Ginsenoside Rb2 (BioDeep_00000018595)
Main id: BioDeep_00000305092
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C53H90O22 (1078.5923)
中文名称: 人参皂甙 Rb2
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)OC7C(C(C(C(O7)COC8C(C(C(CO8)O)O)O)O)O)O)C
InChI: InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-69-45-41(65)34(58)26(57)21-68-45)24-11-16-52(7)33(24)25(56)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)36(60)28(20-55)71-48)74-46-42(66)38(62)35(59)27(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3
描述信息
Ginsenoside Rb3 is found in tea. Ginsenoside Rb3 is a constituent of Panax ginseng (ginseng)
[Raw Data] CB037_Ginsenoside-Rb2_pos_40eV_000003.txt
[Raw Data] CB037_Ginsenoside-Rb2_pos_50eV_000003.txt
[Raw Data] CB037_Ginsenoside-Rb2_pos_30eV_000003.txt
Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.
Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.
同义名列表
7 个代谢物同义名
2-[4,5-dihydroxy-6-(hydroxymethyl)-2-[[12-hydroxy-4,4,8,10,14-pentamethyl-17-[6-methyl-2-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; 2-({4,5-dihydroxy-2-[(16-hydroxy-2,6,6,10,11-pentamethyl-14-{6-methyl-2-[(3,4,5-trihydroxy-6-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxan-2-yl)oxy]hept-5-en-2-yl}tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-yl)oxy]-6-(hydroxymethyl)oxan-3-yl}oxy)-6-(hydroxymethyl)oxane-3,4,5-triol; 2-{[2-(5-{[4,5-dihydroxy-6-(hydroxymethyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-16-hydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-{[(3,4,5-trihydroxyoxan-2-yl)oxy]methyl}oxane-3,4,5-triol; ginsenoside Rb2; Ginsenoside-Rb2; NSC308878; Ginsenoside C
数据库引用编号
13 个数据库交叉引用编号
- PubChem: 432450
- HMDB: HMDB0034996
- Metlin: METLIN90359
- KNApSAcK: C00030395
- KNApSAcK: C00030396
- foodb: FDB013599
- chemspider: 382455
- CAS: 11021-13-9
- MoNA: FIO00102
- MoNA: FIO00103
- MoNA: FIO00104
- PMhub: MS000009328
- medchemexpress: HY-N0040
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ya-Chao Wang, Huan Wang, Chang-le Shao, Xiu-Ya Li, Ji Cui, Hai-Dong Guo. Screening and identification of effective components from modified Taohong Siwu decoction for protecting H9c2 cells from damage.
In vitro cellular & developmental biology. Animal.
2023 Jun; ?(?):. doi:
10.1007/s11626-023-00773-3
. [PMID: 37294373] - Hua Wang, Lin Liu, Huzhi Cai. Ginsenoside Rb3 reduces ox-LDL-induced injury in human aortic endothelial cells by regulating the miR-513a-5p/ZBTB20 axis.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2023 Apr; ?(?):. doi:
10.17219/acem/161804
. [PMID: 37093091] - Qiong Lai, Lingling Wu, Shuhong Dong, Xiaozhou Zhu, Zhaoyang Fan, Junping Kou, Fuming Liu, Boyang Yu, Fang Li. Inhibition of KMO Ameliorates Myocardial Ischemia Injury via Maintaining Mitochondrial Fusion and Fission Balance.
International journal of biological sciences.
2023; 19(10):3077-3098. doi:
10.7150/ijbs.83392
. [PMID: 37416768] - Xu Chen, Tiantian Liu, Qiyan Wang, Hui Wang, Siming Xue, Qianqian Jiang, Junjun Li, Chun Li, Wei Wang, Yong Wang. Synergistic Effects of Ginsenoside Rb3 and Ferruginol in Ischemia-Induced Myocardial Infarction.
International journal of molecular sciences.
2022 Dec; 23(24):. doi:
10.3390/ijms232415935
. [PMID: 36555577] - Hui Zhang, Hongxi Zhu, Xiuyuan Luo, Yuanzhen Deng, Wei Zhang, Shubo Li, Jingjuan Liang, Zongwen Pang. Enzymatic biotransformation of Rb3 from the leaves of Panax notoginseng to ginsenoside rd by a recombinant β-xylosidase from Thermoascus aurantiacus.
World journal of microbiology & biotechnology.
2022 Nov; 39(1):21. doi:
10.1007/s11274-022-03472-5
. [PMID: 36422714] - Mingyan Shao, Pengrong Gao, Wenkun Cheng, Lin Ma, Ye Yang, Linghui Lu, Chun Li, Wei Wang, Yong Wang. Ginsenoside Rb3 upregulates sarcoplasmic reticulum Ca2+-ATPase expression and improves the contractility of cardiomyocytes by inhibiting the NF-κB pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113661. doi:
10.1016/j.biopha.2022.113661
. [PMID: 36942602] - Yuanbin Li, Haifen Liu, Zhaohui Zeng, Hui Lin, Xin Chen, Xianglian Yuan, Jizhe Qiu, Fengchun Fu, Zhuang Chen, Jianjun Kuang. Ginsenoside Rb3 attenuates skin flap ischemia-reperfusion damage by inhibiting STING-IRF3 signaling.
Journal of molecular histology.
2022 Aug; 53(4):763-772. doi:
10.1007/s10735-022-10081-x
. [PMID: 35732862] - Wan Wang, Li Ha, Xinyuan Li, Weiwan Zheng, Encheng Yang. Pharmacokinetic and metabolism study of ginsenoside Rb2 in rat by liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Biomedical chromatography : BMC.
2021 Nov; 35(11):e5191. doi:
10.1002/bmc.5191
. [PMID: 34110039] - Haijun Li, Liwei Cui, Qixiao Liu, Shuang Dou, Wei Wang, Mengshuang Xie, Xia Xu, Chunyan Zheng, Tao Li, Shanying Huang, Xiaopei Cui, Wei Xiao. Ginsenoside Rb3 Alleviates CSE-induced TROP2 Upregulation through p38 MAPK and NF-κB Pathways in Basal Cells.
American journal of respiratory cell and molecular biology.
2021 06; 64(6):747-759. doi:
10.1165/rcmb.2020-0208oc
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Journal of ethnopharmacology.
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Frontiers of medicine.
2020 Jun; 14(3):335-356. doi:
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International journal of molecular medicine.
2020 02; 45(2):519-531. doi:
10.3892/ijmm.2019.4414
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Molecules (Basel, Switzerland).
2020 Jan; 25(3):. doi:
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BioMed research international.
2020; 2020(?):2819658. doi:
10.1155/2020/2819658
. [PMID: 32685460] - Xu Chen, Qiyan Wang, Mingyan Shao, Lin Ma, Dongqing Guo, Yan Wu, Pengrong Gao, Xiaoping Wang, Weili Li, Chun Li, Yong Wang. Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Dec; 120(?):109487. doi:
10.1016/j.biopha.2019.109487
. [PMID: 31577975] - Zhao Chen, Dongmei Sun, Xiaoli Bi, Wenhui Luo, Aili Xu, Weitao Chen, Jieyi Jiang, Dake Cai, Haoliang Guo, Lizhong Cao. Selection and evaluation of quality markers from Yinlan capsule and its LXRα-mediated therapy for hyperlipidemia.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Jun; 59(?):152896. doi:
10.1016/j.phymed.2019.152896
. [PMID: 30978649] - L Yang, Q Liu, Y Yu, H Xu, S Chen, S Shi. Ginsenoside-Rb3 inhibits endothelial-mesenchymal transition of cardiac microvascular endothelial cells.
Herz.
2019 Feb; 44(1):60-68. doi:
10.1007/s00059-017-4628-4
. [PMID: 28983639] - Manying Wang, Xuenan Chen, Wenqi Jin, Xiaohao Xu, Xiangyan Li, Liwei Sun. Ginsenoside Rb3 exerts protective properties against cigarette smoke extract-induced cell injury by inhibiting the p38 MAPK/NF-κB and TGF-β1/VEGF pathways in fibroblasts and epithelial cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):1751-1758. doi:
10.1016/j.biopha.2018.10.018
. [PMID: 30372878] - Fugeng Zhang, Yu Zhang, Xiaofeng Li, Shaoqiang Zhang, Mingdan Zhu, Wuxun Du, Xuefeng Xiao. Research on Q-markers of Qiliqiangxin capsule for chronic heart failure treatment based on pharmacokinetics and pharmacodynamics association.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 May; 44(?):220-230. doi:
10.1016/j.phymed.2018.03.003
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Pharmacology.
2018; 101(3-4):133-139. doi:
10.1159/000481710
. [PMID: 29207398] - Yu-ting Pan, Chun-yu Guo, Xiao-juan Ma, Jing-shang Wang, Xin Liu, Ming-yue Sun, Miao Zhang, Hui-jun Yin. [The estrogen-like protective effect of ginsenoside Rb3 on oxidative stress and dysfunction of endothelial cells induced by oxidized low-density lipoprotein].
Yao xue xue bao = Acta pharmaceutica Sinica.
2014 Oct; 49(10):1406-12. doi:
NULL
. [PMID: 25577870] - Youhua Wang, Jinghui Dong, Ping Liu, Chi Wai Lau, Zhen Gao, Duan Zhou, Jingyi Tang, Chi Fai Ng, Yu Huang. Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats.
British journal of pharmacology.
2014 Jul; 171(13):3171-81. doi:
10.1111/bph.12660
. [PMID: 24571453] - Xiujie Guo, Xiuli Zhang, Zhimou Guo, Yanfang Liu, Aijin Shen, Gaowa Jin, Xinmiao Liang. Hydrophilic interaction chromatography for selective separation of isomeric saponins.
Journal of chromatography. A.
2014 Jan; 1325(?):121-8. doi:
10.1016/j.chroma.2013.12.006
. [PMID: 24369998] - Eun-Young Park, Mi-Hwi Kim, Eung-Hwi Kim, Eun-Kyu Lee, In-Sun Park, Duck-Choon Yang, Hee-Sook Jun. Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters.
The American journal of Chinese medicine.
2014; 42(1):173-87. doi:
10.1142/s0192415x14500128
. [PMID: 24467543] - Lijia Ma, Huimin Liu, Zulong Xie, Shuang Yang, Wei Xu, Jingbo Hou, Bo Yu. Ginsenoside Rb3 protects cardiomyocytes against ischemia-reperfusion injury via the inhibition of JNK-mediated NF-κB pathway: a mouse cardiomyocyte model.
PloS one.
2014; 9(8):e103628. doi:
10.1371/journal.pone.0103628
. [PMID: 25084093] - Qi Tao Bu, Wei Yun Zhang, Quan Cheng Chen, Cheng Zhong Zhang, Xiao Jie Gong, Wen Cong Liu, Wei Li, Yi Nan Zheng. Anti-diabetic effect of ginsenoside Rb(3) in alloxan-induced diabetic mice.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2012 Sep; 8(5):934-41. doi:
10.2174/157340612802084199
. [PMID: 22741793] - Jie Zhao, Chang Su, Cuiping Yang, Menghua Liu, Lan Tang, Weiwei Su, Zhongqiu Liu. Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2012 May; 64-65(?):94-7. doi:
10.1016/j.jpba.2012.02.017
. [PMID: 22421407] - Yaohui Shi, Bing Han, Xiaofeng Yu, Shaochun Qu, Dayuan Sui. Ginsenoside Rb3 ameliorates myocardial ischemia-reperfusion injury in rats.
Pharmaceutical biology.
2011 Sep; 49(9):900-6. doi:
10.3109/13880209.2011.554845
. [PMID: 21591990] - Shan Jiang, Bei Miao, Xuejun Song, Zhenglin Jiang. Inactivation of GABA(A) receptor reduces ginsenoside Rb3 neuroprotection in mouse hippocampal slices after oxygen-glucose deprivation.
Journal of ethnopharmacology.
2011 Jan; 133(2):914-6. doi:
10.1016/j.jep.2010.10.030
. [PMID: 20969942] - Tian Wang, Xiao-Feng Yu, Shao-Chun Qu, Hua-Li Xu, Da-Yuan Sui. Ginsenoside Rb3 inhibits angiotensin II-induced vascular smooth muscle cells proliferation.
Basic & clinical pharmacology & toxicology.
2010 Aug; 107(2):685-9. doi:
10.1111/j.1742-7843.2010.00560.x
. [PMID: 20662827] - Eun Ju Kim, Hyun-Il Lee, Kyung-Jin Chung, Yun-Hee Noh, Youngtae Ro, Ja-Hyun Koo. The ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions.
BMB reports.
2009 Apr; 42(4):194-9. doi:
10.5483/bmbrep.2009.42.4.194
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Archives of toxicology.
2008 Mar; 82(3):183-95. doi:
10.1007/s00204-007-0237-y
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Journal of agricultural and food chemistry.
2006 Mar; 54(6):2261-6. doi:
10.1021/jf052993w
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Chemical & pharmaceutical bulletin.
2005 Feb; 53(2):177-9. doi:
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Journal of pharmaceutical and biomedical analysis.
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