bis(2,4-dibromophenyl) ether (BioDeep_00001868467)
Main id: BioDeep_00000012138
代谢物信息卡片
2,2,4,4-Tetrabromodiphenyl ether
化学式: C12H6Br4O (481.7152066)
中文名称: 2244-四溴联苯醚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1Br)Br)OC2=C(C=C(C=C2)Br)Br
InChI: InChI=1S/C12H6Br4O/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6H
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:81584
- KEGG: C18205
- PubChem: 95170
- ChEMBL: CHEMBL229760
- CAS: 5436-43-1
- PubChem: 96024420
- NIKKAJI: J151.752J
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Beibei Xia, Rongfei Yu, Junxiong Liu, Dongmeng Liu, Shasha Li, Liu Yang, Nan Liu, Bosen Liang, Jiajing Zeng, Jinhua Wei, Guimiao Lin. BDE-47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPARα-induced abnormal fatty acid oxidation in BALB/c mice.
Toxicology letters.
2024 Jan; 391(?):100-110. doi:
10.1016/j.toxlet.2023.11.006. [PMID: 38040069] - Guoguang Wang, Xu Wang, Yu Liu, Shuaihao Liu, Ziao Xing, Pengxu Guo, Chuanyuan Li, Haixia Wang. Novel Insights into Uptake, Translocation, and Transformation Mechanisms of 2,2',4,4'-Tetra Brominated Diphenyl Ether (BDE-47) in Wheat (Triticum aestivum L.): Implication by Compound-Specific Stable Isotope and Transcriptome Analysis.
Environmental science & technology.
2023 10; 57(40):15266-15276. doi:
10.1021/acs.est.3c04898. [PMID: 37773091] - Yating Sheng, Chengpeng Zhang, Dandan Cai, Guangtao Xu, Shipiao Chen, Weijian Li, Jingjian Dong, Bin Shen, Jie Tang, Long Xu. 2,2',4,4'-Tetrabromodiphenyl ether and cadmium co-exposure activates aryl hydrocarbon receptor pathway to induce ROS and GSDME-dependent pyroptosis in renal tubular epithelial cells.
Environmental toxicology.
2023 Sep; ?(?):. doi:
10.1002/tox.23957. [PMID: 37705237] - Wojciech Jerzy Pietron, Pawel Malagocki, Malgorzata Warenik-Bany. Feed as a source of polybrominated diphenyl ethers (PBDEs).
Environmental research.
2023 08; 231(Pt 3):116257. doi:
10.1016/j.envres.2023.116257. [PMID: 37245570] - Zixuan Li, Bernard Robaire, Barbara F Hales. The Organophosphate Esters Used as Flame Retardants and Plasticizers affect H295R Adrenal Cell Phenotypes and Functions.
Endocrinology.
2023 Jul; ?(?):. doi:
10.1210/endocr/bqad119. [PMID: 37522340] - Jie Tang, Nenghua Zhang, Shipiao Chen, Kewei Hu, Yintao Li, Yipeng Fang, Zhenqiang Wu, Yi Zhang, Long Xu. Cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) co-exposure induces acute kidney injury through oxidative stress and RIPK3-dependent necroptosis.
Environmental toxicology.
2023 Jun; ?(?):. doi:
10.1002/tox.23869. [PMID: 37357614] - Sobhy M Yakout, Ahmed M Isa, Amel A El-Sayed, Ibrahim M Aziz. Levels and profiles of pentabromodiphenyl ether contaminants in human breast milk from Riyadh, Saudi Arabia.
Saudi medical journal.
2023 May; 44(5):450-455. doi:
10.15537/smj.2023.44.5.20220902. [PMID: 37182922] - Bei Li, Juanheng Wang, Guocheng Hu, Xiaolin Liu, Yunjiang Yu, Dan Cai, Ping Ding, Xin Li, Lijuan Zhang, Chongdan Xiang. Bioaccumulation Behavior and Human Health Risk of Polybrominated Diphenyl Ethers in a Freshwater Food Web of Typical Shallow Lake, Yangtze River Delta.
International journal of environmental research and public health.
2023 02; 20(3):. doi:
10.3390/ijerph20032671. [PMID: 36768037] - Veronica van der Schyff, Jiři Kalina, Eva Govarts, Liese Gilles, Greet Schoeters, Argelia Castaño, Marta Esteban-López, Jiři Kohoutek, Petr Kukučka, Adrian Covaci, Gudrun Koppen, Lenka Andrýsková, Pavel Piler, Jana Klánová, Tina Kold Jensen, Loic Rambaud, Margaux Riou, Marja Lamoree, Marike Kolossa-Gehring, Nina Vogel, Till Weber, Thomas Göen, Catherine Gabriel, Dimosthenis A Sarigiannis, Amrit Kaur Sakhi, Line Småstuen Haug, Lubica Palkovicova Murinova, Lucia Fabelova, Janja Snoj Tratnik, Darja Mazej, Lisa Melymuk. Exposure to flame retardants in European children - Results from the HBM4EU aligned studies.
International journal of hygiene and environmental health.
2023 01; 247(?):114070. doi:
10.1016/j.ijheh.2022.114070. [PMID: 36442457] - Marialuisa Casella, Gabriele Lori, Lucia Coppola, Cinzia La Rocca, Sabrina Tait. BDE-47, -99, -209 and Their Ternary Mixture Disrupt Glucose and Lipid Metabolism of Hepg2 Cells at Dietary Relevant Concentrations: Mechanistic Insight through Integrated Transcriptomics and Proteomics Analysis.
International journal of molecular sciences.
2022 Nov; 23(22):. doi:
10.3390/ijms232214465. [PMID: 36430946] - Weike Shaoyong, Yalin Liu, Bocheng Xu, Bo Pan, Xinuer Xianmi, Yizhen Wang, Mingliang Jin. Exposure to BDE-47 causes female infertility risk and induces oxidative stress and lipotoxicity-mediated ovarian hormone secretion disruption in mice.
The Science of the total environment.
2022 Oct; 842(?):156885. doi:
10.1016/j.scitotenv.2022.156885. [PMID: 35752246] - Jingjing Sha, Xiaoyang Jian, Qingyun Yu, Miao Wei, Xiaoyu Li, Ludan Zhao, Yanping Qi. Exposure to BDE-47 and BDE-209 impaired antioxidative defense mechanisms in Brachionus plicatilis.
Chemosphere.
2022 Sep; 303(Pt 2):135152. doi:
10.1016/j.chemosphere.2022.135152. [PMID: 35649441] - Zaoling Liu, Menglin Wang, Yong Fan, Jiasui Wang, Shurui Jiang, Haiqiemuhan Abudureman. Bidirectional regulation of BDE-47 on 3T3-L1 cell differentiation based on a restricted cubic spline model.
Toxicology and industrial health.
2022 Aug; 38(8):481-492. doi:
10.1177/07482337221100488. [PMID: 35921494] - Yi Zhang, Bo Hu, Xiaolan Qian, Guangtao Xu, Xin Jin, Deqing Chen, Jie Tang, Long Xu. Transcriptomics-based analysis of co-exposure of cadmium (Cd) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) indicates mitochondrial dysfunction induces NLRP3 inflammasome and inflammatory cell death in renal tubular epithelial cells.
Ecotoxicology and environmental safety.
2022 Aug; 241(?):113790. doi:
10.1016/j.ecoenv.2022.113790. [PMID: 35753275] - Qidong Ren, Xinni Xie, Chuanfang Zhao, Qing Wen, Ruiying Pan, Yuguo Du. 2,2',4,4'-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPARγ Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation.
Chemical research in toxicology.
2022 06; 35(6):1023-1035. doi:
10.1021/acs.chemrestox.2c00043. [PMID: 35575305] - Haixia Qiu, Hui Gao, Fangjin Yu, Boya Xiao, Xiaoning Li, Bo Cai, Long Ge, Yinting Lu, Zhengyi Wan, Yafei Wang, Tao Xia, Aiguo Wang, Shun Zhang. Perinatal exposure to low-level PBDE-47 programs gut microbiota, host metabolism and neurobehavior in adult rats: An integrated analysis.
The Science of the total environment.
2022 Jun; 825(?):154150. doi:
10.1016/j.scitotenv.2022.154150. [PMID: 35218822] - Dalia A Mandour, Asmaa M Tolba, Emtethal M El-Bestawy. Maternal exposure to the environmental pollutant 'BDE-47' impairs the postnatal development of rat cerebellar cortex by modulating neuronal proliferation, synaptogenesis, NGF and BDNF pathways.
Histology and histopathology.
2022 Jun; 37(6):555-573. doi:
10.14670/hh-18-441. [PMID: 35191013] - Peixian Luan, Haoran Zhang, Xiaoming Chen, Yue Zhu, Guo Hu, Jingzeng Cai, Ziwei Zhang. Melatonin relieves 2,2,4,4-tetrabromodiphenyl ether (BDE-47)-induced apoptosis and mitochondrial dysfunction through the AMPK-Sirt1-PGC-1α axis in fish kidney cells (CIK).
Ecotoxicology and environmental safety.
2022 Mar; 232(?):113276. doi:
10.1016/j.ecoenv.2022.113276. [PMID: 35123185] - Chunxue Yang, Juntong Wei, Guodong Cao, Zongwei Cai. Lipid metabolism dysfunction and toxicity of BDE-47 exposure in white adipose tissue revealed by the integration of lipidomics and metabolomics.
The Science of the total environment.
2022 Feb; 806(Pt 1):150350. doi:
10.1016/j.scitotenv.2021.150350. [PMID: 34555606] - Benjamin M Dungar, Chad D Schupbach, Jessie R Jacobson, Phillip G Kopf. Adrenal Corticosteroid Perturbation by the Endocrine Disruptor BDE-47 in a Human Adrenocortical Cell Line and Male Rats.
Endocrinology.
2021 11; 162(11):. doi:
10.1210/endocr/bqab160. [PMID: 34370853] - Hui Gao, Xueyan Wan, Boya Xiao, Kaichao Yang, Yafei Wang, Cheng Zhang, Pei Li, Luming Liu, Tao Xia, Aiguo Wang, Shun Zhang. Impacts of PBDE-47 exposure before, during and after pregnancy on the maternal gut microbiome and its association with host metabolism.
Ecotoxicology and environmental safety.
2021 Oct; 222(?):112530. doi:
10.1016/j.ecoenv.2021.112530. [PMID: 34280840] - Joelma Leão-Buchir, Nilce Mary Turcatti Folle, Tugstênio Lima de Souza, Patricia Manuitt Brito, Elton Celton de Oliveira, Aliciane de Almeida Roque, Wanessa Algarte Ramsdorf, Luis Fernando Fávaro, Juan Ramón Esquivel Garcia, Luíse Esquivel, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro, Maritana Mela Prodocimo. Effects of trophic 2,2', 4,4'-tetrabromodiphenyl ether (BDE-47) exposure in Oreochromis niloticus: A multiple biomarkers analysis.
Environmental toxicology and pharmacology.
2021 Oct; 87(?):103693. doi:
10.1016/j.etap.2021.103693. [PMID: 34166789] - Shiyao Sun, Zhihui Zhao, Qinxiong Rao, XiaoMin Li, Zheng Ruan, Junhua Yang. BDE-47 induces nephrotoxicity through ROS-dependent pathways of mitochondrial dynamics in PK15 cells.
Ecotoxicology and environmental safety.
2021 Oct; 222(?):112549. doi:
10.1016/j.ecoenv.2021.112549. [PMID: 34325200] - Jie Tang, Bo Hu, Huaping Zheng, Xiaolan Qian, Yi Zhang, Jia Zhu, Guangtao Xu, Deqing Chen, Xin Jin, Wanlu Li, Long Xu. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) activates Aryl hydrocarbon receptor (AhR) mediated ROS and NLRP3 inflammasome/p38 MAPK pathway inducing necrosis in cochlear hair cells.
Ecotoxicology and environmental safety.
2021 Sep; 221(?):112423. doi:
10.1016/j.ecoenv.2021.112423. [PMID: 34146985] - Morgan R Peltier, Michael J Fassett, Yuko Arita, Vicki Y Chiu, Jiaxiao M Shi, Harpreet S Takhar, Ali Mahfuz, Gildy S Garcia, Ramkumar Menon, Darios Getahun. Women with high plasma levels of PBDE-47 are at increased risk of preterm birth.
Journal of perinatal medicine.
2021 May; 49(4):439-447. doi:
10.1515/jpm-2020-0349. [PMID: 33554574] - Rulin Ma, Bei Li, Cheng Zhang, Rongrong Lei, Xiao Zhang, Chao Wang, Shun Zhang, Aiguo Wang. Roles of endoplasmic reticulum stress in 2,2',4,4'-tetrabromodiphenylether-induced thyroid cell apoptosis and autophagy.
Ecotoxicology and environmental safety.
2021 May; 214(?):112077. doi:
10.1016/j.ecoenv.2021.112077. [PMID: 33647853] - Yongshun Jiang, You Wang, Tianli Sun, Keyu Lu, Xinyu Zhao, Zhipeng Zhang, Mengchen Lv, Chunchen Liu, Bin Zhou. Depicting an energetic chain involved in physiological responses of blue mussel Mytilus edulis coping with BDE-47 exposure.
Chemosphere.
2021 Apr; 269(?):128736. doi:
10.1016/j.chemosphere.2020.128736. [PMID: 33131734] - Matthew V Gomez, Moumita Dutta, Alexander Suvorov, Xiaojian Shi, Haiwei Gu, Sridhar Mani, Julia Yue Cui. Early Life Exposure to Environmental Contaminants (BDE-47, TBBPA, and BPS) Produced Persistent Alterations in Fecal Microbiome in Adult Male Mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2021 01; 179(1):14-30. doi:
10.1093/toxsci/kfaa161. [PMID: 33078840] - Xiaoning Li, Hui Gao, Pei Li, Wei Chen, Sha Tang, Luming Liu, Guoyu Zhou, Tao Xia, Aiguo Wang, Shun Zhang. Impaired sperm quantity and motility in adult rats following gestational and lactational exposure to environmentally relevant levels of PBDE-47: A potential role of thyroid hormones disruption.
Environmental pollution (Barking, Essex : 1987).
2021 Jan; 268(Pt A):115773. doi:
10.1016/j.envpol.2020.115773. [PMID: 33065364] - Helena T Hogberg, Rita de Cássia da Silveira E Sá, Andre Kleensang, Mounir Bouhifd, Ozge Cemiloglu Ulker, Lena Smirnova, Mamta Behl, Alexandra Maertens, Liang Zhao, Thomas Hartung. Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model.
Archives of toxicology.
2021 01; 95(1):207-228. doi:
10.1007/s00204-020-02903-2. [PMID: 33078273] - Dan Deng, He Xiang Chen, Yuk Shan Wong, Nora Fung Yee Tam. Physiological response and oxidative transformation of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) by a Chlorella isolate.
The Science of the total environment.
2020 Nov; 744(?):140869. doi:
10.1016/j.scitotenv.2020.140869. [PMID: 32711313] - Qian Liu, Xuexi Tang, Xin Zhang, Yingying Yang, Zijie Sun, Xiaoyang Jian, Yan Zhao, Xinxin Zhang. Evaluation of the toxic response induced by BDE-47 in a marine alga, Phaeodactylum tricornutum, based on photosynthesis-related parameters.
Aquatic toxicology (Amsterdam, Netherlands).
2020 Oct; 227(?):105588. doi:
10.1016/j.aquatox.2020.105588. [PMID: 32861020] - Yuqian Li, Nanyang Yu, Meiying Li, Kan Li, Wei Shi, Hongxia Yu, Si Wei. Metabolomic insights into the lasting impacts of early-life exposure to BDE-47 in mice.
Environmental pollution (Barking, Essex : 1987).
2020 Aug; 263(Pt B):114524. doi:
10.1016/j.envpol.2020.114524. [PMID: 32283404] - Joo Eun Lee, Han Bin Oh, Hosub Im, Sang Beom Han, Ki Hun Kim. Multiresidue analysis of 85 persistent organic pollutants in small human serum samples by modified QuEChERS preparation with different ionization sources in mass spectrometry.
Journal of chromatography. A.
2020 Jul; 1623(?):461170. doi:
10.1016/j.chroma.2020.461170. [PMID: 32505276] - Marion Ouidir, Pauline Mendola, Germaine M Buck Louis, Kurunthachalam Kannan, Cuilin Zhang, Fasil Tekola-Ayele. Concentrations of persistent organic pollutants in maternal plasma and epigenome-wide placental DNA methylation.
Clinical epigenetics.
2020 07; 12(1):103. doi:
10.1186/s13148-020-00894-6. [PMID: 32653021] - Zhongyuan Zhou, Xiaoyang Jian, Bin Zhou, Keyu Lu, You Wang. Changes in the immune function of rainbow trout (Oncorhynchus mykiss) provide insights into strategies against BDE-47 stress.
Journal of hazardous materials.
2020 06; 392(?):122212. doi:
10.1016/j.jhazmat.2020.122212. [PMID: 32078968] - Juntong Wei, Xiaona Li, Li Xiang, Yuanyuan Song, Yuanchen Liu, Yuyang Jiang, Zongwei Cai. Metabolomics and lipidomics study unveils the impact of polybrominated diphenyl ether-47 on breast cancer mice.
Journal of hazardous materials.
2020 05; 390(?):121451. doi:
10.1016/j.jhazmat.2019.121451. [PMID: 31796364] - Chao Wang, Jiansheng Zhu, Zhan Zhang, Hang Chen, Minghui Ji, Chao Chen, Yuhuan Hu, Yongquan Yu, Rong Xia, Jiemiao Shen, Xing Gong, Shou-Lin Wang. Rno-miR-224-5p contributes to 2,2',4,4'-tetrabromodiphenyl ether-induced low triiodothyronine in rats by targeting deiodinases.
Chemosphere.
2020 May; 246(?):125774. doi:
10.1016/j.chemosphere.2019.125774. [PMID: 31901531] - Yijing Chen, Aiqin Zhang, Huixiang Li, Yu Peng, Xinyu Lou, Minghui Liu, Jicheng Hu, Chen Liu, Baokai Wei, Jun Jin. Concentrations and distributions of polybrominated diphenyl ethers (PBDEs) in surface soils and tree bark in Inner Mongolia, northern China, and the risks posed to humans.
Chemosphere.
2020 May; 247(?):125950. doi:
10.1016/j.chemosphere.2020.125950. [PMID: 31978667] - Jin-Bo Li, Yuan-Yuan Li, Yan-Ping Shen, Min Zhu, Xing-Hong Li, Zhan-Fen Qin. 2,2',4,4'-tetrabromodipheny ether (BDE-47) disrupts gonadal development of the Africa clawed frog (Xenopus laevis).
Aquatic toxicology (Amsterdam, Netherlands).
2020 Apr; 221(?):105441. doi:
10.1016/j.aquatox.2020.105441. [PMID: 32045789] - Deena M Butryn, Lai-Har Chi, Michael S Gross, Barbara McGarrigle, Arnold Schecter, James R Olson, Diana S Aga. Retention of polybrominated diphenyl ethers and hydroxylated metabolites in paired human serum and milk in relation to CYP2B6 genotype.
Journal of hazardous materials.
2020 03; 386(?):121904. doi:
10.1016/j.jhazmat.2019.121904. [PMID: 31901712] - Juntong Wei, Li Xiang, Xiaona Li, Yuanyuan Song, Chunxue Yang, Fenfen Ji, Arthur Chi Kong Chung, Kun Li, Zian Lin, Zongwei Cai. Derivatization strategy combined with parallel reaction monitoring for the characterization of short-chain fatty acids and their hydroxylated derivatives in mouse.
Analytica chimica acta.
2020 Mar; 1100(?):66-74. doi:
10.1016/j.aca.2019.11.009. [PMID: 31987154] - Alexander Suvorov, Vladimir Naumov, Victoria Shtratnikova, Maria Logacheva, Alex Shershebnev, Haotian Wu, Evgeny Gerasimov, Anna Zheludkevich, Jonathan R Pilsner, Oleg Sergeyev. Rat liver epigenome programing by perinatal exposure to 2,2',4'4'-tetrabromodiphenyl ether.
Epigenomics.
2020 02; 12(3):235-249. doi:
10.2217/epi-2019-0315. [PMID: 31833787] - June K Dunnick, Keith R Shockley, Daniel L Morgan, Gregory S Travlos, Kevin Gerrish, Thai-Vu T Ton, Ralph Wilson, Sukhdev S Brar, Amy E Brix, Suramya Waidyanatha, Esra Mutlu, Arun Kumar R Pandiri. Hepatic Transcriptomic Patterns in the Neonatal Rat After Pentabromodiphenyl Ether Exposure.
Toxicologic pathology.
2020 02; 48(2):338-349. doi:
10.1177/0192623319888433. [PMID: 31826744] - Angela Zhang, Cindy Yanfei Li, Edward J Kelly, Lianne Sheppard, Julia Yue Cui. Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism.
PloS one.
2020; 15(2):e0224644. doi:
10.1371/journal.pone.0224644. [PMID: 32101552] - Jie Chen, X Chris Le, Lizhong Zhu. Metabolomics and transcriptomics reveal defense mechanism of rice (Oryza sativa) grains under stress of 2,2',4,4'-tetrabromodiphenyl ether.
Environment international.
2019 12; 133(Pt A):105154. doi:
10.1016/j.envint.2019.105154. [PMID: 31521816] - Henry Matovu, Mika Sillanpää, Patrick Ssebugere. Polybrominated diphenyl ethers in mothers' breast milk and associated health risk to nursing infants in Uganda.
The Science of the total environment.
2019 Nov; 692(?):1106-1115. doi:
10.1016/j.scitotenv.2019.07.335. [PMID: 31539942] - Ling-Chuan Guo, Shengbing Yu, De Wu, Jinxu Huang, Tao Liu, Jianpeng Xiao, Weixiong Huang, Yanhong Gao, Xing Li, Weilin Zeng, Shannon Rutherford, Wenjun Ma, Yonghui Zhang, Lifeng Lin. Disruption of thyroid hormone regulated proteins and gene expression by polychlorinated biphenyls, polybrominated diphenyl ethers and new flame retardants in residents of an e-waste region.
Environmental pollution (Barking, Essex : 1987).
2019 Nov; 254(Pt B):112925. doi:
10.1016/j.envpol.2019.07.093. [PMID: 31454572] - Chunxue Yang, Lin Zhu, Qingzheng Kang, Hin Kiu Lee, Dapeng Li, Arthur C K Chung, Zongwei Cai. Chronic exposure to tetrabromodiphenyl ether (BDE-47) aggravates hepatic steatosis and liver fibrosis in diet-induced obese mice.
Journal of hazardous materials.
2019 10; 378(?):120766. doi:
10.1016/j.jhazmat.2019.120766. [PMID: 31226595] - Fenfen Ji, Sravan Gopalkrishnashetty Sreenivasmurthy, Juntong Wei, Xiaojian Shao, Hemi Luan, Lin Zhu, Juxian Song, Liangfeng Liu, Min Li, Zongwei Cai. Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis.
Journal of hazardous materials.
2019 10; 378(?):120738. doi:
10.1016/j.jhazmat.2019.06.015. [PMID: 31203119] - Jianhua Zhao, Meng Zhang, Wei Zhang, Fuwen Liu, Kai Huang, Kuangfei Lin. Insight into the tolerance, biochemical and antioxidative response in three moss species on exposure to BDE-47 and BDE-209.
Ecotoxicology and environmental safety.
2019 Oct; 181(?):445-454. doi:
10.1016/j.ecoenv.2019.06.044. [PMID: 31228820] - Beata Drobná, Anna Fabišiková, Kamil Čonka, František Gago, Petra Oravcová, Soňa Wimmerová, Marina Oktapodas Feiler, Eva Šovčíková. PBDE serum concentration and preschool maturity of children from Slovakia.
Chemosphere.
2019 Oct; 233(?):387-395. doi:
10.1016/j.chemosphere.2019.05.284. [PMID: 31176902] - Hui Gao, Pei Li, Luming Liu, Kaichao Yang, Boya Xiao, Guoyu Zhou, Zhiyuan Tian, Chen Luo, Tao Xia, Lixin Dong, Qian Zhao, Aiguo Wang, Shun Zhang. Perigestational low-dose BDE-47 exposure alters maternal serum metabolome and results in sex-specific weight gain in adult offspring.
Chemosphere.
2019 Oct; 233(?):174-182. doi:
10.1016/j.chemosphere.2019.05.277. [PMID: 31173955] - Honglei Ji, Hong Liang, Ziliang Wang, Maohua Miao, Xin Wang, Xiaotian Zhang, Sheng Wen, Aimin Chen, Xiaowei Sun, Wei Yuan. Associations of prenatal exposures to low levels of Polybrominated Diphenyl Ether (PBDE) with thyroid hormones in cord plasma and neurobehavioral development in children at 2 and 4 years.
Environment international.
2019 10; 131(?):105010. doi:
10.1016/j.envint.2019.105010. [PMID: 31326823] - Sujin Kim, Yoon Hee Cho, Sungho Won, Ja-Lok Ku, Hyo-Bang Moon, Jeongim Park, Gyuyeon Choi, Sungkyoon Kim, Kyungho Choi. Maternal exposures to persistent organic pollutants are associated with DNA methylation of thyroid hormone-related genes in placenta differently by infant sex.
Environment international.
2019 09; 130(?):104956. doi:
10.1016/j.envint.2019.104956. [PMID: 31272017] - Lin Hou, Jingyan Jiang, Zhiwei Gan, YuanYuan Dai, Ping Yang, Yan Yan, Sanglan Ding, Shijun Su, Xiaoming Bao. Spatial Distribution of Organophosphorus and Brominated Flame Retardants in Surface Water, Sediment, Groundwater, and Wild Fish in Chengdu, China.
Archives of environmental contamination and toxicology.
2019 Aug; 77(2):279-290. doi:
10.1007/s00244-019-00624-x. [PMID: 30963189] - David K Scoville, Cindy Yanfei Li, Dongfang Wang, Joseph L Dempsey, Daniel Raftery, Sridhar Mani, Haiwei Gu, Julia Yue Cui. Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice.
Drug metabolism and disposition: the biological fate of chemicals.
2019 08; 47(8):928-940. doi:
10.1124/dmd.119.086538. [PMID: 31123037] - Leilei Xiang, Hongjie Sheng, Chenggang Gu, Redmile-Gordon Marc, Yu Wang, Yonrong Bian, Xin Jiang, Fang Wang. Biochar combined with compost to reduce the mobility, bioavailability and plant uptake of 2,2',4,4'-tetrabrominated diphenyl ether in soil.
Journal of hazardous materials.
2019 07; 374(?):341-348. doi:
10.1016/j.jhazmat.2019.04.048. [PMID: 31026627] - Élyse Caron-Beaudoin, Pierre Ayotte, Elhadji Anassour Laouan Sidi, Nancy Gros-Louis McHugh, Mélanie Lemire. Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec.
Environment international.
2019 07; 128(?):13-23. doi:
10.1016/j.envint.2019.04.029. [PMID: 31029975] - Shengxian Liang, Shaojun Liang, Nuoya Yin, Francesco Faiola. Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations.
Ecotoxicology and environmental safety.
2019 Jun; 174(?):353-362. doi:
10.1016/j.ecoenv.2019.02.091. [PMID: 30849655] - Hao Xu, Chao Feng, Yiyi Cao, Ying Lu, Jing Xi, Jieyun Ji, Dasheng Lu, Xin-Yu Zhang, Yang Luan. Distribution of the parent compound and its metabolites in serum, urine, and feces of mice administered 2,2',4,4'-tetrabromodiphenyl ether.
Chemosphere.
2019 Jun; 225(?):217-225. doi:
10.1016/j.chemosphere.2019.03.030. [PMID: 30877916] - Noriko Kanaya, Lauren Bernal, Gregory Chang, Takuro Yamamoto, Duc Nguyen, Yuan-Zhong Wang, June-Soo Park, Charles Warden, Jinhui Wang, Xiwei Wu, Timothy Synold, Michele Rakoff, Susan L Neuhausen, Shiuan Chen. Molecular Mechanisms of Polybrominated Diphenyl Ethers (BDE-47, BDE-100, and BDE-153) in Human Breast Cancer Cells and Patient-Derived Xenografts.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 06; 169(2):380-398. doi:
10.1093/toxsci/kfz054. [PMID: 30796839] - Leilei Xiang, Hongjie Sheng, Min Xu, Marc Redmile-Gordon, Yongrong Bian, Xinglun Yang, Xin Jiang, Fang Wang. Reducing plant uptake of a brominated contaminant (2,2',4,4'‑tetrabrominated diphenyl ether) by incorporation of maize straw into horticultural soil.
The Science of the total environment.
2019 May; 663(?):29-37. doi:
10.1016/j.scitotenv.2019.01.297. [PMID: 30708214] - Whitney J Cowell, Andreas Sjödin, Richard Jones, Ya Wang, Shuang Wang, Robin M Whyatt, Pam Factor-Litvak, Gary Bradwin, Abeer Hassoun, Sharon Oberfield, Julie B Herbstman. Pre- and Postnatal Polybrominated Diphenyl Ether Concentrations in Relation to Thyroid Parameters Measured During Early Childhood.
Thyroid : official journal of the American Thyroid Association.
2019 05; 29(5):631-641. doi:
10.1089/thy.2018.0417. [PMID: 30907253] - Chunchen Liu, Boyuan Wang, Bin Zhou, Xiaoyang Jian, Xinxin Zhang, You Wang. The responses of Oncorhynchus mykiss coping with BDE-47 stress via PXR-mediated detoxification and Nrf2-mediated antioxidation system.
Aquatic toxicology (Amsterdam, Netherlands).
2019 Feb; 207(?):63-71. doi:
10.1016/j.aquatox.2018.11.026. [PMID: 30530205] - Joshua F Robinson, Mirhan Kapidzic, Emily G Hamilton, Hao Chen, Kenisha W Puckett, Yan Zhou, Katherine Ona, Emily Parry, Yunzhu Wang, June-Soo Park, Joseph F Costello, Susan J Fisher. Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 01; 167(1):211-226. doi:
10.1093/toxsci/kfy230. [PMID: 30202865] - Guangxia Liu, Hongjie Sheng, Yuhao Fu, Yang Song, Marc Redmile-Gordon, Yan Qiao, Chenggang Gu, Leilei Xiang, Fang Wang. Extracellular polymeric substances (EPS) modulate adsorption isotherms between biochar and 2,2',4,4'-tetrabromodiphenyl ether.
Chemosphere.
2019 Jan; 214(?):176-183. doi:
10.1016/j.chemosphere.2018.09.081. [PMID: 30265924] - Chunxue Yang, Chi-Ming Wong, Juntong Wei, Arthur C K Chung, Zongwei Cai. The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation.
The Science of the total environment.
2018 Dec; 644(?):1312-1322. doi:
10.1016/j.scitotenv.2018.07.087. [PMID: 30743844] - J K Dunnick, K R Shockley, A R Pandiri, G E Kissling, K E Gerrish, T V Ton, R E Wilson, S S Brar, A E Brix, S Waidyanatha, E Mutlu, D L Morgan. PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero/postnatal exposure in the rat.
Archives of toxicology.
2018 11; 92(11):3415-3433. doi:
10.1007/s00204-018-2292-y. [PMID: 30206662] - Imran Rashid Rajput, Ziyang Xiao, Sun Yajing, Summra Yaqoob, Edmond Sanganyado, Huang Ying, Yu Fei, Wenhua Liu. Establishment of pantropic spotted dolphin (Stenella attenuata) fibroblast cell line and potential influence of polybrominated diphenyl ethers (PBDEs) on cytokines response.
Aquatic toxicology (Amsterdam, Netherlands).
2018 Oct; 203(?):1-9. doi:
10.1016/j.aquatox.2018.07.017. [PMID: 30064049] - Jordan Stubleski, Lars Lind, Samira Salihovic, P Monica Lind, Anna Kärrman. Longitudinal changes in persistent organic pollutants (POPs) from 2001 to 2009 in a sample of elderly Swedish men and women.
Environmental research.
2018 08; 165(?):193-200. doi:
10.1016/j.envres.2018.04.009. [PMID: 29715601] - Mi Feng, Hua Yin, Yajuan Cao, Hui Peng, Guining Lu, Zehua Liu, Zhi Dang. Cadmium-induced stress response of Phanerochaete chrysosporium during the biodegradation of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47).
Ecotoxicology and environmental safety.
2018 Jun; 154(?):45-51. doi:
10.1016/j.ecoenv.2018.02.018. [PMID: 29454270] - Dezhen Wang, Jin Yan, Miaomiao Teng, Sen Yan, Zhiqiang Zhou, Wentao Zhu. In utero and lactational exposure to BDE-47 promotes obesity development in mouse offspring fed a high-fat diet: impaired lipid metabolism and intestinal dysbiosis.
Archives of toxicology.
2018 05; 92(5):1847-1860. doi:
10.1007/s00204-018-2177-0. [PMID: 29523931] - Elizabeth A Krumm, Vipa J Patel, Taylor S Tillery, Ali Yasrebi, Jianliang Shen, Grace L Guo, Stephanie M Marco, Brian T Buckley, Troy A Roepke. Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ERα.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 03; 162(1):212-224. doi:
10.1093/toxsci/kfx238. [PMID: 29112739] - Emily Parry, Ami R Zota, June-Soo Park, Tracey J Woodruff. Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs): A six-year temporal trend in Northern California pregnant women.
Chemosphere.
2018 Mar; 195(?):777-783. doi:
10.1016/j.chemosphere.2017.12.065. [PMID: 29289024] - F Bjurlid, M Dam, K Hoydal, J Hagberg. Occurrence of polybrominated dibenzo-p-dioxins, dibenzofurans (PBDD/Fs) and polybrominated diphenyl ethers (PBDEs) in pilot whales (Globicephala melas) caught around the Faroe Islands.
Chemosphere.
2018 Mar; 195(?):11-20. doi:
10.1016/j.chemosphere.2017.12.044. [PMID: 29248748] - Whitney J Cowell, Andreas Sjödin, Richard Jones, Ya Wang, Shuang Wang, Julie B Herbstman. Determinants of prenatal exposure to polybrominated diphenyl ethers (PBDEs) among urban, minority infants born between 1998 and 2006.
Environmental pollution (Barking, Essex : 1987).
2018 Feb; 233(?):774-781. doi:
10.1016/j.envpol.2017.10.068. [PMID: 29127935] - Juntong Wei, Li Xiang, Zigao Yuan, Shangfu Li, Chunxue Yang, Hongxia Liu, Yuyang Jiang, Zongwei Cai. Metabolic profiling on the effect of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in MCF-7 cells.
Chemosphere.
2018 Feb; 192(?):297-304. doi:
10.1016/j.chemosphere.2017.10.170. [PMID: 29117588] - Nianwei Qiu, Renjun Wang, Yuan Sun, Xiushun Wang, Dacheng Jiang, Yuting Meng, Feng Zhou. Toxic effects and mechanism of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on Lemna minor.
Chemosphere.
2018 Feb; 193(?):711-719. doi:
10.1016/j.chemosphere.2017.10.148. [PMID: 29175398] - Eliezer Brown Mwakalapa, Aviti John Mmochi, Mette Helen Bjorge Müller, Robinson Hammerthon Mdegela, Jan Ludvig Lyche, Anuschka Polder. Occurrence and levels of persistent organic pollutants (POPs) in farmed and wild marine fish from Tanzania. A pilot study.
Chemosphere.
2018 Jan; 191(?):438-449. doi:
10.1016/j.chemosphere.2017.09.121. [PMID: 29054084] - Qun Shan, Gui-Hong Zheng, Xin-Rui Han, Xin Wen, Shan Wang, Meng-Qiu Li, Juan Zhuang, Zi-Feng Zhang, Bin Hu, Yanqiu Zhang, Yuan-Lin Zheng. Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling.
Oxidative medicine and cellular longevity.
2018; 2018(?):9865495. doi:
10.1155/2018/9865495. [PMID: 29849929] - Ahmed Khalil, Sebnem E Cevik, Stephanie Hung, Sridurgadevi Kolla, Monika A Roy, Alexander Suvorov. Developmental Exposure to 2,2',4,4'-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance of Lipids in Male Mice.
Frontiers in endocrinology.
2018; 9(?):548. doi:
10.3389/fendo.2018.00548. [PMID: 30294300] - Cindy Yanfei Li, Julia Yue Cui. Regulation of protein-coding gene and long noncoding RNA pairs in liver of conventional and germ-free mice following oral PBDE exposure.
PloS one.
2018; 13(8):e0201387. doi:
10.1371/journal.pone.0201387. [PMID: 30067809] - Seo-Yeon Gu, Kalu Ibe Ekpeghere, Hee-Young Kim, In-Seok Lee, Da-Hye Kim, Gyojin Choo, Jeong-Eun Oh. Brominated flame retardants in marine environment focused on aquaculture area: Occurrence, source and bioaccumulation.
The Science of the total environment.
2017 Dec; 601-602(?):1182-1191. doi:
10.1016/j.scitotenv.2017.05.209. [PMID: 28605836] - Eliška Čechová, Šimon Vojta, Petr Kukučka, Anton Kočan, Tomáš Trnovec, Ľubica Palkovičová Murínová, Marijke de Cock, Margot van de Bor, Joakim Askevold, Merete Eggesbø, Martin Scheringer. Legacy and alternative halogenated flame retardants in human milk in Europe: Implications for children's health.
Environment international.
2017 11; 108(?):137-145. doi:
10.1016/j.envint.2017.08.008. [PMID: 28843142] - Matthew Lorber, Leisa-Maree L Toms. Use of a simple pharmacokinetic model to study the impact of breast-feeding on infant and toddler body burdens of PCB 153, BDE 47, and DDE.
Chemosphere.
2017 Oct; 185(?):1081-1089. doi:
10.1016/j.chemosphere.2017.07.118. [PMID: 28764132] - Guodong Ding, Jing Yu, Limei Chen, Caifeng Wang, Yijun Zhou, Yi Hu, Rong Shi, Yan Zhang, Chang Cui, Yu Gao, Ying Tian, Fang Liu. Polybrominated diphenyl ethers (PBDEs) and thyroid hormones in cord blood.
Environmental pollution (Barking, Essex : 1987).
2017 Oct; 229(?):489-495. doi:
10.1016/j.envpol.2017.05.065. [PMID: 28628864] - Yun Zhu, Yan Qin Tan, Lai K Leung. Exposure to 2,2',4,4'-tetrabromodiphenyl ether at late gestation modulates placental signaling molecules in the mouse model.
Chemosphere.
2017 Aug; 181(?):289-295. doi:
10.1016/j.chemosphere.2017.04.089. [PMID: 28448910] - Satori A Marchitti, Suzanne E Fenton, Pauline Mendola, John F Kenneke, Erin P Hines. Polybrominated Diphenyl Ethers in Human Milk and Serum from the U.S. EPA MAMA Study: Modeled Predictions of Infant Exposure and Considerations for Risk Assessment.
Environmental health perspectives.
2017 04; 125(4):706-713. doi:
10.1289/ehp332. [PMID: 27405099] - Mi-Yeon Shin, Sunggyu Lee, Hyeyoung Choi, Da-In Jeong, Hyo-Bang Moon, Sungkyoon Kim. Placental and lactational transfer of decabromodiphenyl ether and 2,2',4,4'-tetrabromodiphenyl ether in dam-offspring pairs of Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Apr; 102(?):198-203. doi:
10.1016/j.fct.2017.01.027. [PMID: 28159596] - Beverly H K Po, Ka-Lok Ho, Michael H W Lam, John P Giesy, Jill M Y Chiu. Uptake and biotransformation of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in four marine microalgae species.
Scientific reports.
2017 03; 7(?):44263. doi:
10.1038/srep44263. [PMID: 28287149] - Qun Shan, Juan Zhuang, Guihong Zheng, Zifeng Zhang, Yanqiu Zhang, Jun Lu, Yuanlin Zheng. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity.
Oxidative medicine and cellular longevity.
2017; 2017(?):6034692. doi:
10.1155/2017/6034692. [PMID: 29163754] - Helena Bjermo, Marie Aune, Tatiana Cantillana, Anders Glynn, P Monica Lind, Peter Ridefelt, Per Ola Darnerud. Serum levels of brominated flame retardants (BFRs: PBDE, HBCD) and influence of dietary factors in a population-based study on Swedish adults.
Chemosphere.
2017 Jan; 167(?):485-491. doi:
10.1016/j.chemosphere.2016.10.008. [PMID: 27750173] - Koichi Haraguchi, Yoshiko Ito, Masae Takagi, Yukiko Fujii, Kouji H Harada, Akio Koizumi. Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples.
Environment international.
2016 Dec; 97(?):155-162. doi:
10.1016/j.envint.2016.08.022. [PMID: 27615405] - Min-Chul Lee, Jayesh Puthumana, Seung-Hwi Lee, Hye-Min Kang, Jun Chul Park, Chang-Bum Jeong, Jeonghoon Han, Dae-Sik Hwang, Jung Soo Seo, Heum Gi Park, Ae-Son Om, Jae-Seong Lee. BDE-47 induces oxidative stress, activates MAPK signaling pathway, and elevates de novo lipogenesis in the copepod Paracyclopina nana.
Aquatic toxicology (Amsterdam, Netherlands).
2016 Dec; 181(?):104-112. doi:
10.1016/j.aquatox.2016.10.025. [PMID: 27825063] - Gina Song, Cody R Peeples, Miyoung Yoon, Huali Wu, Marc-André Verner, Melvin E Andersen, Harvey J Clewell, Matthew P Longnecker. Pharmacokinetic bias analysis of the epidemiological associations between serum polybrominated diphenyl ether (BDE-47) and timing of menarche.
Environmental research.
2016 10; 150(?):541-548. doi:
10.1016/j.envres.2016.07.004. [PMID: 27429067] - Ángel García-Bermejo, Susana Mohr, Laura Herrero, María-José González, Belén Gómara. Applicability of Gas Chromatography (GC) Coupled to Triple-Quadrupole (QqQ) Tandem Mass Spectrometry (MS/MS) for Polybrominated Diphenyl Ether (PBDE) and Emerging Brominated Flame Retardant (BFR) Determinations in Functional Foods Enriched in Omega-3.
Journal of agricultural and food chemistry.
2016 Sep; 64(38):7265-74. doi:
10.1021/acs.jafc.6b03118. [PMID: 27600263] - Min-Chul Lee, Jeonghoon Han, Seung-Hwi Lee, Duck-Hyun Kim, Hye-Min Kang, Eun-Ji Won, Dae-Sik Hwang, Jun Chul Park, Ae-Son Om, Jae-Seong Lee. A brominated flame retardant 2,2',4,4' tetrabrominated diphenyl ether (BDE-47) leads to lipogenesis in the copepod Tigriopus japonicus.
Aquatic toxicology (Amsterdam, Netherlands).
2016 Sep; 178(?):19-26. doi:
10.1016/j.aquatox.2016.07.002. [PMID: 27450237] - Thanh Wang, Junchao Yu, Pu Wang, Qinghua Zhang. Levels and distribution of polybrominated diphenyl ethers in the aquatic and terrestrial environment around a wastewater treatment plant.
Environmental science and pollution research international.
2016 Aug; 23(16):16440-7. doi:
10.1007/s11356-016-6828-5. [PMID: 27164882]