1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl- (BioDeep_00001871340)
代谢物信息卡片
1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-
化学式: C9H18NO2 (172.1337468)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(CC(CC(N1[O])(C)C)O)C
InChI: InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
C26170 - Protective Agent > C797 - Radioprotective Agent
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wing-Kee Lee, Stephanie Probst, Bettina Scharner, Timo Deba, Faouzi Dahdouh, Frank Thévenod. Distinct concentration-dependent oxidative stress profiles by cadmium in a rat kidney proximal tubule cell line.
Archives of toxicology.
2024 Jan; ?(?):. doi:
10.1007/s00204-023-03677-z. [PMID: 38289529] - Stella Bujak-Pietrek, Anna Pieniazek, Krzysztof Gwozdzinski, Lukasz Gwozdzinski. The Effect of Piperidine Nitroxides on the Properties of Metalloproteins in Human Red Blood Cells.
Molecules (Basel, Switzerland).
2023 Aug; 28(16):. doi:
10.3390/molecules28166174. [PMID: 37630426] - Yu Fan, Yangmian Yuan, Mingrui Xiong, Muchuan Jin, Donge Zhang, Dong Yang, Chengyu Liu, Robert B Petersen, Kun Huang, Anlin Peng, Ling Zheng. Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase.
Theranostics.
2023; 13(15):5348-5364. doi:
10.7150/thno.87416. [PMID: 37908721] - Garima Singh, Namrata Mittra, Chetna Singh. Tempol and silymarin rescue from zinc-induced degeneration of dopaminergic neurons through modulation of oxidative stress and inflammation.
Molecular and cellular biochemistry.
2022 Dec; ?(?):. doi:
10.1007/s11010-022-04620-z. [PMID: 36562918] - Xiongfei Xu, Fei Xie, Yuping Wang, Hong Zeng, Sen Shi, Xiaolei Sun, Huqiang He, Lei Zhang, Weiming Wang, Tao Xiang, Yanzheng He, Yong Liu. Involvement of endothelial progenitor cells in blood flow recovery through activation of the Wnt/β-catenin signaling pathway and inhibition of high oxidative stress in diabetic hindlimb ischemic rats.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2022 Nov; 31(11):1215-1229. doi:
10.17219/acem/139094. [PMID: 36047895] - Mohd Amir Afjal, Poonam Goswami, Shahzad Ahmad, Sadaf Dabeer, Juheb Akhter, Mohd Salman, Anuradha Mangla, Sheikh Raisuddin. Tempol (4-hydroxy tempo) protects mice from cisplatin-induced acute kidney injury via modulation of expression of aquaporins and kidney injury molecule-1.
Drug and chemical toxicology.
2022 May; 45(3):1355-1363. doi:
10.1080/01480545.2020.1831011. [PMID: 33078650] - Rajani Choudhuri, Anastasia L Sowers, G V R Chandramouli, Janet Gamson, Murali C Krishna, James B Mitchell, John A Cook. The antioxidant tempol transforms gut microbiome to resist obesity in female C3H mice fed a high fat diet.
Free radical biology & medicine.
2022 01; 178(?):380-390. doi:
10.1016/j.freeradbiomed.2021.12.006. [PMID: 34883252] - Kevin M Chacko, Mohammad-Zaman Nouri, Whitney C Schramm, Zeeshan Malik, Lauren P Liu, Nancy D Denslow, Abdel A Alli. Tempol Alters Urinary Extracellular Vesicle Lipid Content and Release While Reducing Blood Pressure during the Development of Salt-Sensitive Hypertension.
Biomolecules.
2021 12; 11(12):. doi:
10.3390/biom11121804. [PMID: 34944449] - Graziele C Ferreira, Lucas C Pinheiro, Gustavo H Oliveira-Paula, Célio D Angelis, Rafael L Portella, Jose E Tanus-Santos. Antioxidant tempol modulates the increases in tissue nitric oxide metabolites concentrations after oral nitrite administration.
Chemico-biological interactions.
2021 Nov; 349(?):109658. doi:
10.1016/j.cbi.2021.109658. [PMID: 34543659] - Afreen Sultana, Mina Zare, Hongrong Luo, Seeram Ramakrishna. Surface Engineering Strategies to Enhance the In Situ Performance of Medical Devices Including Atomic Scale Engineering.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111788. [PMID: 34769219] - Natalya A Maslennikova, Elena A Golysheva, Sergei A Dzuba. Evidence for an Ordering Transition near 120 K in an Intrinsically Disordered Protein, Casein.
Molecules (Basel, Switzerland).
2021 Oct; 26(19):. doi:
10.3390/molecules26195971. [PMID: 34641515] - Kavita Mathi, Yael Rosenberg-Hasson, Holden Maecker, Dennis J Carlo, Ronald B Moss. Brief report: Tempol, a novel antioxidant, inhibits both activated T cell and antigen presenting cell derived cytokines in-vitro from COVID-19 patients.
Clinical immunology (Orlando, Fla.).
2021 10; 231(?):108828. doi:
10.1016/j.clim.2021.108828. [PMID: 34425240] - Evandro M Neto-Neves, Ozelia Sousa-Santos, Karina C Ferraz, Rafael L Portella, Jonas T Sertório, Jose E Tanus-Santos. Nitrite and tempol combination promotes synergic effects and alleviates right ventricular wall stress during acute pulmonary thromboembolism.
Nitric oxide : biology and chemistry.
2021 10; 115(?):23-29. doi:
10.1016/j.niox.2021.06.004. [PMID: 34133975] - Sherouk Fouda, Anwar Khan, Stanley M H Chan, Ali Mahzari, Xiu Zhou, Cheng Xue Qin, Ross Vlahos, Ji-Ming Ye. Exposure to cigarette smoke precipitates simple hepatosteatosis to NASH in high-fat diet fed mice by inducing oxidative stress.
Clinical science (London, England : 1979).
2021 09; 135(17):2103-2119. doi:
10.1042/cs20210628. [PMID: 34427662] - Nunziata Maio, Bernard A P Lafont, Debangsu Sil, Yan Li, J Martin Bollinger, Carsten Krebs, Theodore C Pierson, W Marston Linehan, Tracey A Rouault. Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets.
Science (New York, N.Y.).
2021 07; 373(6551):236-241. doi:
10.1126/science.abi5224. [PMID: 34083449] - Tianhe Li, Tingting Zhang, Huimin Gao, Ruixia Liu, Muqing Gu, Yuxi Yang, Tianyu Cui, Zhongbing Lu, Chenghong Yin. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction.
Redox biology.
2021 05; 41(?):101886. doi:
10.1016/j.redox.2021.101886. [PMID: 33592539] - Zizheng Suo, Yanzhi Liu, Yueyi Li, Cong Xu, Yuhan Liu, Mingming Gao, Jinghui Dong. Calcitriol inhibits COX-1 and COX-2 expressions of renal vasculature in hypertension: Reactive oxygen species involved?.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Jan; 43(1):91-100. doi:
10.1080/10641963.2020.1817473. [PMID: 32909857] - Sukanya Phungphong, Anusak Kijtawornrat, Jonggonnee Wattanapermpool, Tepmanas Bupha-Intr. Improvement in cardiac function of ovariectomized rats by antioxidant tempol.
Free radical biology & medicine.
2020 11; 160(?):239-245. doi:
10.1016/j.freeradbiomed.2020.06.013. [PMID: 32763410] - Chunlei Qi, Xuesong Liu, Ting Xiong, Daxin Wang. Tempol prevents isoprenaline-induced takotsubo syndrome via the reactive oxygen species/mitochondrial/anti-apoptosis /p38 MAPK pathway.
European journal of pharmacology.
2020 Nov; 886(?):173439. doi:
10.1016/j.ejphar.2020.173439. [PMID: 32871175] - Indira D Pokkunuri, Mustafa F Lokhandwala, Anees Ahmad Banday. Protein disulfide isomerase inhibition impairs Keap1/Nrf2 signaling and mitochondrial function and induces apoptosis in renal proximal tubular cells.
American journal of physiology. Renal physiology.
2020 10; 319(4):F686-F696. doi:
10.1152/ajprenal.00049.2020. [PMID: 32830535] - Danielba Almeida da Silva, Thiago Macêdo Lopes Correia, Rafael Pereira, Robson Amaro Augusto da Silva, Ohara Augusto, Raphael Ferreira Queiroz. Tempol reduces inflammation and oxidative damage in cigarette smoke-exposed mice by decreasing neutrophil infiltration and activating the Nrf2 pathway.
Chemico-biological interactions.
2020 Sep; 329(?):109210. doi:
10.1016/j.cbi.2020.109210. [PMID: 32726580] - Iñaki Robles-Vera, Néstor De La Visitación, Marta Toral, Manuel Sánchez, Manuel Gómez-Guzmán, Francisco O'valle, Rosario Jiménez, Juan Duarte, Miguel Romero. Toll-like receptor 7-driven lupus autoimmunity induces hypertension and vascular alterations in mice.
Journal of hypertension.
2020 07; 38(7):1322-1335. doi:
10.1097/hjh.0000000000002368. [PMID: 32004206] - Vienna E Brunt, Rachel A Gioscia-Ryan, Abigail G Casso, Nicholas S VanDongen, Brian P Ziemba, Zachary J Sapinsley, James J Richey, Melanie C Zigler, Andrew P Neilson, Kevin P Davy, Douglas R Seals. Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.
Hypertension (Dallas, Tex. : 1979).
2020 07; 76(1):101-112. doi:
10.1161/hypertensionaha.120.14759. [PMID: 32520619] - Mohamed G Ewees, Basim A S Messiha, Mohamed S Abdel-Bakky, Asmaa M A Bayoumi, Ali A Abo-Saif. Tempol, a superoxide dismutase mimetic agent, reduces cisplatin-induced nephrotoxicity in rats.
Drug and chemical toxicology.
2019 Nov; 42(6):657-664. doi:
10.1080/01480545.2018.1485688. [PMID: 30067109] - Keiko Hosohata, Denan Jin, Shinji Takai, Kazunori Iwanaga. Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats.
International journal of molecular sciences.
2019 Sep; 20(18):. doi:
10.3390/ijms20184481. [PMID: 31514290] - Shuangyan Ye, Sisi Zeng, Mengqiu Huang, Jianping Chen, Xi Chen, Pengfei Xu, Qianli Wang, Wenwen Gao, Bingsheng Yang, Bingtao Hao, Wenhuan Huang, Qiuzhen Liu. [Effect of the chemoprotectant tempol on anti-tumor activity of cisplatin].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2019 Aug; 39(8):883-890. doi:
10.12122/j.issn.1673-4254.2019.08.02. [PMID: 31511206] - M A Afjal, Sa Hasan Abdi, S Sharma, S Ahmad, M Fatima, S Dabeer, J Akhter, S Raisuddin. Anti-inflammatory role of tempol (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl) in nephroprotection.
Human & experimental toxicology.
2019 Jun; 38(6):713-723. doi:
10.1177/0960327119836203. [PMID: 30924375] - Christel Becker, Angelina Mancic, Antoine Ghestem, Victoria Poillerat, Damien Claverie, Fabrice Bartolomei, Franck Brouillard, Jean-Jacques Benoliel, Christophe Bernard. Antioxidant treatment after epileptogenesis onset prevents comorbidities in rats sensitized by a past stressful event.
Epilepsia.
2019 04; 60(4):648-655. doi:
10.1111/epi.14692. [PMID: 30866060] - Hossein Shateri, Akram Ranjbar, Nejat Kheiripour, Hassan Ghasemi, Yasin Pourfarjam, Elahe Habibitabar, Hamid Gholami, Heresh Moridi. Tempol improves oxidant/antioxidant parameters in testicular tissues of diabetic rats.
Life sciences.
2019 Mar; 221(?):65-71. doi:
10.1016/j.lfs.2019.02.016. [PMID: 30738867] - Wesley T Abplanalp, Nalinie S Wickramasinghe, Srinivas D Sithu, Daniel J Conklin, Zhengzhi Xie, Aruni Bhatnagar, Sanjay Srivastava, Timothy E O'Toole. Benzene Exposure Induces Insulin Resistance in Mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 02; 167(2):426-437. doi:
10.1093/toxsci/kfy252. [PMID: 30346588] - Bodong Li, Haibo Xie, Xian Wang, Xiaodong Yang, Ling Yang, Jiaxiang Zhang, Feng Wang, Tong Shen, Qixing Zhu. Oxidative stress mediates renal endothelial cell damage in trichloroethylene-sensitized mice.
The Journal of toxicological sciences.
2019; 44(5):317-326. doi:
10.2131/jts.44.317. [PMID: 31068537] - H-D Lu, Z-C Liu, L-Y Zhou, J Zhou, X-R Feng, B Wang. Influence of the TLR4-mediated p38MAPK signaling pathway on chronic intermittent hypoxic-induced rat's oxidative stress and inflammatory cytokines in rats.
European review for medical and pharmacological sciences.
2019 Jan; 23(1):352-360. doi:
10.26355/eurrev_201901_16783. [PMID: 30657577] - Anees A Banday, Mustafa F Lokhandwala. Oxidative stress impairs cGMP-dependent protein kinase activation and vasodilator-stimulated phosphoprotein serine-phosphorylation.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2019; 41(1):5-13. doi:
10.1080/10641963.2018.1433197. [PMID: 29424564] - Sumit Bhattacharyya, Leo Feferman, Joanne K Tobacman. Distinct Effects of Carrageenan and High-Fat Consumption on the Mechanisms of Insulin Resistance in Nonobese and Obese Models of Type 2 Diabetes.
Journal of diabetes research.
2019; 2019(?):9582714. doi:
10.1155/2019/9582714. [PMID: 31179345] - Yanping Liu, Linglu Qi, Jue Wu, Ting Xu, Chunli Yang, Xueyi Chen, Juanxiu Lv, Zhice Xu. Prenatal high-salt diet impaired vasodilatation with reprogrammed renin-angiotensin system in offspring rats.
Journal of hypertension.
2018 12; 36(12):2369-2379. doi:
10.1097/hjh.0000000000001865. [PMID: 30382958] - Ying Ma, Zhenyu Huang, Zhaoli Zhou, Xiaoyan He, Ying Wang, Chao Meng, Gang Huang, Ningyuan Fang. A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation through restoration of autophagy flux.
Free radical biology & medicine.
2018 12; 129(?):463-472. doi:
10.1016/j.freeradbiomed.2018.10.412. [PMID: 30321700] - Mohammad Saleem, Xitao Wang, Indira Pokkunuri, Mohammad Asghar. Superoxide via Sp3 mechanism increases renal renin activity, renal AT1 receptor function, and blood pressure in rats.
American journal of physiology. Renal physiology.
2018 11; 315(5):F1478-F1483. doi:
10.1152/ajprenal.00194.2018. [PMID: 30110572] - Hitesh Soni, Damian Kaminski, Rajashekhar Gangaraju, Adebowale Adebiyi. Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding.
Renal failure.
2018 Nov; 40(1):314-322. doi:
10.1080/0886022x.2018.1456938. [PMID: 29619879] - Haiyan Zhao, Yaping Zhao, Xin Li, Leiqian Xu, Fangxin Jiang, Wanju Hou, Lixia Dong, Jie Cao. Effects of Antioxidant Tempol on Systematic Inflammation and Endothelial Apoptosis in Emphysematous Rats Exposed to Intermittent Hypoxia.
Yonsei medical journal.
2018 Nov; 59(9):1079-1087. doi:
10.3349/ymj.2018.59.9.1079. [PMID: 30328323] - Hao Luo, Caiyu Chen, Li Guo, Zaicheng Xu, Xiaoyu Peng, Xinquan Wang, Jialiang Wang, Na Wang, Chuanwei Li, Xiaoli Luo, Hongyong Wang, Pedro A Jose, Chunjiang Fu, Yu Huang, Weibin Shi, Chunyu Zeng. Exposure to Maternal Diabetes Mellitus Causes Renal Dopamine D1 Receptor Dysfunction and Hypertension in Adult Rat Offspring.
Hypertension (Dallas, Tex. : 1979).
2018 10; 72(4):962-970. doi:
10.1161/hypertensionaha.118.10908. [PMID: 30354705] - Eun Young Kim, Naghmeh Hassanzadeh Khayyat, Stuart E Dryer. Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases.
Biochimica et biophysica acta. Molecular basis of disease.
2018 10; 1864(10):3527-3536. doi:
10.1016/j.bbadis.2018.08.007. [PMID: 30293571] - Rachael Morris, Shauna-Kay Spencer, Allison Barnes, Teylor Bowles, Patrick B Kyle, Kedra Wallace. Attenuation of oxidative stress and hypertension in an animal model of HELLP syndrome.
European journal of pharmacology.
2018 Sep; 834(?):136-141. doi:
10.1016/j.ejphar.2018.07.013. [PMID: 30012496] - Wasan Abdulmahdi, May M Rabadi, Edson Jules, Yara Marghani, Noor Marji, Jessica Leung, Frank Zhang, Avi Siani, Tamar Siskind, Kiara Vedovino, Nazrul Chowdhury, Miroslav Sekulic, Brian B Ratliff. Kidney dysfunction in the low-birth weight murine adult: implications of oxidative stress.
American journal of physiology. Renal physiology.
2018 09; 315(3):F583-F594. doi:
10.1152/ajprenal.00164.2018. [PMID: 29846114] - Shogo Shimizu, Takahiro Shimizu, Kumiko Nakamura, Youichirou Higashi, Motoaki Saito. Angiotensin II, a stress-related neuropeptide in the CNS, facilitates micturition reflex in rats.
British journal of pharmacology.
2018 09; 175(18):3727-3737. doi:
10.1111/bph.14439. [PMID: 29981238] - Julia Dolinina, Anna Rippe, Peter Bentzer, Carl M Öberg. Glomerular hyperpermeability after acute unilateral ureteral obstruction: effects of Tempol, NOS, RhoA, and Rac-1 inhibition.
American journal of physiology. Renal physiology.
2018 09; 315(3):F445-F453. doi:
10.1152/ajprenal.00610.2017. [PMID: 29465305] - Lei Hou, Junjie Guo, Feng Xu, Xinyu Weng, Wenhui Yue, Junbo Ge. Cardiomyocyte dimethylarginine dimethylaminohydrolase1 attenuates left-ventricular remodeling after acute myocardial infarction: involvement in oxidative stress and apoptosis.
Basic research in cardiology.
2018 06; 113(4):28. doi:
10.1007/s00395-018-0685-y. [PMID: 29892894] - Manik C Ghosh, De-Liang Zhang, Hayden Ollivierre, Michael A Eckhaus, Tracey A Rouault. Translational repression of HIF2α expression in mice with Chuvash polycythemia reverses polycythemia.
The Journal of clinical investigation.
2018 04; 128(4):1317-1325. doi:
10.1172/jci97684. [PMID: 29480820] - Akram Ranjbar, Nejat Kheiripour, Hassan Ghasemi, Mohamad Ali Seif Rabiei, Farahnaz Dadras, Farhad Khoshjou. Antioxidative Effects of Tempol on Mitochondrial Dysfunction in Diabetic Nephropathy.
Iranian journal of kidney diseases.
2018 03; 12(2):84-90. doi:
NULL. [PMID: 29507270] - Li Zou, Valerie Linck, Yu-Jia Zhai, Laura Galarza-Paez, Linda Li, Qiang Yue, Otor Al-Khalili, Hui-Fang Bao, He-Ping Ma, Tiffany L Thai, Jundong Jiao, Douglas C Eaton. Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport.
The Journal of biological chemistry.
2018 02; 293(5):1666-1675. doi:
10.1074/jbc.m117.798645. [PMID: 29180450] - Jun Chen, Zhangzhe Peng, Miaomiao Lu, Xuan Xiong, Zhuo Chen, Qianbin Li, Zeneng Cheng, Dejian Jiang, Lijian Tao, Gaoyun Hu. Discovery of 1-(4-((3-(4-methylpiperazin-1-yl)propyl)amino)benzyl)-5-(trifluoromethyl)pyridin-2(1H)-one, an orally active multi-target agent for the treatment of diabetic nephropathy.
Bioorganic & medicinal chemistry letters.
2018 01; 28(2):222-229. doi:
10.1016/j.bmcl.2017.07.001. [PMID: 29248299] - Zhengmeng Ye, Xi Lu, Yi Deng, Xinquan Wang, Shuo Zheng, Hongmei Ren, Miao Zhang, Tingting Chen, Pedro A Jose, Jian Yang, Chunyu Zeng. In Utero Exposure to Fine Particulate Matter Causes Hypertension Due to Impaired Renal Dopamine D1 Receptor in Offspring.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 46(1):148-159. doi:
10.1159/000488418. [PMID: 29614490] - Kazuhiko Tsuruya, Hisako Yoshida. Brain Atrophy and Cognitive Impairment in Chronic Kidney Disease.
Contributions to nephrology.
2018; 196(?):27-36. doi:
10.1159/000485694. [PMID: 30041201] - Elena Tassi, En Yin Lai, Lingli Li, Glenn Solis, Yifan Chen, William E Kietzman, Patricio E Ray, Anna T Riegel, William J Welch, Christopher S Wilcox, Anton Wellstein. Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein).
Hypertension (Dallas, Tex. : 1979).
2018 01; 71(1):160-167. doi:
10.1161/hypertensionaha.117.10268. [PMID: 29158353] - Douglas Vq Nunes, Cristiane A Costa, Graziele F De Bem, Viviane Sc Cordeiro, Izabelle B Santos, Lenize Crm Carvalho, Alessandro K Jordão, Anna C Cunha, Vitor F Ferreira, Roberto S Moura, Angela C Resende, Dayane T Ognibene. Tempol, a superoxide dismutase-mimetic drug, prevents chronic ischemic renal injury in two-kidney, one-clip hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2018; 40(8):721-729. doi:
10.1080/10641963.2018.1425423. [PMID: 29359965] - Gensheng Zhang, Qin Wang, Wenwen Wang, Minghua Yu, Suping Zhang, Nan Xu, Suhan Zhou, Xiaoyun Cao, Xiaodong Fu, Zufu Ma, Ruisheng Liu, Jianhua Mao, En Yin Lai. Tempol Protects Against Acute Renal Injury by Regulating PI3K/Akt/mTOR and GSK3β Signaling Cascades and Afferent Arteriolar Activity.
Kidney & blood pressure research.
2018; 43(3):904-913. doi:
10.1159/000490338. [PMID: 29870982] - Hiroshi Asanuma, Shoji Sanada, Toru Yoshitomi, Hideyuki Sasaki, Hiroyuki Takahama, Madoka Ihara, Hiroko Takahama, Yoshiro Shinozaki, Hidezo Mori, Masanori Asakura, Atsushi Nakano, Masaru Sugimachi, Yoshihiro Asano, Tetsuo Minamino, Seiji Takashima, Yukio Nagasaki, Masafumi Kitakaze. Novel Synthesized Radical-Containing Nanoparticles Limit Infarct Size Following Ischemia and Reperfusion in Canine Hearts.
Cardiovascular drugs and therapy.
2017 Dec; 31(5-6):501-510. doi:
10.1007/s10557-017-6758-6. [PMID: 29101507] - Pei-Wen Cheng, Yu-Te Lin, Wen-Yu Ho, Pei-Jung Lu, Hsin-Hung Chen, Chi-Cheng Lai, Gwo-Ching Sun, Tung-Chen Yeh, Michael Hsiao, Ching-Jiunn Tseng, Chun-Peng Liu. Fructose induced neurogenic hypertension mediated by overactivation of p38 MAPK to impair insulin signaling transduction caused central insulin resistance.
Free radical biology & medicine.
2017 11; 112(?):298-307. doi:
10.1016/j.freeradbiomed.2017.07.022. [PMID: 28754499] - Tehila Beiser, Ran Numa, Ron Kohen, Rami Yaka. Chronic treatment with Tempol during acquisition or withdrawal from CPP abolishes the expression of cocaine reward and diminishes oxidative damage.
Scientific reports.
2017 09; 7(1):11162. doi:
10.1038/s41598-017-11511-7. [PMID: 28894248] - Lingli Li, En Yin Lai, Zaiming Luo, Glenn Solis, Kathy K Griendling, W Robert Taylor, Pedro A Jose, Anton Wellstein, William J Welch, Christopher S Wilcox. Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease.
Kidney international.
2017 09; 92(3):625-633. doi:
10.1016/j.kint.2017.02.009. [PMID: 28396118] - Igor Cândido Viana Gonçalves, Cláudio Daniel Cerdeira, Eduardo Poletti Camara, José Antônio Dias Garcia, Maísa Ribeiro Pereira Lima Brigagão, Roberta Bessa Veloso Silva, Gérsika Bitencourt Dos Santos. Tempol improves lipid profile and prevents left ventricular hypertrophy in LDL receptor gene knockout (LDLr-/-) mice on a high-fat diet.
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology.
2017 Sep; 36(9):629-638. doi:
10.1016/j.repc.2017.02.014. [PMID: 28826937] - Miles J De Blasio, Anand Ramalingam, Anh H Cao, Darnel Prakoso, Ji-Ming Ye, Raelene Pickering, Anna M D Watson, Judy B de Haan, David M Kaye, Rebecca H Ritchie. The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy.
European journal of pharmacology.
2017 Jul; 807(?):12-20. doi:
10.1016/j.ejphar.2017.04.026. [PMID: 28438648] - N R Oosterhuis, L G Bongartz, M C Verhaar, C Cheng, Y J Xu, A van Koppen, M J Cramer, R Goldschmeding, C A Gaillard, P A Doevendans, B Braam, J A Joles. Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation.
Acta physiologica (Oxford, England).
2017 07; 220(3):382-393. doi:
10.1111/apha.12829. [PMID: 28168814] - Stefan Stamenković, Aleksandra Pavićević, Miloš Mojović, Ana Popović-Bijelić, Vesna Selaković, Pavle Andjus, Goran Bačić. In vivo EPR pharmacokinetic evaluation of the redox status and the blood brain barrier permeability in the SOD1G93A ALS rat model.
Free radical biology & medicine.
2017 07; 108(?):258-269. doi:
10.1016/j.freeradbiomed.2017.03.034. [PMID: 28366802] - Wei Bi, Yue Bi, Xiang Gao, Pengfei Li, Shanshan Hou, Yanrong Zhang, Cathy Bammert, Steffen Jockusch, Thomas D Legalley, K Michael Gibson, Lanrong Bi. Indole-TEMPO conjugates alleviate ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function.
Bioorganic & medicinal chemistry.
2017 05; 25(9):2545-2568. doi:
10.1016/j.bmc.2017.03.033. [PMID: 28359673] - Ahmad F Ahmeda, Mark G Rae, Mohammed F Al Otaibi, Lamyia M Anweigi, Edward J Johns. Effect of tempol and tempol plus catalase on intra-renal haemodynamics in spontaneously hypertensive stroke-prone (SHSP) and Wistar rats.
Journal of physiology and biochemistry.
2017 May; 73(2):207-214. doi:
10.1007/s13105-016-0541-1. [PMID: 27933463] - Z Z Liu, S Mathia, T Pahlitzsch, I C Wennysia, P B Persson, E Y Lai, A Högner, M Z Xu, R Schubert, C Rosenberger, A Patzak. Myoglobin facilitates angiotensin II-induced constriction of renal afferent arterioles.
American journal of physiology. Renal physiology.
2017 05; 312(5):F908-F916. doi:
10.1152/ajprenal.00394.2016. [PMID: 28052871] - Waleska C Dornas, Leonardo M Cardoso, Maísa Silva, Natália L S Machado, Deoclécio A Chianca, Andréia C Alzamora, Wanderson G Lima, Vincent Lagente, Marcelo E Silva. Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments.
Scientific reports.
2017 04; 7(?):46051. doi:
10.1038/srep46051. [PMID: 28397867] - Shuang Chu, Xiaodong Mao, Hengjiang Guo, Li Wang, Zezheng Li, Yang Zhang, Yunman Wang, Hao Wang, Xuemei Zhang, Wen Peng. Indoxyl sulfate potentiates endothelial dysfunction via reciprocal role for reactive oxygen species and RhoA/ROCK signaling in 5/6 nephrectomized rats.
Free radical research.
2017 Mar; 51(3):237-252. doi:
10.1080/10715762.2017.1296575. [PMID: 28277985] - Hui Liu, Xibo Jing, Aiqiao Dong, Baobao Bai, Haiyan Wang. Overexpression of TIMP3 Protects Against Cardiac Ischemia/Reperfusion Injury by Inhibiting Myocardial Apoptosis Through ROS/Mapks Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 44(3):1011-1023. doi:
10.1159/000485401. [PMID: 29179205] - Xingsheng Ren, Feng Zhang, Mingxia Zhao, Zhenzhen Zhao, Shuo Sun, Dustin R Fraidenburg, Haiyang Tang, Ying Han. Angiotensin-(1-7) in Paraventricular Nucleus Contributes to the Enhanced Cardiac Sympathetic Afferent Reflex and Sympathetic Activity in Chronic Heart Failure Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 42(6):2523-2539. doi:
10.1159/000480214. [PMID: 28848201] - Shinichiro Asakawa, Shigeru Shibata, Chikayuki Morimoto, Takeshi Shiraishi, Takashi Nakamura, Yoshifuru Tamura, Takanori Kumagai, Makoto Hosoyamada, Shunya Uchida. Podocyte Injury and Albuminuria in Experimental Hyperuricemic Model Rats.
Oxidative medicine and cellular longevity.
2017; 2017(?):3759153. doi:
10.1155/2017/3759153. [PMID: 28337250] - Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur, Ibrahim F Benter. Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney.
International journal of pharmaceutics.
2016 Dec; 514(2):353-363. doi:
10.1016/j.ijpharm.2016.03.039. [PMID: 27032566] - Mohamed A Saleh, Carmen De Miguel, David I Stevens, Pamela K Carmines, David M Pollock, Jennifer S Pollock. Free radical scavenging decreases endothelin-1 excretion and glomerular albumin permeability during type 1 diabetes.
Physiological reports.
2016 12; 4(24):. doi:
10.14814/phy2.13055. [PMID: 28039404] - YiLin Ren, Branislava Janic, Kristopher Kutskill, Edward L Peterson, Oscar A Carretero. Mechanisms of connecting tubule glomerular feedback enhancement by aldosterone.
American journal of physiology. Renal physiology.
2016 12; 311(6):F1182-F1188. doi:
10.1152/ajprenal.00076.2016. [PMID: 27413197] - N M Kouyoumdzian, Nl Rukavina Mikusic, G Cao, M R Choi, Sl Della Penna, B E Fernández, J E Toblli, M I Rosón. Adverse effects of tempol on hidrosaline balance in rats with acute sodium overload.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2016 Nov; 91(8):510-521. doi:
10.1080/10520295.2016.1249029. [PMID: 27849390] - Adi Lahiani, Adel Hidmi, Jehoshua Katzhendler, Ephraim Yavin, Philip Lazarovici. Novel Synthetic PEGylated Conjugate of α-Lipoic Acid and Tempol Reduces Cell Death in a Neuronal PC12 Clonal Line Subjected to Ischemia.
ACS chemical neuroscience.
2016 10; 7(10):1452-1462. doi:
10.1021/acschemneuro.6b00211. [PMID: 27499112] - Glaucia Vilar-Pereira, Vitor C Carneiro, Hilton Mata-Santos, Amanda R R Vicentino, Isalira P Ramos, Naira L L Giarola, Daniel F Feijó, José R Meyer-Fernandes, Heitor A Paula-Neto, Emiliano Medei, Marcelo T Bozza, Joseli Lannes-Vieira, Claudia N Paiva. Resveratrol Reverses Functional Chagas Heart Disease in Mice.
PLoS pathogens.
2016 Oct; 12(10):e1005947. doi:
10.1371/journal.ppat.1005947. [PMID: 27788262] - Yan Sun, Jiao Fan, Dong Chai, Minghua Zhang. Oxidative Stress Is Involved in the Renal Dysfunction Induced by Sinoaortic Denervation in Rats.
Chemical & pharmaceutical bulletin.
2016 Oct; 64(10):1458-1465. doi:
10.1248/cpb.c16-00318. [PMID: 27489120] - Mayumi Yamato, Kimika Kawano, Yuki Yamanaka, Misako Saiga, Ken-Ichi Yamada. TEMPOL increases NAD(+) and improves redox imbalance in obese mice.
Redox biology.
2016 08; 8(?):316-22. doi:
10.1016/j.redox.2016.02.007. [PMID: 26942863] - Gustavo H Oliveira-Paula, Lucas C Pinheiro, Danielle A Guimaraes, Sandra O Conde Tella, Ana L Furlan Blanco, Celio D Angelis, Alan N Schechter, Jose E Tanus-Santos. Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension.
Redox biology.
2016 08; 8(?):398-406. doi:
10.1016/j.redox.2016.04.001. [PMID: 27078869] - Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume, Tsuyoshi Yokoi. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice.
Drug metabolism and disposition: the biological fate of chemicals.
2016 07; 44(7):888-96. doi:
10.1124/dmd.116.069575. [PMID: 27112166] - Nicholas G Moss, Tayler K Gentle, William J Arendshorst. Modulation of the myogenic mechanism: concordant effects of NO synthesis inhibition and O2- dismutation on renal autoregulation in the time and frequency domains.
American journal of physiology. Renal physiology.
2016 05; 310(9):F832-45. doi:
10.1152/ajprenal.00461.2015. [PMID: 26823282] - David E Stec, Luis A Juncos, Joey P Granger. Renal intramedullary infusion of tempol normalizes the blood pressure response to intrarenal blockade of heme oxygenase-1 in angiotensin II-dependent hypertension.
Journal of the American Society of Hypertension : JASH.
2016 Apr; 10(4):346-51. doi:
10.1016/j.jash.2016.01.023. [PMID: 26922123] - N M Abdel-Hamid, Ahmed Wahid, E M Mohamed, M A Abdel-Aziz, O M Mohafez, Sally Bakar. New pathways driving the experimental hepatoprotective action of tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl) against acute hepatotoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Apr; 79(?):215-21. doi:
10.1016/j.biopha.2016.02.016. [PMID: 27044831] - Jingwei Cai, Limin Zhang, Richard A Jones, Jared B Correll, Emmanuel Hatzakis, Philip B Smith, Frank J Gonzalez, Andrew D Patterson. Antioxidant Drug Tempol Promotes Functional Metabolic Changes in the Gut Microbiota.
Journal of proteome research.
2016 Feb; 15(2):563-71. doi:
10.1021/acs.jproteome.5b00957. [PMID: 26696396] - Naimesh Solanki, Fatin Atrooz, Saman Asghar, Samina Salim. Tempol protects sleep-deprivation induced behavioral deficits in aggressive male Long-Evans rats.
Neuroscience letters.
2016 Jan; 612(?):245-250. doi:
10.1016/j.neulet.2015.12.032. [PMID: 26724222] - Danijela Karanovic, Jelica Grujic-Milanovic, Zoran Miloradovic, Milan Ivanov, Djurdjica Jovovic, Una-Jovana Vajic, Maja Zivotic, Jasmina Markovic-Lipkovski, Nevena Mihailovic-Stanojevic. Effects of Single and Combined Losartan and Tempol Treatments on Oxidative Stress, Kidney Structure and Function in Spontaneously Hypertensive Rats with Early Course of Proteinuric Nephropathy.
PloS one.
2016; 11(8):e0161706. doi:
10.1371/journal.pone.0161706. [PMID: 27560781] - Andrzej Marciniak, Beata Walczyna, Grażyna Rajtar, Sebastian Marciniak, Andrzej Wojtak, Katarzyna Lasiecka. Tempol, a Membrane-Permeable Radical Scavenger, Exhibits Anti-Inflammatory and Cardioprotective Effects in the Cerulein-Induced Pancreatitis Rat Model.
Oxidative medicine and cellular longevity.
2016; 2016(?):4139851. doi:
10.1155/2016/4139851. [PMID: 26770650] - Gensheng Zhang, Qiaoling Wang, Qin Zhou, Renjun Wang, Minze Xu, Huiping Wang, Lei Wang, Christopher S Wilcox, Ruisheng Liu, En Yin Lai. Protective Effect of Tempol on Acute Kidney Injury Through PI3K/Akt/Nrf2 Signaling Pathway.
Kidney & blood pressure research.
2016; 41(2):129-38. doi:
10.1159/000443414. [PMID: 26894882] - Katharina Krueger, Jianlin Shen, Alexandra Maier, Martin Tepel, Alexandra Scholze. Lower Superoxide Dismutase 2 (SOD2) Protein Content in Mononuclear Cells Is Associated with Better Survival in Patients with Hemodialysis Therapy.
Oxidative medicine and cellular longevity.
2016; 2016(?):7423249. doi:
10.1155/2016/7423249. [PMID: 27630759] - Xiqian Lan, Rivka Lederman, Judith M Eng, Seyedeh Shadafarin Marashi Shoshtari, Moin A Saleem, Ashwani Malhotra, Pravin C Singhal. Nicotine Induces Podocyte Apoptosis through Increasing Oxidative Stress.
PloS one.
2016; 11(12):e0167071. doi:
10.1371/journal.pone.0167071. [PMID: 27907022] - Valéria Nunes-Souza, Cheila Juliana César-Gomes, Lucas José Sá Da Fonseca, Glaucevane Da Silva Guedes, Salete Smaniotto, Luíza Antas Rabelo. Aging Increases Susceptibility to High Fat Diet-Induced Metabolic Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile after Antioxidant Therapy.
Oxidative medicine and cellular longevity.
2016; 2016(?):1987960. doi:
10.1155/2016/1987960. [PMID: 27057272] - Perle Totoson, Katy Maguin-Gaté, Maude Nappey, Daniel Wendling, Céline Demougeot. Endothelial Dysfunction in Rheumatoid Arthritis: Mechanistic Insights and Correlation with Circulating Markers of Systemic Inflammation.
PloS one.
2016; 11(1):e0146744. doi:
10.1371/journal.pone.0146744. [PMID: 26761790] - Mekky M Abouzied, Heba M Eltahir, Ashraf Taye, Mahran S Abdelrahman. Experimental evidence for the therapeutic potential of tempol in the treatment of acute liver injury.
Molecular and cellular biochemistry.
2016 Jan; 411(1-2):107-15. doi:
10.1007/s11010-015-2572-2. [PMID: 26441060] - He Li, Xian Liu, Zhongqiao Ren, Jinxia Gu, Yingjie Lu, Xiaoyun Wang, Lan Zhang. Effects of Diabetic Hyperglycemia on Central Ang-(1-7)-Mas-R-nNOS Pathways in Spontaneously Hypertensive Rats.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 40(5):1186-1197. doi:
10.1159/000453172. [PMID: 27960152] - Wai Fun Leong, Claire C Berton-Carabin, Ryan J Elias, Jérôme Lecomte, Pierre Villeneuve, Yu Zhao, John N Coupland. Effect of lipophilization on the distribution and reactivity of ingredients in emulsions.
Journal of colloid and interface science.
2015 Dec; 459(?):36-43. doi:
10.1016/j.jcis.2015.07.070. [PMID: 26263493] - J Zhang, L Zheng, J Cao, B Chen, D Jin. Inflammation induced by increased frequency of intermittent hypoxia is attenuated by tempol administration.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2015 Dec; 48(12):1115-21. doi:
10.1590/1414-431x20154487. [PMID: 26397969] - Anita T Layton, Aurélie Edwards. Predicted effects of nitric oxide and superoxide on the vasoactivity of the afferent arteriole.
American journal of physiology. Renal physiology.
2015 Oct; 309(8):F708-19. doi:
10.1152/ajprenal.00187.2015. [PMID: 26180238] - M Frenzel, A Steffen-Heins. Impact of quercetin and fish oil encapsulation on bilayer membrane and oxidation stability of liposomes.
Food chemistry.
2015 Oct; 185(?):48-57. doi:
10.1016/j.foodchem.2015.03.121. [PMID: 25952840]