2,3,4,7,8-PENTACHLORODIBENZOFURAN (BioDeep_00001868173)

Main id: BioDeep_00000012081

 


代谢物信息卡片


2,3,4,7,8-PENTACHLORODIBENZOFURAN

化学式: C12H3Cl5O (337.8626538)
中文名称: 2,3,4,7,8-五氯二苯并呋喃
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C2C3=CC(=C(C(=C3OC2=CC(=C1Cl)Cl)Cl)Cl)Cl
InChI: InChI=1S/C12H3Cl5O/c13-6-1-4-5-2-8(15)10(16)11(17)12(5)18-9(4)3-7(6)14/h1-3H

描述信息

同义名列表

2 个代谢物同义名

2,3,4,7,8-PENTACHLORODIBENZOFURAN; 2,3,4,7,8-Pentachlorodibenzofuran



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hongyan Xu, Caixia Li, Pacharaporn Suklai, Qinghua Zeng, Raymond Chong, Zhiyuan Gong. Differential sensitivities to dioxin-like compounds PCB 126 and PeCDF between Tg(cyp1a:gfp) transgenic medaka and zebrafish larvae. Chemosphere. 2018 Feb; 192(?):24-30. doi: 10.1016/j.chemosphere.2017.10.130. [PMID: 29091793]
  • Jung-Wei Chang, Hsiu-Ling Chen, Huey-Jen Su, Ching-Chang Lee. Abdominal Obesity and Insulin Resistance in People Exposed to Moderate-to-High Levels of Dioxin. PloS one. 2016; 11(1):e0145818. doi: 10.1371/journal.pone.0145818. [PMID: 26752053]
  • Shinya Matsumoto, Manabu Akahane, Yoshiyuki Kanagawa, Jumboku Kajiwara, Chikage Mitoma, Hiroshi Uchi, Masutaka Furue, Tomoaki Imamura. Unexpectedly long half-lives of blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) levels in Yusho patients. Environmental health : a global access science source. 2015 Sep; 14(?):76. doi: 10.1186/s12940-015-0059-y. [PMID: 26384313]
  • Ken-ichi Yamada, Yuji Ishii, Tomoki Takeda, Hiroaki Kuroki, Chikage Mitoma, Hiroshi Uchi, Masutaka Furue, Hideyuki Yamada. [Effect of Cynaropicrin on 2,3,4,7,8-Pentachlorodibenzofuran-induced Wasting Syndrome and Oxidative Stress]. Fukuoka igaku zasshi = Hukuoka acta medica. 2015 May; 106(5):169-75. doi: . [PMID: 26226680]
  • Karin I van Ede, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicology letters. 2014 Apr; 226(1):43-52. doi: 10.1016/j.toxlet.2014.01.026. [PMID: 24472611]
  • Karin I van Ede, Patrik L Andersson, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female rats after a single oral dose. Archives of toxicology. 2014 Mar; 88(3):637-46. doi: 10.1007/s00204-013-1186-2. [PMID: 24363026]
  • Shinya Matsumoto, Manabu Akahane, Yoshiyuki Kanagawa, Jumboku Kajiwara, Takashi Todaka, Fumiko Yasukawa, Hiroshi Uchi, Masutaka Furue, Tomoaki Imamura. Individuals' half-lives for 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in blood: correlation with clinical manifestations and laboratory results in subjects with Yusho. Chemosphere. 2013 Aug; 92(7):772-7. doi: 10.1016/j.chemosphere.2013.04.005. [PMID: 23651555]
  • Karin I van Ede, Patrik L Andersson, Konrad P J Gaisch, Martin van den Berg, Majorie B M van Duursen. Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female mice after a single oral dose. Environmental health perspectives. 2013 Jul; 121(7):847-53. doi: 10.1289/ehp.1206336. [PMID: 23674508]
  • Sohee Phark, So-Young Park, Seonyoung Choi, Zhi Zheng, Eunkyung Cho, Min Lee, Ji-youn Lim, Jong Bok Seo, Nam Hee Won, Woon-Won Jung, Donggeun Sul. Toxicological biomarkers of 2,3,4,7,8-pentachlorodibenzofuran in proteins secreted by HepG2 cells. Biochimica et biophysica acta. 2012 Apr; 1824(4):656-66. doi: 10.1016/j.bbapap.2012.01.013. [PMID: 22310479]
  • P Monica Lind, Bert van Bavel, Samira Salihovic, Lars Lind. Circulating levels of persistent organic pollutants (POPs) and carotid atherosclerosis in the elderly. Environmental health perspectives. 2012 Jan; 120(1):38-43. doi: 10.1289/ehp.1103563. [PMID: 22222676]
  • Junya Nagayama, Takashi Todaka, Hironori Hirakawa, Tsuguhide Hori, Jumboku Kajiwara, Takesumi Yoshimura. [Time serial changes in the concentrations of the etiological agents of fetal Yusho--PCDDs and PCDFs]. Fukuoka igaku zasshi = Hukuoka acta medica. 2011 Apr; 102(4):109-15. doi: ". [PMID: 21706889]
  • Shoji Tokunaga. [The temporal change rate of 2,3,4,7,8-PCDF level among examinees of annual health checkups of Yusho]. Fukuoka igaku zasshi = Hukuoka acta medica. 2011 Apr; 102(4):87-91. doi: ". [PMID: 21706885]
  • Larry L Needham, Philippe Grandjean, Birger Heinzow, Poul J Jørgensen, Flemming Nielsen, Donald G Patterson, Andreas Sjödin, Wayman E Turner, Pal Weihe. Partition of environmental chemicals between maternal and fetal blood and tissues. Environmental science & technology. 2011 Feb; 45(3):1121-6. doi: 10.1021/es1019614. [PMID: 21166449]
  • Katsuhiko Yoshizawa, Nigel J Walker, Abraham Nyska, Grace E Kissling, Micheal P Jokinen, Amy E Brix, Donald M Sells, Michael E Wyde. Thyroid follicular lesions induced by oral treatment for 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds in female Harlan Sprague-Dawley rats. Toxicologic pathology. 2010 Dec; 38(7):1037-50. doi: 10.1177/0192623310382560. [PMID: 20924081]
  • Alfred Franzblau, Elizabeth Hedgeman, Olivier Jolliet, Kristine Knutson, Tim Towey, Qixuan Chen, Biling Hong, Peter Adriaens, Avery Demond, David H Garabrant, Brenda W Gillespie, James Lepkowski. Case report: the University of Michigan dioxin exposure study: a follow-up investigation of a case with high serum concentration of 2,3,4,7,8-pentachlorodibenzofuran. Environmental health perspectives. 2010 Sep; 118(9):1313-7. doi: 10.1289/ehp.0901723. [PMID: 20813655]
  • Biling Hong, David Garabrant, Elizabeth Hedgeman, Avery Demond, Brenda Gillespie, Qixuan Chen, Chiung-Wen Chang, Timothy Towey, Kristine Knutson, Alfred Franzblau, James Lepkowski, Peter Adriaens. Impact of WHO 2005 revised toxic equivalency factors for dioxins on the TEQs in serum, household dust and soil. Chemosphere. 2009 Aug; 76(6):727-33. doi: 10.1016/j.chemosphere.2009.05.034. [PMID: 19573893]
  • Takumi Ishida, Yuichi Sakai, Yuji Ishii, Masutaka Furue, Hideyuki Yamada. [The accelerated excretion of 2,3,4,7,8-pentachlorodibenzofuran by Cholebine]. Fukuoka igaku zasshi = Hukuoka acta medica. 2009 May; 100(5):210-6. doi: NULL. [PMID: 19588851]
  • Hirokazu Uemura, Kokichi Arisawa, Mineyoshi Hiyoshi, Atsushi Kitayama, Hidenobu Takami, Fusakazu Sawachika, Satoru Dakeshita, Kentaro Nii, Hiroshi Satoh, Yoshio Sumiyoshi, Kenji Morinaga, Kazunori Kodama, Taka-ichiro Suzuki, Masaki Nagai, Tsuguyoshi Suzuki. Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan's general population. Environmental health perspectives. 2009 Apr; 117(4):568-73. doi: 10.1289/ehp.0800012. [PMID: 19440495]
  • Yoshiyuki Kanagawa, Shinya Matsumoto, Soichi Koike, Bunichi Tajima, Noriko Fukiwake, Satoko Shibata, Hiroshi Uchi, Masutaka Furue, Tomoaki Imamura. Association of clinical findings in Yusho patients with serum concentrations of polychlorinated biphenyls, polychlorinated quarterphenyls and 2,3,4,7,8-pentachlorodibenzofuran more than 30 years after the poisoning event. Environmental health : a global access science source. 2008 Oct; 7(?):47. doi: 10.1186/1476-069x-7-47. [PMID: 18831733]
  • Shu Zhang, Craig Rowlands, Stephen Safe. Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicology and applied pharmacology. 2008 Mar; 227(2):196-206. doi: 10.1016/j.taap.2007.10.019. [PMID: 18048071]
  • Shoji Tokunaga, Satoko Shibata, Masutaka Furue. [The past history of diseases and symptoms among the Yusho patients, and its association with blood lipid concentration of 2,3,4,7,8-pentachlorodibenzofuran]. Fukuoka igaku zasshi = Hukuoka acta medica. 2007 May; 98(5):160-5. doi: ". [PMID: 17642292]
  • Shinya Matsumoto, Yoshiyuki Kanagawa, Bunichi Tajima, Takeshi Uenotsuchi, Satoko Shibata, Masutaka Furue, Tomoaki Imamura. [Relationship between blood dioxin levels and present/past clinical symptoms in Kanemi Yusho patients]. Fukuoka igaku zasshi = Hukuoka acta medica. 2007 May; 98(5):153-9. doi: ". [PMID: 17642291]
  • Yoshiko Takao, Daisuke Onozuka, Kyoichiro Kataoka, Takashi Todaka, Hironori Hirakawa, Jumboku Kajiwara, Takesumi Yoshimura. [Trend of 2,3,4,7,8-PeCDF concentrations in the blood of Yusho patients over four years]. Fukuoka igaku zasshi = Hukuoka acta medica. 2007 May; 98(5):149-52. doi: ". [PMID: 17642290]
  • Yoshiyuki Kanagawa, Shinya Matsumoto, Bunichi Tajima, Takeshi Uenotsuchi, Satoko Shibata, Masutaka Furue, Tomoaki Imamura. [Average of the PCDFs value in blood in patients with Yusho in the 2001 to 2003 fiscal year and comparison between the clinical features and PCDFs]. Fukuoka igaku zasshi = Hukuoka acta medica. 2007 May; 98(5):129-35. doi: ". [PMID: 17642286]
  • Takashi Todaka, Hironori Hirakawa, Jumboku Kajiwara, Tsuguhide Hori, Kazuhiro Tobiishi, Daisuke Onozuka, Takao Iida, Takesumi Yoshimura, Masutaka Furue. Dioxin concentration in the blood of patients collected during medical check-up for Yusho in 2004-2005. Fukuoka igaku zasshi = Hukuoka acta medica. 2007 May; 98(5):222-31. doi: ". [PMID: 17642301]
  • Tomoaki Imamura, Yoshiyuki Kanagawa, Shinya Matsumoto, Bunichi Tajima, Takeshi Uenotsuchi, Satoko Shibata, Masutaka Furue. Relationship between clinical features and blood levels of pentachlorodibenzofuran in patients with Yusho. Environmental toxicology. 2007 Apr; 22(2):124-31. doi: 10.1002/tox.20251. [PMID: 17366567]
  • Marcella Warner, Brenda Eskenazi, David L Olive, Steven Samuels, Sunita Quick-Miles, Paolo Vercellini, Pier Mario Gerthoux, Larry Needham, Donald G Patterson, Paolo Mocarelli. Serum dioxin concentrations and quality of ovarian function in women of Seveso. Environmental health perspectives. 2007 Mar; 115(3):336-40. doi: 10.1289/ehp.9667. [PMID: 17431480]
  • Takashi Todaka, Hironori Hirakawa, Tsuguhide Hori, Kazuhiro Tobiishi, Takao Iida, Masutaka Furue. Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and non-ortho and mono-ortho polychlorinated biphenyls in blood of Yusho patients. Chemosphere. 2007 Jan; 66(10):1983-9. doi: 10.1016/j.chemosphere.2006.07.069. [PMID: 16987543]
  • . Toxicology and carcinogenesis studies of a mixture of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (Cas No. 1746-01-6), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (Cas No. 57117-31-4), and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) in female Harlan Sprague-Dawley rats (gavage studies). National Toxicology Program technical report series. 2006 Sep; ?(526):1-180. doi: . [PMID: 17342195]
  • . Toxicology and carcinogenesis studies of 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) (Cas No. 57117-31-4) in female Harlan Sprague-Dawley rats (gavage studies). National Toxicology Program technical report series. 2006 Sep; ?(525):1-198. doi: . [PMID: 17160103]
  • Kevin M Crofton, Elena S Craft, Joan M Hedge, Chris Gennings, Jane E Simmons, Richard A Carchman, W Hans Carter, Michael J DeVito. Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism. Environmental health perspectives. 2005 Nov; 113(11):1549-54. doi: 10.1289/ehp.8195. [PMID: 16263510]
  • Mary S Wolff, Susan L Teitelbaum, Paul J Lioy, Regina M Santella, Richard Y Wang, Robert L Jones, Kathleen L Caldwell, Andreas Sjödin, Wayman E Turner, Wei Li, Panos Georgopoulos, Gertrud S Berkowitz. Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environmental health perspectives. 2005 Jun; 113(6):739-48. doi: 10.1289/ehp.7694. [PMID: 15929898]
  • Chan-Seok Moon, Yoon-Seok Chang, Byung-Hoon Kim, Dongchun Shin, Masayuki Ikeda. Evaluation of serum dioxin congeners among residents near continuously burning municipal solid waste incinerators in Korea. International archives of occupational and environmental health. 2005 Apr; 78(3):205-10. doi: 10.1007/s00420-005-0603-0. [PMID: 15744508]
  • Esteban Abad, Karell Martínez, Josep Caixach, Josep Rivera. Polychlorinated dibenzo-p-dioxin/polychlorinated dibenzofuran releases into the atmosphere from the use of secondary fuels in cement kilns during clinker formation. Environmental science & technology. 2004 Sep; 38(18):4734-8. doi: 10.1021/es049641a. [PMID: 15487780]
  • Junya Nagayama, Takumi Takasuga, Hiroshi Tsuji, Motomi Umehara, Takehiko Sada, Teruaki Iwasaki. Active elimination of causative PCDFs/DDs congeners of Yusho by one year intake of FBRA in Japanese people. Fukuoka igaku zasshi = Hukuoka acta medica. 2003 May; 94(5):118-25. doi: ". [PMID: 12872712]
  • Ezdihar A Hassoun, Hong Wang, Ahmed Abushaban, Sidney J Stohs. Induction of oxidative stress in the tissues of rats after chronic exposure to TCDD, 2,3,4,7,8-pentachlorodibenzofuran, and 3,3',4,4',5-pentachlorobiphenyl. Journal of toxicology and environmental health. Part A. 2002 Jun; 65(12):825-42. doi: 10.1080/00984100290071054. [PMID: 12079609]
  • Travis B Salisbury, Jennifer L Marcinkiewicz. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran reduces growth and disrupts reproductive parameters in female rats. Biology of reproduction. 2002 Jun; 66(6):1621-6. doi: 10.1095/biolreprod66.6.1621. [PMID: 12021039]
  • C Y Chen, J T Hamm, J R Hass, L S Birnbaum. Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho polychlorinated biphenyls in pregnant long evans rats and the transfer to offspring. Toxicology and applied pharmacology. 2001 Jun; 173(2):65-88. doi: 10.1006/taap.2001.9143. [PMID: 11384209]
  • E A Hassoun, F Li, A Abushaban, S J Stohs. Production of superoxide anion, lipid peroxidation and DNA damage in the hepatic and brain tissues of rats after subchronic exposure to mixtures of TCDD and its congeners. Journal of applied toxicology : JAT. 2001 May; 21(3):211-9. doi: 10.1002/jat.744. [PMID: 11404832]
  • E A Hassoun, F Li, A Abushaban, S J Stohs. The relative abilities of TCDD and its congeners to induce oxidative stress in the hepatic and brain tissues of rats after subchronic exposure. Toxicology. 2000 Apr; 145(2-3):103-13. doi: 10.1016/s0300-483x(99)00221-8. [PMID: 10771135]
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  • H Kamimura, H Yoshimura. [Stimulation of fecal excretion of the etiological compounds of yusho in rats]. Fukuoka igaku zasshi = Hukuoka acta medica. 1987 May; 78(5):266-80. doi: NULL. [PMID: 3117660]
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