Angiotensin I (BioDeep_00001868632)
Main id: BioDeep_00000004502
代谢物信息卡片
Angiotensin I
化学式: C62H89N17O14 (1295.6774574)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)NC(CC(C)C)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1
描述信息
A ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from WikiPathways, COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Angiotensin I (human, mouse, rat) is the precursor to the vasoconstrictor peptide angiotensin II, cleaved by the angiotensin-converting enzyme (ACE).
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:2718
- KEGG: C00873
- PubChem: 3081372
- ChEMBL: CHEMBL262670
- MeSH: Angiotensin I
- CAS: 9041-90-1
- CAS: 484-42-4
- MetaboLights: MTBLC2718
- PubChem: 4130
- 3DMET: B04738
- NIKKAJI: J38.546H
- medchemexpress: HY-P1032
- KNApSAcK: 2718
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Longyue Zhou, Shankang Chen, Yuanyi Wei, Yihui Sun, Yifan Yang, Bingqi Lin, Yuhao Li, Chunxia Wang. Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.
European journal of pharmacology.
2024 Feb; ?(?):176365. doi:
10.1016/j.ejphar.2024.176365. [PMID: 38316247] - Na Li, Qiongyu Zhang, Shiyu Dai, Wenzhuo Rao, Haitao Shi, Li Ding, Meiling Hong. Angiotensin-(1-7) plays an important role in regulating spermatogenesis in Trachemys scripta elegans under salinity stress.
The Journal of experimental biology.
2024 Jan; 227(2):. doi:
10.1242/jeb.246742. [PMID: 38149682] - Dan Ye, Jiamin Liu, Long Lin, Pengwei Hou, Tianshun Feng, Shousen Wang. The Ang-(1-7)/MasR axis ameliorates neuroinflammation in hypothermic traumatic brain injury in mice by modulating phenotypic transformation of microglia.
PloS one.
2024; 19(5):e0303150. doi:
10.1371/journal.pone.0303150. [PMID: 38728304] - Jose A Godoy-Lugo, Dora A Mendez, Ruben Rodriguez, Akira Nishiyama, Daisuke Nakano, Jose G Soñanez-Organis, Rudy M Ortiz. Improved lipogenesis gene expression in liver is associated with elevated plasma angiotensin 1-7 after AT1 receptor blockade in insulin-resistant OLETF rats.
Molecular and cellular endocrinology.
2022 09; 555(?):111729. doi:
10.1016/j.mce.2022.111729. [PMID: 35921918] - Danielle Carvalho Oliveira Coutinho, Julliane V Joviano-Santos, Artur Santos-Miranda, Paulo Antônio Martins-Júnior, Analina Da Silva, Robson Augusto Souza Santos, Anderson José Ferreira. Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice.
Biochemical and biophysical research communications.
2022 09; 619(?):90-96. doi:
10.1016/j.bbrc.2022.06.014. [PMID: 35749941] - Xin-Yue Liu, Jing-Chao Su, Xin-Fang Zhang, Shui-Ying Xiang, Chun-Mei Yi, Yu-Wen Wang, Cai-Yun Wang, Zi-Bing Liu. [Electroacupuncture preconditioning improves pulmonary function via inhibiting inflammatory response and up-regulating expression of ACE2 and Ang (1-7) in lipopolysaccharide-induced acute lung injury rats].
Zhen ci yan jiu = Acupuncture research.
2022 Aug; 47(8):684-9. doi:
10.13702/j.1000-0607.20210979. [PMID: 36036101] - Elshymaa A Abdel-Hakeem, Sara Mohamed Naguib Abdel Hafez, Bothina A Kamel, Heba A Abdel-Hamid. Angiotensin 1-7 mitigates rhabdomyolysis induced renal injury in rats via modulation of TLR-4/NF-kB/iNOS and Nrf-2/heme‑oxygenase-1 signaling pathways.
Life sciences.
2022 Aug; 303(?):120678. doi:
10.1016/j.lfs.2022.120678. [PMID: 35654118] - Isabel Cristina Mallostro Emerich de Abreu, Raquel Cristina Melo Ferreira de Albuquerque, Ana Beatriz Pereira Brandão, Leticia Barssotti, Lívia Bruni de Souza, Fabiana Gomes Ferreira, Lilian Caroline Gonçalves de Oliveira, Rodrigo Yokota, Luiz Gustavo Sparvoli, Danielle da Silva Dias, Miguel Angel Castillo Salgado, Carla Taddei, Kátia De Angelis, Dulce Elena Casarini, Tatiana Sousa Cunha. Saccharomyces boulardii exerts renoprotection by modulating oxidative stress, renin angiotensin system and uropathogenic microbiota in a murine model of diabetes.
Life sciences.
2022 Jul; 301(?):120616. doi:
10.1016/j.lfs.2022.120616. [PMID: 35533758] - Andrzej K Ciechanowicz, Wen Xin Lay, Jefte Prado Paulino, Erika Suchocki, Susanne Leszczak, Christian Leszczak, Magdalena Kucia. Angiotensin 1-7 Stimulates Proliferation of Lung Bronchoalveolar Progenitors-Implications for SARS-CoV-2 Infection.
Cells.
2022 Jul; 11(13):. doi:
10.3390/cells11132102. [PMID: 35805187] - Asif Zaman, Anees A Banday. Angiotensin (1-7) protects against renal ischemia-reperfusion injury via regulating expression of NRF2 and microRNAs in Fisher 344 rats.
American journal of physiology. Renal physiology.
2022 07; 323(1):F33-F47. doi:
10.1152/ajprenal.00283.2021. [PMID: 35532070] - Xiu-Yun Chen, Cheng Lin, Guo-Ying Liu, Chun Pei, Gui-Qing Xu, Lie Gao, Shi-Zhong Wang, Yan-Xia Pan. ACE2 gene combined with exercise training attenuates central AngII/AT1 axis function and oxidative stress in a prehypertensive rat model.
Journal of applied physiology (Bethesda, Md. : 1985).
2022 06; 132(6):1460-1467. doi:
10.1152/japplphysiol.00459.2021. [PMID: 35546127] - Shivangi Gupta, Virendra Tiwari, Priya Tiwari, Parul, Akanksha Mishra, Kashif Hanif, Shubha Shukla. Angiotensin-Converting Enzyme 2 Activation Mitigates Behavioral Deficits and Neuroinflammatory Burden in 6-OHDA Induced Experimental Models of Parkinson's Disease.
ACS chemical neuroscience.
2022 05; 13(10):1491-1504. doi:
10.1021/acschemneuro.1c00797. [PMID: 35533351] - Yi Xu, Fang Zhang, Chunhui Li, Huiyao Hao, Yongmei Hao. Angiotensin-(1-7) improves diabetes mellitus-induced erectile dysfunction in rats by regulating nitric oxide synthase levels.
Peptides.
2022 05; 151(?):170765. doi:
10.1016/j.peptides.2022.170765. [PMID: 35181349] - George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier. Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases.
Molecules (Basel, Switzerland).
2022 Mar; 27(7):. doi:
10.3390/molecules27072048. [PMID: 35408447] - Mauro G Silva, Nora L Falcoff, Gerardo R Corradi, José Alfie, Rolando F Seguel, Gabriela C Tabaj, Laura I Iglesias, Myriam Nuñez, Gabriela R Guman, Mariela M Gironacci. Renin-angiotensin system blockade on angiotensin-converting enzyme 2 and TMPRSS2 in human type II pneumocytes.
Life sciences.
2022 Mar; 293(?):120324. doi:
10.1016/j.lfs.2022.120324. [PMID: 35032553] - Che Mohd Nasril Che Mohd Nassir, Mohd K I Zolkefley, Muhammad Danial Ramli, Haziq Hazman Norman, Hafizah Abdul Hamid, Muzaimi Mustapha. Neuroinflammation and COVID-19 Ischemic Stroke Recovery-Evolving Evidence for the Mediating Roles of the ACE2/Angiotensin-(1-7)/Mas Receptor Axis and NLRP3 Inflammasome.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23063085. [PMID: 35328506] - Marta Kuczeriszka, Leszek Dobrowolski, Agnieszka Walkowska, Iwona Baranowska, Joanna D Sitek, Elżbieta Kompanowska-Jezierska. Role of Ang1-7 in renal haemodynamics and excretion in streptozotocin diabetic rats.
Clinical and experimental pharmacology & physiology.
2022 03; 49(3):432-441. doi:
10.1111/1440-1681.13618. [PMID: 34870864] - Kaiming Wang, Mahmoud Gheblawi, Anish Nikhanj, Matt Munan, Erika MacIntyre, Conar O'Neil, Marko Poglitsch, Daniele Colombo, Franca Del Nonno, Zamaneh Kassiri, Wendy Sligl, Gavin Y Oudit. Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries.
Hypertension (Dallas, Tex. : 1979).
2022 02; 79(2):365-378. doi:
10.1161/hypertensionaha.121.18295. [PMID: 34844421] - Santoshi Sahu, C R Patil, Sachin Kumar, Subbu Apparsundaram, Ramesh K Goyal. Role of ACE2-Ang (1-7)-Mas axis in post-COVID-19 complications and its dietary modulation.
Molecular and cellular biochemistry.
2022 Jan; 477(1):225-240. doi:
10.1007/s11010-021-04275-2. [PMID: 34655418] - Hala Attia, Norah Albekairi, Layal Albdeirat, Arwa Soliman, Reem Rajab, Hend Alotaibi, Rehab Ali, Amira Badr. Chrysin Attenuates Fructose-Induced Nonalcoholic Fatty Liver in Rats via Antioxidant and Anti-Inflammatory Effects: The Role of Angiotensin-Converting Enzyme 2/Angiotensin (1-7)/Mas Receptor Axis.
Oxidative medicine and cellular longevity.
2022; 2022(?):9479456. doi:
10.1155/2022/9479456. [PMID: 35720181] - Flavia L Martins, Caio A M Tavares, Pamella A Malagrino, Thiago Rentz, Acaris Benetti, Thiago M S Rios, Gabriel M D Pereira, Bruno Caramelli, Samantha K Teixeira, José E Krieger, Adriana C C Girardi. Sex differences in the lung ACE/ACE2 balance in hypertensive rats.
Bioscience reports.
2021 12; 41(12):. doi:
10.1042/bsr20211201. [PMID: 34751382] - Ralmony de Alcantara Santos, Vinicius Guzzoni, Kleiton Augusto Santos Silva, Danielle Sanches Aragão, Rodolfo de Paula Vieira, Nádia Bertoncello, Nestor Schor, Flávio Aimbire, Dulce Elena Casarini, Tatiana Sousa Cunha. Resistance exercise shifts the balance of renin-angiotensin system toward ACE2/Ang 1-7 axis and reduces inflammation in the kidney of diabetic rats.
Life sciences.
2021 Dec; 287(?):120058. doi:
10.1016/j.lfs.2021.120058. [PMID: 34673118] - Elaine F Barry, Julie O'Neill, Mohammed H Abdulla, Edward J Johns. The renal excretory responses to acute renal interstitial angiotensin (1-7) infusion in anaesthetised spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology.
2021 12; 48(12):1674-1684. doi:
10.1111/1440-1681.13570. [PMID: 34375480] - Wei Hu, Wenchuang Gao, Jiayi Miao, Ziheng Xu, Lei Sun. Alamandine, a derivative of angiotensin-(1-7), alleviates sepsis-associated renal inflammation and apoptosis by inhibiting the PI3K/Ak and MAPK pathways.
Peptides.
2021 12; 146(?):170627. doi:
10.1016/j.peptides.2021.170627. [PMID: 34400214] - Omar Echeverría-Rodríguez, Beatriz Godínez-Chaparro, María V Gómez-García, Alfonso Mata-Bermúdez, Leonardo Del Valle-Mondragón, Itzell A Gallardo-Ortíz, Rafael Villalobos-Molina. Participation of angiotensin-(1-7) in exercise-induced analgesia in rats with neuropathic pain.
Peptides.
2021 12; 146(?):170670. doi:
10.1016/j.peptides.2021.170670. [PMID: 34634392] - Taylor Morganstein, Zahraa Haidar, Joshua Trivlidis, Ilan Azuelos, Megan Jiaxin Huang, David H Eidelman, Carolyn J Baglole. Involvement of the ACE2/Ang-(1-7)/MasR Axis in Pulmonary Fibrosis: Implications for COVID-19.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
10.3390/ijms222312955. [PMID: 34884756] - Tomas Rajtik, Peter Galis, Linda Bartosova, Ludovit Paulis, Eva Goncalvesova, Jan Klimas. Alternative RAS in Various Hypoxic Conditions: From Myocardial Infarction to COVID-19.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
10.3390/ijms222312800. [PMID: 34884604] - Masayoshi Kukida, Lei Cai, Dien Ye, Hisashi Sawada, Yuriko Katsumata, Michael K Franklin, Peter I Hecker, Kenneth S Campbell, A H Jan Danser, Adam E Mullick, Alan Daugherty, Ryan E Temel, Hong S Lu. Renal Angiotensinogen Is Predominantly Liver Derived in Nonhuman Primates.
Arteriosclerosis, thrombosis, and vascular biology.
2021 11; 41(11):2851-2853. doi:
10.1161/atvbaha.121.316590. [PMID: 34496634] - Oliver von Bohlen Und Halbach. The angiotensin converting enzyme 2 (ACE2) system in the brain: possible involvement in Neuro-Covid.
Histology and histopathology.
2021 Nov; 36(11):1125-1131. doi:
10.14670/hh-18-356. [PMID: 34142714] - Christina Hoyer-Kimura, John P Konhilas, Heidi M Mansour, Robin Polt, Kristian P Doyle, Dean Billheimer, Meredith Hay. Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia.
Journal of neuroinflammation.
2021 Oct; 18(1):236. doi:
10.1186/s12974-021-02281-1. [PMID: 34654436] - Juliana Fabiana Gregório, Giselle Santos Magalhães, Maria Glória Rodrigues-Machado, Kézia Emanoeli Ramos Gonzaga, Daisy Motta-Santos, Puebla Cassini-Vieira, Lucíola Silva Barcelos, Maria Aparecida Ribeiro Vieira, Robson Augusto Souza Santos, Maria Jose Campagnole-Santos. Angiotensin-(1-7)/Mas receptor modulates anti-inflammatory effects of exercise training in a model of chronic allergic lung inflammation.
Life sciences.
2021 Oct; 282(?):119792. doi:
10.1016/j.lfs.2021.119792. [PMID: 34229006] - Daniele T Alves, Luiz Felipe Mendes, Walkyria O Sampaio, Leda M C Coimbra-Campos, Maria Aparecida R Vieira, Anderson J Ferreira, Almir S Martins, Elena Popova, Mihail Todiras, Fatimunnisa Qadri, Natalia Alenina, Michael Bader, Robson A S Santos, Maria Jose Campagnole-Santos. Hemodynamic phenotyping of transgenic rats with ubiquitous expression of an angiotensin-(1-7)-producing fusion protein.
Clinical science (London, England : 1979).
2021 09; 135(18):2197-2216. doi:
10.1042/cs20210599. [PMID: 34494083] - Xuming Sun, Hao Wang, Hunter Hodge, Kendra N Wright, Sarfaraz Ahmad, Carlos M Ferrario, Leanne Groban. Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats.
Translational research : the journal of laboratory and clinical medicine.
2021 09; 235(?):62-76. doi:
10.1016/j.trsl.2021.04.004. [PMID: 33915312] - Mohammad Mahmudur Rahman, Maruf Hasan, Asif Ahmed. Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients.
Reviews in medical virology.
2021 09; 31(5):1-12. doi:
10.1002/rmv.2213. [PMID: 33426683] - Fernanda Ribeiro Marins, Aline Cristina Oliveira, Fatimunnisa Qadri, Daisy Motta-Santos, Natalia Alenina, Michael Bader, Marco Antonio Peliky Fontes, Robson Augusto Souza Santos. Alamandine but not angiotensin-(1-7) produces cardiovascular effects at the rostral insular cortex.
American journal of physiology. Regulatory, integrative and comparative physiology.
2021 09; 321(3):R513-R521. doi:
10.1152/ajpregu.00308.2020. [PMID: 34346721] - Mariele Montanari, Barbara Canonico, Evelyn Nordi, Daniela Vandini, Simone Barocci, Serena Benedetti, Eugenio Carlotti, Loris Zamai. Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?.
Advances in biological regulation.
2021 08; 81(?):100820. doi:
10.1016/j.jbior.2021.100820. [PMID: 34419773] - Li Zhu, Zhen Liu, Li-Ping Huang, Hou-Rong Zhou, Yu Cao, Xue-Ping Yang, Bing-Jin Wang, Zi-Li Yang, Jing Chen. Angiotensin (1-7) Alleviates Postresuscitation Myocardial Dysfunction by Suppressing Oxidative Stress Through the Phosphoinositide 3-Kinase, Protein Kinase B, and Endothelial Nitric Oxide Synthase Signaling Pathway.
Journal of cardiovascular pharmacology.
2021 07; 78(1):e65-e76. doi:
10.1097/fjc.0000000000001037. [PMID: 33929390] - Xuefei Wei, Yanyang Wang, Wenbo Zhu, Jingjing Li, Lu Peng, Zhiwei Gao, Bing Bai. Stable Plasma Sample Storage in Acetonitrile for Angiotensin and Aldosterone Analysis.
Laboratory medicine.
2021 Jul; 52(4):352-356. doi:
10.1093/labmed/lmaa079. [PMID: 33098298] - D Clark Files, Kevin W Gibbs, Christopher L Schaich, Sean P Collins, TanYa M Gwathmey, Jonathan D Casey, Wesley H Self, Mark C Chappell. A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure.
American journal of physiology. Lung cellular and molecular physiology.
2021 07; 321(1):L213-L218. doi:
10.1152/ajplung.00129.2021. [PMID: 34009036] - Chengliang Wang, Liying Ren, Shankang Chen, Huihui Zheng, Yifan Yang, Tieguang Gu, Yuhao Li, Chunxia Wang. Longdan Xiegan Tang attenuates liver injury and hepatic insulin resistance by regulating the angiotensin-converting enzyme 2/Ang (1-7)/Mas axis-mediated anti-inflammatory pathway in rats.
Journal of ethnopharmacology.
2021 Jun; 274(?):114072. doi:
10.1016/j.jep.2021.114072. [PMID: 33781876] - Maha M Abdel-Fattah, Abdel Nasser A M Elgendy, Wafaa R Mohamed. Xanthenone, ACE2 activator, counteracted gentamicin-induced nephrotoxicity in rats: Impact on oxidative stress and ACE2/Ang-(1-7) signaling.
Life sciences.
2021 Jun; 275(?):119387. doi:
10.1016/j.lfs.2021.119387. [PMID: 33774027] - Elena Cantero-Navarro, Beatriz Fernández-Fernández, Adrian M Ramos, Sandra Rayego-Mateos, Raúl R Rodrigues-Diez, María Dolores Sánchez-Niño, Ana B Sanz, Marta Ruiz-Ortega, Alberto Ortiz. Renin-angiotensin system and inflammation update.
Molecular and cellular endocrinology.
2021 06; 529(?):111254. doi:
10.1016/j.mce.2021.111254. [PMID: 33798633] - Jorge F Giani, Luciana C Veiras, Justin Z Y Shen, Ellen A Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A Gonzalez-Villalobos, Kenneth E Bernstein. Novel roles of the renal angiotensin-converting enzyme.
Molecular and cellular endocrinology.
2021 06; 529(?):111257. doi:
10.1016/j.mce.2021.111257. [PMID: 33781839] - Carlos M Ferrario, Leanne Groban, Hao Wang, Che Ping Cheng, Jessica L VonCannon, Kendra N Wright, Xuming Sun, Sarfaraz Ahmad. The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system.
Molecular and cellular endocrinology.
2021 06; 529(?):111119. doi:
10.1016/j.mce.2020.111119. [PMID: 33309638] - Fitra Rianto, Thien Hoang, Ritika Revoori, Matthew A Sparks. Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease.
Molecular and cellular endocrinology.
2021 06; 529(?):111259. doi:
10.1016/j.mce.2021.111259. [PMID: 33781840] - María José Soler, Daniel Batlle. Revisiting the renin-angiotensin system.
Molecular and cellular endocrinology.
2021 06; 529(?):111268. doi:
10.1016/j.mce.2021.111268. [PMID: 33819521] - Aneta Stachowicz, Anna Wiśniewska, Katarzyna Kuś, Magdalena Białas, Magdalena Łomnicka, Justyna Totoń-Żurańska, Anna Kiepura, Kamila Stachyra, Maciej Suski, Beata Bujak-Giżycka, Jacek Jawień, Rafał Olszanecki. Diminazene Aceturate Stabilizes Atherosclerotic Plaque and Attenuates Hepatic Steatosis in apoE-Knockout Mice by Influencing Macrophages Polarization and Taurine Biosynthesis.
International journal of molecular sciences.
2021 May; 22(11):. doi:
10.3390/ijms22115861. [PMID: 34070749] - Ali Aghazadeh-Habashi, Sana Khajehpour. Improved pharmacokinetics and bone tissue accumulation of Angiotensin-(1-7) peptide through bisphosphonate conjugation.
Amino acids.
2021 May; 53(5):653-664. doi:
10.1007/s00726-021-02972-2. [PMID: 33791863] - Veselina V Uzunova, Angel Todev, Jacqueline Zarkos, Daniel Addai, Julian Ananiev, Pavel Rashev, Radostina Alexandrova, Anna Tolekova. Strengthening CoViD-19 therapy via combinations of RAS modulators.
Medical hypotheses.
2021 May; 150(?):110571. doi:
10.1016/j.mehy.2021.110571. [PMID: 33799164] - Hiroki Nakano, Kazuki Shiina, Hirofumi Tomiyama. Cardiovascular Outcomes in the Acute Phase of COVID-19.
International journal of molecular sciences.
2021 Apr; 22(8):. doi:
10.3390/ijms22084071. [PMID: 33920790] - Ranjana Tripathi, Ryan D Sullivan, Tai-Hwang M Fan, Radhika M Mehta, Inna P Gladysheva, Guy L Reed. A Low-Sodium Diet Boosts Ang (1-7) Production and NO-cGMP Bioavailability to Reduce Edema and Enhance Survival in Experimental Heart Failure.
International journal of molecular sciences.
2021 Apr; 22(8):. doi:
10.3390/ijms22084035. [PMID: 33919841] - Julia Schrankl, Michaela Fuchs, Katharina Broeker, Christoph Daniel, Armin Kurtz, Charlotte Wagner. Localization of angiotensin II type 1 receptor gene expression in rodent and human kidneys.
American journal of physiology. Renal physiology.
2021 04; 320(4):F644-F653. doi:
10.1152/ajprenal.00550.2020. [PMID: 33615887] - Alexander Kutz, Anna Conen, Claudia Gregoriano, Sebastian Haubitz, Daniel Koch, Oliver Domenig, Luca Bernasconi, Beat Mueller, Philipp Schuetz. Renin-angiotensin-aldosterone system peptide profiles in patients with COVID-19.
European journal of endocrinology.
2021 Apr; 184(4):543-552. doi:
10.1530/eje-20-1445. [PMID: 33539316] - Wessel L du Toit, Aletta E Schutte, Lebo F Gafane-Matemane, Ruan Kruger, Catharina M C Mels. The renin-angiotensin-system and left ventricular mass in young adults: the African-PREDICT study.
Blood pressure.
2021 04; 30(2):98-107. doi:
10.1080/08037051.2020.1831902. [PMID: 33084438] - Mark C Chappell, Nancy T Pirro, Andrew M South, TanYa M Gwathmey. Concerns on the Specificity of Commercial ELISAs for the Measurement of Angiotensin (1-7) and Angiotensin II in Human Plasma.
Hypertension (Dallas, Tex. : 1979).
2021 03; 77(3):e29-e31. doi:
10.1161/hypertensionaha.120.16724. [PMID: 33399002] - Davide Eleuteri, Luca Montini, Salvatore Lucio Cutuli, Cristina Rossi, Francesca Alcaro, Massimo Antonelli. Renin-angiotensin system dysregulation in critically ill patients with acute respiratory distress syndrome due to COVID-19: a preliminary report.
Critical care (London, England).
2021 03; 25(1):91. doi:
10.1186/s13054-021-03507-7. [PMID: 33648544] - Hugo Luca Corrêa, Rodrigo Vanerson Passos Neves, Lysleine Alves Deus, Beatriz Carneiro Habbema Maia, Athila Teles Maya, Carmen Tzanno-Martins, Michel Kendy Souza, José Adeirton Bezerra Silva, Anderson Sola Haro, Fernando Costa, Milton Rocha Moraes, Herbert Gustavo Simões, Jonato Prestes, Whitley Stone, Thiago Santos Rosa. Low-load resistance training with blood flow restriction prevent renal function decline: The role of the redox balance, angiotensin 1-7 and vasopressin✰,✰✰.
Physiology & behavior.
2021 03; 230(?):113295. doi:
10.1016/j.physbeh.2020.113295. [PMID: 33340514] - Sven Kurbel. The renin-angiotensin system in COVID-19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients?.
BioEssays : news and reviews in molecular, cellular and developmental biology.
2021 03; 43(3):e2000112. doi:
10.1002/bies.202000112. [PMID: 33336824] - Juan Liu, Yan Liu, Wenyou Pan, Yongsheng Li. Angiotensin-(1-7) attenuates collagen-induced arthritis via inhibiting oxidative stress in rats.
Amino acids.
2021 Feb; 53(2):171-181. doi:
10.1007/s00726-020-02935-z. [PMID: 33398523] - Brandon M Henry, Justin L Benoit, Brandon A Berger, Christina Pulvino, Carl J Lavie, Giuseppe Lippi, Stefanie W Benoit. Coronavirus disease 2019 is associated with low circulating plasma levels of angiotensin 1 and angiotensin 1,7.
Journal of medical virology.
2021 02; 93(2):678-680. doi:
10.1002/jmv.26479. [PMID: 32880990] - Pawel Namsolleck, Alan Richardson, Gert N Moll, Axel Mescheder. LP2, the first lanthipeptide GPCR agonist in a human pharmacokinetics and safety study.
Peptides.
2021 02; 136(?):170468. doi:
10.1016/j.peptides.2020.170468. [PMID: 33253776] - Jithin Kuriakose, Augusto C Montezano, Rhian M Touyz. ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease.
Clinical science (London, England : 1979).
2021 01; 135(2):387-407. doi:
10.1042/cs20200480. [PMID: 33511992] - Prateek Khanna, Hong Jie Soh, Chun-Hau Chen, Ruchi Saxena, Seema Amin, Maura Naughton, Patrick Neset Joslin, Andrew Moore, Ziad Bakouny, Carol O'Callaghan, Paul Catalano, Sabina Signoretti, Rana McKay, Toni K Choueiri, Manoj Bhasin, Thomas Walther, Rupal S Bhatt. ACE2 abrogates tumor resistance to VEGFR inhibitors suggesting angiotensin-(1-7) as a therapy for clear cell renal cell carcinoma.
Science translational medicine.
2021 01; 13(577):. doi:
10.1126/scitranslmed.abc0170. [PMID: 33472951] - Hsin-Jung Tsai, Chih-Chin Shih, Kuang-Yi Chang, Mei-Hui Liao, Wen-Jinn Liaw, Chin-Chen Wu, Cheng-Ming Tsao. Angiotensin-(1-7) treatment blocks lipopolysaccharide-induced organ damage, platelet dysfunction, and IL-6 and nitric oxide production in rats.
Scientific reports.
2021 01; 11(1):610. doi:
10.1038/s41598-020-79902-x. [PMID: 33436885] - Lílian Fernanda Pacheco, Carlos Henrique de Castro, João Batista Rodrigues Dutra, Ruy de Souza Lino Junior, Patrícia Maria Ferreira, Robson Augusto Souza Dos Santos, Cirano José Ulhoa. Oral Treatment with Angiotensin-(1-7) Attenuates the Kidney Injury Induced by Gentamicin in Wistar Rats.
Protein and peptide letters.
2021; 28(12):1425-1433. doi:
10.2174/0929866528666211118091810. [PMID: 34792000] - Amanda Machado, Janaína Ribeiro Oliveira, Deborah de F Lelis, Victor Hugo D Guimarães, Alfredo M B de Paula, Andre L S Guimarães, Igor V Brandi, Bruna Mara A de Carvalho, Diego Vicente da Costa, Cláudia Regina Vieira, Ulisses Alves Pereira, Theles de Oliveira Costa, João M O Andrade, Robson Augusto Souza Santos, Sérgio H S Santos. Oral Angiotensin-(1-7) Peptide Modulates Intestinal Microbiota Improving Metabolic Profile in Obese Mice.
Protein and peptide letters.
2021; 28(10):1127-1137. doi:
10.2174/0929866528666210816115645. [PMID: 34397321] - A V Morgun, V V Salmin, E B Boytsova, O L Lopatina, A B Salmina. Molecular Mechanisms of Proteins - Targets for SARS-CoV-2 (Review).
Sovremennye tekhnologii v meditsine.
2021; 12(6):98-108. doi:
10.17691/stm2020.12.6.11. [PMID: 34796023] - Ava Soltani Hekmat, Kazem Javanmardi. Alamandine: Potential Protective Effects in SARS-CoV-2 Patients.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2021; 2021(?):6824259. doi:
10.1155/2021/6824259. [PMID: 34853605] - Lasti Erfinanda, Krishnan Ravindran, Franziska Kohse, Kathleen Gallo, Robert Preissner, Thomas Walther, Wolfgang M Kuebler. Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
The European respiratory journal.
2021 01; 57(1):. doi:
10.1183/13993003.00921-2020. [PMID: 32764118] - Gaetano Alfano, Giovanni Guaraldi, Francesco Fontana, Annachiara Ferrari, Riccardo Magistroni, Cristina Mussini, Gianni Cappelli. The Role of the Renin-Angiotensin System in Severe Acute Respiratory Syndrome-CoV-2 Infection.
Blood purification.
2021; 50(2):263-267. doi:
10.1159/000507914. [PMID: 32344395] - Ikram Omar Osman, Cléa Melenotte, Philippe Brouqui, Matthieu Million, Jean-Christophe Lagier, Philippe Parola, Andréas Stein, Bernard La Scola, Line Meddeb, Jean-Louis Mege, Didier Raoult, Christian A Devaux. Expression of ACE2, Soluble ACE2, Angiotensin I, Angiotensin II and Angiotensin-(1-7) Is Modulated in COVID-19 Patients.
Frontiers in immunology.
2021; 12(?):625732. doi:
10.3389/fimmu.2021.625732. [PMID: 34194422] - Eliza M Melo, Juliana Del Sarto, Juliana P Vago, Luciana P Tavares, Flávia Rago, Ana Paula F Gonçalves, Marina G Machado, Irene Aranda-Pardos, Bruno V S Valiate, Geovanni D Cassali, Vanessa Pinho, Lirlândia P Sousa, Noelia A-Gonzalez, Maria José Campagnole-Santos, Michael Bader, Robson A S Santos, Alexandre V Machado, Stephan Ludwig, Mauro M Teixeira. Relevance of angiotensin-(1-7) and its receptor Mas in pneumonia caused by influenza virus and post-influenza pneumococcal infection.
Pharmacological research.
2021 01; 163(?):105292. doi:
10.1016/j.phrs.2020.105292. [PMID: 33171305] - Jingjing Li, Ruifang Zhu, Yalin Liu, Jinhui Yang, Xiaoyan Wang, Lisha Geng, Tingting Xu, Junhua He. Angiotensin-(1-7) Improves Islet Function in a Rat Model of Streptozotocin- Induced Diabetes Mellitus by Up-Regulating the Expression of Pdx1/Glut2.
Endocrine, metabolic & immune disorders drug targets.
2021; 21(1):156-162. doi:
10.2174/1871530320666200717161538. [PMID: 32679026] - Nan-Nan Sha, Jia-Li Zhang, Christina Chui-Wa Poon, Wen-Xiong Li, Yue Li, Yi-Fei Wang, Wei Shi, Fu-Hui Lin, Wen-Ping Lin, Yong-Jun Wang, Yan Zhang. Differential responses of bone to angiotensin II and angiotensin(1-7): beneficial effects of ANG(1-7) on bone with exposure to high glucose.
American journal of physiology. Endocrinology and metabolism.
2021 01; 320(1):E55-E70. doi:
10.1152/ajpendo.00158.2020. [PMID: 33103451] - L Saba, C Gerosa, D Fanni, F Marongiu, G La Nasa, G Caocci, D Barcellona, A Balestrieri, F Coghe, G Orru, P Coni, M Piras, F Ledda, J S Suri, A Ronchi, F D'Andrea, R Cau, M Castagnola, G Faa. Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review.
European review for medical and pharmacological sciences.
2020 12; 24(23):12609-12622. doi:
10.26355/eurrev_202012_24058. [PMID: 33336781] - Li-Ni Song, Jing-Yi Liu, Ting-Ting Shi, Yi-Chen Zhang, Zhong Xin, Xi Cao, Jin-Kui Yang. Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by acting through its receptor Mas to regulate hepatic mitochondrial function and glycolipid metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 12; 34(12):16291-16306. doi:
10.1096/fj.202001639r. [PMID: 33078906] - Sanket Patel, Tahir Hussain. Synergism between Angiotensin receptors ligands: Role of Angiotensin-(1-7) in modulating AT2 R agonist response on nitric oxide in kidney cells.
Pharmacology research & perspectives.
2020 12; 8(6):e00667. doi:
10.1002/prp2.667. [PMID: 33197136] - Andrew M South, Hossam A Shaltout, Patricia A Nixon, Debra I Diz, Elizabeth T Jensen, T Michael O'Shea, Mark C Chappell, Lisa K Washburn. Association of circulating uric acid and angiotensin-(1-7) in relation to higher blood pressure in adolescents and the influence of preterm birth.
Journal of human hypertension.
2020 12; 34(12):818-825. doi:
10.1038/s41371-020-0335-3. [PMID: 32346123] - Fabrizio Pucci, Philippe Bogaerts, Marianne Rooman. Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System.
Viruses.
2020 11; 12(12):. doi:
10.3390/v12121367. [PMID: 33265982] - Koichi Yamamoto, Hikari Takeshita, Hiromi Rakugi. ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19.
Clinical science (London, England : 1979).
2020 11; 134(22):3047-3062. doi:
10.1042/cs20200486. [PMID: 33231620] - Bogusz Trojanowicz, Christof Ulrich, Matthias Girndt. Uremic Apelin and Leucocytic Angiotensin-Converting Enzyme 2 in CKD Patients.
Toxins.
2020 11; 12(12):. doi:
10.3390/toxins12120742. [PMID: 33255902] - Nisha Sharma, Anil Bhanudas Gaikwad. Ameliorative effect of AT2R and ACE2 activation on ischemic renal injury associated cardiac and hepatic dysfunction.
Environmental toxicology and pharmacology.
2020 Nov; 80(?):103501. doi:
10.1016/j.etap.2020.103501. [PMID: 32979558] - Rosemary Gan, Nicholas P Rosoman, David J E Henshaw, Euan P Noble, Peter Georgius, Nigel Sommerfeld. COVID-19 as a viral functional ACE2 deficiency disorder with ACE2 related multi-organ disease.
Medical hypotheses.
2020 Nov; 144(?):110024. doi:
10.1016/j.mehy.2020.110024. [PMID: 32758871] - Xihao Du, Xuejiao Zeng, Jia Zhang, Kun Pan, Liying Song, Ji Zhou, Li Zhou, Yuquan Xie, Qinghua Sun, Wenzhen Ge, Renjie Chen, Jinzhuo Zhao, Haidong Kan. Ambient fine particulate matter induced the elevation of blood pressure through ACE2/Ang(1-7) pathway: The evidence from urine metabolites.
Ecotoxicology and environmental safety.
2020 Oct; 203(?):111044. doi:
10.1016/j.ecoenv.2020.111044. [PMID: 32888613] - Wenzheng Han, Ming Wang, Xinrong Zhai, Qian Gan, Shaofeng Guan, Xinkai Qu. Chemical renal denervation-induced upregulation of the ACE2/Ang (1-7)/Mas axis attenuates blood pressure elevation in spontaneously hypertensive rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2020 Oct; 42(7):661-668. doi:
10.1080/10641963.2020.1772812. [PMID: 32476477] - Laís Bhering Martins, Aline Silva de Miranda, Ana Maria Dos Santos Rodrigues, Jenneffer Rayane Braga Tibaes, Rodrigo Santiago Gomez, Adaliene Versiani Matos Ferreira, Antonio Lúcio Teixeira. Altered Serum Levels of Renin-Angiotensin System Markers in Migraine.
Headache.
2020 Oct; 60(9):1995-2002. doi:
10.1111/head.13949. [PMID: 32880958] - Haoyi Zheng, J Jane Cao. Angiotensin-Converting Enzyme Gene Polymorphism and Severe Lung Injury in Patients with Coronavirus Disease 2019.
The American journal of pathology.
2020 10; 190(10):2013-2017. doi:
10.1016/j.ajpath.2020.07.009. [PMID: 32735889] - Hongguan Zhang, Yude Liu, Lian Rao, Yanyou Cen, Kaili Cheng. Upregulation of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis by a combination of Yinyanghuo (Herba Epimedii Brevicornus) and Cheqianzi (Semen Plantaginis) improves erectile function in spontaneously hypertensive rats.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2020 10; 40(5):836-844. doi:
10.19852/j.cnki.jtcm.2020.05.014. [PMID: 33000585] - Maira Soto, Gere diZerega, Kathleen E Rodgers. Countermeasure and therapeutic: A(1-7) to treat acute respiratory distress syndrome due to COVID-19 infection.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2020 Oct; 21(4):1470320320972018. doi:
10.1177/1470320320972018. [PMID: 33169644] - Thomas W Buford, Yi Sun, Lisa M Roberts, Anisha Banerjee, Sujitha Peramsetty, Anthony Knighton, Amrisha Verma, Drake Morgan, Gonzalo E Torres, Qiuhong Li, Christy S Carter. Angiotensin (1-7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older rats.
GeroScience.
2020 10; 42(5):1307-1321. doi:
10.1007/s11357-020-00196-y. [PMID: 32451847] - Flavia M Cerniello, Mauro G Silva, Oscar A Carretero, Mariela M Gironacci. Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats.
Cardiovascular research.
2020 10; 116(12):1995-2008. doi:
10.1093/cvr/cvz332. [PMID: 31825460] - Francisco Pérez-Vizcaíno. Lung ACE2 and ADAM17 in pulmonary arterial hypertension: Implications for COVID-19?.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2020 10; 39(10):1167-1169. doi:
10.1016/j.healun.2020.07.003. [PMID: 32762876] - Antonis S Manolis, Theodora A Manolis, Antonis A Manolis, Helen Melita. The Controversy of Renin-Angiotensin-System Blocker Facilitation Versus Countering COVID-19 Infection.
Journal of cardiovascular pharmacology.
2020 10; 76(4):397-406. doi:
10.1097/fjc.0000000000000894. [PMID: 32769760] - Daisy Motta-Santos, Robson A S Santos, Sérgio Henrique Sousa Santos. Angiotensin-(1-7) and Obesity: Role in Cardiorespiratory Fitness and COVID-19 Implications.
Obesity (Silver Spring, Md.).
2020 10; 28(10):1786. doi:
10.1002/oby.22949. [PMID: 32621779] - Thaiany G Souza-Silva, Diego F Vilas-Boas, Elda Gonçalves-Santos, Ana Lia Mazzeti, Ivo S Caldas, Reggiani V Gonçalves, Lívia F Diniz, Rômulo D Novaes. Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study.
Life sciences.
2020 Sep; 257(?):118067. doi:
10.1016/j.lfs.2020.118067. [PMID: 32652140] - Kevin S Heffernan, Sae Young Jae. Exercise as medicine for COVID-19: An ACE in the hole?.
Medical hypotheses.
2020 09; 142(?):109835. doi:
10.1016/j.mehy.2020.109835. [PMID: 32428811] - Wenxiu Han, Zhijie Wei, Ruili Dang, Yujin Guo, Hailiang Zhang, Chunmei Geng, Changshui Wang, Qingyan Feng, Pei Jiang. Angiotensin-Ⅱ and angiotensin-(1-7) imbalance affects comorbidity of depression and coronary heart disease.
Peptides.
2020 09; 131(?):170353. doi:
10.1016/j.peptides.2020.170353. [PMID: 32599080] - Daniel L Edmonston, Andrew M South, Matthew A Sparks, Jordana B Cohen. Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.
Advances in chronic kidney disease.
2020 09; 27(5):404-411. doi:
10.1053/j.ackd.2020.07.002. [PMID: 33308506] - Lirlândia P Sousa, Vanessa Pinho, Mauro M Teixeira. Harnessing inflammation resolving-based therapeutic agents to treat pulmonary viral infections: What can the future offer to COVID-19?.
British journal of pharmacology.
2020 09; 177(17):3898-3904. doi:
10.1111/bph.15164. [PMID: 32557557]