Alprostadil (BioDeep_00001867819)

Main id: BioDeep_00000001682

 

Chemicals and Drugs PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11α,13E,15S)-

化学式: C20H34O5 (354.24061140000003)
中文名称: 前列腺素 E1, 前列地尔
谱图信息: 最多检出来源 () 0%

Reviewed

Last reviewed on 2024-07-09.

Cite this Page

Alprostadil. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/alprostadil (retrieved 2024-11-03) (BioDeep RN: BioDeep_00001867819). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCC(C=CC1C(CC(=O)C1CCCCCCC(=O)O)O)O
InChI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

描述信息

Prostaglandin E1. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=745-65-3 (retrieved 2024-07-09) (CAS RN: 745-65-3). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3].

同义名列表

3 个代谢物同义名

Prostaglandin E1; Alprostadil; PGE1



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sebile Azırak. Prevention of nephrotoxicity induced by amikacin: The role of misoprostol, A prostaglandin E1 analogue. Prostaglandins & other lipid mediators. 2023 Feb; 164(?):106682. doi: 10.1016/j.prostaglandins.2022.106682. [PMID: 36349661]
  • Decai Zhu, Dawei Wang, Zhen Zhao, Qingqing Liu, Rongyuan Yang, Qing Liu. Application of Nanoliposome Alprostadil in the Perioperative Period of Percutaneous Coronary Intervention to Reduce In-Stent Restenosis: A Systematic Review and Meta-Analysis. Journal of interventional cardiology. 2023; 2023(?):4100197. doi: 10.1155/2023/4100197. [PMID: 37251365]
  • Yan-Xia Li, Kang-Di Zheng, Yu Duan, Hua-Juan Liu, Yu-Qun Tang, Jun Wu, Dong-Zi Lin, Zhao Zhang. Mass spectrometry-based identification of new serum biomarkers in patients with latent infection pulmonary tuberculosis. Medicine. 2022 Dec; 101(48):e32153. doi: 10.1097/md.0000000000032153. [PMID: 36482536]
  • Meliha Koldemir Gündüz. BGM, a Newly Synthesised Boron Compound, Induces Apoptosis and Reduces Oxidative Stress by Inhibiting Lipogenesis in 3T3-L1 Adipocytes via PPARγ and CTRP3. Biological trace element research. 2022 Nov; 200(11):4807-4816. doi: 10.1007/s12011-022-03261-z. [PMID: 35508889]
  • Yuling Luo, Qingze Fan, Yongqi Yu, Lunhui Zhang, Limei Dong, Hongli Luo. Efficacy of administrative intervention for neurosurgical patients with off-label use of alprostadil lipid microsphere. Scientific reports. 2022 Sep; 12(1):15363. doi: 10.1038/s41598-022-19717-0. [PMID: 36100635]
  • Nina Buchtele, Christian Schörgenhofer, Michael Schwameis, Bernd Jilma, Peter Schellongowski, Harald Herkner, Katharina Riss, Monika Schmid, Alexander Hermann, Oliver Robak, Bernhard Nagler, Ludwig Traby, Andja Bojic, Thomas Staudinger. Add-On Prostaglandin E1 in Venovenous Extracorporeal Membrane Oxygenation: A Randomized, Double-Blind, Placebo-controlled Pilot Trial. American journal of respiratory and critical care medicine. 2022 07; 206(2):170-177. doi: 10.1164/rccm.202110-2359oc. [PMID: 35426776]
  • Steven D Targum, Jeffrey Schappi, Athanasia Koutsouris, Runa Bhaumik, Mark H Rapaport, Natalie Rasgon, Mark M Rasenick. A novel peripheral biomarker for depression and antidepressant response. Molecular psychiatry. 2022 03; 27(3):1640-1646. doi: 10.1038/s41380-021-01399-1. [PMID: 34969978]
  • Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai. Absolute quantification and characterization of oxylipins in lupus nephritis and systemic lupus erythematosus. Frontiers in immunology. 2022; 13(?):964901. doi: 10.3389/fimmu.2022.964901. [PMID: 36275708]
  • Hongfang Fu, Weiwei Hou, Yang Zhang, Xiaoyu Hu. Alprostadil for hypertensive nephropathy: A systematic review and meta-analysis of randomized controlled trials. PloS one. 2022; 17(5):e0269111. doi: 10.1371/journal.pone.0269111. [PMID: 35617324]
  • Xiaogang Liu, Peng Zhang, Jing Zhang, Xue Zhang, Shicheng Yang, Naikuan Fu. The Preventive Effect of Alprostadil on the Contrast-Induced Nephropathy of Coronary Heart Disease Treated by Percutaneous Coronary Intervention in Moderate and High-Risk Population Stratified by Mehran Score. Angiology. 2022 Jan; 73(1):33-41. doi: 10.1177/00033197211015540. [PMID: 34098771]
  • Tiphaine Belleville-Rolland, Alexandre Leuci, Alexandre Mansour, Benoit Decouture, Fanny Martin, Sonia Poirault-Chassac, Margot Rouaud, Hippolyte Guerineau, Blandine Dizier, Dominique Pidard, Pascale Gaussem, Christilla Bachelot-Loza. Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets. Thrombosis and haemostasis. 2021 12; 121(12):1628-1636. doi: 10.1055/a-1481-2663. [PMID: 33851387]
  • Sunny Z Hussain, Barrett Labrum, Shadreck Mareya, Stephen Stripling, Robert Clifford. Safety of Lubiprostone in Pediatric Patients With Functional Constipation: A Nonrandomized, Open-Label Trial. Journal of pediatric gastroenterology and nutrition. 2021 11; 73(5):572-578. doi: 10.1097/mpg.0000000000003280. [PMID: 34387619]
  • Hongling Xu, Hongye Wang, Chuang Zhang, Jun Xiao, Ning Hua, Xuezheng Tang, Jiaqi Xie, Zhengbin Zhang. Efficacy of Alprostadil in Preventing Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis. Angiology. 2021 10; 72(9):878-888. doi: 10.1177/00033197211004412. [PMID: 33853365]
  • Heeju Lee, Bora Lee, Yeonhee Kim, Sohyun Min, Eunjoo Yang, Seungmin Lee. Effects of Sodium Selenite Injection on Serum Metabolic Profiles in Women Diagnosed with Breast Cancer-Related Lymphedema-Secondary Analysis of a Randomized Placebo-Controlled Trial Using Global Metabolomics. Nutrients. 2021 Sep; 13(9):. doi: 10.3390/nu13093253. [PMID: 34579131]
  • Jiaomei Li, Zhaohong Zheng, Min Liu, Yiping Ren, Yue Ruan, Duo Li. Relationship between the n-3 index, serum metabolites and breast cancer risk. Food & function. 2021 Sep; 12(17):7741-7748. doi: 10.1039/d1fo01245b. [PMID: 34296713]
  • Yosuke Ida, Megumi Watanabe, Araya Umetsu, Hiroshi Ohguro, Fumihito Hikage. Addition of EP2 agonists to an FP agonist additively and synergistically modulates adipogenesis and the physical properties of 3D 3T3-L1 sphenoids. Prostaglandins, leukotrienes, and essential fatty acids. 2021 08; 171(?):102315. doi: 10.1016/j.plefa.2021.102315. [PMID: 34246925]
  • Francisco H Velásquez-Forero, Pedro F Valencia-Mayoral. Histomorphometry evaluation of bone anabolism promoted by prostaglandin E1 and its relation to hypercalcemia. Boletin medico del Hospital Infantil de Mexico. 2021 06; 78(4):293-300. doi: 10.24875/bmhim.20000080. [PMID: 34077409]
  • Jenny T Mao, Bingye Xue, Sili Fan, Patricia Neis, Clifford Qualls, Larry Massie, Oliver Fiehn. Leucoselect Phytosome Modulates Serum Eicosapentaenoic Acid, Docosahexaenoic Acid, and Prostaglandin E3 in a Phase I Lung Cancer Chemoprevention Study. Cancer prevention research (Philadelphia, Pa.). 2021 06; 14(6):619-626. doi: 10.1158/1940-6207.capr-20-0585. [PMID: 33707173]
  • Jing Cui, Kai Shan, Qin Yang, Yumin Qi, Hongyan Qu, Jiaqi Li, Rong Wang, Lingling Jia, Wei Chen, Ninghan Feng, Yong Q Chen. Prostaglandin E3 attenuates macrophage-associated inflammation and prostate tumour growth by modulating polarization. Journal of cellular and molecular medicine. 2021 06; 25(12):5586-5601. doi: 10.1111/jcmm.16570. [PMID: 33982835]
  • Wei Xi, Yaqing Zhou, Xiaojun Han, Xiaohua Yang. Effect of hyperbaric oxygen combined with alprostadil in the treatment of elderly diabetic nephropathy and effects on serum miR-126 and miR-342 levels. Pakistan journal of pharmaceutical sciences. 2021 May; 34(3(Special)):1187-1193. doi: . [PMID: 34602388]
  • Jianwen Wang, Shiqi Tang, Yang Xie, Jun Liu, Jishi Liu, Hong Wu, Hao Zhang. Lipid microsphere-coated PGE1 improves peritoneal transport and reduces inflammation in peritoneal dialysis: A randomized clinical pilot trial. Seminars in dialysis. 2021 05; 34(3):235-244. doi: 10.1111/sdi.12954. [PMID: 33592131]
  • Yosuke Ida, Megumi Watanabe, Hiroshi Ohguro, Fumihito Hikage. Simultaneous Use of ROCK Inhibitors and EP2 Agonists Induces Unexpected Effects on Adipogenesis and the Physical Properties of 3T3-L1 Preadipocytes. International journal of molecular sciences. 2021 Apr; 22(9):. doi: 10.3390/ijms22094648. [PMID: 33925005]
  • M Wang, X-F Cai, S-M Zhang, S-Y Xia, W-H Du, Y-L Ma. Alprostadil alleviates liver injury in septic rats via TLR4/NF-κB pathway. European review for medical and pharmacological sciences. 2021 02; 25(3):1592-1599. doi: 10.26355/eurrev_202102_24869. [PMID: 33629328]
  • Wade Muncey, Nicholas Sellke, Tyler Kim, Kirtishri Mishra, Nannan Thirumavalavan, Aram Loeb. Alternative Treatment for Erectile Dysfunction: a Growing Arsenal in Men's Health. Current urology reports. 2021 Jan; 22(2):11. doi: 10.1007/s11934-020-01023-9. [PMID: 33420972]
  • You Jeong Park, Jeffrey Farooq, Justin Cho, Blaise Cozene, Bella Gonzales-Portillo, Nadia Sadanandan, Madeline Saft, Jea Young Lee, Cesar V Borlongan. A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review. Advances in experimental medicine and biology. 2021; 1312(?):165-177. doi: 10.1007/5584_2020_596. [PMID: 33159307]
  • Ksenia M Shestakova, Natalia E Moskaleva, Natalia V Mesonzhnik, Alexey V Kukharenko, Igor V Serkov, Igor I Lyubimov, Elena V Fomina-Ageeva, Vladimir V Bezuglov, Mikhail G Akimov, Svetlana A Appolonova. In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug. Molecules (Basel, Switzerland). 2020 Dec; 25(24):. doi: 10.3390/molecules25245896. [PMID: 33322104]
  • Hailian Guan, Miaomiao Ye, Cao Fang, Limin Zhang, Pengding Han, Shiguang Qiu, Xiangyu Fang, Lanying Li. The clinical effectiveness and safety of alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy: A protocol for systematic review and meta-analysis. Medicine. 2020 Dec; 99(50):e23507. doi: 10.1097/md.0000000000023507. [PMID: 33327292]
  • Junko Tachi, Haruhiko Tokuda, Takashi Onuma, Shinobu Yamaguchi, Woo Kim, Tomoyuki Hioki, Rie Matsushima-Nishiwaki, Kumiko Tanabe, Osamu Kozawa, Hiroki Iida. Duloxetine strengthens osteoblast activation by prostaglandin E1: Upregulation of p38 MAP kinase. Prostaglandins & other lipid mediators. 2020 12; 151(?):106481. doi: 10.1016/j.prostaglandins.2020.106481. [PMID: 33002595]
  • Liang Zhang, Pan Li, Bi-Li Zhang, Man-Li Yu, Rong-Liang Xu, Hong Wu, Shao-Ping Chen. Dysregulation of HULC promotes contrast-induced nephropathy (CIN) via regulating signaling pathway of miRNA-512 and prostaglandin E1 (PGE1). Scientific reports. 2020 07; 10(1):11691. doi: 10.1038/s41598-020-68634-7. [PMID: 32678165]
  • Pengyi Li, Lianbing Gu, Qingming Bian, Jing Tan, Dian Jiao, Fei Wu, Zeping Xu, Lijun Wang. Effects of prostaglandin E1 nebulization of ventilated lung under 60\%O2 one lung ventilation on patients' oxygenation and oxidative stress: a randomised controlled trial. Respiratory research. 2020 May; 21(1):113. doi: 10.1186/s12931-020-01380-6. [PMID: 32404117]
  • Aneta Ostróżka-Cieślik, Barbara Dolińska. The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature. Molecules (Basel, Switzerland). 2020 May; 25(9):. doi: 10.3390/molecules25092185. [PMID: 32392782]
  • X Cheng, J H Zhan, J H Luo, G Y Zheng. [Effect of alprostadil in early wound healing of rats with deep partial-thickness scald]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. 2020 Apr; 36(4):317-322. doi: 10.3760/cma.j.cn501120-20190125-00017. [PMID: 32340424]
  • Yu-Han Zhang, Ya-Qin Zhang, Cong-Cong Guo, Li-Kang Wang, Yu-Jiao Cui, Jian-Jun Dong, Lin Liao. Prostaglandin E1 attenuates high glucose-induced apoptosis in proximal renal tubular cells by inhibiting the JNK/Bim pathway. Acta pharmacologica Sinica. 2020 Apr; 41(4):561-571. doi: 10.1038/s41401-019-0314-9. [PMID: 31685975]
  • Zhenbai Qin, Binghui Kong, Jing Zheng, Xiantao Wang, Lang Li. Alprostadil Injection Attenuates Coronary Microembolization-Induced Myocardial Injury Through GSK-3β/Nrf2/HO-1 Signaling-Mediated Apoptosis Inhibition. Drug design, development and therapy. 2020; 14(?):4407-4422. doi: 10.2147/dddt.s272877. [PMID: 33122886]
  • Jian Xie, Mingyang Jiang, Yunni Lin, Lang Li. Re: Effect of Alprostadil in the Prevention of Contrast-Induced Nephropathy: A Meta-Analysis of 36 Randomized Controlled Trials. Angiology. 2020 01; 71(1):97. doi: 10.1177/0003319719870398. [PMID: 31426651]
  • Verónica Palma-Barqueros, José Miguel Torregrosa, Eva Caparrós-Pérez, Nerea Mota-Pérez, Natalia Bohdan, María Del Carmen Llanos, Antonija Jurak Begonja, Martha Sola-Visner, Vicente Vicente, Raúl Teruel-Montoya, José Rivera, Francisca Ferrer-Marín. Developmental Differences in Platelet Inhibition Response to Prostaglandin E1. Neonatology. 2020; 117(1):15-23. doi: 10.1159/000504173. [PMID: 31786577]
  • J-H Tu, Y Xu, Y Dai, L Dang. Effect of alprostadil on myocardial fibrosis in rats with diabetes mellitus via TGF-β1/Smad signaling pathway. European review for medical and pharmacological sciences. 2019 Nov; 23(21):9633-9641. doi: 10.26355/eurrev_201911_19457. [PMID: 31773714]
  • Shuke Fei, Wei Li, Lei Xiang, Xuewen Xie, Liang Zhang. Protective Effect of Alprostadil on Acute Pancreatitis in Rats via Inhibiting Janus Kinase 2 (JAK2)/STAT3 Signal Transduction Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2019 Oct; 25(?):7694-7701. doi: 10.12659/msm.919148. [PMID: 31606729]
  • Michael Schou Jensen, Henricus A M Mutsaers, Stine Julie Tingskov, Michael Christensen, Mia Gebauer Madsen, Peter Olinga, Tae-Hwan Kwon, Rikke Nørregaard. Activation of the prostaglandin E2 EP2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices. Acta physiologica (Oxford, England). 2019 09; 227(1):e13291. doi: 10.1111/apha.13291. [PMID: 31054202]
  • Jian Xie, Mingyang Jiang, Yunni Lin, Huachu Deng, Lang Li. Effect of Alprostadil on the Prevention of Contrast-Induced Nephropathy: A Meta-Analysis of 36 Randomized Controlled Trials. Angiology. 2019 Aug; 70(7):594-612. doi: 10.1177/0003319719825597. [PMID: 30669852]
  • Undurti N Das. Vitamin C for Type 2 Diabetes Mellitus and Hypertension. Archives of medical research. 2019 02; 50(2):11-14. doi: 10.1016/j.arcmed.2019.05.004. [PMID: 31349946]
  • Liping Zhang, Ying Zhang, Xiaofeng Yu, Huali Xu, Dayuan Sui, Xuezhong Zhao. Alprostadil attenuates myocardial ischemia/reperfusion injury by promoting antioxidant activity and eNOS activation in rats. Acta cirurgica brasileira. 2018 Dec; 33(12):1067-1077. doi: 10.1590/s0102-865020180120000004. [PMID: 30624512]
  • Khalid Ahmed, Terri McVeigh, Raminta Cerneviciute, Sara Mohamed, Mohammad Tubassam, Mohammad Karim, Stewart Walsh. Effectiveness of contrast-associated acute kidney injury prevention methods; a systematic review and network meta-analysis. BMC nephrology. 2018 11; 19(1):323. doi: 10.1186/s12882-018-1113-0. [PMID: 30424723]
  • Xiangying Liu, Yongfu Hang, Lei Shen, Jing Yang, Ling Zhou, Wengang Sha, Guoyuan Lu. Prevention of contrast-induced nephropathy with prostaglandin E1 in patients undergoing percutaneous coronary procedures: A meta-analysis of 24 randomized controlled trials
. Clinical nephrology. 2018 Nov; 90(5):313-324. doi: 10.5414/cn109444. [PMID: 30106366]
  • De-Qi Jiang, Shi-Hua Zhao, Ming-Xing Li, Li-Lin Jiang, Yong Wang, Yan Wang. Prostaglandin E1 plus methylcobalamin combination therapy versus prostaglandin E1 monotherapy for patients with diabetic peripheral neuropathy: A meta-analysis of randomized controlled trials. Medicine. 2018 Nov; 97(44):e13020. doi: 10.1097/md.0000000000013020. [PMID: 30383660]
  • Lili Cui, Meimei Xing, Lanting Xu, Junya Wang, Xiaofeng Zhang, Changyang Ma, Wenyi Kang. Antithrombotic components of Malus halliana Koehne flowers. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Sep; 119(?):326-333. doi: 10.1016/j.fct.2018.02.049. [PMID: 29496530]
  • Zhi-Cheng Li, Yu-Zhe Cai, Zhi-Gang Tang, Pan-Li Zuo, Rong-Bo Liu, Fang Liu. Lipo-prostaglandin E1 improves renal hypoxia evaluated by BOLD-MRI in patients with diabetic kidney disease. Clinical imaging. 2018 Jul; 50(?):239-242. doi: 10.1016/j.clinimag.2018.04.015. [PMID: 29689479]
  • Ning Geng, Deling Zou, Yanli Chen, Li Ren, Lisheng Xu, Wenyue Pang, Yingxian Sun. Prostaglandin E1 administration for prevention of contrast-induced acute kidney injury: A systematic review and meta-analysis of randomized controlled trials. Medicine. 2018 Jul; 97(29):e11416. doi: 10.1097/md.0000000000011416. [PMID: 30024512]
  • Wonnam Kim, Wonil Lee, Jin Gyu Choi, In Gyoung Ju, Yun-Kyung Kim, Tae Hee Lee, Myung Sook Oh. Inhibitory effects of Aconiti Lateralis Radix Preparata on chronic intermittent cold-induced inflammation in the mouse hypothalamus. Journal of ethnopharmacology. 2018 Apr; 215(?):27-33. doi: 10.1016/j.jep.2017.12.042. [PMID: 29288825]
  • Min Liang, Shicheng Yang, Naikuan Fu, Chengzhi Lu, Fengshi Tian, Xiaochun Xing, Wenhua Lin, Jingjing Liu. Efficacy of alprostadil in preventing contrast-induced nephropathy in patients undergoing percutaneous coronary intervention: A multicenter prospective randomized controlled trial. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2018 03; 91(4):742-750. doi: 10.1002/ccd.27353. [PMID: 29024304]
  • Yaru Mou, Yaqin Zhang, Congcong Guo, Junyu Zhao, Zhongwen Zhang, Xiaojun Zhou, Jianjun Dong, Lin Liao. Integrated Treatment of Prostaglandin E1 and Angiotensin-Converting Enzyme Inhibitor in Diabetic Kidney Disease Rats: Possible Role of Antiapoptosis in Renal Tubular Epithelial Cells. DNA and cell biology. 2018 Feb; 37(2):133-141. doi: 10.1089/dna.2017.3690. [PMID: 29185789]
  • Feifei Mo, Guotao Hu, Wei Liu, Li He, Hailan Wang. Prostaglandin E1 Protects the Peripheral Nerve in Diabetics through Preventing Vascular Permeability Changes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2018 02; 126(2):113-122. doi: 10.1055/s-0043-112351. [PMID: 28954306]
  • Wei Wei, Xing-Rong An, Shi-Jie Jin, Xiao-Xue Li, Ming Xu. Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy. Scientific reports. 2018 01; 8(1):9. doi: 10.1038/s41598-017-18427-2. [PMID: 29311680]
  • Mohamed Raâfet Ben Khedher, Houda Bouhajja, Samia Haj Ahmed, Mohamed Abid, Kamel Jamoussi, Mohamed Hammami. Role of disturbed fatty acids metabolism in the pathophysiology of diabetic erectile dysfunction. Lipids in health and disease. 2017 Dec; 16(1):241. doi: 10.1186/s12944-017-0637-9. [PMID: 29233142]
  • Mohamed A Farag, Hildegard Westphal, Tarek F Eissa, Ludger A Wessjohann, Achim Meyer. Effect of Oxylipins, Terpenoid Precursors and Wounding on Soft Corals' Secondary Metabolism as Analyzed via UPLC/MS and Chemometrics. Molecules (Basel, Switzerland). 2017 Dec; 22(12):. doi: 10.3390/molecules22122195. [PMID: 29232862]
  • Hui Li, Hai-Ying Chen, Wen-Xuan Liu, Xian-Xian Jia, Jing-Ge Zhang, Chun-Ling Ma, Xiao-Jing Zhang, Feng Yu, Bin Cong. Prostaglandin E2 restrains human Treg cell differentiation via E prostanoid receptor 2-protein kinase A signaling. Immunology letters. 2017 11; 191(?):63-72. doi: 10.1016/j.imlet.2017.09.009. [PMID: 28963072]
  • Jing Wang, Xiaobo Ai, Li Li, Yanyan Gao, Nina Sun, Changgui Li, Weihong Sun. Alprostadil protects type 2 diabetes mellitus patients treated with metformin from contrast-induced nephropathy. International urology and nephrology. 2017 Nov; 49(11):2019-2026. doi: 10.1007/s11255-017-1639-2. [PMID: 28656510]
  • Gabriel Mayoral-Andrade, Laura Pérez-Campos-Mayoral, Abraham Majluf-Cruz, Eduardo Perez-Campos Mayoral, Carlos Perez Campos Mayoral, Ana Rocha-Núñez, Margarito Martinez, Edgar Zenteno, Leticia Hernandez-Gonzalez, María Guadalupe López Juan, Alma Dolores Pérez-Santiago, Eduardo Pérez-Campos. Reduced platelet aggregation in women after intercourse: a possible role for the cyclooxygenase pathway. Clinical and experimental pharmacology & physiology. 2017 Aug; 44(8):847-853. doi: 10.1111/1440-1681.12783. [PMID: 28502103]
  • Wei Wei, Yong Xie, Shi-Chao Lai, Bo-Fu Liu, Ya-Rong He, Hai Hu, Yu Cao. Benefits of anti‑inflammatory therapy in the treatment of ischemia/reperfusion injury in the renal microvascular endothelium of rats with return of spontaneous circulation. Molecular medicine reports. 2017 Jun; 15(6):4231-4238. doi: 10.3892/mmr.2017.6548. [PMID: 28487973]
  • Jing-Zhan Zhang, Xiao-Jing Kang, Ying Gao, Ying-Ying Zheng, Ting-Ting Wu, Long Li, Fen Liu, Yi-Ning Yang, Xiao-Mei Li, Yi-Tong Ma, Xiang Xie. Efficacy of alprostadil for preventing of contrast-induced nephropathy: A meta-analysis. Scientific reports. 2017 04; 7(1):1045. doi: 10.1038/s41598-017-01160-1. [PMID: 28432310]
  • Gen Kuroyanagi, Haruhiko Tokuda, Naohiro Yamamoto, Shingo Kainuma, Kazuhiko Fujita, Reou Ohguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Takanobu Otsuka. Attenuation of prostaglandin E1‑induced osteoprotegerin synthesis in osteoblasts by normoxic HIF inducers. Molecular medicine reports. 2017 Apr; 15(4):1847-1852. doi: 10.3892/mmr.2017.6177. [PMID: 28259984]
  • Yoolhee Yang, Hee Jung Kim, Kyong-Je Woo, Daeho Cho, Sa Ik Bang. Lipo-PGE1 suppresses collagen production in human dermal fibroblasts via the ERK/Ets-1 signaling pathway. PloS one. 2017; 12(6):e0179614. doi: 10.1371/journal.pone.0179614. [PMID: 28644845]
  • Ho Yun Lee, Dong-Kee Kim, Yong-Ho Park, Wang Woon Cha, Geun Jeon Kim, Seung Hun Lee. Prognostic factors for profound sudden idiopathic sensorineural hearing loss: a multicenter retrospective study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2017 Jan; 274(1):143-149. doi: 10.1007/s00405-016-4276-y. [PMID: 27544193]
  • Ziliang Ye, Haili Lu, Wenqin Guo, Weiran Dai, Hongqing Li, Huafeng Yang, Lang Li. The effect of alprostadil on preventing contrast-induced nephropathy for percutaneous coronary intervention in diabetic patients: A systematic review and meta-analysis. Medicine. 2016 Nov; 95(46):e5306. doi: 10.1097/md.0000000000005306. [PMID: 27861357]
  • Alpa Patel, Grace H Panter, Henry T Trollope, Yohanna C Glennon, Stewart F Owen, John P Sumpter, Mariann Rand-Weaver. Testing the "read-across hypothesis" by investigating the effects of ibuprofen on fish. Chemosphere. 2016 Nov; 163(?):592-600. doi: 10.1016/j.chemosphere.2016.08.041. [PMID: 27572306]
  • Emma T B Olesen, Hanne B Moeller, Mette Assentoft, Nanna MacAulay, Robert A Fenton. The vasopressin type 2 receptor and prostaglandin receptors EP2 and EP4 can increase aquaporin-2 plasma membrane targeting through a cAMP-independent pathway. American journal of physiology. Renal physiology. 2016 11; 311(5):F935-F944. doi: 10.1152/ajprenal.00559.2015. [PMID: 27558562]
  • Jin-Dan Wu, Sha Tao, Xing Jin, Lan-Lan Jiang, Yun Shen, Yong Luo, Peng Zhang, Kok-Onn Lee, Lei Ye, Jian-Hua Ma. PGE1 improves diabetic peripheral neuropathy in patients with type 2 diabetes. Prostaglandins & other lipid mediators. 2016 11; 126(?):24-28. doi: 10.1016/j.prostaglandins.2016.07.006. [PMID: 27421690]
  • L Ossorio-García, D Jiménez-Gallo, C Arjona-Aguilera, M Linares-Barrios. Multimodal Treatment of Calciphylaxis With Sodium Thiosulfate, Alprostadil, and Hyperbaric Oxygen Therapy. Actas dermo-sifiliograficas. 2016 Oct; 107(8):695-7. doi: 10.1016/j.ad.2016.04.004. [PMID: 27208908]
  • Fusun Oztay, Beyhan Kara-Kisla, Nurcan Orhan, Refiye Yanardag, Sehnaz Bolkent. The protective effects of prostaglandin E1 on lung injury following renal ischemia-reperfusion in rats. Toxicology and industrial health. 2016 Sep; 32(9):1684-92. doi: 10.1177/0748233715576615. [PMID: 25883098]
  • Viju Kumar Bharathan, Biju Chandran, Unnikrishnan Gopalakrishnan, Christi Titus Varghese, Ramachandran N Menon, Dinesh Balakrishnan, O V Sudheer, Puneet Dhar, Sudhindran Surendran. Perioperative prostaglandin e1 infusion in living donor liver transplantation: A double-blind, placebo-controlled randomized trial. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2016 08; 22(8):1067-74. doi: 10.1002/lt.24479. [PMID: 27152759]
  • Selda Gezginci-Oktayoglu, Nurcan Orhan, Sehnaz Bolkent. Prostaglandin-E1 has a protective effect on renal ischemia/reperfusion-induced oxidative stress and inflammation mediated gastric damage in rats. International immunopharmacology. 2016 Jul; 36(?):142-150. doi: 10.1016/j.intimp.2016.04.021. [PMID: 27135545]
  • Dimitrios Tsikas, Maria-Theresia Suchy, Klaus Tödter, Joerg Heeren, Ludger Scheja. Utilizing immunoaffinity chromatography (IAC) cross-reactivity in GC-MS/MS exemplified at the measurement of prostaglandin E1 in human plasma using prostaglandin E2-specific IAC columns. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 May; 1021(?):101-107. doi: 10.1016/j.jchromb.2015.04.026. [PMID: 25944643]
  • Kai Maida, Yorihiro Akamatsu, Yasuyuki Hara, Kazuaki Tokodai, Shigehito Miyagi, Toshiaki Kashiwadate, Koji Miyazawa, Naoki Kawagishi, Noriaki Ohuchi. Short Oxygenated Warm Perfusion With Prostaglandin E1 Administration Before Cold Preservation as a Novel Resuscitation Method for Liver Grafts From Donors After Cardiac Death in a Rat In Vivo Model. Transplantation. 2016 05; 100(5):1052-8. doi: 10.1097/tp.0000000000001127. [PMID: 26950723]
  • Ina Willenberg, Katharina Rund, Song Rong, Nelli Shushakova, Faikah Gueler, Nils Helge Schebb. Characterization of changes in plasma and tissue oxylipin levels in LPS and CLP induced murine sepsis. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2016 Feb; 65(2):133-42. doi: 10.1007/s00011-015-0897-7. [PMID: 26645911]
  • Brady S Moffett, Joshua M Garrison, Aimee Hang, Shaine A Morris, Rocky Tsang, Kimberly Dinh, Pamela Griffiths, Ronald Bronicki, Paul A Checchia. Prostaglandin Availability and Association with Outcomes for Infants with Congenital Heart Disease. Pediatric cardiology. 2016 Feb; 37(2):338-44. doi: 10.1007/s00246-015-1282-6. [PMID: 26499357]
  • Tomoka Gose, Takeo Nakanishi, Shunsuke Kamo, Hiroaki Shimada, Katsumasa Otake, Ikumi Tamai. Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3. Prostaglandins & other lipid mediators. 2016 Jan; 122(?):10-7. doi: 10.1016/j.prostaglandins.2015.12.003. [PMID: 26692285]
  • Dilek Erer, Abdullah Özer, Hüseyin Demirtaş, İpek Işık Gönül, Halil Kara, Hande Arpacı, Faruk Metin Çomu, Gürsel Levent Oktar, Mustafa Arslan, Ayşegül Küçük. Effects of alprostadil and iloprost on renal, lung, and skeletal muscle injury following hindlimb ischemia-reperfusion injury in rats. Drug design, development and therapy. 2016; 10(?):2651-8. doi: 10.2147/dddt.s110529. [PMID: 27601882]
  • Yanming Fan, Yunfa Jiang, Xianghua Fu, Junna Cai, Yanbo Wang, Wei Li, Xinshun Gu, Kun Xing, Shiru Bai, Xile Bi. Effects of liposomal prostaglandin E1 on periprocedural myocardial injury in patients with unstable angina undergoing an elective percutaneous coronary intervention. Coronary artery disease. 2015 Dec; 26(8):671-7. doi: 10.1097/mca.0000000000000294. [PMID: 26267747]
  • Lin Shi, Gui-ming Guo. [Adverse reactions occurred in four cases induced by intravenous injection of Alprostadil and Shuxuening Injection in normal saline]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2015 Dec; 35(12):1524-5. doi: ". [PMID: 26882620]
  • Kuan Zeng, Bao Ping Deng, Hui-Qi Jiang, Meng Wang, Ping Hua, Hong-Wu Zhang, Yu-Bin Deng, Yan-Qi Yang. Prostaglandin E₁ protects bone marrow-derived mesenchymal stem cells against serum deprivation-induced apoptosis. Molecular medicine reports. 2015 Oct; 12(4):5723-9. doi: 10.3892/mmr.2015.4176. [PMID: 26252504]
  • Eikan Mishima, Shinji Fukuda, Hisato Shima, Akiyoshi Hirayama, Yasutoshi Akiyama, Yoichi Takeuchi, Noriko N Fukuda, Takehiro Suzuki, Chitose Suzuki, Akinori Yuri, Koichi Kikuchi, Yoshihisa Tomioka, Sadayoshi Ito, Tomoyoshi Soga, Takaaki Abe. Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD. Journal of the American Society of Nephrology : JASN. 2015 Aug; 26(8):1787-94. doi: 10.1681/asn.2014060530. [PMID: 25525179]
  • Elisabeth Holen, Juyun He, Marit Espe, Liqiou Chen, Pedro Araujo. Combining eicosapentaenoic acid, decosahexaenoic acid and arachidonic acid, using a fully crossed design, affect gene expression and eicosanoid secretion in salmon head kidney cells in vitro. Fish & shellfish immunology. 2015 Aug; 45(2):695-703. doi: 10.1016/j.fsi.2015.05.017. [PMID: 26003739]
  • Wei Zhang, Linjing Shi, Hao Zhang, Chen Wang, Shan Gao, Yarong Ma, Wei Li, Jian Liu, Jinwei Wang, Jishi Liu. [Effect of alprostadil on serum level of miRNA-155 
in uremic patients]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2015 Jul; 40(7):735-41. doi: 10.11817/j.issn.1672-7347.2015.07.006. [PMID: 26267685]
  • Shuqiang Jin, Haili Cao, Kaibing Wang, Ying Li, Bin Bai. Preventative effects of prostaglandin E1 in combination with iodized olive oil on liver fibrosis after transcatheter arterial chemoembolization in a rabbit model of CCl4-induced liver fibrosis. Canadian journal of physiology and pharmacology. 2015 Jun; 93(6):451-7. doi: 10.1139/cjpp-2014-0561. [PMID: 25928762]
  • S D Upadhaya, J C Kim, B P Mullan, J R Pluske, I H Kim. Vitamin E and omega-3 fatty acids independently attenuate plasma concentrations of proinflammatory cytokines and prostaglandin E3 in Escherichia coli lipopolysaccharide-challenged growing-finishing pigs. Journal of animal science. 2015 Jun; 93(6):2926-34. doi: 10.2527/jas.2014-8330. [PMID: 26115279]
  • B Uzun, O Atli, B O Perk, D Burukoglu, S Ilgin. Evaluation of the reproductive toxicity of naproxen sodium and meloxicam in male rats. Human & experimental toxicology. 2015 Apr; 34(4):415-29. doi: 10.1177/0960327114542886. [PMID: 25034942]
  • Hong Chen, Qi Zhang, Xiaojiao Li, Hong Zhang, Yanfu Sun, Lei Yin, Chengjiao Liu, Yuchen Cao, Jingkai Gu, Yanhua Ding. Single- and multiple-dose pharmacokinetics and tolerability of limaprost in healthy Chinese subjects. Clinical drug investigation. 2015 Mar; 35(3):151-7. doi: 10.1007/s40261-014-0265-3. [PMID: 25586152]
  • Seon Min Woo, Kyoung-Jin Min, In Gyeong Chae, Kyung-Soo Chun, Taeg Kyu Kwon. Silymarin suppresses the PGE2 -induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways. Molecular carcinogenesis. 2015 Mar; 54(3):216-28. doi: 10.1002/mc.22092. [PMID: 24127286]
  • Undurti N Das. Nutritional factors in the prevention and management of coronary artery disease and heart failure. Nutrition (Burbank, Los Angeles County, Calif.). 2015 Feb; 31(2):283-91. doi: 10.1016/j.nut.2014.08.011. [PMID: 25592005]
  • Naohiro Yamamoto, Takanobu Otsuka, Gen Kuroyanagi, Akira Kondo, Shingo Kainuma, Akira Nakakami, Rie Matsushima-Nishiwaki, Osamu Kozawa, Haruhiko Tokuda. Resveratrol reduces prostaglandin E1-stimulated osteoprotegerin synthesis in osteoblasts: suppression of stress-activated protein kinase/c-Jun N-terminal kinase. Prostaglandins & other lipid mediators. 2015 Jan; 116-117(?):57-63. doi: 10.1016/j.prostaglandins.2015.01.003. [PMID: 25677506]
  • Chenglin Mo, Ruonan Zhao, Julian Vallejo, Orisa Igwe, Lynda Bonewald, Lori Wetmore, Marco Brotto. Prostaglandin E2 promotes proliferation of skeletal muscle myoblasts via EP4 receptor activation. Cell cycle (Georgetown, Tex.). 2015; 14(10):1507-16. doi: 10.1080/15384101.2015.1026520. [PMID: 25785867]
  • Zora Djuric, D Kim Turgeon, Jianwei Ren, Andrew Neilson, Missy Plegue, Ian G Waters, Alexander Chan, Leah M Askew, Mack T Ruffin, Ananda Sen, Dean E Brenner. Effects of a Mediterranean Diet Intervention on Anti- and Pro-Inflammatory Eicosanoids, Epithelial Proliferation, and Nuclear Morphology in Biopsies of Normal Colon Tissue. Nutrition and cancer. 2015; 67(5):721-9. doi: 10.1080/01635581.2015.1029637. [PMID: 25869112]
  • Rosemeire M Kanashiro-Takeuchi, Luca Szalontay, Andrew V Schally, Lauro M Takeuchi, Petra Popovics, Miklos Jaszberenyi, Irving Vidaurre, Marta Zarandi, Ren-Zhi Cai, Norman L Block, Joshua M Hare, Ferenc G Rick. New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget. 2015; 6(12):9728-39. doi: 10.18632/oncotarget.3303. [PMID: 25797248]
  • Kamal M Kassem, Margarette H Clevenger, David L Szandzik, Edward Peterson, Pamela Harding. PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts. Prostaglandins & other lipid mediators. 2014 Oct; 113-115(?):62-8. doi: 10.1016/j.prostaglandins.2014.09.002. [PMID: 25263346]
  • Noritaka Ota, Masaya Murata, Yuko Tosaka, Yujiro Ide, Maiko Tachi, Hiroki Ito, Ai Sugimoto, Kisaburo Sakamoto. Is routine rapid-staged bilateral pulmonary artery banding before stage 1 Norwood a viable strategy?. The Journal of thoracic and cardiovascular surgery. 2014 Oct; 148(4):1519-25. doi: 10.1016/j.jtcvs.2013.11.053. [PMID: 24472315]
  • Yoshie S Weems, John Pang, Aaron Raney, Tracie Uchima, Esther Lennon, Drew Johnson, Torrance M Nett, Ronald D Randel, Charles W Weems. Prostaglandin E1 or E2 inhibits an oxytocin-induced premature luteolysis in ewes when oxytocin is given early in the estrous cycle. Theriogenology. 2014 Aug; 82(3):440-6. doi: 10.1016/j.theriogenology.2014.04.024. [PMID: 24908337]
  • Wen-Hua Li, Dong-Ye Li, Wen-Hao Qian, Jia-Li Liu, Tong-Da Xu, Hong Zhu, Hai-Yan He. Prevention of contrast-induced nephropathy with prostaglandin E1 in high-risk patients undergoing percutaneous coronary intervention. International urology and nephrology. 2014 Apr; 46(4):781-6. doi: 10.1007/s11255-014-0674-5. [PMID: 24570327]
  • J R Glenn, N Dovlatova, A E White, K Dhillon, S Heptinstall, S C Fox. 'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists. Thrombosis and haemostasis. 2014 Mar; 111(3):539-48. doi: 10.1160/th13-07-0581. [PMID: 24258486]
  • Suzanne M Pilkington, Lesley E Rhodes, Naser M I Al-Aasswad, Karen A Massey, Anna Nicolaou. Impact of EPA ingestion on COX- and LOX-mediated eicosanoid synthesis in skin with and without a pro-inflammatory UVR challenge--report of a randomised controlled study in humans. Molecular nutrition & food research. 2014 Mar; 58(3):580-90. doi: 10.1002/mnfr.201300405. [PMID: 24311515]