Hexamethylenediamine (BioDeep_00001871353)
代谢物信息卡片
化学式: C6H16N2 (116.1313416)
中文名称: 1,6-己二胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CCCN)CCN
InChI: InChI=1S/C6H16N2/c7-5-3-1-2-4-6-8/h1-8H2
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:39618
- PubChem: 16402
- DrugBank: DB03260
- ChEMBL: CHEMBL303004
- CAS: 284474-80-2
- CAS: 73398-58-0
- CAS: 124-09-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Sophie Maiocchi, Jacqueline Ku, Tom Hawtrey, Irene De Silvestro, Ernst Malle, Martin Rees, Shane R Thomas, Jonathan C Morris. Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase.
Chemical research in toxicology.
2021 06; 34(6):1681-1692. doi:
10.1021/acs.chemrestox.1c00094
. [PMID: 34085520] - Wenwen Wang, Hao Zhang, Zhifeng Zhang, Mengying Luo, Yuedan Wang, Qiongzhen Liu, Yuanli Chen, Mufang Li, Dong Wang. Amine-functionalized PVA-co-PE nanofibrous membrane as affinity membrane with high adsorption capacity for bilirubin.
Colloids and surfaces. B, Biointerfaces.
2017 Feb; 150(?):271-278. doi:
10.1016/j.colsurfb.2016.10.034
. [PMID: 28029549] - Venkateswarlu Yarlagadda, Paramita Sarkar, Sandip Samaddar, Jayanta Haldar. A Vancomycin Derivative with a Pyrophosphate-Binding Group: A Strategy to Combat Vancomycin-Resistant Bacteria.
Angewandte Chemie (International ed. in English).
2016 06; 55(27):7836-40. doi:
10.1002/anie.201601621
. [PMID: 27010764] - Leena A Nylander-French, Michael C Wu, John E French, Jayne C Boyer, Lisa Smeester, Alison P Sanders, Rebecca C Fry. DNA methylation modifies urine biomarker levels in 1,6-hexamethylene diisocyanate exposed workers: a pilot study.
Toxicology letters.
2014 Dec; 231(2):217-26. doi:
10.1016/j.toxlet.2014.10.024
. [PMID: 25445006] - Shiwali Thakur, Sapana Kumari, Priyanka Dogra, Ghanshyam S Chauhan. A new guar gum-based adsorbent for the removal of Hg(II) from its aqueous solutions.
Carbohydrate polymers.
2014 Jun; 106(?):276-82. doi:
10.1016/j.carbpol.2014.02.041
. [PMID: 24721079] - Xiaojuan Deng, Qianjin Guo, Xiaoping Chen, Tao Xue, Hui Wang, Pei Yao. Rapid and effective sample clean-up based on magnetic multiwalled carbon nanotubes for the determination of pesticide residues in tea by gas chromatography-mass spectrometry.
Food chemistry.
2014 Feb; 145(?):853-8. doi:
10.1016/j.foodchem.2013.08.137
. [PMID: 24128556] - Richard F G Fröhlich, Richard H Furneaux, Don J Mahuran, Robert Saf, Arnold E Stütz, Michael B Tropak, Jacqueline Wicki, Stephen G Withers, Tanja M Wrodnigg. 1-Deoxy-D-galactonojirimycins with dansyl capped N-substituents as β-galactosidase inhibitors and potential probes for GM1 gangliosidosis affected cell lines.
Carbohydrate research.
2011 Sep; 346(12):1592-8. doi:
10.1016/j.carres.2011.05.010
. [PMID: 21645885] - Lygia T Budnik, Dennis Nowak, Rolf Merget, Catherine Lemiere, Xaver Baur. Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies.
Journal of occupational medicine and toxicology (London, England).
2011 Mar; 6(1):9. doi:
10.1186/1745-6673-6-9
. [PMID: 21447151] - John Cocker. Biological monitoring for isocyanates.
The Annals of occupational hygiene.
2011 Mar; 55(2):127-31. doi:
10.1093/annhyg/meq083
. [PMID: 21252056] - Ran Liu, Ying Jia, Weiming Cheng, Junhong Ling, Lili Liu, Kaishun Bi, Qing Li. Determination of polyamines in human urine by precolumn derivatization with benzoyl chloride and high-performance liquid chromatography coupled with Q-time-of-flight mass spectrometry.
Talanta.
2011 Jan; 83(3):751-6. doi:
10.1016/j.talanta.2010.10.039
. [PMID: 21147316] - Linda G T Gaines, Kenneth W Fent, Sheila L Flack, Jennifer M Thomasen, Stephen G Whittaker, Leena A Nylander-French. Factors affecting variability in the urinary biomarker 1,6-hexamethylene diamine in workers exposed to 1,6-hexamethylene diisocyanate.
Journal of environmental monitoring : JEM.
2011 Jan; 13(1):119-27. doi:
10.1039/c0em00122h
. [PMID: 20978689] - Carla Cruz, Elisa Cairrao, Samuel Silvestre, Luiza Breitenfeld, Paulo Almeida, João A Queiroz. Targeting of mitochondria-endoplasmic reticulum by fluorescent macrocyclic compounds.
PloS one.
2011; 6(11):e27078. doi:
10.1371/journal.pone.0027078
. [PMID: 22132086] - Leman Tarhan, Hulya Ayar-Kayali. Immobilization of phenylalanine dehydrogenase and its application in flow-injection analysis system for determination of plasma phenylalanine.
Applied biochemistry and biotechnology.
2011 Jan; 163(2):258-67. doi:
10.1007/s12010-010-9035-8
. [PMID: 20658209] - Ahmed Besheer, Thomas C Hertel, Jörg Kressler, Karsten Mäder, Markus Pietzsch. Enzymatically catalyzed conjugation of a biodegradable polymer to proteins and small molecules using microbial transglutaminase.
Methods in molecular biology (Clifton, N.J.).
2011; 751(?):17-27. doi:
10.1007/978-1-61779-151-2_2
. [PMID: 21674322] - Linda G T Gaines, Kenneth W Fent, Sheila L Flack, Jennifer M Thomasen, Louise M Ball, David B Richardson, Kai Ding, Stephen G Whittaker, Leena A Nylander-French. Urine 1,6-hexamethylene diamine (HDA) levels among workers exposed to 1,6-hexamethylene diisocyanate (HDI).
The Annals of occupational hygiene.
2010 Aug; 54(6):678-91. doi:
10.1093/annhyg/meq041
. [PMID: 20530123] - Mirtaghi Mirmohammadi, M Hakimi Ibrahim, Anees Ahmad, Mohd Omar Abdul Kadir, M Mohammadyan, S B Mirashrafi. Indoor air pollution evaluation with emphasize on HDI and biological assessment of HDA in the polyurethane factories.
Environmental monitoring and assessment.
2010 Jun; 165(1-4):341-7. doi:
10.1007/s10661-009-0950-5
. [PMID: 19444630] - Linda G T Gaines, Kenneth W Fent, Sheila L Flack, Jennifer M Thomasen, Louise M Ball, Haibo Zhou, Stephen G Whittaker, Leena A Nylander-French. Effect of creatinine and specific gravity normalization on urinary biomarker 1,6-hexamethylene diamine.
Journal of environmental monitoring : JEM.
2010 Mar; 12(3):591-9. doi:
10.1039/b921073c
. [PMID: 20445846] - Horacio F Olivo, Nury Perez-Hernandez, Dongmin Liu, Mary Iruthayanathan, Brianne O'Leary, Laurie L Homan, Joseph S Dillon. Synthesis and application of a photoaffinity analog of dehydroepiandrosterone (DHEA).
Bioorganic & medicinal chemistry letters.
2010 Feb; 20(3):1153-5. doi:
10.1016/j.bmcl.2009.12.019
. [PMID: 20031404] - Sheila L Flack, Kenneth W Fent, Linda G Trelles Gaines, Jennifer M Thomasen, Steve Whittaker, Louise M Ball, Leena A Nylander-French. Quantitative plasma biomarker analysis in HDI exposure assessment.
The Annals of occupational hygiene.
2010 Jan; 54(1):41-54. doi:
10.1093/annhyg/mep069
. [PMID: 19805392] - Ahmed Besheer, Thomas C Hertel, Jörg Kressler, Karsten Mäder, Markus Pietzsch. Enzymatically catalyzed HES conjugation using microbial transglutaminase: Proof of feasibility.
Journal of pharmaceutical sciences.
2009 Nov; 98(11):4420-8. doi:
10.1002/jps.21675
. [PMID: 19156844] - Hyuncheol Kim, Shaun B Robinson, Karl G Csaky. Investigating the movement of intravitreal human serum albumin nanoparticles in the vitreous and retina.
Pharmaceutical research.
2009 Feb; 26(2):329-37. doi:
10.1007/s11095-008-9745-6
. [PMID: 18958405] - Shin-Ichi Kondo, Yasuyo Fukunaga, Michinori Oikawa, Yasushi Sasai, Masayuki Kuzuya. Plasma-assisted immobilization of heparin onto low-density polyethylene surface.
Chemical & pharmaceutical bulletin.
2008 Jul; 56(7):921-5. doi:
10.1248/cpb.56.921
. [PMID: 18591802] - Changjun Hou, Quan Yuan, Danqun Huo, Shujia Zheng, Dongli Zhan. Investigation on clotting and hemolysis characteristics of heparin-immobilized polyether sulfones biomembrane.
Journal of biomedical materials research. Part A.
2008 Jun; 85(3):847-52. doi:
10.1002/jbm.a.31502
. [PMID: 17876803] - Ananthu Sateesh, Jürgen Vogel, Evelyn Dayss, Beate Fricke, Karin Dölling, Ulrich Rothe. Surface modification of medical-grade polyurethane by cyanurchloride-activated tetraether lipid (a new approach for bacterial antiadhesion).
Journal of biomedical materials research. Part A.
2008 Mar; 84(3):672-81. doi:
10.1002/jbm.a.31345
. [PMID: 17635021] - Jeong Ah Byun, Sang Hee Lee, Byung Hwa Jung, Man Ho Choi, Myeong Hee Moon, Bong Chul Chung. Analysis of polyamines as carbamoyl derivatives in urine and serum by liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2008 Jan; 22(1):73-80. doi:
10.1002/bmc.898
. [PMID: 17668437] - L Francesch, S Borros, W Knoll, R Förch. Surface reactivity of pulsed-plasma polymerized pentafluorophenyl methacrylate (PFM) toward amines and proteins in solution.
Langmuir : the ACS journal of surfaces and colloids.
2007 Mar; 23(7):3927-31. doi:
10.1021/la062422d
. [PMID: 17338554] - A Pronk, F Yu, J Vlaanderen, E Tielemans, L Preller, I Bobeldijk, J A Deddens, U Latza, X Baur, D Heederik. Dermal, inhalation, and internal exposure to 1,6-HDI and its oligomers in car body repair shop workers and industrial spray painters.
Occupational and environmental medicine.
2006 Sep; 63(9):624-31. doi:
10.1136/oem.2005.023226
. [PMID: 16728504] - Knut A Eliassen, Bjørn P Brodal, Aud Svindland, Harald Osmundsen, Helle Rønning, Srdjan Djurovic, Kåre Berg. Activity of peroxisomal enzymes, and levels of polyamines in LPA-transgenic mice on two different diets.
Lipids in health and disease.
2005 Oct; 4(?):23. doi:
10.1186/1476-511x-4-23
. [PMID: 16202171] - Kyoung Hoon Kim, Hyung Jun Ahn, Do Jin Kim, Hyung Ho Lee, Jun-Yong Ha, Hye-Kyung Kim, Hye-Jin Yoon, Se Won Suh. Expression, crystallization and preliminary X-ray crystallographic analysis of human agmatinase.
Acta crystallographica. Section F, Structural biology and crystallization communications.
2005 Oct; 61(Pt 10):889-91. doi:
10.1107/s1744309105027193
. [PMID: 16511187] - P Persico, C Carfagna, L Danicher, Y Frere. Polyamide microcapsules containing jojoba oil prepared by inter-facial polymerization.
Journal of microencapsulation.
2005 Aug; 22(5):471-86. doi:
10.1080/02652040500161933
. [PMID: 16361191] - Li-Yao Zhang, Xing-Chun Tang, Meng-Xiang Sun. Simultaneous determination of histamine and polyamines by capillary zone electrophoresis with 4-fluor-7-nitro-2,1,3-benzoxadiazole derivatization and fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jun; 820(2):211-9. doi:
10.1016/j.jchromb.2005.03.033
. [PMID: 15869910] - Shen-Feng Ma, Makiya Nishikawa, Hidemasa Katsumi, Fumiyoshi Yamashita, Mitsuru Hashida. Cationic charge-dependent hepatic delivery of amidated serum albumin.
Journal of controlled release : official journal of the Controlled Release Society.
2005 Feb; 102(3):583-94. doi:
10.1016/j.jconrel.2004.11.006
. [PMID: 15681081] - Youcheng Liu, Michele Berode, Meredith H Stowe, Carole T Holm, Frank X Walsh, Martin D Slade, Mark F Boeniger, Carrie A Redlich. Urinary hexane diamine to assess respiratory exposure to hexamethylene diisocyanate aerosol: a human inhalation study.
International journal of occupational and environmental health.
2004 Jul; 10(3):262-71. doi:
10.1179/oeh.2004.10.3.262
. [PMID: 15473079] - Asa Marand, Daniel Karlsson, Marianne Dalene, Gunnar Skarping. Determination of amines as pentafluoropropionic acid anhydride derivatives in biological samples using liquid chromatography and tandem mass spectrometry.
The Analyst.
2004 Jun; 129(6):522-8. doi:
10.1039/b403439b
. [PMID: 15152330] - G Ignesti. Equations of substrate-inhibition kinetics applied to pig kidney diamine oxidase (DAO, E.C. 1.4.3.6).
Journal of enzyme inhibition and medicinal chemistry.
2003 Dec; 18(6):463-73. doi:
10.1080/14756360310001605543
. [PMID: 15008510] - David R Plant, Gordon S Lynch. Depolarization-induced contraction and SR function in mechanically skinned muscle fibers from dystrophic mdx mice.
American journal of physiology. Cell physiology.
2003 Sep; 285(3):C522-8. doi:
10.1152/ajpcell.00369.2002
. [PMID: 12724137] - Hwa Jeong Lee, William M Pardridge. Monoclonal antibody radiopharmaceuticals: cationization, pegylation, radiometal chelation, pharmacokinetics, and tumor imaging.
Bioconjugate chemistry.
2003 May; 14(3):546-53. doi:
10.1021/bc0256648
. [PMID: 12757378] - F Ayhan, A Yousefi Rad, H Ayhan. Biocompatibility investigation and urea removal from blood by urease-immobilized HEMA incorporated poly(ethyleneglycol dimethacrylate) microbeads.
Journal of biomedical materials research. Part B, Applied biomaterials.
2003 Jan; 64(1):13-8. doi:
10.1002/jbm.b.10411
. [PMID: 12474242] - Christina Rosenberg, Kirsi Nikkilä, Maj-Len Henriks-Eckerman, Kimmo Peltonen, Kerstin Engströrm. Biological monitoring of aromatic diisocyanates in workers exposed to thermal degradation products of polyurethanes.
Journal of environmental monitoring : JEM.
2002 Oct; 4(5):711-6. doi:
10.1039/b206340a
. [PMID: 12400919] - Yukitaka Nakano, Hitoshi Nohta, Hideyuki Yoshida, Tetsuya Saita, Hiroshi Fujito, Masato Mori, Masatoshi Yamaguchi. Liquid chromatographic determination of triethylenetetramine in human and rabbit sera based on intramolecular excimer-forming fluorescence derivatization.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Jul; 774(2):165-72. doi:
10.1016/s1570-0232(02)00185-x
. [PMID: 12076686] - Vinoy Thomas, Muthu Jayabalan. The effect of virtual cross linking on the oxidative stability and lipid uptake of aliphatic poly(urethane urea).
Biomaterials.
2002 Jan; 23(1):273-82. doi:
10.1016/s0142-9612(01)00106-5
. [PMID: 11762847] - M Nishikawa, H Nagatomi, M Nishijima, G Ohira, B J Chang, E Sato, M Inoue. Targeting superoxide dismutase to renal proximal tubule cells inhibits nephrotoxicity of cisplatin and increases the survival of cancer-bearing mice.
Cancer letters.
2001 Oct; 171(2):133-8. doi:
10.1016/s0304-3835(01)00591-2
. [PMID: 11520596] - M McKegney, I Taggart, M H Grant. The influence of crosslinking agents and diamines on the pore size, morphology and the biological stability of collagen sponges and their effect on cell penetration through the sponge matrix.
Journal of materials science. Materials in medicine.
2001 Sep; 12(9):833-44. doi:
10.1023/a:1017989305873
. [PMID: 15348233] - D Fischer, T Bieber, S Brüsselbach, H Elsässer, T Kissel. Cationized human serum albumin as a non-viral vector system for gene delivery? Characterization of complex formation with plasmid DNA and transfection efficiency.
International journal of pharmaceutics.
2001 Aug; 225(1-2):97-111. doi:
10.1016/s0378-5173(01)00765-7
. [PMID: 11489558] - M C Gennaro, R Calvino, C Abrigo. Ion interaction reagent reversed-phase high-performance liquid chromatography determination of anti-tuberculosis drugs and metabolites in biological fluids.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 754(2):477-86. doi:
10.1016/s0378-4347(01)00037-8
. [PMID: 11339291] - F Hervé, J Ouzilou-Girod, J M Scherrmann. [Cationization, a process for the delivery of antibodies to the central nervous system. Problems encountered in its application for immunotherapy strategies such as those for clostridial poisoning].
Journal de la Societe de biologie.
2001; 195(3):201-27. doi:
NULL
. [PMID: 11833458] - H Ayhan, E Pişkin. A potential cell affinity sorbent: fibronectin carrying poly(EGDMA/HEMA) microbeads.
Journal of biomaterials science. Polymer edition.
1999; 10(1):109-22. doi:
10.1163/156856299x00315
. [PMID: 10091926] - A Denizli, F Denizli, E Pişkin. Diamine-plasma treated and Cu(II)-incorporated poly(hydroxyethylmethacrylate) microbeads for albumin adsorption.
Journal of biomaterials science. Polymer edition.
1999; 10(3):305-18. doi:
10.1163/156856299x00379
. [PMID: 10189099] - A Maître, M Berode, A Perdrix, M Stoklov, J M Mallion, H Savolainen. Urinary hexane diamine as an indicator of occupational exposure to hexamethylene diisocyanate.
International archives of occupational and environmental health.
1996; 69(1):65-8. doi:
10.1007/bf02630741
. [PMID: 9017437] - H Tinnerberg, G Skarping, M Dalene, L Hagmar. Test chamber exposure of humans to 1,6-hexamethylene diisocyanate and isophorone diisocyanate.
International archives of occupational and environmental health.
1995; 67(6):367-74. doi:
10.1007/bf00381050
. [PMID: 8567087] - Y Nishimura, M Nakayama, T Sato, K Tomita, M Inoue. Inhibition of puromycin-induced renal injury by a superoxide dismutase derivative with prolonged in vivo half-life.
Nephron.
1995; 70(4):460-5. doi:
10.1159/000188646
. [PMID: 7477653] - G Skarping, M D Dalene, H Tinnerberg. Biological monitoring of hexamethylene- and isophorone-diisocyanate by the determination of hexamethylene- and isophorone-diamine in hydrolysed urine using liquid chromatography and mass spectrometry.
The Analyst.
1994 Sep; 119(9):2051-5. doi:
10.1039/an9941902051
. [PMID: 7978332] - M Dalene, G Skarping, H Tinnerberg. Biological monitoring of hexamethylene diisocyanate by determination of 1,6-hexamethylene diamine as the trifluoroethyl chloroformate derivative using capillary gas chromatography with thermoionic and selective-ion monitoring.
Journal of chromatography. B, Biomedical applications.
1994 Jun; 656(2):319-28. doi:
10.1016/0378-4347(94)00137-5
. [PMID: 7987483] - M Berode. Detoxification of an aliphatic amine by N-acetylation: experimental and clinical studies.
Biochemistry international.
1991 Jul; 24(5):947-50. doi:
NULL
. [PMID: 1663742] - M Dalene, G Skarping, T Brorson. Chromatographic determination of amines in biological fluids with special reference to the biological monitoring of isocyanates and amines. IV. Determination of 1,6-hexamethylenediamine in human urine using capillary gas chromatography and selective ion monitoring.
Journal of chromatography.
1990 Sep; 516(2):405-13. doi:
10.1016/s0021-9673(01)89281-5
. [PMID: 2079495] - T Brorson, G Skarping, J Nielsen. Biological monitoring of isocyanates and related amines. II. Test chamber exposure of humans to 1,6-hexamethylene diisocyanate (HDI).
International archives of occupational and environmental health.
1990; 62(5):385-9. doi:
10.1007/bf00381369
. [PMID: 2228259] - T Brorson, G Skarping, J F Sandström, M Stenberg. Biological monitoring of isocyanates and related amines. I. Determination of 1,6-hexamethylene diamine (HDA) in hydrolysed human urine after oral administration of HDA.
International archives of occupational and environmental health.
1990; 62(1):79-84. doi:
10.1007/bf00397852
. [PMID: 2295527] - M Berode, P Leuenberger, H Savolainen. Phenotype-dependent inhibition of human alpha 1-antitrypsin by 1,6-hexane diamine in vitro.
Biochemistry international.
1988 Jul; 17(1):141-5. doi:
NULL
. [PMID: 3263859] - A C Povey, I Brouet, J R Nixon, I K O'Neill. Trapping of chemical carcinogens with magnetic polyethyleneimine microcapsules: III. In vivo trapping of electrophiles from N-methyl-N-nitrosourea and recovery from feces.
Journal of pharmaceutical sciences.
1987 Mar; 76(3):201-7. doi:
10.1002/jps.2600760304
. [PMID: 3585735] - M Suter. A modified ELISA technique for anti-hapten antibodies.
Journal of immunological methods.
1982 Aug; 53(1):103-8. doi:
10.1016/0022-1759(82)90244-7
. [PMID: 6182245] - E Lauritzen, M Lauritzen, I Rubin. Purification of rat renal renin from crude kidney extracts by diaminohexamethylene-sepharose chromatography.
Biochemical and biophysical research communications.
1980 Sep; 96(2):907-14. doi:
10.1016/0006-291x(80)91441-2
. [PMID: 7000074]