Asiatic (BioDeep_00001867493)

PANOMIX_OTCML-2023 Chemicals and Drugs

代谢物信息卡片

化学式: C30H48O5 (488.3501558)
中文名称: 积雪草酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)CO)O)O)C)C)C2C1C)C)C(=O)O
InChI: InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s1

描述信息

Asiatic acid is a pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). It is isolated from Symplocos lancifolia and Vateria indica and exhibits anti-angiogenic activity. It has a role as an angiogenesis modulating agent and a metabolite. It is a monocarboxylic acid, a triol and a pentacyclic triterpenoid. It derives from a hydride of an ursane.
From Centella asiatica and other plants; shows a variety of bioactivities.
Asiatic acid is a natural product found in Psidium guajava, Combretum fruticosum, and other organisms with data available.
See also: Holy basil leaf (part of); Lagerstroemia speciosa leaf (part of); Centella asiatica flowering top (part of).
A pentacyclic triterpenoid that is ursane substituted by a carboxy group at position 28 and hydroxy groups at positions 2, 3 and 23 (the 2alpha,3beta stereoisomer). It is isolated from Symplocos lancifolia and Vateria indica and exhibits anti-angiogenic activity.
C1907 - Drug, Natural Product > C28269 - Phytochemical > C1905 - Triterpenoid Compound
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product
Asiatic acid, a pentacyclic triterpene found in Centella asiatica, induces apoptosis in melanoma cells. Asiatic acid has the potential for skin cancer treatment[1]. Asiatic acid also has anti-inflammatory activities[2].
Asiatic acid, a pentacyclic triterpene found in Centella asiatica, induces apoptosis in melanoma cells. Asiatic acid has the potential for skin cancer treatment[1]. Asiatic acid also has anti-inflammatory activities[2].

同义名列表

38 个代谢物同义名

(1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid; (1S,2R,4aS,6aS,6bR,8aR,9R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid; (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid; (1S,2R,4aS,6aR,6aS,6bR,8aR,9R,10R,11R,12aR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylicacid; Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2.alpha.,3.beta.,4.alpha.)-; Urs-12en-28-oic acid, 2,3,23-trihydroxy-, (2alpha, 3beta, 4alpha)-; (2.ALPHA.,3.BETA.,4.ALPHA.)-2,3,23-TRIHYDROXYURS-12-EN-28-OIC ACID; (2alpha,3beta,5beta,20beta)-2,3,23-trihydroxyurs-12-en-28-oic acid; Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2alpha,3beta,4alpha)-; (4I+/-)-a?I+/-,a?I(2),a?3-atrihydroxy-aurs-a?2-aen-a?8-aoic acid; (2alpha,3beta,4alpha)-2,3,23-TRIHYDROXYURS-12-EN-28-OIC ACID; (4alpha)-2alpha,3beta,23-trihydroxy-urs-12-en-28-oic acid; Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2a,3b,4a)-; (2alpha,3beta)-2,3,23-trihydroxyurs-12-en-28-oic acid; ASIATIC ACID (CONSTITUENT OF CENTELLA ASIATICA) [DSC]; ASIATIC ACID (CONSTITUENT OF HOLY BASIL LEAF) [DSC]; Asiatic acid, >=98\\% (HPLC), from Centella asiatica; ASIATIC ACID (CONSTITUENT OF BANABA LEAF) [DSC]; ASIATIC ACID (CONSTITUENT OF CENTELLA ASIATICA); 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid; ASIATIC ACID (CONSTITUENT OF HOLY BASIL LEAF); ASIATIC ACID (CONSTITUENT OF BANABA LEAF); 2,3,23-trihydroxyurs-12-en-28-oic acid; Asiatic acid, analytical standard; Esculentic acid (Diplazium); ASIATIC ACID [WHO-DD]; ASIATIC ACID [INCI]; ASIATIC ACID [HSDB]; Asiatic acid, 97\\%; Dammarolic acid; UNII-9PA5A687X5; Asiantic acid; Asiatic-acid; Asiatic Acid; Asiaticacid; 9PA5A687X5; Asiatic; 0AS

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:2873
KEGG: C08617
PubChem: 119034
DrugBank: DB14054
ChEMBL: CHEMBL404313
MeSH: asiatic acid
ChemIDplus: 0000464926
chemspider: 106361
CAS: 464-92-6
medchemexpress: HY-N0194
MetaboLights: MTBLC2873
PubChem: 10810
KNApSAcK: C00003739
PDB-CCD: 0AS
3DMET: B02271
NIKKAJI: J11.338G

分类词条

萜类

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

62 个相关的物种来源信息

33090 积雪草: -
420630 Siphoneugena densiflora:
48106 Centella asiatica:
1924228 Terminalia glabrescens: 10.1590/S0103-50532003000300021
219860 Syzygium claviflorum: 10.1021/NP9800710
28501 Cornus kousa: 10.1007/S10600-010-9550-4
497234 Hedyotis lawsoniae: 10.1248/CPB.32.3906
239704 Symplocos lancifolia: 10.1021/NP100502Y
43069 Centella erecta: 10.1016/J.FITOTE.2010.03.018
22663 Punica granatum: 10.1248/CPB.56.1628
666687 Shorea robusta:
1401399 Combretum fruticosum: 10.3390/MOLECULES13112717
1504168 Combretum laxum: 10.3390/MOLECULES13112717
73757 Melaleuca ericifolia: 10.1021/NP800360A
3625 Actinidia chinensis:
120290 Psidium guajava: 10.1016/S0031-9422(02)00190-5
178121 Calyptranthes pallens: 10.1021/NP0496688
39358 Prunella vulgaris: 10.1002/HLCA.200790023
365537 Dipterocarpus hispidus: 10.1016/0031-9422(75)83122-0
64480 Actinidia polygama:
49140 Craibiodendron yunnanense:
260145 Ugni molinae: 10.1016/J.BMC.2006.04.021
39993 Terminalia catappa:
183845 Eucalyptus perriniana: 10.1016/S0031-9422(00)84771-8
652505 Terminalia complanata: 10.1016/0031-9422(92)80177-G
1548808 Terminalia brassii: 10.1016/0031-9422(92)80177-G
327218 Heptapleurum heptaphyllum: 10.1016/0031-9422(91)83042-J
334478 Syzygium crebrinerve: 10.1071/CH9761135
219887 Syzygium gustavioides: 10.1071/CH9761135
1747497 Mucuna birdwoodiana: 10.1016/0031-9422(91)80094-H
420630 Siphoneugena densiflora:
48106 Centella asiatica:
1924228 Terminalia glabrescens: 10.1590/S0103-50532003000300021
219860 Syzygium claviflorum: 10.1021/NP9800710
28501 Cornus kousa: 10.1007/S10600-010-9550-4
497234 Hedyotis lawsoniae: 10.1248/CPB.32.3906
239704 Symplocos lancifolia: 10.1021/NP100502Y
43069 Centella erecta: 10.1016/J.FITOTE.2010.03.018
22663 Punica granatum: 10.1248/CPB.56.1628
666687 Shorea robusta:
1401399 Combretum fruticosum: 10.3390/MOLECULES13112717
1504168 Combretum laxum: 10.3390/MOLECULES13112717
73757 Melaleuca ericifolia: 10.1021/NP800360A
3625 Actinidia chinensis:
120290 Psidium guajava: 10.1016/S0031-9422(02)00190-5
178121 Calyptranthes pallens: 10.1021/NP0496688
39358 Prunella vulgaris: 10.1002/HLCA.200790023
365537 Dipterocarpus hispidus: 10.1016/0031-9422(75)83122-0
64480 Actinidia polygama:
49140 Craibiodendron yunnanense:
260145 Ugni molinae: 10.1016/J.BMC.2006.04.021
39993 Terminalia catappa:
183845 Eucalyptus perriniana: 10.1016/S0031-9422(00)84771-8
652505 Terminalia complanata: 10.1016/0031-9422(92)80177-G
1548808 Terminalia brassii: 10.1016/0031-9422(92)80177-G
327218 Heptapleurum heptaphyllum: 10.1016/0031-9422(91)83042-J
334478 Syzygium crebrinerve: 10.1071/CH9761135
219887 Syzygium gustavioides: 10.1071/CH9761135
1747497 Mucuna birdwoodiana: 10.1016/0031-9422(91)80094-H
313920 Blumea balsamifera DC.: -
48106 Centella asiatica (L.)Urb.: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Maha S Lokman, Rami B Kassab, Fatma A M Salem, Gehad E Elshopakey, Akram Hussein, Ahmed A Aldarmahi, Abdulrahman Theyab, Khalid J Alzahrani, Khalid E Hassan, Khalaf F Alsharif, Ashraf Albrakati, Jehad Z Tayyeb, Manal El-Khadragy, Mariam A Alkhateeb, Ali O Al-Ghamdy, Hussam A Althagafi, Ahmed E Abdel Moneim, Rehab E El-Hennamy. Asiatic acid rescues intestinal tissue by suppressing molecular, biochemical, and histopathological changes associated with the development of ulcerative colitis. Bioscience reports. 2024 May; 44(5):. doi: 10.1042/bsr20232004. [PMID: 38699907]
Zaynab Mando, Huda Mando, Adlin Afzan, Khozirah Shaari, Zurina Hassan, Mohamad Nurul Azmi Mohamad Taib, Fauziahanim Zakaria. Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies. Behavioural brain research. 2024 May; 466(?):114976. doi: 10.1016/j.bbr.2024.114976. [PMID: 38599249]
Zeba Firdaus, Gopichand Gutti, Ankit Ganeshpurkar, Ashok Kumar, Sairam Krishnamurthy, Sushil Kumar Singh, Tryambak Deo Singh. Centella asiatica improves memory and executive function in middle-aged rats by controlling oxidative stress and cholinergic transmission. Journal of ethnopharmacology. 2024 May; 325(?):117888. doi: 10.1016/j.jep.2024.117888. [PMID: 38336185]
Romchat Chutoprapat, Jatuporn Witarat, Panalee Jongpanyangarm, Lucy Mang Sung Thluai, Pichanon Khankaew, Lai Wah Chan. Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment. International journal of pharmaceutics. 2024 Apr; 654(?):123980. doi: 10.1016/j.ijpharm.2024.123980. [PMID: 38460769]
Tripti Halder, Bijit Saha, Namdev Dhas, Sanjeev Acharya, Niyati Acharya. Development and evaluation of multi-functionalized sialic acid conjugated asiatic acid nanoconstruct to mitigate cognitive deficits in Alzheimer's disease. Drug development research. 2024 Feb; 85(1):e22146. doi: 10.1002/ddr.22146. [PMID: 38349270]
Narumon Changsan, Teerapol Srichana, Apichart Atipairin, Somchai Sawatdee. Wound healing efficacy of a polymeric spray film solution containing Centella asiatica leaf extract on acute wounds. Journal of wound care. 2023 Dec; 32(Sup12):S22-S32. doi: 10.12968/jowc.2023.32.sup12.s22. [PMID: 38063299]
Temitope Akinwumi Ajani, Kenechukwu Obikeze, Zandisiwe E Magwebu, Samuel Egieyeh, Chesa G Chauke. In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme. BMC pharmacology & toxicology. 2023 11; 24(1):67. doi: 10.1186/s40360-023-00701-x. [PMID: 38007481]
Sirikool Thamnium, Chavee Laomeephol, Prasit Pavasant, Thanaphum Osathanon, Yasuhiko Tabata, Chao Wang, Jittima A Luckanagul. Osteogenic induction of asiatic acid derivatives in human periodontal ligament stem cells. Scientific reports. 2023 Aug; 13(1):14102. doi: 10.1038/s41598-023-41388-8. [PMID: 37644086]
Ridho Islamie, Su Lwin Lwin Myint, Tissana Rojanaratha, Garnpimol Ritthidej, Oraphan Wanakhachornkrai, Onsurang Wattanathamsan, Ratchanee Rodsiri. Neuroprotective effect of nose-to-brain delivery of Asiatic acid in solid lipid nanoparticles and its mechanisms against memory dysfunction induced by Amyloid Beta1-42 in mice. BMC complementary medicine and therapies. 2023 Aug; 23(1):294. doi: 10.1186/s12906-023-04125-2. [PMID: 37608290]
Abdul Qadir, Shehla Nasar Mir Najib Ullah, Dipak Kumar Gupta, Nausheen Khan, Musarrat Husain Warsi, Mehnaz Kamal. Combinatorial drug-loaded quality by design adapted transliposome gel formulation for dermal delivery: In vitro and dermatokinetic study. Journal of cosmetic dermatology. 2023 Jun; ?(?):. doi: 10.1111/jocd.15792. [PMID: 37309263]
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
Ariani Ariani, Imelda Febriana Ghofar, Husnul Khotimah, Nurdiana Nurdiana, Masruroh Rahayu. Asiatic acid in Centella asiatica extract towards morphological development in an intermittent hypoxia intrauterine embryo model and molecular prediction pathway of insulin-like growth factor-1 receptor signalling. Open veterinary journal. 2023 05; 13(5):629-637. doi: 10.5455/ovj.2023.v13.i5.16. [PMID: 37304601]
Priyanka Maitra, Priyanka Basak, Keinosuke Okamoto, Shin-Ichi Miyoshi, Shanta Dutta, Sushmita Bhattacharya. Asiatic acid inhibits intracellular Shigella flexneri growth by inducing antimicrobial peptide gene expression. Journal of applied microbiology. 2023 Feb; 134(2):. doi: 10.1093/jambio/lxac076. [PMID: 36626757]
Wenshu Zou, Kai Zhang, Zhengying Qiu, Ruihua Xin, Guibo Wang, Jingyan Zhang, Jianxi Li. Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Feb; 172(?):113584. doi: 10.1016/j.fct.2022.113584. [PMID: 36581090]
Tripti Halder, Bharat Patel, Niyati Acharya. Asiatic Acid Fabricated Nanoconstructs to Mitigate Amyloid Beta1-42 Induced Injury in SH-SY5Y Cells In-Vitro and Ameliorates Cognitive Impairment by Dual Cholinesterase Inhibition and Attenuation of Oxidative Stress In-Vivo. Pharmaceutical research. 2023 Jan; 40(1):197-213. doi: 10.1007/s11095-022-03428-2. [PMID: 36376605]
Yali Ji, Xuanxuan Zhang, Jicong Chen, Sijia Song, Siyang Fang, Zihan Wang, Susu Xu, Yinying Xu, Jianjing Liu, Cuihua Jiang, Ke Pan, Jian Zhang, Lei Wang, Zhiqi Yin. Asiatic acid attenuates tubular injury in diabetic kidney disease by regulating mitochondrial dynamics via the Nrf-2 pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154552. doi: 10.1016/j.phymed.2022.154552. [PMID: 36610157]
Tussapon Boonyarattanasoonthorn, Teetat Kongratanapasert, Arnatchai Maiuthed, Robert Hamlin, Anusak Kijtawornrat, Phisit Khemawoot. Bioenhancing effects of piperine and curcumin on triterpenoid pharmacokinetics and neurodegenerative metabolomes from Centella asiatica extract in beagle dogs. Scientific reports. 2022 12; 12(1):20789. doi: 10.1038/s41598-022-24935-7. [PMID: 36456663]
Wenshu Zou, Jingyan Zhang, Kai Zhang, Zhiping Peng, Ruihua Xin, Lei Wang, Jianxi Li. Asiatic Acid Attenuates Inflammation Induced by Salmonella via Upregulating LncRNA TVX1 in Microglia. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810978. [PMID: 36142890]
Yong Li, Xu-Lin He, Li-Ping Zhou, Xiao-Zhong Huang, Shan Li, Su Guan, Jing Li, Lei Zhang. Asiatic acid alleviates liver fibrosis via multiple signaling pathways based on integrated network pharmacology and lipidomics. European journal of pharmacology. 2022 Sep; 931(?):175193. doi: 10.1016/j.ejphar.2022.175193. [PMID: 35963324]
Jyoti Suryavanshi, Chandra Prakash, Deepak Sharma. Asiatic acid attenuates aluminium chloride-induced behavioral changes, neuronal loss and astrocyte activation in rats. Metabolic brain disease. 2022 08; 37(6):1773-1785. doi: 10.1007/s11011-022-00998-3. [PMID: 35554794]
Kaixia Niu, Pengpeng Bai, Bingbing Yang, Xinchi Feng, Feng Qiu. Asiatic acid alleviates metabolism disorders in ob/ob mice: mechanistic insights. Food & function. 2022 Jul; 13(13):6934-6946. doi: 10.1039/d2fo01069k. [PMID: 35696250]
Osman Kukula, Seda Kırmızıkan, Emre Soner Tiryaki, Mustafa Nusret Çiçekli, Caner Günaydın. Asiatic acid exerts an anti-psoriatic effect in the imiquimod-induced psoriasis model in mice. Immunopharmacology and immunotoxicology. 2022 Jun; 44(3):367-372. doi: 10.1080/08923973.2022.2048849. [PMID: 35253588]
Fan Qiu, Yi Yuan, Wei Luo, Yan-Shan Gong, Zhong-Ming Zhang, Zhong-Min Liu, Ling Gao. Asiatic acid alleviates ischemic myocardial injury in mice by modulating mitophagy- and glycophagy-based energy metabolism. Acta pharmacologica Sinica. 2022 Jun; 43(6):1395-1407. doi: 10.1038/s41401-021-00763-9. [PMID: 34522006]
Chien-Feng Huang, Tung-Wei Hung, Shun-Fa Yang, Yi-Lun Tsai, Jen-Te Yang, Chia-Liang Lin, Yi-Hsien Hsieh. Asiatic acid from centella asiatica exert anti-invasive ability in human renal cancer cells by modulation of ERK/p38MAPK-mediated MMP15 expression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 100(?):154036. doi: 10.1016/j.phymed.2022.154036. [PMID: 35316724]
Huiqiang Wei, Jianghong Guo, Xiao Sun, Wenfeng Gou, Hongxin Ning, Haihua Shang, Qiang Liu, Wenbin Hou, Yiliang Li. Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study. Journal of natural products. 2022 05; 85(5):1248-1255. doi: 10.1021/acs.jnatprod.1c01166. [PMID: 35500202]
Xuan-Xuan Zhang, Yao Liu, Su-Su Xu, Ru Yang, Cui-Hua Jiang, Li-Ping Zhu, Yin-Ying Xu, Ke Pan, Jian Zhang, Zhi-Qi Yin. Asiatic acid from Cyclocarya paliurus regulates the autophagy-lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis. Food & function. 2022 May; 13(10):5536-5546. doi: 10.1039/d1fo02445k. [PMID: 35531774]
Tussapon Boonyarattanasoonthorn, Anusak Kijtawornrat, Phanit Songvut, Nitra Nuengchamnong, Visarut Buranasudja, Phisit Khemawoot. Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs. Scientific reports. 2022 02; 12(1):2909. doi: 10.1038/s41598-022-06967-1. [PMID: 35190633]
Zuzanna Sycz, Dorota Tichaczek-Goska, Dorota Wojnicz. Anti-Planktonic and Anti-Biofilm Properties of Pentacyclic Triterpenes-Asiatic Acid and Ursolic Acid as Promising Antibacterial Future Pharmaceuticals. Biomolecules. 2022 01; 12(1):. doi: 10.3390/biom12010098. [PMID: 35053246]
Chenlong Yi, Meijuan Song, Lifu Sun, Linjie Si, Dongmin Yu, Ben Li, Peng Lu, Wei Wang, Xiaowei Wang. Asiatic Acid Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting the ROS-Mediated Mitochondria-Dependent Apoptosis Pathway. Oxidative medicine and cellular longevity. 2022; 2022(?):3267450. doi: 10.1155/2022/3267450. [PMID: 35198095]
Tao Jiang, Jinhong Xu, Yang Lu, Xiaojin Chen, Yongxia Li. Network Pharmacology Analysis and Experimental Validation to Explore the Anti-inflammatory Mechanism of Asiatic Acid on Alcoholic Steatohepatitis. Mediators of inflammation. 2022; 2022(?):1708030. doi: 10.1155/2022/1708030. [PMID: 36262544]
Ya-Wen Zhang, Ling-Lan Tu, Yi Zhang, Jie-Chao Pan, Gao-Li Zheng, Li-Na Yin. Liver-targeted delivery of asiatic acid nanostructured lipid carrier for the treatment of liver fibrosis. Drug delivery. 2021 Dec; 28(1):2534-2547. doi: 10.1080/10717544.2021.2008054. [PMID: 34854788]
Tianming Chen, Changhao Zhu, Xing Wang, Yaozhen Pan, Bin Huang. Asiatic Acid Encapsulated Exosomes of Hepatocellular Carcinoma Inhibit Epithelial-Mesenchymal Transition Through Transforming Growth Factor Beta/Smad Signaling Pathway. Journal of biomedical nanotechnology. 2021 Dec; 17(12):2338-2350. doi: 10.1166/jbn.2021.3208. [PMID: 34974857]
Zuzanna Sycz, Dorota Tichaczek-Goska, Anna Jezierska-Domaradzka, Dorota Wojnicz. Are Uropathogenic Bacteria Living in Multispecies Biofilm Susceptible to Active Plant Ingredient-Asiatic Acid?. Biomolecules. 2021 11; 11(12):. doi: 10.3390/biom11121754. [PMID: 34944398]
Ahmed Alafnan, Talib Hussain, Syed Mohd Danish Rizvi, Afrasim Moin, Abdulwahab Alamri. Prostate Apoptotic Induction and NFκB Suppression by Dammarolic Acid: Mechanistic Insight into Onco-Therapeutic Action of an Aglycone Asiaticoside. Current issues in molecular biology. 2021 Aug; 43(2):932-940. doi: 10.3390/cimb43020066. [PMID: 34449548]
Nur Aziah Hanapi, Ahmad Saifuddin Mohamad Arshad, Jafri Malin Abdullah, Tengku Sifzizul Tengku Muhammad, Siti R Yusof. Blood-Brain Barrier Permeability of Asiaticoside, Madecassoside and Asiatic Acid in Porcine Brain Endothelial Cell Model. Journal of pharmaceutical sciences. 2021 02; 110(2):698-706. doi: 10.1016/j.xphs.2020.09.015. [PMID: 32949562]
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