3-(Methylthio)propionic acid (BioDeep_00001867955)
Main id: BioDeep_00000006704
PANOMIX_OTCML-2023 Toxin BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
化学式: C4H8O2S (120.0244988)
中文名称: 3-(甲硫基)丙酸, 3-甲基硫代丙酸, 3-（甲硫基）丙酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CSCCC(=O)O
InChI: InChI=1S/C4H8O2S/c1-7-3-2-4(5)6/h2-3H2,1H3,(H,5,6)
描述信息
A thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position; an intermediate in mammalian methionine metabolism in vitro. The simplest known phytotoxin, it is a blight-inducing toxin produced by the cassava pathogen Xanthomonas campestris manihotis.
3-(Methylthio)propionic acid is an intermediate in the methionine metabolism.
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:1438
- KEGG: C08276
- KEGGdrug: D87669
- PubChem: 563
- ChEMBL: CHEMBL116212
- CAS: 646-01-5
- MetaboLights: MTBLC1438
- PubChem: 10474
- LipidMAPS: LMFA01130006
- KNApSAcK: C00001194
- PDB-CCD: A8C
- 3DMET: B02154
- NIKKAJI: J22.485E
- medchemexpress: HY-101401
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-985
- KNApSAcK: 1438
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Miyu Kamimura, Azusa Sasaki, Shimpei Watanabe, Shiho Tanaka, Akiko Fukukawa, Kazuya Takeda, Yasushi Nakamura, Takako Nakamura, Kouji Kuramochi, Yui Otani, Fumio Hashimoto, Kanji Ishimaru, Tomoaki Matsuo, Shigehisa Okamoto. Chemical and molecular bases of dome formation in human colorectal cancer cells mediated by sulphur compounds from Cucumis melo var. conomon.
FEBS open bio.
2020 12; 10(12):2640-2655. doi:
10.1002/2211-5463.13001. [PMID: 33048473] - Hidenori Yamada, Noriyuki Akahoshi, Shotaro Kamata, Yoshifumi Hagiya, Takako Hishiki, Yoshiko Nagahata, Tomomi Matsuura, Naoharu Takano, Masatomo Mori, Yasuki Ishizaki, Takashi Izumi, Yoshito Kumagai, Tadashi Kasahara, Makoto Suematsu, Isao Ishii. Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
Free radical biology & medicine.
2012 May; 52(9):1716-26. doi:
10.1016/j.freeradbiomed.2012.02.033. [PMID: 22387178] - Gaik-Lean Chee, Bharat Bhattarai, R Daniel Gietz, Samaa Alrushaid, John L Nitiss, Brian B Hasinoff. Chemical reactivity and microbicidal action of bethoxazin.
Bioorganic & medicinal chemistry.
2012 Feb; 20(4):1494-501. doi:
10.1016/j.bmc.2011.12.051. [PMID: 22264763] - Young Cheol Kim, Hyo-Jeong Kim, Keun-Hyung Park, Jeung-Yong Cho, Kil-Yong Kim, Baik-Ho Cho. 3-methylthiopropanoic acid produced by Enterobacter intermedium 60-2G inhibits fungal growth and weed seedling development.
The Journal of antibiotics.
2003 Feb; 56(2):177-80. doi:
10.7164/antibiotics.56.177. [PMID: 12715879] - H J Blom, G H Boers, J P van den Elzen, W A Gahl, A Tangerman. Transamination of methionine in humans.
Clinical science (London, England : 1979).
1989 Jan; 76(1):43-9. doi:
10.1042/cs0760043. [PMID: 2920533] - H Kaji, T Niioka, Y Kojima, Y Yoshida, Y Kawakami. Urinary 3-methylthiopropionate excretion and the effect of D- or L-methionine ingestion studied in healthy subjects.
Research communications in chemical pathology and pharmacology.
1987 Apr; 56(1):101-9. doi:
. [PMID: 3589145] - Y Yoshida. [Analysis of methionine metabolism studied by the gas chromatographic determination of 3-methylthiopropionate in urine and its clinical application].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science.
1985 Mar; 60(2):183-94. doi:
. [PMID: 3997054] - H Kaji, K Saito, N Saito, M Hisamura, M Ishimoto, H Kondo. Simple gas chromatographic analysis of 3-methylthiopropionate in human urine.
Journal of chromatography.
1983 Jan; 272(1):166-9. doi:
10.1016/s0378-4347(00)86113-7. [PMID: 6841536] - R D Steele, N J Benevenga. Identification of 3-methylthiopropionic acid as an intermediate in mammalian methionine metabolism in vitro.
The Journal of biological chemistry.
1978 Nov; 253(21):7844-50. doi:
10.1016/s0021-9258(17)34448-4. [PMID: 100496] - J M Harter, D H Baker. Factors affecting methionine toxicity and its alleviation in the chick.
The Journal of nutrition.
1978 Jul; 108(7):1061-70. doi:
10.1093/jn/108.7.1061. [PMID: 660299]