trichlormethiazide (BioDeep_00001867797)
Main id: BioDeep_00000002117
Volatile Flavor Compounds
代谢物信息卡片
trichlormethiazide
化学式: C8H8Cl3N3O4S2 (378.9021818)
中文名称: 三氯噻嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl
InChI: InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
描述信息
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:9683
- KEGG: C07767
- KEGG: C72338
- KEGGdrug: D00658
- PubChem: 5560
- DrugBank: DB01021
- ChEMBL: CHEMBL1054
- MeSH: Trichlormethiazide
- CAS: 133-67-5
- PubChem: 9969
- NIKKAJI: J2.527E
- KNApSAcK: 9683
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kiyotaka Uchiyama, Chigusa Kitayama, Akane Yanai, Yoshitaka Ishibashi. The effect of trichlormethiazide in autosomal dominant polycystic kidney disease patients receiving tolvaptan: a randomized crossover controlled trial.
Scientific reports.
2021 09; 11(1):17666. doi:
10.1038/s41598-021-97113-w. [PMID: 34480075] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Takashi Sakoh, Akinari Sekine, Takayasu Mori, Hiroki Mizuno, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Noriko Hayami, Masayuki Yamanouchi, Tatsuya Suwabe, Naoki Sawa, Yoshifumi Ubara, Takuya Fujimaru, Eisei Sohara, Uchida Shinichi, Junichi Hoshino, Kenmei Takaichi. A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4.
Molecular genetics & genomic medicine.
2019 06; 7(6):e705. doi:
10.1002/mgg3.705. [PMID: 31044551] - Miki Hosaka, Ryusuke Inoue, Michihiro Satoh, Daisuke Watabe, Tomohiro Hanazawa, Takayoshi Ohkubo, Kei Asayama, Taku Obara, Yutaka Imai. Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients.
Clinical and experimental hypertension (New York, N.Y. : 1993).
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10.1080/10641963.2017.1403617. [PMID: 29172732] - Kazuomi Kario, Naoko Tomitani, Hiroshi Kanegae, Hajime Ishii, Kazuaki Uchiyama, Kayo Yamagiwa, Toshihiko Shiraiwa, Tomohiro Katsuya, Tetsuro Yoshida, Kiyomi Kanda, Shinji Hasegawa, Satoshi Hoshide. Comparative Effects of an Angiotensin II Receptor Blocker (ARB)/Diuretic vs. ARB/Calcium-Channel Blocker Combination on Uncontrolled Nocturnal Hypertension Evaluated by Information and Communication Technology-Based Nocturnal Home Blood Pressure Monitoring - The NOCTURNE Study.
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Clinical and experimental hypertension (New York, N.Y. : 1993).
2009 Nov; 31(8):648-56. doi:
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2006 Apr; 47(4):699-705. doi:
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2005 Apr; 23(4):861-5. doi:
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2004 Jun; 24(1):55-9. doi:
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2003 Jun; 26(6):509-13. doi:
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2003 Jun; 21(6):1171-81. doi:
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Hormone research.
2003; 59(6):297-300. doi:
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2001 Oct; 39(10):417-22. doi:
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2001 Sep; 19(9):1601-6. doi:
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2000 Nov; 23(6):593-600. doi:
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2000 Nov; 23(6):567-72. doi:
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2000 Jul; 23(4):317-22. doi:
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1996 Nov; 279(2):983-90. doi:
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1996 Mar; 37(2):251-9. doi:
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1996 Feb; 27(2):209-18. doi:
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1995 Dec; 22(1):S374-6. doi:
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Japanese journal of pharmacology.
1995 Aug; 68(4):389-96. doi:
10.1254/jjp.68.389. [PMID: 8531413] - H Kusaka, K Nagashima, A Karasawa. Effects of KW-3902, an adenosine A1-receptor antagonist, on ascites volume in puromycin aminonucleoside (PAN)-induced nephrotic rats.
Japanese journal of pharmacology.
1995 Jun; 68(2):213-6. doi:
10.1254/jjp.68.213. [PMID: 7563979] - K Nagashima, H Kusaka, A Karasawa. Protective effects of KW-3902, an adenosine A1-receptor antagonist, against cisplatin-induced acute renal failure in rats.
Japanese journal of pharmacology.
1995 Apr; 67(4):349-57. doi:
10.1254/jjp.67.349. [PMID: 7650867] - M Kähönen, H Mäkynen, P Arvola, H Wuorela, I Pörsti. Arterial function after trichlormethiazide therapy in spontaneously hypertensive rats.
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Kidney international.
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1994 Dec; 17(12):1599-603. doi:
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1994 Jun; 65(2):167-70. doi:
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