Ethylpyruvate (BioDeep_00001871318)
PANOMIX_OTCML-2023
代谢物信息卡片
ETHYL PYRUVATE
化学式: C5H8O3 (116.0473418)
中文名称: 丙酮酸乙酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(OCC)=O)=O
InChI: InChI=1S/C5H8O3/c1-3-8-5(7)4(2)6/h3H2,1-2H3
描述信息
Ethyl pyruvate is a simple derivative of the endogenous metabolite, pyruvic acid. Ethyl pyruvate is an anti-inflammatory agent[1].
同义名列表
3 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:173421
- PubChem: 12041
- DrugBank: DB05869
- ChEMBL: CHEMBL173373
- CAS: 617-35-6
- medchemexpress: HY-Y1362
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 354530 - Zanthoxylum schinifolium: 10.1021/JF0728101
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shu-Qiang Gao, Shu-Hui Gao, Chen-Hui Zhu, Xiao-Yan Yuan, Li-Xia Ren. [Effect of Anti-Oxidative of Ethyl Pyruvate and Taurine on the Red Blood Cell Storage at 4 ℃].
Zhongguo shi yan xue ye xue za zhi.
2022 Jun; 30(3):890-896. doi:
10.19746/j.cnki.issn.1009-2137.2022.03.037. [PMID: 35680823] - M R Nourani, A Kalantari Hesari, R Shahrooz, M R Asadi. Effect of Sodium Cyanide-induced Tissue Hypoxia on Reproductive Capability of Male Mice and the Protective Effect of Ethyl Pyruvate.
Archives of Razi Institute.
2021 07; 76(2):323-333. doi:
10.22092/ari.2020.126806.1362. [PMID: 34223731] - Xiang Liang, Yang Shen, Xiaowei Zhang, Guangxiang He, Guolin Tan. Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis.
Scientific reports.
2021 03; 11(1):6206. doi:
10.1038/s41598-021-85785-3. [PMID: 33737667] - Je-Ming Hu, Chih-Hsueng Hsu, Yu-Chun Lin, Ching-Wen Kung, Shu-Ying Chen, Wen-Ting Lin, Pao-Yun Cheng, Hsin-Hsueh Shen, Yen-Mei Lee. Ethyl pyruvate ameliorates heat stroke-induced multiple organ dysfunction and inflammatory responses by induction of stress proteins and activation of autophagy in rats.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.
2021; 38(1):862-874. doi:
10.1080/02656736.2021.1931479. [PMID: 34078225] - Yan He, Jun An, Jun-Jun Yin, Qiang Miao, Ruo-Xuan Sui, Qing-Xian Han, Zhi-Bin Ding, Jian-Jun Huang, Cun-Gen Ma, Bao-Guo Xiao. Ethyl Pyruvate-Derived Transdifferentiation of Astrocytes to Oligodendrogenesis in Cuprizone-Induced Demyelinating Model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2021 01; 18(1):488-502. doi:
10.1007/s13311-020-00947-x. [PMID: 33140235] - Vijaya Durga Chavali, Milee Agarwal, Vivek Kumar Vyas, Bhagawati Saxena. Neuroprotective Effects of Ethyl Pyruvate against Aluminum Chloride-Induced Alzheimer's Disease in Rats via Inhibiting Toll-Like Receptor 4.
Journal of molecular neuroscience : MN.
2020 Jun; 70(6):836-850. doi:
10.1007/s12031-020-01489-9. [PMID: 32030557] - Deepti Sharma, Anju Singh, Shrikant Kukreti, Mallika Pathak, Lajpreet Kaur, Vinod Kaushik, Himanshu Ojha. Protection by ethyl pyruvate against gamma radiation induced damage in bovine serum albumin.
International journal of biological macromolecules.
2020 May; 150(?):1053-1060. doi:
10.1016/j.ijbiomac.2019.10.110. [PMID: 31739068] - Victoria A Guarino, William M Oldham, Joseph Loscalzo, Ying-Yi Zhang. Reaction rate of pyruvate and hydrogen peroxide: assessing antioxidant capacity of pyruvate under biological conditions.
Scientific reports.
2019 12; 9(1):19568. doi:
10.1038/s41598-019-55951-9. [PMID: 31862934] - Yan He, Jun An, Jun-Jun Yin, Ruo-Xuan Sui, Qiang Miao, Zhi-Bin Ding, Qing-Xian Han, Qing Wang, Cun-Gen Ma, Bao-Guo Xiao. Ethyl pyruvate enhances spontaneous remyelination by targeting microglia phagocytosis.
International immunopharmacology.
2019 Dec; 77(?):105929. doi:
10.1016/j.intimp.2019.105929. [PMID: 31677497] - Ning Liu, Zhiyi Jiang, Yao Nie, Yongjun Liu, Xiangdong Guan, Minying Chen. [Effect of ethyl pyruvate on mitochondrial dynamics of lipopolysaccharide-induced human kidney-2 cells].
Zhonghua wei zhong bing ji jiu yi xue.
2019 Dec; 31(12):1501-1505. doi:
10.3760/cma.j.issn.2095-4352.2019.12.013. [PMID: 32029037] - Chu Wang, Yu Niu, Qiuxia Meng, Lizhen Zhang. Ethyl pyruvate (EP) suppressed post-harvest blue mold of sweet cherry fruit by inhibiting the growth of Penicillium oxalicum.
Journal of the science of food and agriculture.
2019 May; 99(7):3517-3524. doi:
10.1002/jsfa.9571. [PMID: 30623442] - Linbo Yao, Chunru Cheng, Xinmin Yang, Chenxia Han, Dan Du, Tingting Liu, Michael Chvanov, John Windsor, Robert Sutton, Wei Huang, Qing Xia. Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of in vitro and in vivo studies.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2019 Mar; 19(2):209-216. doi:
10.1016/j.pan.2018.12.007. [PMID: 30611702] - Lin Sun, Man Li, Xun Ma, Li Zhang, Junlai Song, Cong Lv, Yajun He. Inhibiting High Mobility Group Box-1 Reduces Early Spinal Cord Edema and Attenuates Astrocyte Activation and Aquaporin-4 Expression after Spinal Cord Injury in Rats.
Journal of neurotrauma.
2019 02; 36(3):421-435. doi:
10.1089/neu.2018.5642. [PMID: 29929431] - Eunsoo Jung, Wan Seok Kang, Kyuhyung Jo, Junghyun Kim. Ethyl Pyruvate Prevents Renal Damage Induced by Methylglyoxal-Derived Advanced Glycation End Products.
Journal of diabetes research.
2019; 2019(?):4058280. doi:
10.1155/2019/4058280. [PMID: 31737683] - Jonathan Bloom, Neel Patel, Jonathan Wagmaister, Muhammad Choudhury, Majid Eshghi, Sensuke Konno. Prophylactic effect of ethyl pyruvate on renal ischemia/reperfusion injury mediated through oxidative stress.
International urology and nephrology.
2019 Jan; 51(1):85-92. doi:
10.1007/s11255-018-2020-9. [PMID: 30382544] - Ji Hae Jun, Jong Wook Song, Eun-Jung Shin, Young-Lan Kwak, Nakcheol Choi, Jae-Kwang Shim. Ethyl pyruvate is renoprotective against ischemia-reperfusion injury under hyperglycemia.
The Journal of thoracic and cardiovascular surgery.
2018 04; 155(4):1650-1658. doi:
10.1016/j.jtcvs.2017.10.069. [PMID: 29195627] - H Sayan Ozacmak, V H Ozacmak, I Turan. Ethyl pyruvate prevents from chronic cerebral hypoperfusion via preserving cognitive function and decreasing oxidative stress, caspase 3 activation and IL-1β level.
Bratislavske lekarske listy.
2018 ; 119(8):469-475. doi:
10.4149/bll_2018_086. [PMID: 30160153] - Jiawen Zhao, Jiwen Cheng, Chengyang Li, Mingbin Xu, Chenjun Ma, Lei Qin, Kai Yi, Naikai Liao. Ethyl Pyruvate Attenuates CaCl2-Induced Tubular Epithelial Cell Injury by Inhibiting Autophagy and Inflammatory Responses.
Kidney & blood pressure research.
2018; 43(5):1585-1595. doi:
10.1159/000494445. [PMID: 30352436] - Christine Rossmann, Christoph Nusshold, Margret Paar, Gerhard Ledinski, Erwin Tafeit, Martin Koestenberger, Eva Maria Bernhart, Wolfgang Sattler, Gerhard Cvirn, Seth Hallström. Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells.
PloS one.
2018; 13(1):e0191477. doi:
10.1371/journal.pone.0191477. [PMID: 29370236] - Wei Chen, Jie Lian, Jing-Jing Ye, Qing-Fei Mo, Jie Qin, Guang-Liang Hong, Long-Wang Chen, Shao-Ce Zhi, Guang-Ju Zhao, Zhong-Qiu Lu. Ethyl pyruvate reverses development of Pseudomonas aeruginosa pneumonia during sepsis-induced immunosuppression.
International immunopharmacology.
2017 Nov; 52(?):61-69. doi:
10.1016/j.intimp.2017.08.024. [PMID: 28863323] - Baoqing Chen, Feifei Na, Hui Yang, Rui Li, Mengqian Li, Xiaowen Sun, Binbin Hu, Guodong Huang, Jie Lan, He Xu, Ruizhan Tong, Xianming Mo, Jianxin Xue, You Lu. Ethyl pyruvate alleviates radiation-induced lung injury in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Aug; 92(?):468-478. doi:
10.1016/j.biopha.2017.05.111. [PMID: 28570981] - Laura Pellegrini, Jiaming Xue, David Larson, Sandra Pastorino, Sandro Jube, Kelly H Forest, Zeyana Salim Saad-Jube, Andrea Napolitano, Ian Pagano, Vishal S Negi, Marco E Bianchi, Paul Morris, Harvey I Pass, Giovanni Gaudino, Michele Carbone, Haining Yang. HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma.
Oncotarget.
2017 Apr; 8(14):22649-22661. doi:
10.18632/oncotarget.15152. [PMID: 28186988] - Qingteng Zhu, Hui Wang, Hairong Wang, Yong Luo, Yang Yu, Qirong Du, Aihua Fei, Shuming Pan. Protective effects of ethyl pyruvate on lipopolysaccharide‑induced acute lung injury through inhibition of autophagy in neutrophils.
Molecular medicine reports.
2017 Mar; 15(3):1272-1278. doi:
10.3892/mmr.2017.6118. [PMID: 28098908] - Jiyi Xia, Xiaolan Yu, Xueqin Song, Gang Li, Xiguang Mao, Yujiao Zhang. Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells.
Molecular medicine reports.
2017 Jan; 15(1):488-494. doi:
10.3892/mmr.2016.6003. [PMID: 27959427] - Turkmen Suha, Mutlu Asli, Sahin Aynur, Karaca Yunus, Mentese Ahmet, Demir Selim, Yulug Esin, Tatli Ozgur, Neziha Senem Ari, Turedi Süleyman. Effects of N-acetylcysteine and ethyl pyruvate on ischemia-reperfusion injury in experimental electrical burn model.
The American journal of emergency medicine.
2016 Jul; 34(7):1217-24. doi:
10.1016/j.ajem.2016.03.032. [PMID: 27085456] - Hunan Xiao, Hongbin Liu, Congcong Hou, Yang Liu, Qian Yu. Effects of Ethyl Pyruvate in Preventing the Development of Diet-induced Atherosclerosis by Blocking the HMGB1 Expression in ApoE-Deficient Mice.
Journal of cardiovascular pharmacology.
2016 Apr; 67(4):299-304. doi:
10.1097/fjc.0000000000000353. [PMID: 26696442] - Yun-Jiang Zheng, Wei-Ping Xu, Gang Ding, Yu-Hua Gao, Hai-Rong Wang, Shu-Ming Pan. Expression of HMGB1 in septic serum induces vascular endothelial hyperpermeability.
Molecular medicine reports.
2016 Jan; 13(1):513-21. doi:
10.3892/mmr.2015.4536. [PMID: 26572550] - Kai Liu, Xiquan Zhang, Guangqing Cao, Yongjun Liu, Chuanzhen Liu, Hourong Sun, Xinyan Pang. Intratracheal instillation of ethyl pyruvate nanoparticles prevents the development of shunt-flow-induced pulmonary arterial hypertension in a rat model.
International journal of nanomedicine.
2016; 11(?):2587-99. doi:
10.2147/ijn.s103183. [PMID: 27354791] - Mehmet Veysi Bahadir, Yasar Yildirim, Ozlem Pamukcu Baran, Sait Polat, Hasan Akkoc, Selcuk Tunik. The potential beneficial effects of ethyl pyruvate on diabetic nephropathy: an experimental and ultrastructural study.
Polish journal of pathology : official journal of the Polish Society of Pathologists.
2016 ; 67(3):250-257. doi:
10.5114/pjp.2016.63777. [PMID: 28155974] - Xianghua Guo, Runhua Guo, Xia Luo, Lian Zhou. Ethyl pyruvate ameliorates experimental colitis in mice by inhibiting the HMGB1-Th17 and Th1/Tc1 responses.
International immunopharmacology.
2015 Dec; 29(2):454-461. doi:
10.1016/j.intimp.2015.10.015. [PMID: 26541861] - J R Bauquier, E Tudor, S R Bailey. Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays.
Journal of veterinary pharmacology and therapeutics.
2015 Jun; 38(3):290-6. doi:
10.1111/jvp.12182. [PMID: 25407884] - Emel Kiyak Caglayan, Kasim Caglayan, Ayse Yesim Göcmen, Hamza Cinar, Levent Seckin, Selda Seckin, Bülent Güngör, Muhammet Fevzi Polat. Protective effect of ethyl pyruvate on ischemia-reperfusion injury in rat ovary: biochemical and histopathological evaluation.
European journal of obstetrics, gynecology, and reproductive biology.
2014 Nov; 182(?):154-9. doi:
10.1016/j.ejogrb.2014.09.023. [PMID: 25291349] - Chuanzhen Liu, Changcun Fang, Guangqing Cao, Kai Liu, Biao Wang, Zhaojie Wan, Sijie Li, Shuming Wu. Ethyl pyruvate ameliorates monocrotaline-induced pulmonary arterial hypertension in rats.
Journal of cardiovascular pharmacology.
2014 Jul; 64(1):7-15. doi:
10.1097/fjc.0000000000000083. [PMID: 24492475] - Martin Baunacke, Lars-Christian Horn, Susanne Trettner, Kathrin M Y Engel, Nasr Y A Hemdan, Volker Wiechmann, Jens-Uwe Stolzenburg, Marina Bigl, Gerd Birkenmeier. Exploring glyoxalase 1 expression in prostate cancer tissues: targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties.
The Prostate.
2014 Jan; 74(1):48-60. doi:
10.1002/pros.22728. [PMID: 24105621] - Zerrin Pulathan, Gökalp Altun, Doğuş Hemşinli, Ahmet Menteşe, Esin Yuluğ, Ali Civelek. Role of ethyl pyruvate in systemic inflammatory response and lung injury in an experimental model of ruptured abdominal aortic aneurysm.
BioMed research international.
2014; 2014(?):857109. doi:
10.1155/2014/857109. [PMID: 24575415] - R Satpute, V Lomash, M Kaushal, R Bhattacharya. Neuroprotective effects of α-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice.
Human & experimental toxicology.
2013 Jul; 32(7):747-58. doi:
10.1177/0960327112468172. [PMID: 23821591] - Li-Kun Wang, Lu-Wen Wang, Xun Li, Xiao-Qun Han, Zuo-Jiong Gong. Ethyl pyruvate prevents inflammatory factors release and decreases intestinal permeability in rats with D-galactosamine-induced acute liver failure.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2013 Apr; 12(2):180-8. doi:
10.1016/s1499-3872(13)60029-6. [PMID: 23558073] - Robert Antoni Olek, Wieslaw Ziolkowski, Damian Jozef Flis, Donatella Fedeli, Dennis Fiorini, Tomasz Henryk Wierzba, Rosita Gabbianelli. The effect of ethyl pyruvate supplementation on rat fatty liver induced by a high-fat diet.
Journal of nutritional science and vitaminology.
2013; 59(3):232-7. doi:
10.3177/jnsv.59.232. [PMID: 23883694] - Miao Shen, Jie Lu, Weiqi Dai, Fan Wang, Ling Xu, Kan Chen, Lei He, Ping Cheng, Yan Zhang, Chengfen Wang, Dong Wu, Jing Yang, Rong Zhu, Huawei Zhang, Yinqun Zhou, Chuanyong Guo. Ethyl pyruvate ameliorates hepatic ischemia-reperfusion injury by inhibiting intrinsic pathway of apoptosis and autophagy.
Mediators of inflammation.
2013; 2013(?):461536. doi:
10.1155/2013/461536. [PMID: 24453420] - Lu-Wen Wang, Li-Kun Wang, Hui Chen, Cheng Fan, Xun Li, Can-Ming He, Zuo-Jiong Gong. Ethyl pyruvate protects against experimental acute-on-chronic liver failure in rats.
World journal of gastroenterology.
2012 Oct; 18(40):5709-18. doi:
10.3748/wjg.v18.i40.5709. [PMID: 23155311] - Hwa Jin Jang, Young Min Kim, Konstantin Tsoyi, Eun Jung Park, Young Soo Lee, Hye Jung Kim, Jae Heun Lee, Yeonsoo Joe, Hun Taeg Chung, Ki Churl Chang. Ethyl pyruvate induces heme oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals.
Antioxidants & redox signaling.
2012 Sep; 17(6):878-89. doi:
10.1089/ars.2011.3994. [PMID: 22369644] - May M Rabadi, Tammer Ghaly, Michael S Goligorksy, Brian B Ratliff. HMGB1 in renal ischemic injury.
American journal of physiology. Renal physiology.
2012 Sep; 303(6):F873-85. doi:
10.1152/ajprenal.00092.2012. [PMID: 22759395] - Suha Turkmen, Ahmet Mentese, Ersagun Karaguzel, Yunus Karaca, Adem Kucuk, Aysegul Uzun, Esin Yulug, Suleyman Turedi. A comparison of the effects of N-acetylcysteine and ethyl pyruvate on experimental testicular ischemia-reperfusion injury.
Fertility and sterility.
2012 Sep; 98(3):626-31. doi:
10.1016/j.fertnstert.2012.05.034. [PMID: 22717346] - Kyung Don Ju, Eun Kyoung Shin, Eun Jin Cho, Hyun Bae Yoon, Hyo Sang Kim, Hwajung Kim, Jaeseok Yang, Young-Hwan Hwang, Curie Ahn, Kook-Hwan Oh. Ethyl pyruvate ameliorates albuminuria and glomerular injury in the animal model of diabetic nephropathy.
American journal of physiology. Renal physiology.
2012 Mar; 302(5):F606-13. doi:
10.1152/ajprenal.00415.2011. [PMID: 22129969] - Simon J Finney, Susannah K Leaver, Timothy W Evans, Anne Burke-Gaffney. Differences in lipopolysaccharide- and lipoteichoic acid-induced cytokine/chemokine expression.
Intensive care medicine.
2012 Feb; 38(2):324-32. doi:
10.1007/s00134-011-2444-5. [PMID: 22183712] - Runkuan Yang, Xiaoping Zou, Marja-Leena Koskinen, Jyrki Tenhunen. Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose.
Critical care (London, England).
2012 Jan; 16(1):R9. doi:
10.1186/cc11149. [PMID: 22248080] - Camila E Rodrigues, Talita R Sanches, Rildo A Volpini, Maria H M Shimizu, Patrícia S Kuriki, Niels O S Camara, Antonio C Seguro, Lúcia Andrade. Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multi-organ dysfunction.
PloS one.
2012; 7(1):e29893. doi:
10.1371/journal.pone.0029893. [PMID: 22235348] - Prodyot K Chatterjee, Michael M Yeboah, Oonagh Dowling, Xiangying Xue, Saul R Powell, Yousef Al-Abed, Christine N Metz. Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity.
PloS one.
2012; 7(5):e35361. doi:
10.1371/journal.pone.0035361. [PMID: 22586448] - Maite Duhalde-Vega, Lilia A Retegui. Uric acid and HMGB1 are involved in the induction of autoantibodies elicited in mice infected with mouse hepatitis virus A59.
Autoimmunity.
2011 Dec; 44(8):631-40. doi:
10.3109/08916934.2011.579927. [PMID: 21604970] - Ching-Wen Kung, Yen-Mei Lee, Mao-Hsiung Yen. In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats.
Thrombosis research.
2011 Jun; 127(6):582-8. doi:
10.1016/j.thromres.2011.01.017. [PMID: 21396682] - Ching-Wen Kung, Yen-Mei Lee, Pao-Yun Cheng, Yi-Jen Peng, Mao-Hsiung Yen. Ethyl pyruvate reduces acute lung injury via regulation of iNOS and HO-1 expression in endotoxemic rats.
The Journal of surgical research.
2011 May; 167(2):e323-31. doi:
10.1016/j.jss.2011.01.006. [PMID: 21324485] - Wei Li, Shu Zhu, Jianhua Li, Yan Huang, Rongrong Zhou, Xuegong Fan, Huan Yang, Xing Gong, N Tony Eissa, Willi Jahnen-Dechent, Ping Wang, Kevin J Tracey, Andrew E Sama, Haichao Wang. A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation.
PloS one.
2011 Feb; 6(2):e16945. doi:
10.1371/journal.pone.0016945. [PMID: 21347455] - Ruy J Cruz, Tomoyuki Harada, Eizaburo Sasatomi, Mitchell P Fink. Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion.
The Journal of surgical research.
2011 Jan; 165(1):151-7. doi:
10.1016/j.jss.2009.07.008. [PMID: 19959189] - Christabelle J Darcy, Joshua S Davis, Tonia Woodberry, Yvette R McNeil, Dianne P Stephens, Tsin W Yeo, Nicholas M Anstey. An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.
PloS one.
2011; 6(6):e21185. doi:
10.1371/journal.pone.0021185. [PMID: 21731667] - Jia Liu, Lawrence Litt, Mark R Segal, Mark J S Kelly, Jeffrey G Pelton, Myungwon Kim. Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.
International journal of molecular sciences.
2011; 12(10):6469-501. doi:
10.3390/ijms12106469. [PMID: 22072900] - Xin-hui Xu, Qi Chen, Yi Chen, Li-xiong Lv, Chang-qing Zhu, Hui-li Dai, Jia-qi Qian. [Effect of ethyl pyruvate on expression of inflammatory factors and mitogen-activated protein kinase proteins in renal ischemic/reperfusion injury in BABL/c mice].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2010 Dec; 22(12):750-3. doi:
NULL. [PMID: 21190605] - In-Seok Jang, Mi-Young Park, Il-Woo Shin, Ju-Tae Sohn, Heon-Keun Lee, Young-Kyun Chung. Ethyl pyruvate has anti-inflammatory and delayed myocardial protective effects after regional ischemia/reperfusion injury.
Yonsei medical journal.
2010 Nov; 51(6):838-44. doi:
10.3349/ymj.2010.51.6.838. [PMID: 20879048] - R Di Paola, E Mazzon, M Galuppo, E Esposito, P Bramanti, M P Fink, S Cuzzocrea. Ethyl pyruvate therapy attenuates experimental severe arthritis caused by type II collagen (CII) in the mouse (CIA).
International journal of immunopathology and pharmacology.
2010 Oct; 23(4):1087-98. doi:
10.1177/039463201002300413. [PMID: 21244758] - WeiHong Dong, Bolin Cai, Geber Peña, Vadim Pisarenko, Gergely Vida, Danielle Doucet, Marlon Lee, Susan Sharpe, Qi Lu, Da-Zhong Xu, Laura Ramos, Edwin A Deitch, Luis Ulloa. Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage.
Shock (Augusta, Ga.).
2010 Aug; 34(2):205-13. doi:
10.1097/shk.0b013e3181cc0c63. [PMID: 19953001] - Pushpa Sharma, Paul D Mongan. Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shock.
Shock (Augusta, Ga.).
2010 May; 33(5):532-40. doi:
10.1097/shk.0b013e3181cc02b3. [PMID: 19953008] - Zheng-Gang Luan, Hao Zhang, Xiao-Chun Ma, Cheng Zhang, Ren-Xuan Guo. Role of high-mobility group box 1 protein in the pathogenesis of intestinal barrier injury in rats with severe acute pancreatitis.
Pancreas.
2010 Mar; 39(2):216-23. doi:
10.1097/mpa.0b013e3181bab5c5. [PMID: 19786932] - Guan-Hong Shang, Dian-Jie Lin, Wei Xiao, Chong-Qi Jia, Yu Li, Ai-Hua Wang, Liang Dong. Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model.
Respiratory research.
2009 Oct; 10(?):91. doi:
10.1186/1465-9921-10-91. [PMID: 19799777] - Borbala Daroczi, Gabor Kari, Qing Ren, Adam P Dicker, Ulrich Rodeck. Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.
Molecular cancer therapeutics.
2009 Sep; 8(9):2625-34. doi:
10.1158/1535-7163.mct-09-0198. [PMID: 19723885] - Xiaoyan Liang, Antonio Romo de Vivar Chavez, Nicole E Schapiro, Patricia Loughran, Stephen H Thorne, Andrew A Amoscato, Herbert J Zeh, Donna Beer-Stolz, Michael T Lotze, Michael E de Vera. Ethyl pyruvate administration inhibits hepatic tumor growth.
Journal of leukocyte biology.
2009 Sep; 86(3):599-607. doi:
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2009 Aug; 21(8):460-2. doi:
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Expert opinion on investigational drugs.
2009 Aug; 18(8):1047-60. doi:
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Naunyn-Schmiedeberg's archives of pharmacology.
2009 Aug; 380(2):179-92. doi:
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Anesthesiology.
2009 Jun; 110(6):1279-86. doi:
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The Journal of trauma.
2009 Jun; 66(6):1632-9; discussion 1639. doi:
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The Journal of surgical research.
2009 May; 153(2):302-9. doi:
10.1016/j.jss.2008.04.004. [PMID: 19027919] - Bolin Cai, Michael Brunner, Haichao Wang, Ping Wang, Edwin A Deitch, Luis Ulloa. Ethyl pyruvate improves survival in awake hemorrhage.
Journal of molecular medicine (Berlin, Germany).
2009 Apr; 87(4):423-33. doi:
10.1007/s00109-009-0441-8. [PMID: 19172241] - Toru Takahashi, Hiroko Shimizu, Hiroshi Morimatsu, Kyoichiro Maeshima, Kazuyoshi Inoue, Reiko Akagi, Masaki Matsumi, Hiroshi Katayama, Kiyoshi Morita. Heme Oxygenase-1 is an Essential Cytoprotective Component in Oxidative Tissue Injury Induced by Hemorrhagic Shock.
Journal of clinical biochemistry and nutrition.
2009 Jan; 44(1):28-40. doi:
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American journal of physiology. Renal physiology.
2008 Dec; 295(6):F1825-35. doi:
10.1152/ajprenal.90442.2008. [PMID: 18922884] - Li-tian Zhang, Yong-ming Yao, Yue-Qing Dong, Ning Dong, Yan Yu, Zhi-yong Sheng. Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury.
Shock (Augusta, Ga.).
2008 Oct; 30(4):449-55. doi:
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American journal of respiratory cell and molecular biology.
2008 Oct; 39(4):440-7. doi:
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Transplantation proceedings.
2008 Sep; 40(7):2136-8. doi:
10.1016/j.transproceed.2008.06.040. [PMID: 18790172] - Zhi-Yong Yang, Yan Ling, Tao Yin, Jing Tao, Jiong-Xin Xiong, He-Shui Wu, Chun-You Wang. Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats.
World journal of gastroenterology.
2008 Jul; 14(28):4546-50. doi:
10.3748/wjg.14.4546. [PMID: 18680237] - Lisa M Alleva, Alison C Budd, Ian A Clark. Systemic release of high mobility group box 1 protein during severe murine influenza.
Journal of immunology (Baltimore, Md. : 1950).
2008 Jul; 181(2):1454-9. doi:
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Critical care medicine.
2008 Apr; 36(4):1059-67. doi:
10.1097/ccm.0b013e318164403b. [PMID: 18176313] - Seyedmehdi Payabvash, Saman Kiumehr, Seyed Mohammad Tavangar, Ahmad Reza Dehpour. Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion.
Journal of pediatric surgery.
2008 Apr; 43(4):705-12. doi:
10.1016/j.jpedsurg.2007.12.063. [PMID: 18405719] - Raquel Nahra, R Phillip Dellinger. Targeting the lipopolysaccharides: still a matter of debate?.
Current opinion in anaesthesiology.
2008 Apr; 21(2):98-104. doi:
10.1097/aco.0b013e3282f5335c. [PMID: 18443474] - Qiu-Ye Kou, Xiang-Dong Guan. [Protective effect of ethyl pyruvate on barrier function of intestinal mucosa in dogs with septic shock].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery.
2008 Mar; 11(2):177-80. doi:
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Human & experimental toxicology.
2008 Jan; 27(1):49-54. doi:
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2008 Jan; 20(1):34-6. doi:
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PloS one.
2007 Nov; 2(11):e1153. doi:
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Journal of burns and wounds.
2007 Oct; 7(?):e7. doi:
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Pancreas.
2007 Oct; 35(3):256-61. doi:
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Saudi medical journal.
2007 Oct; 28(10):1489-92. doi:
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Zhonghua wai ke za zhi [Chinese journal of surgery].
2007 Sep; 45(17):1210-3. doi:
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Chemico-biological interactions.
2007 Aug; 169(2):122-31. doi:
10.1016/j.cbi.2007.06.001. [PMID: 17644081] - Fuhong Su, Zhen Wang, Ying Cai, Myriam Remmelink, Jean-Louis Vincent. Beneficial effects of ethyl pyruvate in septic shock from peritonitis.
Archives of surgery (Chicago, Ill. : 1960).
2007 Feb; 142(2):166-71. doi:
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Critical care (London, England).
2007; 11(5):229. doi:
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2006 Nov; 18(11):668-72. doi:
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Acta anaesthesiologica Scandinavica.
2006 Nov; 50(10):1198-206. doi:
10.1111/j.1399-6576.2006.01140.x. [PMID: 16999840] - Kun Li, Cheng-tang Wu, Xue-hong Qiu. [Effect of ethyl pyruvate on peroxidation injury of intestinal mucosa in rats with severe abdominal infection].
Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2006 Mar; 18(3):154-6. doi:
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2006 Mar; 18(3):132-5. doi:
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Biochemical pharmacology.
2005 Nov; 70(11):1579-92. doi:
10.1016/j.bcp.2005.08.015. [PMID: 16226725] - Balázs Hauser, Jochen Kick, Pierre Asfar, Ulrich Ehrmann, Maura Albicini, Josef Vogt, Ulrich Wachter, Uwe Bernd Brückner, Mitchell P Fink, Peter Radermacher, Hendrik Bracht. Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia.
Critical care medicine.
2005 Sep; 33(9):2034-42. doi:
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Kidney international.
2005 Jun; 67(6):2159-67. doi:
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