probucol (BioDeep_00001867985)
Main id: BioDeep_00000006491
代谢物信息卡片
probucol
化学式: C31H48O2S2 (516.3095548)
中文名称: 丙丁酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C
InChI: InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
描述信息
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
D020011 - Protective Agents > D000975 - Antioxidants
D009676 - Noxae > D000963 - Antimetabolites
同义名列表
1 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:8427
- KEGG: C07373
- KEGGdrug: D00476
- PubChem: 4912
- DrugBank: DB01599
- ChEMBL: CHEMBL608
- MeSH: Probucol
- CAS: 23288-49-5
- PubChem: 9577
- NIKKAJI: J20.410B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Arazu Sharif, John Mamo, Virginie Lam, Hani Al-Salami, Armin Mooranian, Gerald F Watts, Roger Clarnette, Giuseppe Luna, Ryu Takechi. The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases.
Translational neurodegeneration.
2024 Jan; 13(1):6. doi:
10.1186/s40035-024-00398-w. [PMID: 38247000] - Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis.
The Cochrane database of systematic reviews.
2023 Aug; 8(?):CD013573. doi:
10.1002/14651858.cd013573.pub2. [PMID: 37565307] - Mauricio Tavares Jacques, Viviane de Souza, Flávio Augusto Rocha Barbosa, Rômulo Faria Santos Canto, Samantha Cristiane Lopes, Rui Daniel Prediger, Antônio Luiz Braga, Michael Aschner, Marcelo Farina. Novel Probucol Analogue, 4,4'-Diselanediylbis (2,6-Di-tert-Butylphenol), Prevents Oxidative Glutamate Neurotoxicity In Vitro and Confers Neuroprotection in a Rodent Model of Ischemic Stroke.
ACS chemical neuroscience.
2023 Jul; ?(?):. doi:
10.1021/acschemneuro.3c00138. [PMID: 37499207] - Ranjitha Guttapadu, Kalyani Korla, Safnaz Uk, Vamseedhar Annam, Purnima Ashok, Nagasuma Chandra. Identification of Probucol as a candidate for combination therapy with Metformin for Type 2 diabetes.
NPJ systems biology and applications.
2023 May; 9(1):18. doi:
10.1038/s41540-023-00275-8. [PMID: 37221264] - Natalia Moskal, Naomi P Visanji, Olena Gorbenko, Vijay Narasimhan, Hannah Tyrrell, Jess Nash, Peter N Lewis, G Angus McQuibban. An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets.
PLoS biology.
2023 Mar; 21(3):e3001977. doi:
10.1371/journal.pbio.3001977. [PMID: 36862640] - Hidenori Arai, Hideaki Bujo, Daisaku Masuda, Toshiyuki Ishibashi, Satoshi Nakagawa, Kenichiro Tanabe, Tatsuo Kagimura, Hyun-Jae Kang, Moo Hyun Kim, Jidong Sung, Sang-Hyun Kim, Cheol-Ho Kim, Jeong Euy Park, Junbo Ge, Byung-Hee Oh, Toru Kita, Yasushi Saito, Masanori Fukushima, Yuji Matsuzawa, Shizuya Yamashita. Integrated Analysis of Two Probucol Trials for the Secondary Prevention of Atherosclerotic Cardiovascular Events: PROSPECTIVE and IMPACT.
Journal of atherosclerosis and thrombosis.
2022 Jun; 29(6):850-865. doi:
10.5551/jat.62821. [PMID: 33867420] - Shizuya Yamashita, Daisaku Masuda, Mariko Harada-Shiba, Hidenori Arai, Hideaki Bujo, Shun Ishibashi, Hiroyuki Daida, Nobuhiko Koga, Shinichi Oikawa. Effectiveness and Safety of Lipid-Lowering Drug Treatments in Japanese Patients with Familial Hypercholesterolemia: Familial Hypercholesterolemia Expert Forum (FAME) Study.
Journal of atherosclerosis and thrombosis.
2022 May; 29(5):608-638. doi:
10.5551/jat.62764. [PMID: 33980760] - Virginie Lam, Roger Clarnette, Roslyn Francis, Michael Bynevelt, Gerald Watts, Leon Flicker, Carolyn F Orr, Poh Loh, Nicola Lautenschlager, Christopher M Reid, Jonathan K Foster, Satvinder S Dhaliwal, Suzanne Robinson, Emily Corti, Mauro Vaccarezza, Ben Horgan, Ryusuke Takechi, John Mamo. Efficacy of probucol on cognitive function in Alzheimer's disease: study protocol for a double-blind, placebo-controlled, randomised phase II trial (PIA study).
BMJ open.
2022 Feb; 12(2):e058826. doi:
10.1136/bmjopen-2021-058826. [PMID: 35190446] - Erica Blenda da Silva, Tuany Eichwald, Viviane Glaser, Karina Giacomini Varela, Antuani Rafael Baptistella, Diego de Carvalho, Aline Pertile Remor. Protective Effects of Probucol on Different Brain Cells Exposed to Manganese.
Neurotoxicity research.
2022 Feb; 40(1):276-285. doi:
10.1007/s12640-021-00458-3. [PMID: 35043377] - Aline Aita Naime, Flavio Augusto Rocha Barbosa, Diones Caeran Bueno, Rozangela Curi Pedrosa, Rômulo Faria Santos Canto, Dirleise Colle, Antônio Luiz Braga, Marcelo Farina. Prevention of ferroptosis in acute scenarios: an in vitro study with classic and novel anti-ferroptotic compounds.
Free radical research.
2021 Dec; 55(11-12):1062-1079. doi:
10.1080/10715762.2021.2017912. [PMID: 34895012] - Firoozeh Farahmand, Akshi Malik, Anita Sharma, Ashim K Bagchi, Pawan K Singal. Role of oxidative stress versus lipids in monocrotaline-induced pulmonary hypertension and right heart failure.
Physiological reports.
2021 11; 9(22):e15090. doi:
10.14814/phy2.15090. [PMID: 34816616] - Sergey V Stovbun, Tatiana S Kalinina, Dmitry V Zlenko, Aleksei V Kiselev, Alexander A Litvin, Alexander A Bukhvostov, Sergey V Usachev, Dmitry A Kuznetsov. Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity.
International journal of biological macromolecules.
2021 Jul; 182(?):743-749. doi:
10.1016/j.ijbiomac.2021.03.135. [PMID: 33831450] - Takeshi Okada, Mizuki Sumida, Tohru Ohama, Yuki Katayama, Ayami Saga, Hiroyasu Inui, Kotaro Kanno, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita. Development and Clinical Application of an Enzyme-Linked Immunosorbent Assay for Oxidized High-Density Lipoprotein.
Journal of atherosclerosis and thrombosis.
2021 Jul; 28(7):703-715. doi:
10.5551/jat.56887. [PMID: 33028763] - Shengyu Zhang, Lingli Li, Wenxu Chen, Suowen Xu, Xiaojun Feng, Lei Zhang. Natural products: The role and mechanism in low-density lipoprotein oxidation and atherosclerosis.
Phytotherapy research : PTR.
2021 Jun; 35(6):2945-2967. doi:
10.1002/ptr.7002. [PMID: 33368763] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Xi Mei, Jun Zeng, Dong-Fang Liu, Ye Zhao, Hui-Lan Yang, Yao Li, Ping Qiu, Ming-Wei Tang. Abnormalities of the PRMT1-ADMA-DDAH1 metabolism axis and probucol treatment in diabetic patients and diabetic rats.
Annals of palliative medicine.
2021 Mar; 10(3):3343-3353. doi:
10.21037/apm-21-417. [PMID: 33849119] - Zhengmao Wu, Xuan Wang, Xianxun Jiang. Study on the Mechanism of Probucol Nanosuspension on Hyperlipidemic Pancreatitis and Regulation of Blood Lipid Function.
Journal of nanoscience and nanotechnology.
2021 02; 21(2):1286-1292. doi:
10.1166/jnn.2021.18663. [PMID: 33183474] - Shizuya Yamashita, Hidenori Arai, Hideaki Bujo, Daisaku Masuda, Tohru Ohama, Toshiyuki Ishibashi, Koji Yanagi, Yasuji Doi, Satoshi Nakagawa, Koichi Yamashiro, Kenichiro Tanabe, Toru Kita, Masunori Matsuzaki, Yasushi Saito, Masanori Fukushima, Yuji Matsuzawa. Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Coronary Heart Disease (PROSPECTIVE).
Journal of atherosclerosis and thrombosis.
2021 Feb; 28(2):103-123. doi:
10.5551/jat.55327. [PMID: 32336695] - Raymond Pranata, Emir Yonas, Rachel Vania, Antonia Anna Lukito. The role of probucol preventing contrast-induced nephropathy in patients undergoing invasive coronary procedures - Systematic review and meta-analysis of randomized controlled trials.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir.
2021 01; 49(1):51-59. doi:
10.5543/tkda.2020.14568. [PMID: 33390574] - Susbin Raj Wagle, Daniel Walker, Bozica Kovacevic, Ahmed Gedawy, Momir Mikov, Svetlana Golocorbin-Kon, Armin Mooranian, Hani Al-Salami. Micro-Nano formulation of bile-gut delivery: rheological, stability and cell survival, basal and maximum respiration studies.
Scientific reports.
2020 05; 10(1):7715. doi:
10.1038/s41598-020-64355-z. [PMID: 32382021] - Armin Mooranian, Susbin Raj Wagle, Bozica Kovacevic, Ryu Takechi, John Mamo, Virginie Lam, Gerald F Watts, Momir Mikov, Svetlana Golocorbin-Kon, Goran Stojanovic, Hesham Al-Sallami, Hani Al-Salami. Bile acid bio-nanoencapsulation improved drug targeted-delivery and pharmacological effects via cellular flux: 6-months diabetes preclinical study.
Scientific reports.
2020 01; 10(1):106. doi:
10.1038/s41598-019-53999-1. [PMID: 31919411] - Maki Tsujita, Nobukatsu Akita, Tomo Yokota, Fumihiko Kobayashi, Shinji Yokoyama. Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation.
Journal of atherosclerosis and thrombosis.
2020 Jan; 27(1):25-37. doi:
10.5551/jat.48967. [PMID: 31092744] - Armin Mooranian, Nassim Zamani, Giuseppe Luna, Hesham Al-Sallami, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Bozica Kovacevic, Hani Al-Salami. Bile acid-polymer-probucol microparticles: protective effect on pancreatic β-cells and decrease in type 1 diabetes development in a murine model.
Pharmaceutical development and technology.
2019 Dec; 24(10):1272-1277. doi:
10.1080/10837450.2019.1665069. [PMID: 31557068] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Na-Qiong Wu, Yuan-Lin Guo, Cheng-Gang Zhu, Ying Gao, Geng Liu, Qian Dong, Jian-Jun Li. Rapid Regression of Multiple-Site Xanthomas in an Adult With Homozygous Familial Hypercholesterolemia by Triple Lipid-Lowering Drugs.
American journal of therapeutics.
2019 Nov; 26(6):e775-e777. doi:
10.1097/mjt.0000000000000868. [PMID: 31703038] - Jin-Lan Huang, Chao Yu, Min Su, Si-Man Yang, Fan Zhang, Yuan-Yuan Chen, Jin-Yuan Liu, Yi-Fan Jiang, Zhen-Guo Zhong, Deng-Pan Wu. Probucol, a "non-statin" cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice.
Aging.
2019 10; 11(19):8542-8555. doi:
10.18632/aging.102337. [PMID: 31590160] - Elham Fanaee-Danesh, Chaitanya Chakravarthi Gali, Jelena Tadic, Martina Zandl-Lang, Alexandra Carmen Kober, Vicente Roca Agujetas, Cristina de Dios, Carmen Tam-Amersdorfer, Anika Stracke, Nicole Maria Albrecher, Anil Paul Chirackal Manavalan, Marielies Reiter, Yidan Sun, Anna Colell, Frank Madeo, Ernst Malle, Ute Panzenboeck. Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells.
Biochimica et biophysica acta. Molecular basis of disease.
2019 09; 1865(9):2224-2245. doi:
10.1016/j.bbadis.2019.04.019. [PMID: 31055081] - Amanda Z Zucoloto, Marília F Manchope, Sergio M Borghi, Telma S Dos Santos, Victor Fattori, Stephanie Badaro-Garcia, Doumit Camilios-Neto, Rubia Casagrande, Waldiceu A Verri. Probucol Ameliorates Complete Freund's Adjuvant-Induced Hyperalgesia by Targeting Peripheral and Spinal Cord Inflammation.
Inflammation.
2019 Aug; 42(4):1474-1490. doi:
10.1007/s10753-019-01011-3. [PMID: 31011926] - Wei Xin, Zhiqin Lin, Tao Zhang, Shujie Jia. Probucol for the prevention of contrast-induced acute kidney injury in patients undergoing coronary angiography or percutaneous coronary intervention: A meta-analysis of randomized controlled trials
.
Clinical nephrology.
2019 Jul; 92(1):36-43. doi:
10.5414/cn109701. [PMID: 30964433] - Yong Wang, Yun Shi, Xuesheng Xu, Wenkun Ge, Shuo Yang, Chengzhi Lu. Effects of probucol on contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention.
Medicine.
2019 Jun; 98(25):e16049. doi:
10.1097/md.0000000000016049. [PMID: 31232940] - Yingjie Xu, Wenlong Zhu, Tingting Wang, Liying Jin, Tianwei Liu, Xu Li, Zijiao Guan, Zhifeng Jiang, Xianze Meng, Jigang Wang, Yunliang Guo. Low molecule weight fucoidan mitigates atherosclerosis in ApoE (-/-) mouse model through activating multiple signal pathway.
Carbohydrate polymers.
2019 Feb; 206(?):110-120. doi:
10.1016/j.carbpol.2018.10.097. [PMID: 30553304] - Xingxing Ma, Zhanquan Jiao, Yanhong Liu, Jun Chen, Guangping Li, Tong Liu, Gary Tse, Ruyu Yuan. Probucol Protects Against Contrast-Induced Acute Kidney Injury via the Extracellular Signal-Regulated Kinases 1 and 2 (ERK1/2)/JNK-Caspase 3 Pathway in Diabetic Rats.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Feb; 25(?):1038-1045. doi:
10.12659/msm.913106. [PMID: 30728344] - Alexios N Matralis, Angeliki P Kourounakis. Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives.
ACS medicinal chemistry letters.
2019 Jan; 10(1):98-104. doi:
10.1021/acsmedchemlett.8b00469. [PMID: 30655954] - Xiaokun Guo, Lin Wang, Xiaoshuang Xia, Peilu Wang, Xin Li. Effects of atorvastatin and/or probucol on recovery of atherosclerosis in high-fat-diet-fed apolipoprotein E-deficient mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jan; 109(?):1445-1453. doi:
10.1016/j.biopha.2018.10.184. [PMID: 30551396] - Kentaro Higashi, Asami Mori, Kenji Sakamoto, Kunio Ishii, Tsutomu Nakahara. Probucol Slows the Progression of Cataracts in Streptozotocin-Induced Hyperglycemic Rats.
Pharmacology.
2019; 103(3-4):212-219. doi:
10.1159/000496055. [PMID: 30721902] - Armin Mooranian, Nassim Zamani, Ryu Takechi, Giuseppe Luna, Momir Mikov, Svetlana Goločorbin-Kon, Magdy Elnashar, Frank Arfuso, Hani Al-Salami. An in vivo pharmacological study: Variation in tissue-accumulation for the drug probucol as the result of targeted microtechnology and matrix-acrylic acid optimization and stabilization techniques.
PloS one.
2019; 14(4):e0214984. doi:
10.1371/journal.pone.0214984. [PMID: 30947243] - Wei Syun Hu, Wei Jen Ting, Shanmugam Tamilselvi, Cecilia Hsuan Day, Ting Wang, Wen-Dee Chiang, Vijaya Padma Viswanadha, Yu Lan Yeh, Wan Teng Lin, Chih Yang Huang. Oral administration of alcalase potato protein hydrolysate-APPH attenuates high fat diet-induced cardiac complications via TGF-β/GSN axis in aging rats.
Environmental toxicology.
2019 Jan; 34(1):5-12. doi:
10.1002/tox.22651. [PMID: 30240538] - Bhagu R Bhavnani, Anthony Cecutti, Alan Gerulath, Allan C Woolever, Mauricio Berco. Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women.
Menopause (New York, N.Y.).
2018 11; 25(11):1214-1223. doi:
10.1097/gme.0000000000001222. [PMID: 30358716] - Ronald J van der Sluis, Robin A F Verwilligen, Zsuzsanna Lendvai, Robbert Wever, Menno Hoekstra, Miranda Van Eck. HDL is essential for atherosclerotic lesion regression in Apoe knockout mice by bone marrow Apoe reconstitution.
Atherosclerosis.
2018 11; 278(?):240-249. doi:
10.1016/j.atherosclerosis.2018.09.038. [PMID: 30340108] - Yiwen Qian, Guoguang Chen, Jin Wang, Lili Ren. Preparation and Evaluation of Probucol-Phospholipid Complex with Enhanced Bioavailability and No Food Effect.
AAPS PharmSciTech.
2018 Nov; 19(8):3599-3608. doi:
10.1208/s12249-018-1157-2. [PMID: 30238303] - John Cl Mamo, Virginie Lam, Hani Al-Salami, Emily Brook, Armin Mooranian, Michael Nesbit, Liam Graneri, Zachary D'Alonzo, Nicholas Fimognari, Andrea Stephenson, Ryusuke Takechi. Sodium alginate capsulation increased brain delivery of probucol and suppressed neuroinflammation and neurodegeneration.
Therapeutic delivery.
2018 10; 9(10):703-709. doi:
10.4155/tde-2018-0033. [PMID: 30277134] - Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan, Hong Yu. Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice.
Journal of translational medicine.
2018 06; 16(1):155. doi:
10.1186/s12967-018-1502-y. [PMID: 29879989] - Armin Mooranian, Rebecca Negrulj, Ryu Takechi, John Mamo, Hesham Al-Sallami, Hani Al-Salami. The biological effects of the hypolipidaemic drug probucol microcapsules fed daily for 4 weeks, to an insulin-resistant mouse model: potential hypoglycaemic and anti-inflammatory effects.
Drug delivery and translational research.
2018 06; 8(3):543-551. doi:
10.1007/s13346-017-0473-5. [PMID: 29313296] - Xin Guo, Jiawei Liao, Xiaomin Huang, Yuhui Wang, Wei Huang, George Liu. Reversal of adipose tissue loss by probucol in mice with deficiency of both scavenger receptor class B type 1 and LDL receptor on high fat diet.
Biochemical and biophysical research communications.
2018 03; 497(3):930-936. doi:
10.1016/j.bbrc.2017.05.017. [PMID: 28522295] - Ankita Shah, Prajwal Thool, Komal Sorathiya, Hetal Prajapati, Damon Dalrymple, Abu T M Serajuddin. Effect of different polysorbates on development of self-microemulsifying drug delivery systems using medium chain lipids.
Drug development and industrial pharmacy.
2018 Feb; 44(2):215-223. doi:
10.1080/03639045.2017.1386202. [PMID: 29057677] - Stanley Dumeus, Marthandam Asokan Shibu, Wan-Teng Lin, Ming-Fu Wang, Chao-Hung Lai, Chia-Yao Shen, Yueh-Min Lin, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang. Bioactive Peptide Improves Diet-Induced Hepatic Fat Deposition and Hepatocyte Proinflammatory Response in SAMP8 Ageing Mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 48(5):1942-1952. doi:
10.1159/000492518. [PMID: 30092591] - Armin Mooranian, Nassim Zamani, Ryu Takechi, Hesham Al-Sallami, Momir Mikov, Svetlana Goločorbin-Kon, Bozica Kovacevic, Frank Arfuso, Hani Al-Salami. Pharmacological effects of nanoencapsulation of human-based dosing of probucol on ratio of secondary to primary bile acids in gut, during induction and progression of type 1 diabetes.
Artificial cells, nanomedicine, and biotechnology.
2018; 46(sup3):S748-S754. doi:
10.1080/21691401.2018.1511572. [PMID: 30422681] - Bing Bing Zhu, Hao Wang, Yang Feng Chi, Yun Man Wang, Xing Mei Yao, Shuang Liu, Huiling Qiu, Ji Fang, Pei Hao Yin, Xue Mei Zhang, Wen Peng. Protective effects of probucol on Ox-LDL-induced epithelial-mesenchymal transition in human renal proximal tubular epithelial cells via LOX‑1/ROS/MAPK signaling.
Molecular medicine reports.
2018 Jan; 17(1):1289-1296. doi:
10.3892/mmr.2017.7935. [PMID: 29115480] - Naikuan Fu, Shicheng Yang, Jing Zhang, Peng Zhang, Min Liang, Hongliang Cong, Wenhua Lin, Fengshi Tian, Chengzhi Lu. The efficacy of probucol combined with hydration in preventing contrast-induced nephropathy in patients with coronary heart disease undergoing percutaneous coronary intervention: a multicenter, prospective, randomized controlled study.
International urology and nephrology.
2018 Jan; 50(1):105-112. doi:
10.1007/s11255-017-1718-4. [PMID: 29071556] - Suhas G Gumaste, Abu T M Serajuddin. Development of solid SEDDS, VII: Effect of pore size of silica on drug release from adsorbed self-emulsifying lipid-based formulations.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Dec; 110(?):134-147. doi:
10.1016/j.ejps.2017.05.014. [PMID: 28506870] - X Q Suo, S C Yang, Z H Ma, T T Sun, W Y Zhang, H L Cong, W H Lin, C Z Lu, F S Tian, N K Fu. [Effect of probucol on preventing contrast-induced nephropathy in patients undergoing percutaneous coronary intervention].
Zhonghua yi xue za zhi.
2017 Nov; 97(41):3234-3238. doi:
10.3760/cma.j.issn.0376-2491.2017.41.008. [PMID: 29141361] - Shikun Yang, Li Zhao, Yachun Han, Yu Liu, Chao Chen, Ming Zhan, Xiaofen Xiong, Xuejing Zhu, Li Xiao, Chun Hu, Fuyou Liu, Zhiguang Zhou, Yashpal S Kanwar, Lin Sun. Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc.
Redox biology.
2017 10; 13(?):482-497. doi:
10.1016/j.redox.2017.07.002. [PMID: 28728079] - Maria G Katselou, Alexios N Matralis, Angeliki P Kourounakis. Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
European journal of medicinal chemistry.
2017 Sep; 138(?):748-760. doi:
10.1016/j.ejmech.2017.06.042. [PMID: 28728107] - Norsharina Ismail, Maznah Ismail, Nur Hanisah Azmi, Muhammad Firdaus Abu Bakar, Zhang Yida, Johnson Stanslas, Dahiru Sani, Hamidon Basri, Maizaton Atmadini Abdullah. Beneficial effects of TQRF and TQ nano- and conventional emulsions on memory deficit, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble Aβ levels in high fat-cholesterol diet-induced rats.
Chemico-biological interactions.
2017 Sep; 275(?):61-73. doi:
10.1016/j.cbi.2017.07.014. [PMID: 28734741] - Peng He, Harukiyo Kawamura, Minoru Takemoto, Yoshiro Maezawa, Takahiro Ishikawa, Ryoichi Ishibashi, Kenichi Sakamoto, Mayumi Shoji, Akiko Hattori, Masaya Yamaga, Shintaro Ide, Kana Ide, Aiko Hayashi, Hirotake Tokuyama, Kazuki Kobayashi, Koutaro Yokote. Combination of cilostazol and probucol protected podocytes from lipopolysaccharide-induced injury by both anti-inflammatory and anti-oxidative mechanisms.
Journal of nephrology.
2017 Aug; 30(4):531-541. doi:
10.1007/s40620-016-0361-y. [PMID: 28005239] - Stephanie A Houston, Azizah Ugusman, Sukanya Gnanadesikan, Simon Kennedy. An investigation of the antiplatelet effects of succinobucol (AGI-1067).
Platelets.
2017 May; 28(3):295-300. doi:
10.1080/09537104.2016.1218456. [PMID: 27681689] - Anouar Hafiane, Jacques Genest. ATP binding cassette A1 (ABCA1) mediates microparticle formation during high-density lipoprotein (HDL) biogenesis.
Atherosclerosis.
2017 02; 257(?):90-99. doi:
10.1016/j.atherosclerosis.2017.01.013. [PMID: 28129550] - Xu Xiao, Huiyuan Hou, Victor Lin, Daisy Ho, Kyle Tran, Briana Che, Adam May, Jiancheng Zhang, Zhigang Lu, Zhongping Lu, Peter X Shaw. Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation.
Oxidative medicine and cellular longevity.
2017; 2017(?):1284804. doi:
10.1155/2017/1284804. [PMID: 29213348] - Duyen Quach, Cecilia Vitali, Fiona M La, Angel X Xiao, John S Millar, Chongren Tang, Daniel J Rader, Michael C Phillips, Nicholas N Lyssenko. Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly.
Biochimica et biophysica acta.
2016 12; 1861(12 Pt A):1968-1979. doi:
10.1016/j.bbalip.2016.09.017. [PMID: 27671775] - Mayuko Morita, Yuji Naito, Toshikazu Yoshikawa, Etsuo Niki. Inhibition of plasma lipid oxidation induced by peroxyl radicals, peroxynitrite, hypochlorite, 15-lipoxygenase, and singlet oxygen by clinical drugs.
Bioorganic & medicinal chemistry letters.
2016 11; 26(22):5411-5417. doi:
10.1016/j.bmcl.2016.10.033. [PMID: 27777006] - Sang-Man Jin, Kyung Ah Han, Jae Myung Yu, Tae Seo Sohn, Sung Hee Choi, Choon Hee Chung, Ie Byung Park, Eun Jung Rhee, Sei Hyun Baik, Tae Sun Park, In-Kyu Lee, Seung-Hyun Ko, You-Cheol Hwang, Bong Soo Cha, Hyoung Woo Lee, Moon-Suk Nam, Moon-Kyu Lee. Probucol in Albuminuric Type 2 Diabetes Mellitus Patients on Renin-Angiotensin System Blockade: A 16-Week, Randomized, Double-Blind, Placebo-Controlled Trial.
Arteriosclerosis, thrombosis, and vascular biology.
2016 10; 36(10):2108-14. doi:
10.1161/atvbaha.116.308034. [PMID: 27493100] - Bei Guo, Yuanyuan Pei, Xiaoting Li, Meng Zhu, Longshan Zhao, Tianhong Zhang. Supercritical fluid chromatography with tandem mass spectrometry combined with postcolumn compensation and one-step acetone protein precipitation to evaluate the bioavailability of probucol solid dispersion tablet.
Journal of separation science.
2016 Oct; 39(19):3677-3682. doi:
10.1002/jssc.201600595. [PMID: 27481567] - Rui Lu, Tomoe Tsuboi, Kuniko Okumura-Noji, Noriyuki Iwamoto, Shinji Yokoyama. Caveolin-1 facilitates internalization and degradation of ABCA1 and probucol oxidative products interfere with this reaction to increase HDL biogenesis.
Atherosclerosis.
2016 10; 253(?):54-60. doi:
10.1016/j.atherosclerosis.2016.08.025. [PMID: 27579791] - Aiko Kume, Dang Trinh Minh Anh, Mototada Shichiri, Noriko Ishida, Hiroshi Suzuki. Probucol dramatically enhances dihydroartemisinin effect in murine malaria.
Malaria journal.
2016 09; 15(?):472. doi:
10.1186/s12936-016-1532-y. [PMID: 27634686] - Hanyu Zhu, Xiangmei Chen, Guangyan Cai, Ying Zheng, Moyan Liu, Wenhu Liu, Hebin Yao, Yaping Wang, Wenge Li, Hua Wu, Lide Lun, Jianrong Zhang, Xiaohong Guan, Shinan Yin, Xiaoming Zhuang, Jijun Li, Yanjun Liu, Chunhua Zhou. Telmisartan combined with probucol effectively reduces urinary protein in patients with type 2 diabetes: A randomized double-blind placebo-controlled multicenter clinical study.
Journal of diabetes.
2016 Sep; 8(5):677-85. doi:
10.1111/1753-0407.12347. [PMID: 26458146] - G Liu, W Ji, J Huang, L Liu, Y Wang. 4-HNE expression in diabetic rat kidneys and the protective effects of probucol.
Journal of endocrinological investigation.
2016 Aug; 39(8):865-73. doi:
10.1007/s40618-015-0428-y. [PMID: 26830905] - Kyung-Ho Yu, Keun-Sik Hong, Mi-Sun Oh, Juneyoung Lee, Ji Sung Lee, Sun U Kwon. Design and Rationale for a Cognitive Outcome Substudy in Ischemic Stroke Patients with High Risk of Cerebral Hemorrhage.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2016 Aug; 25(8):2061-6. doi:
10.1016/j.jstrokecerebrovasdis.2016.04.028. [PMID: 27263034] - Yeon Suk Jung, Jung Hwa Park, Hyunha Kim, So Young Kim, Ji Young Hwang, Ki Whan Hong, Sun Sik Bae, Byung Tae Choi, Sae-Won Lee, Hwa Kyoung Shin. Probucol inhibits LPS-induced microglia activation and ameliorates brain ischemic injury in normal and hyperlipidemic mice.
Acta pharmacologica Sinica.
2016 Aug; 37(8):1031-44. doi:
10.1038/aps.2016.51. [PMID: 27345627] - Limei Han, Qiushi Yang, Teng Shen, Jin Qing, Jianxin Wang. Lymphatic transport of orally administered probucol-loaded mPEG-DSPE micelles.
Drug delivery.
2016 Jul; 23(6):1955-61. doi:
10.3109/10717544.2015.1028600. [PMID: 25816053] - Shizuya Yamashita, Daisaku Masuda, Tohru Ohama, Hidenori Arai, Hideaki Bujo, Tatsuo Kagimura, Toru Kita, Masunori Matsuzaki, Yasushi Saito, Masanori Fukushima, Yuji Matsuzawa. Rationale and Design of the PROSPECTIVE Trial: Probucol Trial for Secondary Prevention of Atherosclerotic Events in Patients with Prior Coronary Heart Disease.
Journal of atherosclerosis and thrombosis.
2016 Jun; 23(6):746-56. doi:
10.5551/jat.32813. [PMID: 26803913] - John D Bagdade, James T Lane, P V Subbaiah. Probucol normalizes cholesteryl ester transfer in type 2 diabetes.
Diabetes research and clinical practice.
2016 Jun; 116(?):29-35. doi:
10.1016/j.diabres.2016.04.020. [PMID: 27321313] - Renata Pietsch Ribeiro, Danúbia Bonfanti Santos, Dirleise Colle, Aline Aita Naime, Cinara Ludvig Gonçalves, Heloisa Ghizoni, Mariana Appel Hort, Marcelo Godoi, Paulo Fernando Dias, Antonio Luiz Braga, Marcelo Farina. Decreased forelimb ability in mice intracerebroventricularly injected with low dose 6-hydroxidopamine: A model on the dissociation of bradykinesia from hypokinesia.
Behavioural brain research.
2016 May; 305(?):30-6. doi:
10.1016/j.bbr.2016.02.023. [PMID: 26921691] - Emi Yakushiji, Makoto Ayaori, Takafumi Nishida, Kazusa Shiotani, Shunichi Takiguchi, Kazuhiro Nakaya, Harumi Uto-Kondo, Masatsune Ogura, Makoto Sasaki, Makiko Yogo, Tomohiro Komatsu, Rui Lu, Shinji Yokoyama, Katsunori Ikewaki. Probucol-Oxidized Products, Spiroquinone and Diphenoquinone, Promote Reverse Cholesterol Transport in Mice.
Arteriosclerosis, thrombosis, and vascular biology.
2016 Apr; 36(4):591-7. doi:
10.1161/atvbaha.115.306376. [PMID: 26848156] - Yuan-Yuan Wang, Hui Li, Xing-Hua Wang, Meng Yuan, Guang-Ping Li. Probucol inhibits MMP-9 expression through regulating miR-497 in HUVECs and apoE knockout mice.
Thrombosis research.
2016 Apr; 140(?):51-58. doi:
10.1016/j.thromres.2016.02.012. [PMID: 26897284] - Dirleise Colle, Danúbia Bonfanti Santos, Juliana Montagna Hartwig, Marcelo Godoi, Daiane Fátima Engel, Andreza Fabro de Bem, Antonio L Braga, Marcelo Farina. Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity.
Molecular neurobiology.
2016 Mar; 53(2):1280-1295. doi:
10.1007/s12035-014-9086-x. [PMID: 25619973] - Qingbin Zhang, Liming Chen, Zhihua Si, Haoran Bu, Chandrakala A Narasimhulu, Xueling Song, Ming-Yu Cui, Hang Liu, Tiewei Lu, Guanglong He, Sampath Parthasarathy, Lianqun Cui, Zhenguo Liu, Yuqi Cui. Probucol Protects Endothelial Progenitor Cells Against Oxidized Low-Density Lipoprotein via Suppression of Reactive Oxygen Species Formation In Vivo.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 39(1):89-101. doi:
10.1159/000445608. [PMID: 27322674] - Aiko Kume, Maria Shirley Herbas, Mototada Shichiri, Noriko Ishida, Hiroshi Suzuki. Effect of anti-hyperlipidemia drugs on the alpha-tocopherol concentration and their potential for murine malaria infection.
Parasitology research.
2016 Jan; 115(1):69-75. doi:
10.1007/s00436-015-4722-6. [PMID: 26358099] - Jiwei Ma, Shupeng Zhao, Guojun Gao, Haigang Chang, Pengju Ma, Baozhe Jin. Probucol Protects Against Asymmetric Dimethylarginine-Induced Apoptosis in the Cultured Human Brain Microvascular Endothelial Cells.
Journal of molecular neuroscience : MN.
2015 Dec; 57(4):546-53. doi:
10.1007/s12031-015-0635-1. [PMID: 26254912] - Na Wang, Ri-Bao Wei, Qing-Ping Li, Xi Yang, Ping Li, Meng-Jie Huang, Rui Wang, Guang-Yan Cai, Xiang-Mei Chen. Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism.
Medical science monitor : international medical journal of experimental and clinical research.
2015 Sep; 21(?):2886-92. doi:
10.12659/msm.895543. [PMID: 26408630] - Min Peng, Julian Ostrovsky, Young Joon Kwon, Erzsebet Polyak, Joseph Licata, Mai Tsukikawa, Eric Marty, Jeffrey Thomas, Carolyn A Felix, Rui Xiao, Zhe Zhang, David L Gasser, Yair Argon, Marni J Falk. Inhibiting cytosolic translation and autophagy improves health in mitochondrial disease.
Human molecular genetics.
2015 Sep; 24(17):4829-47. doi:
10.1093/hmg/ddv207. [PMID: 26041819] - Xueting Jin, Sebastian R Freeman, Boris Vaisman, Ying Liu, Janet Chang, Neta Varsano, Lia Addadi, Alan Remaley, Howard S Kruth. ABCA1 contributes to macrophage deposition of extracellular cholesterol.
Journal of lipid research.
2015 Sep; 56(9):1720-6. doi:
10.1194/jlr.m060053. [PMID: 26203076] - Shizuya Yamashita, Daisaku Masuda, Yuji Matsuzawa. Did we abandon probucol too soon?.
Current opinion in lipidology.
2015 Aug; 26(4):304-16. doi:
10.1097/mol.0000000000000199. [PMID: 26125504] - Yanli Wang, Liang Bai, Yan Lin, Yulong Chen, Hua Guan, Ninghong Zhu, Yafeng Li, Shoucui Gao, Lijing Sun, Sihai Zhao, Jianglin Fan, Enqi Liu. Combined use of probucol and cilostazol with atorvastatin attenuates atherosclerosis in moderately hypercholesterolemic rabbits.
Lipids in health and disease.
2015 Jul; 14(?):82. doi:
10.1186/s12944-015-0083-5. [PMID: 26220196] - Rong Qi, Yan-Zhi Li, Cong Chen, Yi-Ni Cao, Mao-Mao Yu, Lu Xu, Bing He, Xu Jie, Wen-Wen Shen, Yu-Nan Wang, Mallory A van Dongen, Guo-Qing Liu, Mark M Banaszak Holl, Qiang Zhang, Xue Ke. G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol.
Journal of controlled release : official journal of the Controlled Release Society.
2015 Jul; 210(?):160-8. doi:
10.1016/j.jconrel.2015.05.281. [PMID: 26003044] - W B Zhu, Y H Wang, G F Sun, J H Wu. Protective effect and mechanism of probucol in the treatment of spinal cord injury.
Genetics and molecular research : GMR.
2015 Jul; 14(3):8029-37. doi:
10.4238/2015.july.17.11. [PMID: 26214485] - Jiawei Liao, Mingming Gao, Mengyu Wang, Xin Guo, Wei Huang, George Liu. Spontaneous and diet-aggravated hemolysis and its correction by probucol in SR-BI knockout mice with LDL-R deficiency.
Biochemical and biophysical research communications.
2015 Jul; 463(1-2):48-53. doi:
10.1016/j.bbrc.2015.05.015. [PMID: 25983325] - Hong Zhu, Xueting Jin, Jingjing Zhao, Zhen Dong, Xin Ma, Fang Xu, Wei Huang, George Liu, Yunzeng Zou, Keqiang Wang, Kai Hu, Aijun Sun, Junbo Ge. Probucol Protects Against Atherosclerosis Through Lipid-lowering and Suppressing Immune Maturation of CD11c+ Dendritic Cells in STZ-induced Diabetic LDLR-/- Mice.
Journal of cardiovascular pharmacology.
2015 Jun; 65(6):620-7. doi:
10.1097/fjc.0000000000000234. [PMID: 25714599] - Shilpa Raut, Basel Karzuon, Eman Atef. Using in situ Raman spectroscopy to study the drug precipitation inhibition and supersaturation mechanism of Vitamin E TPGS from self-emulsifying drug delivery systems (SEDDS).
Journal of pharmaceutical and biomedical analysis.
2015 May; 109(?):121-7. doi:
10.1016/j.jpba.2015.02.027. [PMID: 25767907] - Wei-Syun Hu, Wei-Jen Ting, Wen-Dee Chiang, Peiying Pai, Yu-Lan Yeh, Chung-Ho Chang, Wan-Teng Lin, Chih-Yang Huang. The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets.
International journal of molecular sciences.
2015 May; 16(5):10158-72. doi:
10.3390/ijms160510158. [PMID: 25950762] - Qian Ma, Yingchun Han, Cong Chen, Yini Cao, Siling Wang, Wenwen Shen, Huayu Zhang, Yanzhi Li, Mallory A van Dongen, Bing He, Maomao Yu, Lu Xu, Mark M Banaszak Holl, George Liu, Qiang Zhang, Rong Qi. Oral absorption enhancement of probucol by PEGylated G5 PAMAM dendrimer modified nanoliposomes.
Molecular pharmaceutics.
2015 Mar; 12(3):665-74. doi:
10.1021/mp500388m. [PMID: 25587935] - Huaying Fu, Guangping Li, Changle Liu, Jian Li, Xinghua Wang, Lijun Cheng, Tong Liu. Probucol prevents atrial remodeling by inhibiting oxidative stress and TNF-α/NF-κB/TGF-β signal transduction pathway in alloxan-induced diabetic rabbits.
Journal of cardiovascular electrophysiology.
2015 Feb; 26(2):211-22. doi:
10.1111/jce.12540. [PMID: 25199622] - Jichen Liu, Menghao Li, Hao Lu, Weiguang Qiao, Dan Xi, TianTian Luo, Haowei Xiong, Zhigang Guo. Effects of probucol on restenosis after percutaneous coronary intervention: a systematic review and meta-analysis.
PloS one.
2015; 10(4):e0124021. doi:
10.1371/journal.pone.0124021. [PMID: 25898372] - Hyeongmin Kim, Ilkyeong Seong, Jieun Ro, Seong-Ha Hwang, Gyiae Yun, Jaehwi Lee. Enhanced association of probucol with chylomicron by pharmaceutical excipients: an in vitro study.
Drug development and industrial pharmacy.
2015; 41(7):1073-9. doi:
10.3109/03639045.2014.927479. [PMID: 24934664] - Yuan-Qi Shi, Cai-Chuan Yan, Xiao Zhang, Meng Yan, Li-Rong Liu, Huai-Ze Geng, Lin Lv, Bao-Xin Li. Mechanisms underlying probucol-induced hERG-channel deficiency.
Drug design, development and therapy.
2015; 9(?):3695-704. doi:
10.2147/dddt.s86724. [PMID: 26229434] - Maria Shirely Herbas, Mototada Shichiri, Noriko Ishida, Aiko Kume, Yoshihisa Hagihara, Yasukazu Yoshida, Hiroshi Suzuki. Probucol-Induced α-Tocopherol Deficiency Protects Mice against Malaria Infection.
PloS one.
2015; 10(8):e0136014. doi:
10.1371/journal.pone.0136014. [PMID: 26296197] - Yanli Wang, Liang Bai, Yan Lin, Hua Guan, Ninghong Zhu, Yulong Chen, Yafeng Li, Shoucui Gao, Sihai Zhao, Jianglin Fan, Enqi Liu. Demonstration of an add-on effect of probucol and cilostazol on the statin-induced anti-atherogenic effects.
Histology and histopathology.
2014 Dec; 29(12):1593-600. doi:
10.14670/hh-29.1593. [PMID: 25078428] - Bei Guo, Hongzhuo Liu, Yun Li, Juanhang Zhao, Dan Yang, Xianglin Wang, Tianhong Zhang. Application of phospholipid complex technique to improve the dissolution and pharmacokinetic of probucol by solvent-evaporation and co-grinding methods.
International journal of pharmaceutics.
2014 Oct; 474(1-2):50-6. doi:
10.1016/j.ijpharm.2014.08.006. [PMID: 25108049] - Zuoyuan Chen, Shan Li, Wenna Zhao, Xiuhua Chen, Xiaxia Wang. Protective effect of co-administration of rosuvastatin and probucol on atherosclerosis in rats.
Canadian journal of physiology and pharmacology.
2014 Oct; 92(10):797-803. doi:
10.1139/cjpp-2014-0169. [PMID: 25203284] - Vadim Lankin, Galina Konovalova, Alla Tikhaze, Konstantin Shumaev, Elena Kumskova, Margus Viigimaa. The initiation of free radical peroxidation of low-density lipoproteins by glucose and its metabolite methylglyoxal: a common molecular mechanism of vascular wall injure in atherosclerosis and diabetes.
Molecular and cellular biochemistry.
2014 Oct; 395(1-2):241-52. doi:
10.1007/s11010-014-2131-2. [PMID: 24997046]