner, David J Elliot, Kushari Bowalgaha, John O Miners. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. British journal of clinical pharmacology. 2009 Sep; 68(3):402-12. doi: 10.1111/j.1365-2125.2009.03469.x. [PMID: 19740398]
  • Prabagar Balakrishnan, Beom-Jin Lee, Dong Hoon Oh, Jong Oh Kim, Myung Ja Hong, Jun-Pil Jee, Jung Ae Kim, Bong Kyu Yoo, Jong Soo Woo, Chul Soon Yong, Han-Gon Choi. Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS). European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2009 Aug; 72(3):539-45. doi: 10.1016/j.ejpb.2009.03.001. [PMID: 19298857]
  • Víctor Matamoros, María Hijosa, Josep M Bayona. Assessment of the pharmaceutical active compounds removal in wastewater treatment systems at enantiomeric level. Ibuprofen and naproxen. Chemosphere. 2009 Apr; 75(2):200-5. doi: 10.1016/j.chemosphere.2008.12.008. [PMID: 19155040]
  • Nicolas Gregoire, Luc Desfrere, Jean-Christophe Roze, Yves Kibleur, Petra Koehne. Population pharmacokinetic analysis of Ibuprofen enantiomers in preterm newborn infants. Journal of clinical pharmacology. 2008 Dec; 48(12):1460-8. doi: 10.1177/0091270008323752. [PMID: 18796580]
  • S Uno, M Uraki, H Komura, H Ikuta, A Kawase, M Iwaki. Impaired intrinsic chiral inversion activity of ibuprofen in rats with adjuvant-induced arthritis. Xenobiotica; the fate of foreign compounds in biological systems. 2008 Nov; 38(11):1410-21. doi: 10.1080/00498250802483768. [PMID: 18988084]
  • Thaer Barri, Tatjana Trtić-Petrović, Michael Karlsson, Jan Ake Jönsson. Characterization of drug-protein binding process by employing equilibrium sampling through hollow-fiber supported liquid membrane and Bjerrum and Scatchard plots. Journal of pharmaceutical and biomedical analysis. 2008 Sep; 48(1):49-56. doi: 10.1016/j.jpba.2008.04.030. [PMID: 18565712]
  • Rangan Mallik, David S Hage. Development of an affinity silica monolith containing human serum albumin for chiral separations. Journal of pharmaceutical and biomedical analysis. 2008 Apr; 46(5):820-30. doi: 10.1016/j.jpba.2007.03.017. [PMID: 17475436]
  • S Menon, N Kadam, G Patil, P Mhatre. A randomized, crossover study to determine bioequivalence of two brands of dexibuprofen 400 mg tablets in healthy Asian adult male subjects of Indian origin. International journal of clinical pharmacology and therapeutics. 2008 Jan; 46(1):48-54. doi: 10.5414/cpp46048. [PMID: 18218298]
  • Stefan Kaehler, Claudia Marsik, Birgit Heinisch, Christiane Thallinger, Robert Sauermann, Lili Kazemi-Shirazi, Oswald Wagner, Christian Joukhadar. S-ibuprofen effectively inhibits thromboxane B2 levels and platelet function in an experimental model of lipopolysaccharide-stimulated and non-stimulated whole blood. Pharmacology. 2008; 81(2):181-6. doi: 10.1159/000111759. [PMID: 18043009]
  • Chaonan Zheng, Haiping Hao, Guangji Wang, Guowei Sang, Jianguo Sun, Peng Li, Jing Li. Chiral separation of ibuprofen and chiral pharmacokinetics in healthy Chinese volunteers. European journal of drug metabolism and pharmacokinetics. 2008 Jan; 33(1):45-51. doi: 10.1007/bf03191018. [PMID: 18543584]
  • Uttam Mandal, Ayan Das, Sangita Agarwal, Uday Chakraborty, Utpal Nandi, Tapas Kumar Chattaraj, Tapan Kumar Pal. Bioequivalence study of two formulations containing 400 mg dexibuprofen in healthy Indian subjects. Arzneimittel-Forschung. 2008; 58(7):342-7. doi: 10.1055/s-0031-1296517. [PMID: 18751500]
  • Caroline H Johnson, Ian D Wilson, John R Harding, Andrew V Stachulski, Lisa Iddon, Jeremy K Nicholson, John C Lindon. NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues. Analytical chemistry. 2007 Nov; 79(22):8720-7. doi: 10.1021/ac071368i. [PMID: 17944439]
  • Guohua Ding, Yang Liu, Jiewen Sun, Yuriko Takeuchi, Takaki Toda, Toru Hayakawa, Shoji Fukushima, Shuichi Kishimoto, Wenhui Lin, Nobuo Inotsume. Effect of absorption rate on pharmacokinetics of ibuprofen in relation to chiral inversion in humans. The Journal of pharmacy and pharmacology. 2007 Nov; 59(11):1509-13. doi: 10.1211/jpp.59.11.0007. [PMID: 17976261]
  • E K Kuffner, J L Green, G M Bogdan, P C Knox, R B Palmer, K Heard, J T Slattery, R C Dart. The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study. BMC medicine. 2007 May; 5(?):13. doi: 10.1186/1741-7015-5-13. [PMID: 17537264]
  • Aleksi Tornio, Mikko Niemi, Pertti J Neuvonen, Janne T Backman. Stereoselective interaction between the CYP2C8 inhibitor gemfibrozil and racemic ibuprofen. European journal of clinical pharmacology. 2007 May; 63(5):463-9. doi: 10.1007/s00228-007-0273-9. [PMID: 17333159]
  • Edward C Bell, William R Ravis, Kimberly Braxton Lloyd, Thomas J Stokes. Effects of St. John's wort supplementation on ibuprofen pharmacokinetics. The Annals of pharmacotherapy. 2007 Feb; 41(2):229-34. doi: 10.1345/aph.1h602. [PMID: 17284505]
  • Ioanna C Siskou, Eleni A Rekka, Angeliki P Kourounakis, Michael C Chrysselis, Kariofyllis Tsiakitzis, Panos N Kourounakis. Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties. Bioorganic & medicinal chemistry. 2007 Jan; 15(2):951-61. doi: 10.1016/j.bmc.2006.10.056. [PMID: 17126019]
  • Carlo Bertucci, Samanta Cimitan, Antonella Riva, Paolo Morazzoni. Binding studies of taxanes to human serum albumin by bioaffinity chromatography and circular dichroism. Journal of pharmaceutical and biomedical analysis. 2006 Sep; 42(1):81-7. doi: 10.1016/j.jpba.2005.12.002. [PMID: 16413734]
  • Ignacio Vayá, Carlos J Bueno, M Consuelo Jiménez, Miguel A Miranda. Use of triplet excited States for the study of drug binding to human and bovine serum albumins. ChemMedChem. 2006 Sep; 1(9):1015-20. doi: 10.1002/cmdc.200600061. [PMID: 16906502]
  • Mai Ramadan, Susanne Goeters, Bernhard Watzer, Eva Krause, Klaus Lohmann, Rudolf Bauer, Bernd Hempel, Peter Imming. Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances. Journal of natural products. 2006 Jul; 69(7):1041-5. doi: 10.1021/np0601556. [PMID: 16872141]
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  • Jianzhong Chen, Ilona Fitos, David S Hage. Chromatographic analysis of allosteric effects between ibuprofen and benzodiazepines on human serum albumin. Chirality. 2006 Jan; 18(1):24-36. doi: 10.1002/chir.20216. [PMID: 16278829]
  • Matti Kyllönen, Klaus T Olkkola, Timo Seppälä, Pauli Ryhänen. Perioperative pharmacokinetics of ibuprofen enantiomers after rectal administration. Paediatric anaesthesia. 2005 Jul; 15(7):566-73. doi: 10.1111/j.1460-9592.2005.01499.x. [PMID: 15960640]
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