Platensimycin (BioDeep_00001868927)

Main id: BioDeep_00000013243

 


代谢物信息卡片


Platensimycin

化学式: C24H27NO7 (441.17874320000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CC34CC1CC(C3C(C(=O)C=C4)(C)CCC(=O)NC5=C(C=CC(=C5O)C(=O)O)O)O2
InChI: InChI=1S/C24H27NO7/c1-22(7-6-17(28)25-18-14(26)4-3-13(19(18)29)21(30)31)16(27)5-8-24-10-12-9-15(20(22)24)32-23(12,2)11-24/h3-5,8,12,15,20,26,29H,6-7,9-11H2,1-2H3,(H,25,28)(H,30,31)/t12-,15+,20+,22-,23+,24+/m1/s1

描述信息

A monocarboxylic acid amide obtained by the formal condensation of the amino group of 3-amino-2,4-dihydroxybenzoic acid with the carboxy group of the oxatetracyclic cage component. It is an antibiotic isolated from Streptomyces platensis and exhibits inhibitory activity against fatty acid synthase.
D000963 - Antimetabolites > D000960 - Hypolipidemic Agents > D054872 - Fatty Acid Synthesis Inhibitors
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
D000890 - Anti-Infective Agents

同义名列表

1 个代谢物同义名

Platensimycin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liao-Bin Dong, Xiao Zhang, Jeffrey D Rudolf, Ming-Rong Deng, Edward Kalkreuter, Alexis J Cepeda, Hans Renata, Ben Shen. Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. 2019 03; 141(9):4043-4050. doi: 10.1021/jacs.8b13452. [PMID: 30735041]
  • Sergio A Mojica, Olli Salin, Robert J Bastidas, Naresh Sunduru, Mattias Hedenström, C David Andersson, Carlos Núñez-Otero, Patrik Engström, Raphael H Valdivia, Mikael Elofsson, Åsa Gylfe. N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF. Antimicrobial agents and chemotherapy. 2017 10; 61(10):. doi: 10.1128/aac.00716-17. [PMID: 28784680]
  • Fernanda C Moraes, Elson S Alvarenga, Kariny B Amorim, Antonio J Demuner, Milton E Pereira-Flores. Novel platensimycin derivatives with herbicidal activity. Pest management science. 2016 Mar; 72(3):580-4. doi: 10.1002/ps.4028. [PMID: 25914183]
  • Ian Rowe, Min Guo, Anthony Yasmann, Abigail Cember, Herman O Sintim, Sergei Sukharev. Membrane Affinity of Platensimycin and Its Dialkylamine Analogs. International journal of molecular sciences. 2015 Aug; 16(8):17909-32. doi: 10.3390/ijms160817909. [PMID: 26247942]
  • Evan Martens, Arnold L Demain. Platensimycin and platencin: promising antibiotics for future application in human medicine. The Journal of antibiotics. 2011 Nov; 64(11):705-10. doi: 10.1038/ja.2011.80. [PMID: 21915133]
  • K C Nicolaou, G Scott Tria, David J Edmonds, Moumita Kar. Total syntheses of (+/-)-platencin and (-)-platencin. Journal of the American Chemical Society. 2009 Nov; 131(43):15909-17. doi: 10.1021/ja906801g. [PMID: 19824676]
  • Xun Chen, Charlotte Burton, Xuelei Song, Lesley McNamara, Annunziata Langella, Simona Cianetti, Ching H Chang, Jun Wang. An apoA-I mimetic peptide increases LCAT activity in mice through increasing HDL concentration. International journal of biological sciences. 2009 Jul; 5(5):489-99. doi: 10.7150/ijbs.5.489. [PMID: 19680471]
  • Patrik Johansson, Birgit Wiltschi, Preeti Kumari, Brigitte Kessler, Clemens Vonrhein, Janet Vonck, Dieter Oesterhelt, Martin Grininger. Inhibition of the fungal fatty acid synthase type I multienzyme complex. Proceedings of the National Academy of Sciences of the United States of America. 2008 Sep; 105(35):12803-8. doi: 10.1073/pnas.0805827105. [PMID: 18725634]
  • Günter Pappenberger, Tanja Schulz-Gasch, Eric Kusznir, Francis Müller, Michael Hennig. Structure-assisted discovery of an aminothiazole derivative as a lead molecule for inhibition of bacterial fatty-acid synthesis. Acta crystallographica. Section D, Biological crystallography. 2007 Dec; 63(Pt 12):1208-16. doi: 10.1107/s0907444907049852. [PMID: 18084068]
  • H Tonie Wright, Kevin A Reynolds. Antibacterial targets in fatty acid biosynthesis. Current opinion in microbiology. 2007 Oct; 10(5):447-53. doi: 10.1016/j.mib.2007.07.001. [PMID: 17707686]
  • Caspar Elo Christensen, Birthe B Kragelund, Penny von Wettstein-Knowles, Anette Henriksen. Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase. Protein science : a publication of the Protein Society. 2007 Feb; 16(2):261-72. doi: 10.1110/ps.062473707. [PMID: 17242430]
  • Jun Wang, Stephen M Soisson, Katherine Young, Wesley Shoop, Srinivas Kodali, Andrew Galgoci, Ronald Painter, Gopalakrishnan Parthasarathy, Yui S Tang, Richard Cummings, Sookhee Ha, Karen Dorso, Mary Motyl, Hiranthi Jayasuriya, John Ondeyka, Kithsiri Herath, Chaowei Zhang, Lorraine Hernandez, John Allocco, Angela Basilio, José R Tormo, Olga Genilloud, Francisca Vicente, Fernando Pelaez, Lawrence Colwell, Sang Ho Lee, Bruce Michael, Thomas Felcetto, Charles Gill, Lynn L Silver, Jeffery D Hermes, Ken Bartizal, John Barrett, Dennis Schmatz, Joseph W Becker, Doris Cully, Sheo B Singh. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature. 2006 May; 441(7091):358-61. doi: 10.1038/nature04784. [PMID: 16710421]
  • C T Richardson, J H Walsh, M I Hicks. The effect of cimetidine, a new histamine H2-receptor antagonist, on meal-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcer. Gastroenterology. 1976 Jul; 71(1):19-23. doi: 10.1016/s0016-5085(76)80090-x. [PMID: 6359]