Cefonicid (BioDeep_00001868424)
Main id: BioDeep_00000006365
代谢物信息卡片
Cefonicid
化学式: C18H18N6O8S3 (542.0348228)
中文名称: 头孢尼西
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)O)C(=O)O)CSC4=NN=NN4CS(=O)(=O)O
InChI: InChI=1S/C18H18N6O8S3/c25-13(9-4-2-1-3-5-9)14(26)19-11-15(27)24-12(17(28)29)10(6-33-16(11)24)7-34-18-20-21-22-23(18)8-35(30,31)32/h1-5,11,13,16,25H,6-8H2,(H,19,26)(H,28,29)(H,30,31,32)/t11-,13-,16-/m1/s1
描述信息
A cephalosporin bearing {[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and (R)-2-hydroxy-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DC - Second-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:3491
- KEGG: C06882
- KEGGdrug: D07644
- PubChem: 43594
- DrugBank: DB01328
- ChEMBL: CHEMBL1601
- MeSH: Cefonicid
- CAS: 61270-58-4
- MetaboLights: MTBLC3491
- PubChem: 9099
- NIKKAJI: J18.085H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Elena Badillo, Elisa Escudero, Verónica Hernandis, Juan Sebastián Galecio, Pedro Marín. Pharmacokinetics of cefonicid in lactating goats after intravenous, intramuscular and subcutaneous administration, and after a long-acting formulation for subcutaneous administration.
Journal of veterinary pharmacology and therapeutics.
2020 Jan; 43(1):50-56. doi:
10.1111/jvp.12825. [PMID: 31724779] - Yi-Tsung Lin, L Kristopher Siu, Jung-Chung Lin, Te-Li Chen, Chih-Peng Tseng, Kuo-Ming Yeh, Feng-Yee Chang, Chang-Phone Fung. Seroepidemiology of Klebsiella pneumoniae colonizing the intestinal tract of healthy Chinese and overseas Chinese adults in Asian countries.
BMC microbiology.
2012 Jan; 12(?):13. doi:
10.1186/1471-2180-12-13. [PMID: 22260182] - A Radi, T Wahdan, N Abd El-Ghany. Determination of cefonicid in human urine by adsorptive square-wave stripping voltammetry.
Journal of pharmaceutical and biomedical analysis.
2003 Apr; 31(6):1041-6. doi:
10.1016/s0731-7085(02)00701-x. [PMID: 12667920] - V Tullio, A M Cuffini, A Bonino, F Giacchino, C Merlino, G M Bosticardo, G Paizis, N A Carlone. Cefonicid 'restores' the depressed activities of polymorphonuclear cells from chronic haemodialysis patients and renal transplant recipients in vitro.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1998 Aug; 13(8):2017-22. doi:
10.1093/ndt/13.8.2017. [PMID: 9719157] - M Ortega Calvo, J L Méndez Mora, E Soriano Crespo, D Fernández Martínez, J Torello Iserte, J R Castillo Ferrando. [Adverse reaction to cefonicid analogous to serum sickness].
Anales de medicina interna (Madrid, Spain : 1984).
1995 Jun; 12(6):289-90. doi:
NULL. [PMID: 7548647] - B Kelentey, I Fekete, J Kozma. [Excretion of cefonicid and ceftriaxone into the saliva].
Fogorvosi szemle.
1995 May; 88(5):159-62. doi:
. [PMID: 8522009] - S D Karki, D W Bentley, A Luzier, C Taylor, G D Morse. Disposition of intramuscular cefonicid in elderly patients.
Journal of the American Geriatrics Society.
1993 Aug; 41(8):808-10. doi:
10.1111/j.1532-5415.1993.tb06174.x. [PMID: 8340557] - J M Benson, F D Boudinot, A T Pennell, F E Cunningham, J T DiPiro. In vitro protein binding of cefonicid and cefuroxime in adult and neonatal sera.
Antimicrobial agents and chemotherapy.
1993 Jun; 37(6):1343-7. doi:
10.1128/aac.37.6.1343. [PMID: 8328784] - G del Rio, F Dalet, G Chechile. Antimicrobial prophylaxis in urologic surgery: does it give some benefit?.
European urology.
1993; 24(3):305-11; discussion 312. doi:
10.1159/000474318. [PMID: 8262097] - S A Slavis, J B Miller, H Golji, C J Dunshee. Comparison of single-dose antibiotic prophylaxis in uncomplicated transurethral resection of the prostate.
The Journal of urology.
1992 May; 147(5):1303-6. doi:
10.1016/s0022-5347(17)37548-1. [PMID: 1569672] - C A Rodríguez, D E Smith. Influence of angiotensin II-induced alterations in renal flow on excretion of cefonicid in isolated perfused rat kidneys.
Antimicrobial agents and chemotherapy.
1992 Mar; 36(3):616-9. doi:
10.1128/aac.36.3.616. [PMID: 1622172] - C A Rodriguez, D E Smith. Influence of the unbound concentration of cefonicid on its renal elimination in isolated perfused rat kidneys.
Antimicrobial agents and chemotherapy.
1991 Nov; 35(11):2395-400. doi:
10.1128/aac.35.11.2395. [PMID: 1804013] - D Swanson, R A Maxwell, J T Johnson, R L Wagner, V L Yu. Cefonicid versus clindamycin prophylaxis for head and neck surgery in a randomized, double-blind trial, with pharmacokinetic implications.
Antimicrobial agents and chemotherapy.
1991 Jul; 35(7):1360-4. doi:
10.1128/aac.35.7.1360. [PMID: 1929293] - M Goisis, F Grossi, R Soncini, A Gusmitta. Penetration of cefonicid into serum, salpinges, cervix and vaginal tissue.
Journal of chemotherapy (Florence, Italy).
1991 Feb; 3(1):28-9. doi:
10.1080/1120009x.1991.11739059. [PMID: 2019859] - C Donadio, G Tramonti, G Garcea, M Costagli, A Lucchetti, R Giordani, G Paizis, R Pierotti, G Falcone, C Bianchi. Therapeutic efficacy and renal effects of cefonicid in the treatment of difficult urinary tract infections.
Journal of chemotherapy (Florence, Italy).
1991 Jan; 3 Suppl 1(?):233-6. doi:
. [PMID: 12041774] - A L Ney, P H Kelly, D T Tsukayama, M P Bubrick. Fibrin glue-antibiotic suspension in the prevention of prosthetic graft infection.
The Journal of trauma.
1990 Aug; 30(8):1000-5; discussion 1005. doi:
10.1097/00005373-199008000-00009. [PMID: 2201786] - C Salzman, C U Tuazon, A M Labriola, B L Aaron, W Gooch. Serum and atrial tissue concentrations of cefonicid and cefamandole in patients undergoing coronary artery bypass graft surgery.
The Journal of antimicrobial chemotherapy.
1990 Aug; 26(2):292-3. doi:
10.1093/jac/26.2.292. [PMID: 2211461] - M Cazzola, M Polverino, E Guidetti, G Santangelo, G Paizis, G Monaco, G D'Amato, G Girbino. Penetration of cefonicid into human lung tissue and lymph nodes.
Chemotherapy.
1990; 36(5):325-31. doi:
10.1159/000238784. [PMID: 2209166] - F Scaglione, M Falchi, F Ferrara, S Signorelli, R Aimini, S D'Orsi, G P Pintucci, F Fraschini. Cefonicid distribution into tonsillar tissue.
International journal of clinical pharmacology research.
1990; 10(5):265-70. doi:
NULL. [PMID: 2127771] - J A Roberts, M B Kaack, G Baskin. Treatment of experimental pyelonephritis in the monkey.
The Journal of urology.
1990 Jan; 143(1):150-4. doi:
10.1016/s0022-5347(17)39900-7. [PMID: 2403597] - F Fraschini, F Scaglione. [Pulmonary and tonsillar distribution of ceftriaxone and cefonicid and the resultant bactericidal activity of the organ].
Recenti progressi in medicina.
1990 Jan; 81(1):41-6. doi:
. [PMID: 2236826] - J M Trang, T P Monson, B H Ackerman, F L Underwood, J T Manning, G L Kearns. Effect of age and renal function on cefonicid pharmacokinetics.
Antimicrobial agents and chemotherapy.
1989 Feb; 33(2):142-6. doi:
10.1128/aac.33.2.142. [PMID: 2719458] - G Furlan, G Besa, G Broccali, A Gusmitta. Pharmacokinetics of cefonicid in serum and its penetration into lung tissue, bronchial mucosa and pleura.
International journal of clinical pharmacology research.
1989; 9(1):49-53. doi:
NULL. [PMID: 2707925] - F Scaglione, F Ferrara, G Maierna, M Falchi, G Comeri, F Fraschini. Cortical and medullary kidney tissue levels of cefonicid in human beings.
International journal of clinical pharmacology research.
1989; 9(5):313-7. doi:
NULL. [PMID: 2625370] - M Furlanut, R D'Elia, E Riva, F Pasinelli. Pharmacokinetics of cefonicid in children.
European journal of clinical pharmacology.
1989; 36(1):79-82. doi:
10.1007/bf00561029. [PMID: 2917594] - B H Ackerman, J M Trang, C L Nelson, C E Pearce, J T Manning, B H Harrison. Disposition of cefonicid in orthopedic surgery patients.
Drug intelligence & clinical pharmacy.
1988 Nov; 22(11):864-8. doi:
10.1177/106002808802201104. [PMID: 3234250] - W Brumfitt, I James, J M Hamilton-Miller, D Grady, C Price. Bioavailability in human volunteers of three intramuscular formulations of cefonicid: a long-acting cephalosporin.
Biopharmaceutics & drug disposition.
1988 May; 9(3):251-7. doi:
10.1002/bod.2510090303. [PMID: 3395666] - K L Heim-Duthoy, G L Peltier, D R Guay, G R Matzke. Pharmacokinetics of cefonicid in patients with skin and skin structure infections.
Antimicrobial agents and chemotherapy.
1988 Apr; 32(4):485-7. doi:
10.1128/aac.32.4.485. [PMID: 3377460] - A Robertson, S Fink, W Karp. Effect of cephalosporins on bilirubin-albumin binding.
The Journal of pediatrics.
1988 Feb; 112(2):291-4. doi:
10.1016/s0022-3476(88)80072-6. [PMID: 3339510] - W C Shyu, R Quintiliani, C H Nightingale, M N Dudley. Effect of protein binding on drug penetration into blister fluid.
Antimicrobial agents and chemotherapy.
1988 Jan; 32(1):128-30. doi:
10.1128/aac.32.1.128. [PMID: 3162360] - W A Davis, J G Kane. Antimicrobial prophylaxis for arthroplasty: a comparative study of cefonicid and cefazolin.
Orthopedics.
1987 Oct; 10(10):1405-9. doi:
10.3928/0147-7447-19871001-10. [PMID: 3317328] - E Mini, T Mazzei, P Periti, E F Reali, P Bordonaro, E Balocchini, B Ninu. Microbiological and pharmacokinetic evaluation of cefonicid, a long-acting cephalosporin.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
1987 Apr; 6(2):95-8. doi:
. [PMID: 3594635] - G D Morse, T Lane, D K Nairn, J Deterding, J Curry, P Gal. Peritoneal transport of cefonicid.
Antimicrobial agents and chemotherapy.
1987 Feb; 31(2):292-4. doi:
10.1128/aac.31.2.292. [PMID: 3566253] - H A Nadworny, A Markowitz. Parenteral antibiotic therapy at home: experience with intramuscular cefonicid.
Clinical therapeutics.
1987; 10(1):82-91. doi:
. [PMID: 3450394] - M Cruciani, E Concia, E Passarella, R Soncini. Penetration of cefonicid in skin suction blister fluid in healthy volunteers.
International journal of clinical pharmacology research.
1987; 7(3):225-7. doi:
. [PMID: 3596863] - J V Uri. A comparison of cefonicid with other beta-lactams regarding the effect of human and mouse sera on antibacterial activity.
Acta microbiologica Hungarica.
1987; 34(1):39-44. doi:
. [PMID: 3630630] - M Cruciani, S Savio, E Concia. Cefonicid concentration in lung tissue after intramuscular administration.
International journal of clinical pharmacology research.
1987; 7(6):481-4. doi:
NULL. [PMID: 3440639] - M N Dudley, W C Shyu, C H Nightingale, R Quintiliani. Effect of saturable serum protein binding on the pharmacokinetics of unbound cefonicid in humans.
Antimicrobial agents and chemotherapy.
1986 Oct; 30(4):565-9. doi:
10.1128/aac.30.4.565. [PMID: 3789691] - E Saltiel, R N Brogden. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use.
Drugs.
1986 Sep; 32(3):222-59. doi:
10.2165/00003495-198632030-00002. [PMID: 3530703] - J P Fillastre, J B Fourtillan, A Leroy, N Ramis, M A Lefevre, G Reumont, G Humbert. Pharmacokinetics of cefonicid in uraemic patients.
The Journal of antimicrobial chemotherapy.
1986 Aug; 18(2):203-11. doi:
10.1093/jac/18.2.203. [PMID: 3759731] - R T Phelps, J E Conte. Multiple-dose pharmacokinetics of cefonicid in patients with impaired renal function.
Antimicrobial agents and chemotherapy.
1986 May; 29(5):913-7. doi:
10.1128/aac.29.5.913. [PMID: 3729349] - A L Barry, R N Jones, R R Packer. Antistaphylococcal activity of ceforanide and cefonicid in the presence of human serum.
Antimicrobial agents and chemotherapy.
1986 Jan; 29(1):147-9. doi:
10.1128/aac.29.1.147. [PMID: 3729326] - J B Fourtillan, A Leroy, M A Lefebvre, G Humbert, J P Fillastre, G Reumont, N Ramis. Cross-over study of the pharmacokinetics of cefonicid administered intravenously or intramuscularly to healthy adult humans.
European journal of drug metabolism and pharmacokinetics.
1985 Jul; 10(3):225-30. doi:
10.1007/bf03189746. [PMID: 3936717] - E Brendel, M Zschunke, I Meineke. High-performance liquid chromatographic determination of cefonicid in human plasma and urine.
Journal of chromatography.
1985 May; 339(2):359-65. doi:
10.1016/s0378-4347(00)84663-0. [PMID: 4008574] - F di Nola. [Update on antibiotic therapy. 30) Cefonicid].
Minerva medica.
1985 Apr; 76(16):819-25. doi:
NULL. [PMID: 4000526] - S L Barriere, J G Gambertoglio, D P Alexander, R J Stagg, J E Conte. Pharmacokinetic disposition of cefonicid in patients with renal failure and receiving hemodialysis.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S809-15. doi:
10.1093/clinids/6.supplement_4.s809. [PMID: 6522922] - D Kaye. An overview: evaluation of cefonicid in infections of the urinary tract, lower respiratory tract, and skin and soft tissue.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S835-8. doi:
10.1093/clinids/6.supplement_4.s835. [PMID: 6522926] - J T Mader, J A Reinarz. Treatment of bacterial osteomyelitis and Staphylococcus aureus endocarditis and single-dose therapy for uncomplicated Neisseria gonorrhoeae infections: an overview.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S857-64. doi:
10.1093/clinids/6.supplement_4.s857. [PMID: 6395277] - S I Morgan, R E Pontzer, L M Cortez, S L Guice, W Brannan, R E Krieger, W McNamee, J A Boscia, M E Levison, D Kaye. Single-dose regimen of cefonicid for the treatment of uncomplicated infections of the lower urinary tract.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S844-6. doi:
10.1093/clinids/6.supplement_4.s844. [PMID: 6395274] - D G Maki, J L Lammers, D R Aughey. Comparative studies of multiple-dose cefoxitin vs. single-dose cefonicid for surgical prophylaxis in patients undergoing biliary tract operations or hysterectomy.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S887-95. doi:
10.1093/clinids/6.supplement_4.s887. [PMID: 6395279] - H F Chambers, J Mills, T A Drake, M A Sande. Failure of a once-daily regimen of cefonicid for treatment of endocarditis due to Staphylococcus aureus.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S870-4. doi:
10.1093/clinids/6.supplement_4.s870. [PMID: 6522927] - R W Geckler, G D McCormack, J S Goodman. Comparison of cefonicid and cefamandole for the treatment of community-acquired infections of the lower respiratory tract.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S847-52. doi:
10.1093/clinids/6.supplement_4.s847. [PMID: 6395275] - R Platt, B Rosner. Effect of hydrogen ion and protein concentrations on the activity of beta-lactam antibiotics.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S829-34. doi:
10.1093/clinids/6.supplement_4.s829. [PMID: 6522925] - W C Duncan, M E McBride. Single-dose treatment of uncomplicated gonorrhea: a comparison of cefonicid and penicillin.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S875-9. doi:
10.1093/clinids/6.supplement_4.s875. [PMID: 6441224] - R E Pontzer, D Kaye. Cefonicid: a long-acting, second-generation cephalosporin. Antimicrobial activity, pharmacokinetics, clinical efficacy and adverse effects.
Pharmacotherapy.
1984 Nov; 4(6):325-33. doi:
10.1002/j.1875-9114.1984.tb03392.x. [PMID: 6393074] - M A Lou, Y H Wu, L S Jacob, D H Pitkin. Penetration of cefonicid into human breast milk and various body fluids and tissues.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S816-20. doi:
10.1093/clinids/6.supplement_4.s816. [PMID: 6522923] - R E Cutler. An overview of pharmacokinetics.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S803-8. doi:
10.1093/clinids/6.supplement_4.s803. [PMID: 6522921] - C H Nightingale, R Quintiliani, M N Dudley, P Gough, M Hickingbotham, N S Jordan, D Rose, M Toscani. Tissue penetration and half-life of cefonicid.
Reviews of infectious diseases.
1984 Nov; 6 Suppl 4(?):S821-8. doi:
10.1093/clinids/6.supplement_4.s821. [PMID: 6522924] - J T Summersgill, L G Harrod, M J Raff. Azlocillin and cefonicid penetration into bone enhanced by probenecid.
Antimicrobial agents and chemotherapy.
1984 Sep; 26(3):292-4. doi:
10.1128/aac.26.3.292. [PMID: 6508259] - M N Dudley, C H Nightingale, A D Drezner, H B Low, R Quintiliani. Comparative penetration of cefonicid and cefazolin into the atrial appendage and pericardial fluid of patients undergoing open-heart surgery.
Antimicrobial agents and chemotherapy.
1984 Sep; 26(3):347-50. doi:
10.1128/aac.26.3.347. [PMID: 6334490] - A D Blair, B M Maxwell, S C Forland, L Jacob, R E Cutler. Cefonicid kinetics in subjects with normal and impaired renal function.
Clinical pharmacology and therapeutics.
1984 Jun; 35(6):798-803. doi:
10.1038/clpt.1984.115. [PMID: 6734031] - J L Axelrod, R S Kochman. Cefonicid concentrations in human aqueous humor.
Archives of ophthalmology (Chicago, Ill. : 1960).
1984 Mar; 102(3):433-4. doi:
10.1001/archopht.1984.01040030347035. [PMID: 6608343] - M N Dudley, R Quintiliani, C H Nightingale. Review of cefonicid, a long-acting cephalosporin.
Clinical pharmacy.
1984 Jan; 3(1):23-32. doi:
. [PMID: 6365414] - R P Sterling, D J Connor, J C Norman. Plasma and myocardial levels of cefonicid during open-heart surgery.
Journal of the National Medical Association.
1983 Nov; 75(11):1075-80. doi:
NULL. [PMID: 6655710] - R P Sterling, D J Connor, J C Norman, D A Cooley. Cefonicid concentrations in serum and atrial tissue during open-heart surgery.
Antimicrobial agents and chemotherapy.
1983 May; 23(5):790-2. doi:
10.1128/aac.23.5.790. [PMID: 6870226] - A L Barry, R N Jones, C Thornsberry. Evaluation of the cefonicid disk test criteria, including disk quality control guidelines.
Journal of clinical microbiology.
1983 Feb; 17(2):232-9. doi:
10.1128/jcm.17.2.232-239.1983. [PMID: 6601113] - S L Barriere, G J Hatheway, J G Gambertoglio, E T Lin, J E Conte. Pharmacokinetics of cefonicid, a new broad-spectrum cephalosporin.
Antimicrobial agents and chemotherapy.
1982 Jun; 21(6):935-8. doi:
10.1128/aac.21.6.935. [PMID: 7114840] - W C Duncan, M E McBride. Single-dose treatment of uncomplicated gonococcal urethritis: a comparison of cefonicid and penicillin.
Sexually transmitted diseases.
1982 Apr; 9(2):93-5. doi:
10.1097/00007435-198204000-00008. [PMID: 7101088] - R J Wallace, S L Niefield, S Waters, B Waters, R J Awe, K Wiss, R R Martin, S B Greenberg. Comparative trial of cefonicid and cefamandole in the therapy of community-acquired pneumonia.
Antimicrobial agents and chemotherapy.
1982 Feb; 21(2):231-5. doi:
10.1128/aac.21.2.231. [PMID: 7041813] - D Pitkin, J Dubb, P Actor, F Alexander, S Ehrlich, R Familiar, R Stote. Kinetics and renal handling of cefonicid.
Clinical pharmacology and therapeutics.
1981 Nov; 30(5):587-93. doi:
10.1038/clpt.1981.208. [PMID: 7297018]