(2R)-2-[[(2S,3R)-3-Amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid (BioDeep_00001870112)
Main id: BioDeep_00000003100
PANOMIX_OTCML-2023 Antitumor activity Volatile Flavor Compounds
代谢物信息卡片
化学式: C16H24N2O4 (308.1735984)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O
InChI: InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13-,14+/m1/s1
描述信息
Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects[1][2].
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:140702
- ChEBI: CHEBI:3070
- KEGG: C00732
- KEGGdrug: D00087
- PubChem: 439299
- ChEMBL: CHEMBL476869
- PubChem: 3996
- KNApSAcK: C00018078
- CAS: 58970-76-6
- NIKKAJI: J12.831G
- medchemexpress: HY-B0134
- KNApSAcK: 3070
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Patricia Gangoiti, Caterina Bernacchioni, Chiara Donati, Francesca Cencetti, Alberto Ouro, Antonio Gómez-Muñoz, Paola Bruni. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
Biochimie.
2012 Mar; 94(3):597-607. doi:
10.1016/j.biochi.2011.09.009
. [PMID: 21945811] - Detina Zalli, Richard Bayliss, Andrew M Fry. The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.
Human molecular genetics.
2012 Mar; 21(5):1155-71. doi:
10.1093/hmg/ddr544
. [PMID: 22106379] - Yanna Zhu, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Taiichi Kaku, Kexin Liu. Organic anion transporters involved in the excretion of bestatin in the kidney.
Peptides.
2012 Feb; 33(2):265-71. doi:
10.1016/j.peptides.2012.01.007
. [PMID: 22273603] - Ching-Feng Huang, Chia-Hsiang Chu, Chia-Chao Wu, Zo-Nan Chang, Fung-Lin Chue, Ho-Jen Peng. Induction of specific Th1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Cyn d 1.
International archives of allergy and immunology.
2012; 158(2):142-50. doi:
10.1159/000331140
. [PMID: 22286313] - Thérèse Keravis, Fanny Monneaux, Issaka Yougbaré, Lucien Gazi, Jean-Jacques Bourguignon, Sylviane Muller, Claire Lugnier. Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor.
PloS one.
2012; 7(1):e28899. doi:
10.1371/journal.pone.0028899
. [PMID: 22247763] - Maria Luisa Sirico, Bruna Guida, Alfredo Procino, Andrea Pota, Maurizio Sodo, Giuseppe Grandaliano, Simona Simone, Giovanni Pertosa, Eleonora Riccio, Bruno Memoli. Human mature adipocytes express albumin and this expression is not regulated by inflammation.
Mediators of inflammation.
2012; 2012(?):236796. doi:
10.1155/2012/236796
. [PMID: 22675238] - Kunio Fujiwara, Masashi Shin, Yohei Yoshizaki, Tsubasa Miyazaki, Tetsuya Saita. Immunocytochemistry for bestatin and its application to drug accumulation studies in rat intestine and kidney.
Journal of molecular histology.
2011 Dec; 42(6):589-96. doi:
10.1007/s10735-011-9365-z
. [PMID: 22006287] - Cynthia Wei-Sheng Lee, Jia-Ying Yan, Yao-Chang Chiang, Tsai-Wei Hung, Hung-Li Wang, Lih-Chu Chiou, Ing-Kang Ho. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
Neurochemical research.
2011 Nov; 36(11):2008-21. doi:
10.1007/s11064-011-0525-z
. [PMID: 21671107] - Purushottam R Lomate, Vandana K Hivrale. Changes and induction of aminopeptidase activities in response to pathogen infection during germination of pigeonpea (Cajanas cajan) seeds.
Journal of plant physiology.
2011 Oct; 168(15):1735-42. doi:
10.1016/j.jplph.2011.05.002
. [PMID: 21640431] - L Tao, H Zhou, X S Guo, R J Long, Y Zhu, W Cheng. Contribution of exopeptidases to formation of nonprotein nitrogen during ensiling of alfalfa.
Journal of dairy science.
2011 Aug; 94(8):3928-35. doi:
10.3168/jds.2010-3752
. [PMID: 21787929] - Purushottam R Lomate, Vandana K Hivrale. Induction of leucine aminopeptidase (LAP) like activity with wounding and methyl jasmonate in pigeonpea (Cajanas cajan) suggests the role of these enzymes in plant defense in leguminosae.
Plant physiology and biochemistry : PPB.
2011 Jun; 49(6):609-16. doi:
10.1016/j.plaphy.2011.02.023
. [PMID: 21420308] - Julie A Martellini, Amy L Cole, Pavel Svoboda, Olga Stuchlik, Li-Mei Chen, Karl X Chai, Bhushan K Gangrade, Ole E Sørensen, Jan Pohl, Alexander M Cole. HIV-1 enhancing effect of prostatic acid phosphatase peptides is reduced in human seminal plasma.
PloS one.
2011 Jan; 6(1):e16285. doi:
10.1371/journal.pone.0016285
. [PMID: 21283773] - Yasuo Ariumi, Misao Kuroki, Masatoshi Maki, Masanori Ikeda, Hiromichi Dansako, Takaji Wakita, Nobuyuki Kato. The ESCRT system is required for hepatitis C virus production.
PloS one.
2011 Jan; 6(1):e14517. doi:
10.1371/journal.pone.0014517
. [PMID: 21264300] - Monika Mahajan, Paramvir Singh Ahuja, Sudesh Kumar Yadav. Post-transcriptional silencing of flavonol synthase mRNA in tobacco leads to fruits with arrested seed set.
PloS one.
2011; 6(12):e28315. doi:
10.1371/journal.pone.0028315
. [PMID: 22145036] - Natália Pereira de Almeida Nogueira, Cintia Fernandes de Souza, Francis Monique de Souza Saraiva, Pedro Elias Sultano, Sergio Ranto Dalmau, Roberta Eitler Bruno, Renata de Lima Sales Gonçalves, Gustavo Augusto Travassos Laranja, Luís Henrique Monteiro Leal, Marsen Garcia Pinto Coelho, Claudio A Masuda, Marcus F Oliveira, Marcia Cristina Paes. Heme-induced ROS in Trypanosoma cruzi activates CaMKII-like that triggers epimastigote proliferation. One helpful effect of ROS.
PloS one.
2011; 6(10):e25935. doi:
10.1371/journal.pone.0025935
. [PMID: 22022475] - Kristy R Howell, Ammar Kutiyanawalla, Anilkumar Pillai. Long-term continuous corticosterone treatment decreases VEGF receptor-2 expression in frontal cortex.
PloS one.
2011; 6(5):e20198. doi:
10.1371/journal.pone.0020198
. [PMID: 21647420] - Jun Ni, Yongfeng Guo, Huiyan Jin, Jennifer Hartsell, Steven E Clark. Characterization of a CLE processing activity.
Plant molecular biology.
2011 Jan; 75(1-2):67-75. doi:
10.1007/s11103-010-9708-2
. [PMID: 21052783] - Shaun P Murphy, Carl R Simmons, Hank W Bass. Structure and expression of the maize (Zea mays L.) SUN-domain protein gene family: evidence for the existence of two divergent classes of SUN proteins in plants.
BMC plant biology.
2010 Dec; 10(?):269. doi:
10.1186/1471-2229-10-269
. [PMID: 21143845] - Matthias Becker, Wolf-Eberhard Siems, Reinhart Kluge, Florian Gembardt, Heinz-Peter Schultheiss, Michael Schirner, Thomas Walther. New function for an old enzyme: NEP deficient mice develop late-onset obesity.
PloS one.
2010 Sep; 5(9):. doi:
10.1371/journal.pone.0012793
. [PMID: 20862277] - F H Passam, S Rahgozar, M Qi, M J Raftery, J W H Wong, K Tanaka, Y Ioannou, J Y Zhang, R Gemmell, J C Qi, B Giannakopoulos, W E Hughes, P J Hogg, S A Krilis. Redox control of β2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1.
Journal of thrombosis and haemostasis : JTH.
2010 Aug; 8(8):1754-62. doi:
10.1111/j.1538-7836.2010.03944.x
. [PMID: 20979592] - Simon P Brooks, Margherita Coccia, Hao R Tang, Naheed Kanuga, Laura M Machesky, Maryse Bailly, Michael E Cheetham, Alison J Hardcastle. The Nance-Horan syndrome protein encodes a functional WAVE homology domain (WHD) and is important for co-ordinating actin remodelling and maintaining cell morphology.
Human molecular genetics.
2010 Jun; 19(12):2421-32. doi:
10.1093/hmg/ddq125
. [PMID: 20332100] - José Antonio Monreal, Francisco Javier López-Baena, Jean Vidal, Cristina Echevarría, Sofía García-Mauriño. Involvement of phospholipase D and phosphatidic acid in the light-dependent up-regulation of sorghum leaf phosphoenolpyruvate carboxylase-kinase.
Journal of experimental botany.
2010 Jun; 61(10):2819-27. doi:
10.1093/jxb/erq114
. [PMID: 20410319] - Franco Folli, Valeria Guzzi, Lucia Perego, Dawn K Coletta, Giovanna Finzi, Claudia Placidi, Stefano La Rosa, Carlo Capella, Carlo Socci, Davide Lauro, Devjit Tripathy, Christopher Jenkinson, Rita Paroni, Elena Orsenigo, Giuliana Cighetti, Luisa Gregorini, Carlo Staudacher, Antonio Secchi, Angela Bachi, Michael Brownlee, Paolo Fiorina. Proteomics reveals novel oxidative and glycolytic mechanisms in type 1 diabetic patients' skin which are normalized by kidney-pancreas transplantation.
PloS one.
2010 Mar; 5(3):e9923. doi:
10.1371/journal.pone.0009923
. [PMID: 20360867] - Robert Nilsson, Katja Bernfur, Niklas Gustavsson, Joakim Bygdell, Gunnar Wingsle, Christer Larsson. Proteomics of plasma membranes from poplar trees reveals tissue distribution of transporters, receptors, and proteins in cell wall formation.
Molecular & cellular proteomics : MCP.
2010 Feb; 9(2):368-87. doi:
10.1074/mcp.m900289-mcp200
. [PMID: 19955078] - Kevin C Doerschug, Angela S Delsing, Gregory A Schmidt, Alix Ashare. Renin-angiotensin system activation correlates with microvascular dysfunction in a prospective cohort study of clinical sepsis.
Critical care (London, England).
2010; 14(1):R24. doi:
10.1186/cc8887
. [PMID: 20175923] - Abigail A Lamikanra, Michel Theron, Taco W A Kooij, David J Roberts. Hemozoin (malarial pigment) directly promotes apoptosis of erythroid precursors.
PloS one.
2009 Dec; 4(12):e8446. doi:
10.1371/journal.pone.0008446
. [PMID: 20041181] - Flavia Axelband, Juliana Dias, Filipe Miranda, Fernanda M Ferrão, Nilana M Barros, Adriana K Carmona, Lucienne S Lara, Adalberto Vieyra. A scrutiny of the biochemical pathways from Ang II to Ang-(3-4) in renal basolateral membranes.
Regulatory peptides.
2009 Nov; 158(1-3):47-56. doi:
10.1016/j.regpep.2009.08.004
. [PMID: 19703499] - Rajeswari Jinka, Vadde Ramakrishna, Sridhar K Rao, Ramakrishna P Rao. Purification and characterization of cysteine protease from germinating cotyledons of horse gram.
BMC biochemistry.
2009 Nov; 10(?):28. doi:
10.1186/1471-2091-10-28
. [PMID: 19919695] - Anna Gustafsson, Anna-Karin Boström, Börje Ljungberg, Håkan Axelson, Björn Dahlbäck. Gas6 and the receptor tyrosine kinase Axl in clear cell renal cell carcinoma.
PloS one.
2009 Oct; 4(10):e7575. doi:
10.1371/journal.pone.0007575
. [PMID: 19888345] - Valentina Bangiyeva, Ava Rosenbloom, Ashlynn E Alexander, Bella Isanova, Timothy Popko, Alan R Schoenfeld. Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes.
BMC cancer.
2009 Jul; 9(?):229. doi:
10.1186/1471-2407-9-229
. [PMID: 19602254] - Fariba Nayeri, Tayeb Nayeri, Daniel Aili, Lars Brudin, Bo Liedberg. Clinical impact of real-time evaluation of the biological activity and degradation of hepatocyte growth factor.
Growth factors (Chur, Switzerland).
2008 Jun; 26(3):163-71. doi:
10.1080/08977190802128083
. [PMID: 18569024] - Keon-Hyoung Song, Alessio Fasano, Natalie D Eddington. Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A.
International journal of pharmaceutics.
2008 Mar; 351(1-2):8-14. doi:
10.1016/j.ijpharm.2007.09.011
. [PMID: 17954018] - Hideo Kubo, Masaharu Kotani, Yukio Yamamoto, Tadahiko Hazato. Involvement of sperm proteases in the binding of sperm to the vitelline envelope in Xenopus laevis.
Zoological science.
2008 Jan; 25(1):80-7. doi:
10.2108/zsj.25.80
. [PMID: 18275249] - M Snyman, M J Cronjé. Modulation of heat shock factors accompanies salicylic acid-mediated potentiation of Hsp70 in tomato seedlings.
Journal of experimental botany.
2008; 59(8):2125-32. doi:
10.1093/jxb/ern075
. [PMID: 18468986] - Viet-Laï Pham, Marie-Sandrine Cadel, Cécile Gouzy-Darmon, Chantal Hanquez, Margery C Beinfeld, Pierre Nicolas, Catherine Etchebest, Thierry Foulon. Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn2+-binding motif and molecular modelling.
BMC biochemistry.
2007 Oct; 8(?):21. doi:
10.1186/1471-2091-8-21
. [PMID: 17974014] - Thaysa Paschoalin, Adriana K Carmona, Elaine G Rodrigues, Vitor Oliveira, Hugo P Monteiro, Maria A Juliano, Luiz Juliano, Luiz R Travassos. Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.
Molecular cancer.
2007 Jul; 6(?):44. doi:
10.1186/1476-4598-6-44
. [PMID: 17620116] - Chen Wang, Guorong Fan, Mei Lin, Yi Chen, Weiquan Zhao, Yutian Wu. Development of a liquid chromatography/tandem mass spectrometry assay for the determination of bestatin in rat plasma and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 May; 850(1-2):101-8. doi:
10.1016/j.jchromb.2006.11.015
. [PMID: 17141585] - Anja Thielitz, Dirk Reinhold, Robert Vetter, Ute Bank, Martin Helmuth, Roland Hartig, Sabine Wrenger, Ingrid Wiswedel, Uwe Lendeckel, Thilo Kähne, Klaus Neubert, Jürgen Faust, Christos C Zouboulis, Siegfried Ansorge, Harald Gollnick. Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation.
The Journal of investigative dermatology.
2007 May; 127(5):1042-51. doi:
10.1038/sj.jid.5700439
. [PMID: 16778789] - Colin M Stack, Jonathan Lowther, Eithne Cunningham, Sheila Donnelly, Donald L Gardiner, Katharine R Trenholme, Tina S Skinner-Adams, Franka Teuscher, Jolanta Grembecka, Artur Mucha, Pawel Kafarski, Linda Lua, Angus Bell, John P Dalton. Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.
The Journal of biological chemistry.
2007 Jan; 282(3):2069-80. doi:
10.1074/jbc.m609251200
. [PMID: 17107951] - Noel N Kim, Miljan Stankovic, Abdullah Armagan, Tulay T Cushman, Irwin Goldstein, Abdulmaged M Traish. Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat.
BMC women's health.
2006 Sep; 6(?):14. doi:
10.1186/1472-6874-6-14
. [PMID: 16970814] - Wenguang Zheng, Qingzhe Zhai, Jiaqiang Sun, Chang-Bao Li, Lei Zhang, Hongmei Li, Xiaoli Zhang, Shuyu Li, Yingxiu Xu, Hongling Jiang, Xiaoyan Wu, Chuanyou Li. Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in Arabidopsis.
Plant physiology.
2006 Aug; 141(4):1400-13. doi:
10.1104/pp.106.080390
. [PMID: 16798948] - Noel N Kim, Miljan Stankovic, Tulay T Cushman, Irwin Goldstein, Ricardo Munarriz, Abdulmaged M Traish. Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers.
BMC physiology.
2006 May; 6(?):4. doi:
10.1186/1472-6793-6-4
. [PMID: 16734901] - Marina Krstanović, Marija Brgles, Beata Halassy, Ruza Frkanec, Anto Vrdoljak, Karmen Branović, Jelka Tomasić, Fabio Benedetti. Purification and characterization of l,(l/d)-aminopeptidase from Guinea pig serum.
Preparative biochemistry & biotechnology.
2006; 36(2):175-95. doi:
10.1080/10826060500534099
. [PMID: 16513561] - Dilip Chandu, Stacey S Huppert, Raphael Kopan. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase.
Journal of neurochemistry.
2006 Jan; 96(1):228-35. doi:
10.1111/j.1471-4159.2005.03547.x
. [PMID: 16300632] - Glen L Kelley, Salman Azhar. Reversal of high dietary fructose-induced PPARalpha suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors.
Nutrition & metabolism.
2005 Aug; 2(?):18. doi:
10.1186/1743-7075-2-18
. [PMID: 16091142] - Ljubica Glavas-Obrovac, Andreja Jakas, Saska Marczi, Stefica Horvat. The influence of cell growth media on the stability and antitumour activity of methionine enkephalin.
Journal of peptide science : an official publication of the European Peptide Society.
2005 Jul; 11(8):506-11. doi:
10.1002/psc.643
. [PMID: 15685713] - J J Ord, E Streeter, A Jones, K Le Monnier, D Cranston, J Crew, S P Joel, M A Rogers, R E Banks, I S D Roberts, A L Harris. Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma.
British journal of cancer.
2005 Jun; 92(12):2140-7. doi:
10.1038/sj.bjc.6602650
. [PMID: 15928663] - Fariba Nayeri, Daniel Aili, Tayeb Nayeri, Junyang Xu, Sven Almer, Ingemar Lundström, Britt Akerlind, Bo Liedberg. Hepatocyte growth factor (HGF) in fecal samples: rapid detection by surface plasmon resonance.
BMC gastroenterology.
2005 Apr; 5(?):13. doi:
10.1186/1471-230x-5-13
. [PMID: 15826299] - A M Baker, D C Batchelor, G B Thomas, J Y Wen, M Rafiee, H Lin, J Guan. Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat.
Neuropeptides.
2005 Apr; 39(2):81-7. doi:
10.1016/j.npep.2004.11.001
. [PMID: 15752541] - Paul J Lijnen, Victor V Petrov, G Diaz-Araya, Robert H Fagard. Reversal of angiotensin II-stimulated collagen gel contraction in cardiac fibroblasts by aminopeptidase inhibition.
Journal of cardiovascular pharmacology.
2005 Jan; 45(1):68-73. doi:
10.1097/00005344-200501000-00012
. [PMID: 15613982] - Paul Lijnen, Victor Petrov, Guillermo Diaz-Araya, Robert Fagard. Effect of bestatin on angiotensin I-, II- and III-induced collagen gel contraction in cardiac fibroblasts.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2004 Dec; 5(4):183-8. doi:
10.3317/jraas.2004.038
. [PMID: 15803436] - Aron D Mosnaim, Javier Puente, Vasant Ranade, Catherine Hoang, Marion E Wolf. Inhibition of human plasma leucine5-enkephalin aminopeptidase hydrolysis by various endogenous peptides and a select number of clinically used drugs.
American journal of therapeutics.
2004 Nov; 11(6):459-65. doi:
10.1097/01.mjt.0000134785.42464.17
. [PMID: 15543085] - Thomas Tallant, Amitabha Deb, Niladri Kar, Joseph Lupica, Michael J de Veer, Joseph A DiDonato. Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells.
BMC microbiology.
2004 Aug; 4(?):33. doi:
10.1186/1471-2180-4-33
. [PMID: 15324458] - Seamus J Buckley, Patrick J Collins, Brendan F O'Connor. The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum.
The international journal of biochemistry & cell biology.
2004 Jul; 36(7):1281-96. doi:
10.1016/j.biocel.2003.02.001
. [PMID: 15109572] - Iu A Zolotarev, O Iu Sokolov, N V Kost, B V Vas'kovskiĭ, N F Miasoedov, A A Zozulia. [Leu-enkephalin homogeneously labeled with tritium in studying the Selank inhibiting effect on the enkephalin-degrading enzymes of human plasma].
Bioorganicheskaia khimiia.
2004 May; 30(3):234-40. doi:
10.1023/b:rubi.0000030126.09208.c3
. [PMID: 15344652] - G Ronzitti, F Callegari, C Malaguti, G P Rossini. Selective disruption of the E-cadherin-catenin system by an algal toxin.
British journal of cancer.
2004 Mar; 90(5):1100-7. doi:
10.1038/sj.bjc.6601640
. [PMID: 14997213] - Hui Liu, Wei-san Pan, Rong Du, Xiao-dong Li, Ren Tang. [Effects of protease inhibitors on intestinal absorption of insulin].
Yao xue xue bao = Acta pharmaceutica Sinica.
2004 Feb; 39(2):140-3. doi:
NULL
. [PMID: 15127624] - Paul J Lijnen, Victor V Petrov, Robert H Fagard. Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases.
Journal of hypertension.
2004 Jan; 22(1):209-16. doi:
10.1097/00004872-200401000-00031
. [PMID: 15106813] - Hui Liu, Ren Tang, Wei-San Pan, Yi Zhang, Hong Liu. Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats.
The Journal of pharmacy and pharmacology.
2003 Nov; 55(11):1523-9. doi:
10.1211/0022357022052
. [PMID: 14713363] - Osamu Sugano, Akinori Muto, Masanori Kato, Kunio Ono. [A case of renal cell carcinoma with lymph node metastasis keeping remission for five years by adjuvant immunotherapy with ubenimex].
Gan to kagaku ryoho. Cancer & chemotherapy.
2003 Oct; 30(10):1519-22. doi:
NULL
. [PMID: 14584289] - Joachim F Schindler. Aminopeptidases function as endocytic receptors in the trophotaenial placenta of the goodeid fish, Ameca splendens (Teleostei: Atheriniformes).
Journal of experimental zoology. Part A, Comparative experimental biology.
2003 Oct; 299(2):213-22. doi:
10.1002/jez.a.10282
. [PMID: 12975809] - Yasuo Hirayama, Sumio Sakamaki, Norihiro Takayanagi, Yasushi Tsuji, Tamotsu Sagawa, Hiroki Chiba, Takuya Matsunaga, Yoshiro Niitsu. [Chemotherapy with ubenimex corresponding to patient age and organ disorder for 18 cases of acute myelogeneous leukemia in elderly patients--effects, complications and long-term survival].
Gan to kagaku ryoho. Cancer & chemotherapy.
2003 Aug; 30(8):1113-8. doi:
NULL
. [PMID: 12938265] - C U Nielsen, B Brodin. Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions.
Current drug targets.
2003 Jul; 4(5):373-88. doi:
10.2174/1389450033491028
. [PMID: 12816347] - Michael Teufel, Vladimir Saudek, Jean-Pierre Ledig, Annie Bernhardt, Sylviane Boularand, Alexandra Carreau, Nigel J Cairns, Christopher Carter, David J Cowley, Danielle Duverger, Axel J Ganzhorn, Chantal Guenet, Blanche Heintzelmann, Veronique Laucher, Claude Sauvage, Tatiana Smirnova. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase.
The Journal of biological chemistry.
2003 Feb; 278(8):6521-31. doi:
10.1074/jbc.m209764200
. [PMID: 12473676] - R Ledger, I G Tucker, G F Walker. The metabolic barrier of the lower intestinal tract of salmon to the oral delivery of protein and peptide drugs.
Journal of controlled release : official journal of the Controlled Release Society.
2002 Dec; 85(1-3):91-103. doi:
10.1016/s0168-3659(02)00289-4
. [PMID: 12480315] - Márcia Carvalho, Gabrielle Hawksworth, Nuno Milhazes, Fernanda Borges, Terrence J Monks, Eduarda Fernandes, Félix Carvalho, Maria Lourdes Bastos. Role of metabolites in MDMA (ecstasy)-induced nephrotoxicity: an in vitro study using rat and human renal proximal tubular cells.
Archives of toxicology.
2002 Oct; 76(10):581-8. doi:
10.1007/s00204-002-0381-3
. [PMID: 12373454] - J-Y Wen, R Ledger, A G Butt, B J McLeod, N M Davies, I G Tucker. Inhibition of proteolysis in luminal extracts from the intestine of the brushtail possum.
The Journal of pharmacy and pharmacology.
2002 Oct; 54(10):1365-72. doi:
10.1211/002235702760345446
. [PMID: 12396298] - Rory E Morty, Jennifer Morehead. Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species.
The Journal of biological chemistry.
2002 Jul; 277(29):26057-65. doi:
10.1074/jbc.m202779200
. [PMID: 12006595] - Christiane Stuhlfelder, Friedrich Lottspeich, Martin J Mueller. Purification and partial amino acid sequences of an esterase from tomato.
Phytochemistry.
2002 Jun; 60(3):233-40. doi:
10.1016/s0031-9422(02)00126-7
. [PMID: 12031441] - Angus S Murphy, Karen R Hoogner, Wendy Ann Peer, Lincoln Taiz. Identification, purification, and molecular cloning of N-1-naphthylphthalmic acid-binding plasma membrane-associated aminopeptidases from Arabidopsis.
Plant physiology.
2002 Mar; 128(3):935-50. doi:
10.1104/pp.010519
. [PMID: 11891249] - H Katoh, Y Ping Ge, T Tsuda, S Hayashi. High density lipoprotein binding protein of eel (Anguilla japonica) liver with specificity of binding to apoAI as a ligand.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2001 Jul; 129(4):843-52. doi:
10.1016/s1096-4959(01)00393-1
. [PMID: 11435139] - K Ishii, S Usui, Y Sugimura, H Yamamoto, K Yoshikawa, K Hirano. Inhibition of aminopeptidase N (AP-N) and urokinase-type plasminogen activator (uPA) by zinc suppresses the invasion activity in human urological cancer cells.
Biological & pharmaceutical bulletin.
2001 Mar; 24(3):226-30. doi:
10.1248/bpb.24.226
. [PMID: 11256475] - O A Scornik, V Botbol. Bestatin as an experimental tool in mammals.
Current drug metabolism.
2001 Mar; 2(1):67-85. doi:
10.2174/1389200013338748
. [PMID: 11465152] - M M Thunnissen, P Nordlund, J Z Haeggström. Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
Nature structural biology.
2001 Feb; 8(2):131-5. doi:
10.1038/84117
. [PMID: 11175901] - . .
.
. doi:
. [PMID: 22180785]