Carbachol (BioDeep_00000018616)
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-(trimethylazaniumyl)ethyl carbamate
化学式: C6H15N2O2+ (147.1133)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(blood) 7.06%
分子结构信息
SMILES: C[N+](C)(C)CCOC(=O)N
InChI: InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1
描述信息
Carbachol is only found in individuals that have used or taken this drug. It is a slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. [PubChem]Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow.
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D008916 - Miotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D020011 - Protective Agents > D002316 - Cardiotonic Agents
D002317 - Cardiovascular Agents
同义名列表
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Journal of ethnopharmacology.
2015 Aug; 172(?):1-9. doi:
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BMC complementary and alternative medicine.
2015 Jun; 15(?):169. doi:
10.1186/s12906-015-0697-1. [PMID: 26048286] - Luis Águila, Jenny Ruedlinger, Karina Mansilla, José Ordenes, Raúl Salvatici, Rui Ribeiro de Campos, Fernando Romero. Relaxant effects of a hydroalcoholic extract of Ruta graveolens on isolated rat tracheal rings.
Biological research.
2015 Jun; 48(?):28. doi:
10.1186/s40659-015-0017-8. [PMID: 26044818] - Khalid Hussain Janbaz, Tashfeen Akhtar, Fatima Saqib, Imran Imran, Muhammad Zia-Ul-Haq, Chaweeewan Jansakul, Vincenzo De Feo, Marius Moga. Pharmacological justification of use of Solena heterophylla Lour. in gastrointestinal, respiratory and vascular disorders.
Journal of translational medicine.
2015 Apr; 13(?):134. doi:
10.1186/s12967-015-0470-8. [PMID: 25925396] - Yohan D'Souza, Ahmed Elharram, Raquel Soon-Shiong, R David Andrew, Brian M Bennett. Characterization of Aldh2 (-/-) mice as an age-related model of cognitive impairment and Alzheimer's disease.
Molecular brain.
2015 Apr; 8(?):27. doi:
10.1186/s13041-015-0117-y. [PMID: 25910195] - Aline F Brito, Alexandre S Silva, Iara L L Souza, Joedna C Pereira, Italo R R Martins, Bagnólia A Silva. Intensity of swimming exercise influences tracheal reactivity in rats.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2015; 51(?):70-81. doi:
10.1540/jsmr.51.70. [PMID: 26497013] - Yuan-Qi Shi, Cai-Chuan Yan, Xiao Zhang, Meng Yan, Li-Rong Liu, Huai-Ze Geng, Lin Lv, Bao-Xin Li. Mechanisms underlying probucol-induced hERG-channel deficiency.
Drug design, development and therapy.
2015; 9(?):3695-704. doi:
10.2147/dddt.s86724. [PMID: 26229434] - Mário Angelo Claudino, Luiz Osório Silveira Leiria, Fábio Henrique da Silva, Eduardo Costa Alexandre, Andre Renno, Fabiola Zakia Mónica, Gilberto de Nucci, Kleber Yotsumoto Fertrin, Edson Antunes, Fernando Ferreira Costa, Carla Fernanda Franco-Penteado. Urinary Bladder Dysfunction in Transgenic Sickle Cell Disease Mice.
PloS one.
2015; 10(8):e0133996. doi:
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International journal of clinical and experimental pathology.
2015; 8(5):4514-24. doi:
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Digestion.
2015; 91(3):187-96. doi:
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BMC complementary and alternative medicine.
2014 Dec; 14(?):479. doi:
10.1186/1472-6882-14-479. [PMID: 25496022] - Mamoona Yasin, Khalid Hussain Janbaz, Imran Imran, Anwar-ul-Hassan Gilani, Samra Bashir. Pharmacological studies on the antispasmodic, bronchodilator and anti-platelet activities of Abies webbiana.
Phytotherapy research : PTR.
2014 Aug; 28(8):1182-7. doi:
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Science signaling.
2014 Jun; 7(331):ra59. doi:
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Molecular pharmacology.
2014 Jun; 85(6):877-86. doi:
10.1124/mol.113.091553. [PMID: 24688054] - Min-jian Zhang, Ya-lei Shi, Wan-jun Cheng, Zhen-wei Li, Xiang Lin. Relaxant effects of Aike Mixture on isolated bladder and prostatic urethral smooth muscle of rabbits.
Chinese journal of integrative medicine.
2014 Jun; 20(6):420-4. doi:
10.1007/s11655-012-1088-9. [PMID: 22610953] - Yoko Suzuki, Hiroyuki Shimizu, Noriko Ishizuka, Naoto Kubota, Tetsuya Kubota, Akira Senoo, Haruaki Kageyama, Toshimasa Osaka, Satoshi Hirako, Hyoun-Ju Kim, Akiyo Matsumoto, Seiji Shioda, Masatomo Mori, Takashi Kadowaki, Shuji Inoue. Vagal hyperactivity due to ventromedial hypothalamic lesions increases adiponectin production and release.
Diabetes.
2014 May; 63(5):1637-48. doi:
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Journal of natural products.
2014 Apr; 77(4):1074-7. doi:
10.1021/np4008969. [PMID: 24761833] - Rodopi Stamatiou, Efrosini Paraskeva, Anna Vasilaki, Ilias Mylonis, Paschalis Adam Molyvdas, Konstantinos Gourgoulianis, Apostolia Hatziefthimiou. Long-term exposure to muscarinic agonists decreases expression of contractile proteins and responsiveness of rabbit tracheal smooth muscle cells.
BMC pulmonary medicine.
2014 Mar; 14(?):39. doi:
10.1186/1471-2466-14-39. [PMID: 24607024] - C Ding, X Cong, Y Zhang, N Y Yang, S L Li, L L Wu, G Y Yu. Hypersensitive mAChRs are involved in the epiphora of transplanted glands.
Journal of dental research.
2014 Mar; 93(3):306-12. doi:
10.1177/0022034513519107. [PMID: 24389807] - Cristina I López Sanjurjo, Stephen C Tovey, Colin W Taylor. Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes.
PloS one.
2014; 9(10):e111275. doi:
10.1371/journal.pone.0111275. [PMID: 25337829] - Muhammad Jan. Effects of Ammi visnaga (Bisnaga) extract on the volume and acidity of stimulated gastric secretion in fasting rabbits.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2014 Jan; 24(1):39-42. doi:
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Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2014; 50(?):103-19. doi:
10.1540/jsmr.50.103. [PMID: 25891767] - Nicholas C Zachos, Bharath Alamelumangpuram, Luke J Lee, Peng Wang, Olga Kovbasnjuk. Carbachol-mediated endocytosis of NHE3 involves a clathrin-independent mechanism requiring lipid rafts and Cdc42.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2014; 33(3):869-81. doi:
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African journal of traditional, complementary, and alternative medicines : AJTCAM.
2014; 11(4):120-5. doi:
10.4314/ajtcam.v11i4.18. [PMID: 25392590] - Maulik R Patel, Yagnik S Bhalodia, Nimish L Pathak, Maulik S Patel, Kunal Suthar, Nilesh Patel, Dharmesh K Golwala, Nurudin P Jivani. Study on the mechanism of the bronchodilatory effects of Cynodon dactylon (Linn.) and identification of the active ingredient.
Journal of ethnopharmacology.
2013 Dec; 150(3):946-52. doi:
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The Journal of biological chemistry.
2013 Nov; 288(48):34777-90. doi:
10.1074/jbc.m113.503714. [PMID: 24133207] - Antonio Celso S Ramos-Filho, Juliana A Faria, Fabiano B Calmasini, Simone A Teixeira, Fabíola Z Mónica, Marcelo N Muscará, José A R Gontijo, Gabriel Forato Anhê, Angelina Zanesco, Edson Antunes. The renin-angiotensin system plays a major role in voiding dysfunction of ovariectomized rats.
Life sciences.
2013 Nov; 93(22):820-9. doi:
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The American journal of pathology.
2013 Nov; 183(5):1585-1595. doi:
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Urology.
2013 Oct; 82(4):975.e7-975.e12. doi:
10.1016/j.urology.2013.07.016. [PMID: 24075004] - Haroon Khan, Muhammad Saeed, Anwarul Hassan Gilani, Malik Hassan Mehmood, Najeeb-Ur Rehman, Naveed Muhammad, Muzaffar Abbas, Ikram-Ul Haq. Bronchodilator activity of aerial parts of Polygonatum verticillatum augmented by anti-inflammatory activity: attenuation of Ca²⁺ channels and lipoxygenase.
Phytotherapy research : PTR.
2013 Sep; 27(9):1288-92. doi:
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Fitoterapia.
2013 Sep; 89(?):68-73. doi:
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BMC complementary and alternative medicine.
2013 Jul; 13(?):197. doi:
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American journal of physiology. Cell physiology.
2013 Jul; 305(2):C207-14. doi:
10.1152/ajpcell.00113.2013. [PMID: 23703523] - Anwarul-Hassan Gilani, Najeeb-Ur Rehman, Malik Hassan Mehmood, Khalid M Alkharfy. Species differences in the antidiarrheal and antispasmodic activities of Lepidium sativum and insight into underlying mechanisms.
Phytotherapy research : PTR.
2013 Jul; 27(7):1086-94. doi:
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Journal of cell science.
2013 May; 126(Pt 10):2305-13. doi:
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The Journal of pharmacology and experimental therapeutics.
2013 Apr; 345(1):62-8. doi:
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PloS one.
2013; 8(1):e53113. doi:
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PloS one.
2013; 8(9):e74608. doi:
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The Journal of pharmacy and pharmacology.
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