2,3,4,4,5-PCB (BioDeep_00001868328)

Main id: BioDeep_00000012092

 

Industrial Pollutants


代谢物信息卡片


2,3,4,4,5-PENTACHLOROBIPHENYL

化学式: C12H5Cl5 (323.8834)
中文名称: 2,3,4,4,5-五氯联苯标准溶液
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=CC(=C(C=C2Cl)Cl)Cl)Cl)Cl
InChI: InChI=1S/C12H5Cl5/c13-8-2-1-6(3-10(8)15)7-4-11(16)12(17)5-9(7)14/h1-5H

描述信息

D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls

同义名列表

3 个代谢物同义名

2,3,4,4,5-PENTACHLOROBIPHENYL; 2,3,4,4,5-PCB; 2,3',4,4',5-Pentachlorobiphenyl



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qi-Long He, Xu-Yu Wei, Xiao-Ying Han, Qian Zhou, Hai-Quan Wang, Nai-Zheng Ding, Xiao-Qian Meng, Heide Schatten, Qing-Yuan Sun, Shu-Zhen Liu. Effects of 2,3',4,4'5-pentachlorobiphenyl exposure during pregnancy on epigenetic imprinting and maturation of offspring's oocytes in mice. Archives of toxicology. 2019 09; 93(9):2575-2592. doi: 10.1007/s00204-019-02529-z. [PMID: 31388691]
  • Mu Lin, Yulong Ma, Haodong Yuan, Xinghua Luo, Qinghua Wang, Anming Liu, Ying Wang, Jun Jin. Temporal trends in dioxin-like polychlorinated biphenyl concentrations in serum from the general population of Shandong Province, China: A longitudinal study from 2011 to 2017. Environmental pollution (Barking, Essex : 1987). 2018 Dec; 243(Pt A):59-65. doi: 10.1016/j.envpol.2018.06.021. [PMID: 30172124]
  • Mads Troldborg, Dominic Duckett, Richard Allan, Emily Hastings, Rupert L Hough. A risk-based approach for developing standards for irrigation with reclaimed water. Water research. 2017 12; 126(?):372-384. doi: 10.1016/j.watres.2017.09.041. [PMID: 28985601]
  • Hao-Dong Yuan, Yao Bai, Qiu-Xu Li, Ying Wang, Jun Jin. [Exposure Route of Dioxin-like Polychlorinated Biphenyls in Hair Based on Passive Sampling]. Huan jing ke xue= Huanjing kexue. 2017 Jun; 38(6):2594-2599. doi: 10.13227/j.hjkx.201611077. [PMID: 29965382]
  • Hye Young Kim, Woo Young Kwon, Yeon A Kim, Yoo Jin Oh, Seung Hee Yoo, Mi Hwa Lee, Ju Yong Bae, Jong-Min Kim, Young Hyun Yoo. Polychlorinated biphenyls exposure-induced insulin resistance is mediated by lipid droplet enlargement through Fsp27. Archives of toxicology. 2017 Jun; 91(6):2353-2363. doi: 10.1007/s00204-016-1889-2. [PMID: 27837308]
  • Yoshihisa Kato, Aki Fujii, Koichi Haraguchi, Yukiko Fujii, Kazutaka Atobe, Tetsuya Endo, Osamu Kimura, Nobuyuki Koga, Chiho Ohta, Shizuo Yamada, Masakuni Degawa. Possible mechanism for the polychlorinated bipheny-linduced liver-selective accumulation of thyroxine in rats. The Journal of toxicological sciences. 2017; 42(6):663-669. doi: 10.2131/jts.42.663. [PMID: 29142165]
  • M Elizabeth Marder, Parinya Panuwet, Ronald E Hunter, P Barry Ryan, Michele Marcus, Dana Boyd Barr. Quantification of Polybrominated and Polychlorinated Biphenyls in Human Matrices by Isotope-Dilution Gas Chromatography-Tandem Mass Spectrometry. Journal of analytical toxicology. 2016 Sep; 40(7):511-8. doi: 10.1093/jat/bkw041. [PMID: 27445313]
  • Hongwei Guo, Hui Yang, Huanhuan Chen, Wen Li, Jinmei Tang, Pei Cheng, Yuchun Xie, Yun Liu, Guoxian Ding, Dai Cui, Xuqin Zheng, Yu Duan. Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway. Journal of applied toxicology : JAT. 2015 Sep; 35(9):992-8. doi: 10.1002/jat.3032. [PMID: 25644787]
  • Esther Ng, Samira Salihovic, P Monica Lind, Anubha Mahajan, Anne-Christine Syvänen, Tomas Axelsson, Erik Ingelsson, Cecilia M Lindgren, Bert van Bavel, Andrew P Morris, Lars Lind. Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample. Environmental research. 2015 Jul; 140(?):95-101. doi: 10.1016/j.envres.2015.03.022. [PMID: 25839716]
  • Aurélia Mesnier, Serge Champion, Laurence Louis, Christophe Sauzet, Phealay May, Henri Portugal, Karim Benbrahim, Joelle Abraldes, Marie-Christine Alessi, Marie-Josephe Amiot-Carlin, Franck Peiretti, Philippe Piccerelle, Gilles Nalbone, Pierre-Henri Villard. The Transcriptional Effects of PCB118 and PCB153 on the Liver, Adipose Tissue, Muscle and Colon of Mice: Highlighting of Glut4 and Lipin1 as Main Target Genes for PCB Induced Metabolic Disorders. PloS one. 2015; 10(6):e0128847. doi: 10.1371/journal.pone.0128847. [PMID: 26086818]
  • Karin I van Ede, Patrik L Andersson, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female rats after a single oral dose. Archives of toxicology. 2014 Mar; 88(3):637-46. doi: 10.1007/s00204-013-1186-2. [PMID: 24363026]
  • Susanne Hansen, Marin Strøm, Sjurdur F Olsen, Ekaterina Maslova, Panu Rantakokko, Hannu Kiviranta, Dorte Rytter, Bodil H Bech, Linda V Hansen, Thorhallur I Halldorsson. Maternal concentrations of persistent organochlorine pollutants and the risk of asthma in offspring: results from a prospective cohort with 20 years of follow-up. Environmental health perspectives. 2014 Jan; 122(1):93-9. doi: 10.1289/ehp.1206397. [PMID: 24162035]
  • Jin-Mei Tang, Wen Li, Yu-Chun Xie, Hong-Wei Guo, Pei Cheng, Huan-Huan Chen, Xu-Qin Zheng, Lin Jiang, Dai Cui, Yun Liu, Guo-Xian Ding, Yu Duan. Morphological and functional deterioration of the rat thyroid following chronic exposure to low-dose PCB118. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2013 Nov; 65(7-8):989-94. doi: 10.1016/j.etp.2013.02.001. [PMID: 23557935]
  • Chengmin Xu, Jianrong Chai, Yaling Qian. [Effect of in utero and lactational exposure to a binary mixture of 3,3',4,4', 5-pentachlorobiphenyl (PCB126) and 2,3',4,4',5-pentachlorobiphenyl (PCB118) on reproductive function in male rat offsprings]. Wei sheng yan jiu = Journal of hygiene research. 2013 Sep; 42(5):758-63. doi: . [PMID: 24218881]
  • Karin I van Ede, Patrik L Andersson, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female mice after a single oral dose. Environmental health perspectives. 2013 Jul; 121(7):847-53. doi: 10.1289/ehp.1206336. [PMID: 23674508]
  • Karin E Zimmer, Marianne Kraugerud, Mona Aleksandersen, Arno C Gutleb, Gunn C Østby, Ellen Dahl, Vidar Berg, Janneche U Skaare, Ingrid Olsaker, Erik Ropstad. Fetal adrenal development: comparing effects of combined exposures to PCB 118 and PCB 153 in a sheep model. Environmental toxicology. 2013 Mar; 28(3):164-77. doi: 10.1002/tox.20703. [PMID: 21544918]
  • Yoshihisa Kato, Mao Onishi, Koichi Haraguchi, Shinichi Ikushiro, Chiho Ohta, Nobuyuki Koga, Tetsuya Endo, Shizuo Yamada, Masakuni Degawa. A possible mechanism for 2,3',4,4',5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level in mice. Biological & pharmaceutical bulletin. 2013; 36(10):1594-601. doi: 10.1248/bpb.b13-00440. [PMID: 23877638]
  • Helena Bjermo, Per Ola Darnerud, Sanna Lignell, Monika Pearson, Panu Rantakokko, Cecilia Nälsén, Heléne Enghardt Barbieri, Hannu Kiviranta, Anna Karin Lindroos, Anders Glynn. Fish intake and breastfeeding time are associated with serum concentrations of organochlorines in a Swedish population. Environment international. 2013 Jan; 51(?):88-96. doi: 10.1016/j.envint.2012.10.010. [PMID: 23201820]
  • Jeong June Choi, Yean Jung Choi, Lei Chen, Bei Zhang, Sung Yong Eum, Maria T Abreu, Michal Toborek. Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood-brain barrier via TLR4/IRF-3 signaling. Toxicology. 2012 Dec; 302(2-3):212-20. doi: 10.1016/j.tox.2012.08.001. [PMID: 22906770]
  • Marianne Kraugerud, Mona Aleksandersen, Jens Randel Nyengaard, Gunn C Ostby, Arno C Gutleb, Ellen Dahl, Vidar Berg, Wenche Farstad, Tore Schweder, Janneche U Skaare, Erik Ropstad. In utero and lactational exposure to PCB 118 and PCB 153 alter ovarian follicular dynamics and GnRH-induced luteinizing hormone secretion in female lambs. Environmental toxicology. 2012 Nov; 27(11):623-34. doi: 10.1002/tox.20679. [PMID: 21344607]
  • Sophie Bourez, Soazig Le Lay, Carine Van den Daelen, Caroline Louis, Yvan Larondelle, Jean-Pierre Thomé, Yves-Jacques Schneider, Isabelle Dugail, Cathy Debier. Accumulation of polychlorinated biphenyls in adipocytes: selective targeting to lipid droplets and role of caveolin-1. PloS one. 2012; 7(2):e31834. doi: 10.1371/journal.pone.0031834. [PMID: 22363745]
  • Katsuhiko Yoshizawa, Nigel J Walker, Abraham Nyska, Grace E Kissling, Micheal P Jokinen, Amy E Brix, Donald M Sells, Michael E Wyde. Thyroid follicular lesions induced by oral treatment for 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds in female Harlan Sprague-Dawley rats. Toxicologic pathology. 2010 Dec; 38(7):1037-50. doi: 10.1177/0192623310382560. [PMID: 20924081]
  • Matt Cave, Savitri Appana, Mihir Patel, Keith Cameron Falkner, Craig J McClain, Guy Brock. Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004. Environmental health perspectives. 2010 Dec; 118(12):1735-42. doi: 10.1289/ehp.1002720. [PMID: 21126940]
  • . Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies). National Toxicology Program technical report series. 2010 Nov; ?(559):1-174. doi: . [PMID: 21383778]
  • Lori Martin, Curtis D Klaassen. Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2010 Sep; 117(1):36-44. doi: 10.1093/toxsci/kfq187. [PMID: 20573785]
  • Jordi Sunyer, Raquel Garcia-Esteban, Mar Alvarez, Mònica Guxens, Fernando Goñi, Mikel Basterrechea, Martine Vrijheid, Stefano Guerra, Josep M Antó. DDE in mothers' blood during pregnancy and lower respiratory tract infections in their infants. Epidemiology (Cambridge, Mass.). 2010 Sep; 21(5):729-35. doi: 10.1097/ede.0b013e3181e5ea96. [PMID: 20616741]
  • Renée Dallaire, Eric Dewailly, Daria Pereg, Serge Dery, Pierre Ayotte. Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environmental health perspectives. 2009 Sep; 117(9):1380-6. doi: 10.1289/ehp.0900633. [PMID: 19750101]
  • Hirokazu Uemura, Kokichi Arisawa, Mineyoshi Hiyoshi, Atsushi Kitayama, Hidenobu Takami, Fusakazu Sawachika, Satoru Dakeshita, Kentaro Nii, Hiroshi Satoh, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Taka-ichiro Suzuki, Masaki Nagai, Tsuguyoshi Suzuki. Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population. Environmental health perspectives. 2009 Apr; 117(4):568-73. doi: 10.1289/ehp.0800012. [PMID: 19440495]
  • Milena Cerná, Marek Malý, Roman Grabic, Andrea Batáriová, Jirí Smíd, Bohuslav Benes. Serum concentrations of indicator PCB congeners in the Czech adult population. Chemosphere. 2008 Jul; 72(8):1124-31. doi: 10.1016/j.chemosphere.2008.04.019. [PMID: 18547604]
  • Takashi Todaka, Hironori Hirakawa, Jumboku Kajiwara, Tsuguhide Hori, Kazuhiro Tobiishi, Daisuke Onozuka, Shizue Kato, Seiko Sasaki, Sonomi Nakajima, Yasuaki Saijo, Fumihiro Sata, Reiko Kishi, Takao Iida, Masutaka Furue. Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood and breast milk collected from 60 mothers in Sapporo City, Japan. Chemosphere. 2008 Jul; 72(8):1152-8. doi: 10.1016/j.chemosphere.2008.03.050. [PMID: 18474391]
  • Stuart Harrad, Matthew Robson, Sadegh Hazrati, Victoria S Baxter-Plant, Kevin Deplanche, Mark D Redwood, Lynne E Macaskie. Dehalogenation of polychlorinated biphenyls and polybrominated diphenyl ethers using a hybrid bioinorganic catalyst. Journal of environmental monitoring : JEM. 2007 Apr; 9(4):314-8. doi: 10.1039/b616567b. [PMID: 17410306]
  • . Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies). National Toxicology Program technical report series. 2006 Nov; ?(531):1-218. doi: . [PMID: 17342196]
  • Mike Howsam, Joan O Grimalt, Elisabet Guinó, Matilde Navarro, Juan Martí-Ragué, Miguel A Peinado, Gabriel Capellá, Victor Moreno. Organochlorine exposure and colorectal cancer risk. Environmental health perspectives. 2004 Nov; 112(15):1460-6. doi: 10.1289/ehp.7143. [PMID: 15531428]
  • Britt-Marie Bäcklin, Carolina Bredhult, Matts Olovsson. Proliferative effects of estradiol, progesterone, and two CB congeners and their metabolites on gray seal (Halichoerus grypus) uterine myocytes in vitro. Toxicological sciences : an official journal of the Society of Toxicology. 2003 Sep; 75(1):154-60. doi: 10.1093/toxsci/kfg161. [PMID: 12805643]
  • Ilonka A T M Meerts, Yvonne Assink, Peter H Cenijn, Johannes H J Van Den Berg, Bert M Weijers, Ake Bergman, Jan H Koeman, Abraham Brouwer. Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. Toxicological sciences : an official journal of the Society of Toxicology. 2002 Aug; 68(2):361-71. doi: 10.1093/toxsci/68.2.361. [PMID: 12151632]
  • T L Gallant, A Singh, I Chu. PCB 118 induces ultrastructural alterations in the rat liver. Toxicology. 2000 Apr; 145(2-3):127-34. doi: 10.1016/s0300-483x(00)00141-4. [PMID: 10771137]
  • I Chu, D C Villeneuve, A Yagminas, P Lecavalier, H Håkansson, U G Ahlborg, V E Valli, S W Kennedy, A Bergman, R F Seegal. Toxicity of PCB 77 (3,3',4,4'-tetrachlorobiphenyl) and PCB 118 (2,3',4,4'5-pentachlorobiphenyl) in the rat following subchronic dietary exposure. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1995 Jul; 26(2):282-92. doi: 10.1006/faat.1995.1099. [PMID: 7589917]
  • K MacLellan, A Singh, I Chu, R Poon, D C Villeneuve. Subchronic toxicity of pentachlorobiphenyl congeners n. 126 or 118 in the rat liver. An electron microscope study. Journal of submicroscopic cytology and pathology. 1994 Apr; 26(2):279-91. doi: . [PMID: 8019951]
  • D K Ness, S L Schantz, J Moshtaghian, L G Hansen. Effects of perinatal exposure to specific PCB congeners on thyroid hormone concentrations and thyroid histology in the rat. Toxicology letters. 1993 Jun; 68(3):311-23. doi: 10.1016/0378-4274(93)90023-q. [PMID: 8516785]