Artocarpin (BioDeep_00000018708)
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C26H28O6 (436.1885788)
中文名称: 2,4,5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 4.76%
分子结构信息
SMILES: c1(c(c(c2c(c1)oc(c(c2=O)CC=C(C)C)c1ccc(cc1O)O)O)CC=C(C)C)OC
InChI: InChI=1S/C26H28O6/c1-14(2)6-9-18-21(31-5)13-22-23(24(18)29)25(30)19(10-7-15(3)4)26(32-22)17-11-8-16(27)12-20(17)28/h6-8,11-13,27-29H,9-10H2,1-5H3
描述信息
Isolated from Artocarpus heterophyllus (jackfruit). Artocarpin is found in breadfruit, jackfruit, and fruits.
Artocarpin is found in breadfruit. Artocarpin is isolated from Artocarpus heterophyllus (jackfruit
D007155 - Immunologic Factors > D000373 - Agglutinins > D037121 - Plant Lectins
D007155 - Immunologic Factors > D000373 - Agglutinins > D037102 - Lectins
同义名列表
9 个代谢物同义名
2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(1E)-3-methylbut-1-en-1-yl]-3-(3-methylbut-2-en-1-yl)-4H-chromen-4-one; 2-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methyl-1-butenyl)-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one, 9ci; 2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(1E)-3-methylbut-1-en-1-yl]-3-(3-methylbut-2-en-1-yl)chromen-4-one; 2-(2,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-6-(3-methyl-1-butenyl)-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one; 5-Hydroxy-7-methoxy-3-(3-methyl-2-butenyl)-6-(3-methyl-1-butenyl)-2-(2,4-dihydroxyphenyl)-4H-1-benzopyran-4-one; 2,4,5-Trihydroxy-7-methoxy-6-(3-methyl-1-butenyl)-3-(3-methyl-2-butenyl)flavone; Artocarpin lectin; Spectrum4_000097; Artocarpin
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:65439
- PubChem: 5458461
- PubChem: 5358260
- HMDB: HMDB0030849
- ChEMBL: CHEMBL72617
- KNApSAcK: C00004032
- foodb: FDB002808
- chemspider: 4572407
- CAS: 7608-44-8
- PMhub: MS000010469
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
8 个相关的物种来源信息
- 194251 - Artocarpus altilis:
- 709040 - Artocarpus chama:
- 709040 - Artocarpus chama: 10.1021/NP030467Y
- 1867283 - Artocarpus gomezianus: 10.1055/S-2000-8656
- 3489 - Artocarpus heterophyllus:
- 3490 - Artocarpus integer: 10.1016/0031-9422(95)00135-T
- 709053 - Artocarpus nitidus: 10.1002/CBDV.200900130
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Murugan Thulasi Meenu, Grace Kaul, Abdul Akhir, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra. Developing the Natural Prenylflavone Artocarpin from Artocarpus hirsutus as a Potential Lead Targeting Pathogenic, Multidrug-Resistant Staphylococcus aureus, Persisters and Biofilms with No Detectable Resistance.
Journal of natural products.
2022 10; 85(10):2413-2423. doi:
10.1021/acs.jnatprod.2c00621
. [PMID: 36222797] - Qirou Wang, Ruilin Li, Nannan Li, Yanan Jia, Yajie Wang, Yue Chen, Pharkphoom Panichayupakaranant, Haixia Chen. The antioxidant activities, inhibitory effects, kinetics, and mechanisms of artocarpin and α-mangostin on α-glucosidase and α-amylase.
International journal of biological macromolecules.
2022 Jul; 213(?):880-891. doi:
10.1016/j.ijbiomac.2022.06.017
. [PMID: 35688278] - R R Bazmi, P Panichayupakaranant. Synergistic interactions between artocarpin-rich extract, lawsone methyl ether and ampicillin on anti-MRSA and their antibiofilm formation.
Letters in applied microbiology.
2022 May; 74(5):777-786. doi:
10.1111/lam.13662
. [PMID: 35100449] - Abdi Wira Septama, Eldiza Puji Rahmi, Lucia Dwi Antika, Rizna Triana Dewi, Amit Jaisi. A synergy interaction of artocarpin and tetracycline against Pseudomonas aeruginosa and its mechanism of action on membrane permeability.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2022 Jan; 77(1-2):57-63. doi:
10.1515/znc-2021-0076
. [PMID: 34105319] - Sukanya Dej-Adisai, Kedsaraporn Parndaeng, Chatchai Wattanapiromsakul, Jae Sung Hwang. Three New Isoprenylated Flavones from Artocarpus chama Stem and Their Bioactivities.
Molecules (Basel, Switzerland).
2021 Dec; 27(1):. doi:
10.3390/molecules27010003
. [PMID: 35011235] - Yana Sharapova, Vytas Švedas, Dmitry Suplatov. Catalytic and lectin domains in neuraminidase A from Streptococcus pneumoniae are capable of an intermolecular assembly: Implications for biofilm formation.
The FEBS journal.
2021 05; 288(10):3217-3230. doi:
10.1111/febs.15610
. [PMID: 33108702] - Isaac J Morrison, Jianan Zhang, Jingwen Lin, JeAnn E Murray, Roy Porter, Moses K Langat, Nicholas J Sadgrove, James Barker, Guodong Zhang, Rupika Delgoda. Potential chemopreventive, anticancer and anti-inflammatory properties of a refined artocarpin-rich wood extract of Artocarpus heterophyllus Lam.
Scientific reports.
2021 03; 11(1):6854. doi:
10.1038/s41598-021-86040-5
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Oxidative medicine and cellular longevity.
2021; 2021(?):5067957. doi:
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Bioscience, biotechnology, and biochemistry.
2020 Apr; 84(4):661-669. doi:
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Oxidative medicine and cellular longevity.
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10.1155/2020/1042451
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Journal of cellular physiology.
2019 08; 234(8):13157-13168. doi:
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Biomedical chromatography : BMC.
2018 Apr; 32(4):. doi:
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Journal of natural products.
2017 12; 80(12):3172-3178. doi:
10.1021/acs.jnatprod.7b00453
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Scientific reports.
2017 Nov; 7(1):15599. doi:
10.1038/s41598-017-15876-7
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Photochemistry and photobiology.
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10.1111/php.12788
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Journal of cosmetic science.
2017 Jul; 68(4):257-269. doi:
"
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Journal of agricultural and food chemistry.
2017 May; 65(17):3474-3480. doi:
10.1021/acs.jafc.7b00278
. [PMID: 28391699] - Siti Awanis Abdullah, Shajarahtunnur Jamil, Norazah Basar, Siti Mariam Abdul Lathiff, Norzafneza Mohd Arriffin. Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities.
Natural product research.
2017 May; 31(10):1113-1120. doi:
10.1080/14786419.2016.1222387
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Oncotarget.
2017 Apr; 8(17):28342-28358. doi:
10.18632/oncotarget.16058
. [PMID: 28423703] - Cheng-Wei Tzeng, Wen-Sheng Tzeng, Liang-Tzung Lin, Chiang-Wen Lee, Feng-Lin Yen, Chun-Ching Lin. Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 May; 23(5):528-40. doi:
10.1016/j.phymed.2016.02.010
. [PMID: 27064012] - Abdi Wira Septama, Pharkphoom Panichayupakaranant. Synergistic effect of artocarpin on antibacterial activity of some antibiotics against methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli.
Pharmaceutical biology.
2016; 54(4):686-91. doi:
10.3109/13880209.2015.1072566
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International journal of medical microbiology : IJMM.
2015 May; 305(3):289-97. doi:
10.1016/j.ijmm.2014.12.004
. [PMID: 25592264] - Sukanya Dej-Adisai, Imron Meechai, Jindaporn Puripattanavong, Sopa Kummee. Antityrosinase and antimicrobial activities from Thai medicinal plants.
Archives of pharmacal research.
2014 Apr; 37(4):473-83. doi:
10.1007/s12272-013-0198-z
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TheScientificWorldJournal.
2014; 2014(?):978525. doi:
10.1155/2014/978525
. [PMID: 25133268] - Chiang-Wen Lee, Horng-Huey Ko, Chun-Ching Lin, Chee-Yin Chai, Wan-Tzu Chen, Feng-Lin Yen. Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 Oct; 60(?):123-9. doi:
10.1016/j.fct.2013.07.029
. [PMID: 23871788] - David Giménez-Romero, Paulo R Bueno, Naira C Pesquero, Isidro S Monzó, Rosa Puchades, Ángel Maquieira. Elucidation of carbohydrate molecular interaction mechanism of recombinant and native ArtinM.
The journal of physical chemistry. B.
2013 Jul; 117(28):8360-9. doi:
10.1021/jp403087p
. [PMID: 23799777] - Supasiri Buranajaree, Piyaporn Donsing, Rattima Jeenapongsa, Jarupa Viyoch. Depigmenting action of a nanoemulsion containing heartwood extract of Artocarpus incisus on UVB-induced hyperpigmentation in C57BL/6 mice.
Journal of cosmetic science.
2011 Jan; 62(1):1-14. doi:
"
. [PMID: 21443841] - Enos Tangke Arung, Britanto Dani Wicaksono, Yohana Ayupriyanti Handoko, Irawan Wijaya Kusuma, Kuniyoshi Shimizu, Dina Yulia, Ferry Sandra. Cytotoxic effect of artocarpin on T47D cells.
Journal of natural medicines.
2010 Oct; 64(4):423-9. doi:
10.1007/s11418-010-0425-6
. [PMID: 20544395] - Yan-long Yang, Ai-jun Hou, Hui-qing Zhang, Hong Shen, Qiu-shuang Li, Cong-cong Zhang, Guo-fu Zhu. [Effects of cycloartocarpin A and artocarpin extracted from Fructus Artocarpin Heterophylli on apoptosis of SMMC-7721 and SGC-7901 cells].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2010 Jan; 8(1):61-6. doi:
10.3736/jcim20100112
. [PMID: 20082761] - Henri Debray, Bernadette Coddeville, Liezelotte R Bomfim, Márcio V Ramos. A simple micro-method for determining precise oligosaccharidic specificity of mannose-binding lectins.
Glycobiology.
2009 Dec; 19(12):1417-26. doi:
10.1093/glycob/cwp091
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Journal of leukocyte biology.
2009 Jul; 86(1):103-14. doi:
10.1189/jlb.0708434
. [PMID: 19401384] - Fernando Chahud, Leandra N Z Ramalho, Fernando S Ramalho, Antonio Haddad, Maria C Roque-Barreira. The lectin KM+ induces corneal epithelial wound healing in rabbits.
International journal of experimental pathology.
2009 Apr; 90(2):166-73. doi:
10.1111/j.1365-2613.2008.00626.x
. [PMID: 19335555] - Karina Alves Toledo, Carolina Scwartz, Aline Ferreira Oliveira, Marina Cavalcanti Albuquerque Veiga Conrado, Emerson Soares Bernardes, Luiz Cláudio Fernandes, Maria Cristina Roque-Barreira, Gabriela Pereira-da-Silva, Andréa Novais Moreno. Neutrophil activation induced by ArtinM: release of inflammatory mediators and enhancement of effector functions.
Immunology letters.
2009 Mar; 123(1):14-20. doi:
10.1016/j.imlet.2009.01.009
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Immunology letters.
2008 Aug; 119(1-2):114-5. doi:
10.1016/j.imlet.2008.06.002
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Journal of cosmetic science.
2008 Jan; 59(1):41-58. doi:
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2007 Nov; 67(3):639-45. doi:
10.1016/j.ejpb.2007.03.019
. [PMID: 17493791] - Ah-Reum Han, You-Jin Kang, Tri Windono, Sang Kook Lee, Eun-Kyoung Seo. Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
Journal of natural products.
2006 Apr; 69(4):719-21. doi:
10.1021/np0600346
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Biochimica et biophysica acta.
2006 Jan; 1760(1):86-94. doi:
10.1016/j.bbagen.2005.09.011
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Biochimica et biophysica acta.
2005 Jan; 1721(1-3):152-63. doi:
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Journal of agricultural and food chemistry.
2004 Dec; 52(24):7389-94. doi:
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Biochimie.
2004 Sep; 86(9-10):685-91. doi:
10.1016/j.biochi.2004.09.001
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Journal of molecular biology.
2004 May; 338(4):757-70. doi:
10.1016/j.jmb.2004.03.040
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Journal of natural products.
2004 May; 67(5):757-61. doi:
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Journal of molecular biology.
2002 Mar; 317(2):237-47. doi:
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Planta medica.
2002 Jan; 68(1):79-81. doi:
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Biochemistry.
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