Iohexol (BioDeep_00000018588)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N1,N3-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide

化学式: C19H26I3N3O9 (820.8803276000001)
中文名称: 碘海醇
谱图信息: 最多检出来源 Homo sapiens(blood) 99.19%

分子结构信息

SMILES: CC(=O)N(CC(CO)O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I
InChI: InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)

描述信息

Iohexol is only found in individuals that have used or taken this drug. It is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. [PubChem]Organic iodine compounds block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intrathecal administration into the subarachnoid space, diffusion of iohexol in the CSF allows the visualization of the subarachnoid spaces of the head and spinal canal. After intravascular administration, iohexol makes opaque those vessels in its path of flow, allowing visualization of the internal structures until significant hemodilution occurs.
V - Various > V08 - Contrast media > V08A - X-ray contrast media, iodinated > V08AB - Watersoluble, nephrotropic, low osmolar x-ray contrast media
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D014283 - Triiodobenzoic Acids

同义名列表

10 个代谢物同义名

N1,N3-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide; N,N-bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide; Iohexol injection; Compound 545; Iohexol 350; Omnipaque; Iohexolum; Nycodenz; Exypaque; iohexol



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Ji'an He, Mei Li, Yan Xu, Ning Fan, Chong Tian, Tianye Lv, Wenge Xing, Haipeng Yu. In vitro characteristics of Epirubicin-loaded thermosensitive liquid embolic agent. Journal of cancer research and therapeutics. 2023 Dec; 19(6):1597-1602. doi: 10.4103/jcrt.jcrt_334_23. [PMID: 38156927]
  • Yu-Han Fan, Yu-Wei Lu, Faisal Hayat, Yu-Han Mei, Ming Chen. Overcoming slow removal efficiency-induced highly toxic I-DBPs in water by oxygen vacancies enriched invasive plant biochar catalyst: Experimental and theoretical studies. Journal of hazardous materials. 2023 10; 459(?):132086. doi: 10.1016/j.jhazmat.2023.132086. [PMID: 37480607]
  • Hsing-Yu Chen, Yi-Hong Wu, Cheng-Yu Wei, Zhi-Yao Liao, Hsiao-Ting Wu, Yung-Chang Chen, Jong-Hwei S Pang. Incomplete Recovery from the Radiocontrast-Induced Dysregulated Cell Cycle, Adhesion, and Fibrogenesis in Renal Tubular Cells after Radiocontrast (Iohexol) Removal. International journal of molecular sciences. 2023 Jun; 24(13):. doi: 10.3390/ijms241310945. [PMID: 37446141]
  • Patricia K Akao, Aviv Kaplan, Dror Avisar, Amit Dhir, Adi Avni, Hadas Mamane. Removal of carbamazepine, venlafaxine and iohexol from wastewater effluent using coupled microalgal-bacterial biofilm. Chemosphere. 2022 Dec; 308(Pt 2):136399. doi: 10.1016/j.chemosphere.2022.136399. [PMID: 36099989]
  • Chang Ho Hwang. Swallowing study using water-soluble contrast agents may increase aspiration sensitivity and antedate oral feeding without respiratory and drug complications: A STROBE-compliant prospective, observational, case-control trial. Medicine. 2022 Jul; 101(27):e29422. doi: 10.1097/md.0000000000029422. [PMID: 35801762]
  • R Bammer, S A Amukotuwa. Navigating Supply Chain Disruptions of Iodinated Contrast Agent for Neuroimaging and How Business Intelligence Can Help the Decision Process. AJNR. American journal of neuroradiology. 2022 Jul; 43(7):944-950. doi: 10.3174/ajnr.a7544. [PMID: 35649725]
  • Hiie Soeorg, Aveli Noortoots, Maarja Karu, Kadri Saks, Jana Lass, Irja Lutsar, Lenne-Triin Kõrgvee. Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients. European journal of clinical pharmacology. 2022 Jun; 78(6):989-1001. doi: 10.1007/s00228-022-03307-0. [PMID: 35275224]
  • Alexandre Destere, Charlotte Salmon Gandonnière, Anders Åsberg, Véronique Loustaud-Ratti, Paul Carrier, Stephan Ehrmann, Chantal Barin-Le Guellec, Pierre Marquet, Jean-Baptiste Woillard. A single Bayesian estimator for iohexol clearance estimation in ICU, liver failure and renal transplant patients. British journal of clinical pharmacology. 2022 06; 88(6):2793-2801. doi: 10.1111/bcp.15197. [PMID: 34951499]
  • Ulla B Berg, Henrike Häbel, Antal Németh. Preserved renal function during long-term follow-up in children with chronic liver disease. Acta paediatrica (Oslo, Norway : 1992). 2022 Jun; 111(6):1267-1273. doi: 10.1111/apa.16306. [PMID: 35188684]
  • Shu Fujino, Jying Sun, Shinya Nakayama, Yasunori Horikoshi, Yasuha Kinugasa, Mari Ishida, Chiemi Sakai, Takeshi Ike, Shigehiro Doi, Takao Masaki, Satoshi Tashiro. A Combination of Iohexol Treatment and Ionizing Radiation Exposure Enhances Kidney Injury in Contrast-Induced Nephropathy by Increasing DNA Damage. Radiation research. 2022 04; 197(4):384-395. doi: 10.1667/rade-21-00178.1. [PMID: 35090038]
  • Sudeep Kuchibhotla, Zvonimir Krajcer. Iso-osmolar versus low-osmolar contrast agents to reduce the incidence of renal and cardiovascular side effects. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2022 03; 99(4):1343-1344. doi: 10.1002/ccd.30170. [PMID: 35441821]
  • Liming Wang, Shuo Huang, Tongtong Zhu, Xiaoyan Ge, Chenxi Pei, Ge Hong, Lifeng Han. Metabolomic Study on Iohexol-Induced Nephrotoxicity in Rats Based on NMR and LC-MS Analyses. Chemical research in toxicology. 2022 02; 35(2):244-253. doi: 10.1021/acs.chemrestox.1c00299. [PMID: 35081708]
  • Ke Gong, Yingshu Zou, Haifeng Zhu, Xu Peng, Dongfang Qin, Bixuan Sun, Xuejing Wang. Comparative study of plasma clearance of iohexol at different injection doses. Clinica chimica acta; international journal of clinical chemistry. 2022 Jan; 525(?):34-39. doi: 10.1016/j.cca.2021.12.009. [PMID: 34906558]
  • Md Mahamodun Nabi, Takumi Sakamoto, Md Al Mamun, Ariful Islam, A S M Waliullah, Shuhei Aramaki, Md Mahmudul Hasan, Shingo Ema, Akihiko Kato, Yutaka Takahashi, Tomoaki Kahyo, Mitsutoshi Setou, Tomohito Sato. A convenient online desalination tube coupled with mass spectrometry for the direct detection of iodinated contrast media in untreated human spent hemodialysates. PloS one. 2022; 17(6):e0268751. doi: 10.1371/journal.pone.0268751. [PMID: 35666735]
  • Duangdaun Kaenkangploo, Naruepon Kampa, Supranee Jitpean, Suvaluk Seesupa, Karn Yongvanit. Assessment of glomerular filtration rate measurement in dogs using dynamic contrast CT compared to serum iohexol clearance. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 2022 Jan; 63(1):38-46. doi: 10.1111/vru.13024. [PMID: 34637569]
  • Yanyan Li, Junda Wang, Dan Huang, Chao Yu. Baicalin Alleviates Contrast-Induced Acute Kidney Injury Through ROS/NLRP3/Caspase-1/GSDMD Pathway-Mediated Proptosis in vitro. Drug design, development and therapy. 2022; 16(?):3353-3364. doi: 10.2147/dddt.s379629. [PMID: 36196145]
  • Yiyu Feng, Guoping Qiu, Chengyun Xu, Zhibing Duan, Manting Wang, Lamei Wang, Wenjie Hu, Peifang Li, Hui Zhou. Iopromide and Iodixanol in the Development of Postoperative Contrast Nephropathy in Patients with Renal Insufficiency: A Meta-Analysis. Journal of healthcare engineering. 2022; 2022(?):1469370. doi: 10.1155/2022/1469370. [PMID: 35422982]
  • Hiie Soeorg, Aveli Noortoots, Maarja Karu, Kadri Saks, Jana Lass, Irja Lutsar, Lenne-Triin Kõrgvee. Glomerular filtration rate in children and young adults with haemato-oncological disease and infection is best described by three-compartment iohexol model. Pediatric blood & cancer. 2022 01; 69(1):e29305. doi: 10.1002/pbc.29305. [PMID: 34472203]
  • Charlotte Pronier, Jérémy Bomo, Juliette Besombes, Valentine Genet, Syria Laperche, Philippe Gripon, Vincent Thibault. Characterization of hepatitis B viral forms from patient plasma using velocity gradient: Evidence for an excess of capsids in fractions enriched in Dane particles. PloS one. 2022; 17(11):e0272474. doi: 10.1371/journal.pone.0272474. [PMID: 36383523]
  • Bjørn Steinar Lillås, Camilla Tøndel, Jörg Aßmus, Bjørn Egil Vikse. Low birthweight is associated with lower glomerular filtration rate in middle-aged mainly healthy women. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2021 12; 37(1):92-99. doi: 10.1093/ndt/gfaa306. [PMID: 33313893]
  • Thea Tislevoll Eide, Karl Ove Hufthammer, Atle Brun, Damien Brackman, Einar Svarstad, Camilla Tøndel. Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination. Scientific reports. 2021 12; 11(1):23224. doi: 10.1038/s41598-021-02759-1. [PMID: 34853376]
  • Max Taubert, Elke Schaeffner, Peter Martus, Markus van der Giet, Uwe Fuhr, Amina Lösment, Natalie Ebert. Advancement of pharmacokinetic models of iohexol in patients aged 70 years or older with impaired kidney function. Scientific reports. 2021 11; 11(1):22656. doi: 10.1038/s41598-021-01892-1. [PMID: 34811403]
  • Jiajia Yang, Qingye Sun, Chaonan Huang, Shenjun Qin, Shuai Han, Zhongchao Huo, Yun Li, Xiaoli Sun, Jiping Chen. 3-Aminophenylboronic acid-mediated aggregation of gold nanoparticles for colorimetric sensing of iohexol in environmental and biological samples. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Nov; 261(?):120004. doi: 10.1016/j.saa.2021.120004. [PMID: 34098478]
  • Yuh-Feng Tsai, Jai-Sing Yang, Fuu-Jen Tsai, Yih-Dih Cheng, Yu-Jen Chiu, Shih-Chang Tsai. High Concentration of Iopromide Induces Apoptosis and Autophagy in Human Embryonic Kidney Cells via Activating a ROS-dependent Cellular Stress Pathway. In vivo (Athens, Greece). 2021 Nov; 35(6):3221-3232. doi: 10.21873/invivo.12617. [PMID: 34697153]
  • Emil Bluhme, Silvia Malenicka, Bjorn Fischler, Antal Nemeth, Ulla B Berg, Carl Jorns. Comparison of cystatin C, creatinine, and iohexol clearance in pediatric liver transplantation-a retrospective cohort study. Pediatric transplantation. 2021 Sep; 25(6):e13993. doi: 10.1111/petr.13993. [PMID: 34010490]
  • Tom C Zwart, Aiko P J de Vries, Aline G J Engbers, Ruth E Dam, Paul J M van der Boog, Jesse J Swen, Ron J Keizer, R Neil Dalton, Henk-Jan Guchelaar, Johan W de Fijter, Dirk Jan A R Moes. Model-Based Estimation of Iohexol Plasma Clearance for Pragmatic Renal Function Determination in the Renal Transplantation Setting. Clinical pharmacokinetics. 2021 09; 60(9):1201-1215. doi: 10.1007/s40262-021-00998-z. [PMID: 33864239]
  • Maxime Desgrouas, Hamid Merdji, Anne Bretagnol, Chantal Barin-Le Guellec, Jean-Michel Halimi, Stephan Ehrmann, Charlotte Salmon Gandonnière. Kinetic Glomerular Filtration Rate Equations in Patients With Shock: Comparison With the Iohexol-Based Gold-Standard Method. Critical care medicine. 2021 08; 49(8):e761-e770. doi: 10.1097/ccm.0000000000004946. [PMID: 33710029]
  • Kangho Suh, John A Kellum, Sandra L Kane-Gill. A systematic review of cost-effectiveness analyses across the acute kidney injury landscape. Expert review of pharmacoeconomics & outcomes research. 2021 Aug; 21(4):571-578. doi: 10.1080/14737167.2021.1882307. [PMID: 33522323]
  • Sean Currin, Mwawi Gondwe, Nokthula Mayindi, Shingirai Chipungu, Bongekile Khoza, Lungile Khambule, Tracy Snyman, Stephen Tollman, June Fabian, Jaya George. Evaluating chronic kidney disease in rural South Africa: comparing estimated glomerular filtration rate using point-of-care creatinine to iohexol measured GFR. Clinical chemistry and laboratory medicine. 2021 07; 59(8):1409-1420. doi: 10.1515/cclm-2020-1882. [PMID: 33711217]
  • Satoru Shibata, Norihito Moniwa, Atsushi Kuno, Ayumu Kimura, Wataru Ohwada, Hirohito Sugawara, Yufu Gocho, Marenao Tanaka, Toshiyuki Yano, Masato Furuhashi, Masaya Tanno, Takayuki Miki, Tetsuji Miura. Involvement of necroptosis in contrast-induced nephropathy in a rat CKD model. Clinical and experimental nephrology. 2021 Jul; 25(7):708-717. doi: 10.1007/s10157-021-02048-1. [PMID: 33728555]
  • Elizabeth S Rowe, Vernon D Rowe, John Hunter, Michael R Gralinski, Liomar A Neves. A nephroprotective iodinated contrast agent with cardioprotective properties: A pilot study. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2021 07; 31(4):706-713. doi: 10.1111/jon.12873. [PMID: 33979019]
  • Ian T Mark, Daniel E Maddox, Robert J McDonald, David F Kallmes, Jennifer S McDonald. Immunologic biomarker changes in patients exposed to intravenous iodinated contrast material. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2021 07; 127(1):135-136. doi: 10.1016/j.anai.2021.03.021. [PMID: 33781935]
  • Magalie Collet, Dany Hijazi, Pauline Sevrain, Romain Barthélémy, Marc-Antoine Labeyrie, Dominique Prié, Nahid Tabibzadeh, Alexandre Mebazaa, Benjamin G Chousterman. Evaluation of glomerular filtration rate using iohexol plasma clearance in critically ill patients with augmented renal creatinine clearance: A single-centre retrospective study. European journal of anaesthesiology. 2021 Jun; 38(6):652-658. doi: 10.1097/eja.0000000000001501. [PMID: 33742973]
  • Andreu F Costa, Kris Peet. Contrast media injection protocol for portovenous phase abdominal CT: does a fixed injection duration improve hepatic enhancement over a fixed injection rate?. Abdominal radiology (New York). 2021 06; 46(6):2968-2975. doi: 10.1007/s00261-020-02919-3. [PMID: 33386915]
  • Bunyong Phakdeekitcharoen, Watcharapong Treesinchai, Pornphan Wibulpolprasert, Sarinya Boongird, Pinkael Klytrayong. The correlation between kidney volume and measured glomerular filtration rate in an Asian ADPKD population: a prospective cohort study. BMC nephrology. 2021 05; 22(1):178. doi: 10.1186/s12882-021-02392-0. [PMID: 33992075]
  • Hans Pottel, Elke Schaeffner, Natalie Ebert, Markus van der Giet, Pierre Delanaye. Iohexol plasma clearance for measuring glomerular filtration rate: effect of different ways to calculate the area under the curve. BMC nephrology. 2021 05; 22(1):166. doi: 10.1186/s12882-021-02376-0. [PMID: 33952185]
  • Feng Yuan, Chi Zhang, Maji Sun, Dongying Wu, Lin Cheng, Bin Pan, Ting Li, Delu Che. MRGPRX2 mediates immediate-type pseudo-allergic reactions induced by iodine-containing iohexol. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111323. doi: 10.1016/j.biopha.2021.111323. [PMID: 33524790]
  • Laura Dhondt, Siska Croubels, Pieter De Cock, Evelyn Dhont, Siegrid De Baere, Peter De Paepe, Mathias Devreese. Volumetric absorptive microsampling as alternative sampling technique for renal function assessment in the paediatric population using iohexol. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 May; 1171(?):122623. doi: 10.1016/j.jchromb.2021.122623. [PMID: 33735803]
  • Lesley A Inker, Sara J Couture, Hocine Tighiouart, Alison G Abraham, Gerald J Beck, Harold I Feldman, Tom Greene, Vilmundur Gudnason, Amy B Karger, John H Eckfeldt, Bertram L Kasiske, Michael Mauer, Gerjan Navis, Emilio D Poggio, Peter Rossing, Michael G Shlipak, Andrew S Levey. A New Panel-Estimated GFR, Including β2-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 05; 77(5):673-683.e1. doi: 10.1053/j.ajkd.2020.11.005. [PMID: 33301877]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Christine A White, Ayub Akbari, Celine Allen, Andrew G Day, Patrick A Norman, David Holland, Michael A Adams, Greg A Knoll. Simultaneous glomerular filtration rate determination using inulin, iohexol, and 99mTc-DTPA demonstrates the need for customized measurement protocols. Kidney international. 2021 04; 99(4):957-966. doi: 10.1016/j.kint.2020.06.044. [PMID: 32750458]
  • Christopher B Pierce, Alvaro Muñoz, Derek K Ng, Bradley A Warady, Susan L Furth, George J Schwartz. Age- and sex-dependent clinical equations to estimate glomerular filtration rates in children and young adults with chronic kidney disease. Kidney international. 2021 04; 99(4):948-956. doi: 10.1016/j.kint.2020.10.047. [PMID: 33301749]
  • Ana Elena Rodríguez-Rodríguez, Sergio Luis-Lima, Javier Donate-Correa, Laura Diaz-Martín, María Rosa Arnau, Alejandro Jiménez-Sosa, Flavio Gaspari, Alberto Ortiz, Esteban Porrini. Iohexol plasma clearance simplified by Dried Blood Spot (DBS) sampling to measure renal function in conscious mice. Scientific reports. 2021 02; 11(1):4591. doi: 10.1038/s41598-021-83934-2. [PMID: 33633207]
  • Laurence Dubourg, Sandrine Lemoine, Brune Joannard, Laurence Chardon, Vandréa de Souza, Pierre Cochat, Jean Iwaz, Muriel Rabilloud, Luciano Selistre. Comparison of iohexol plasma clearance formulas vs. inulin urinary clearance for measuring glomerular filtration rate. Clinical chemistry and laboratory medicine. 2021 02; 59(3):571-579. doi: 10.1515/cclm-2020-0770. [PMID: 33068376]
  • Jean-Baptiste Woillard, Charlotte Salmon Gandonnière, Alexandre Destere, Stephan Ehrmann, Hamid Merdji, Armelle Mathonnet, Pierre Marquet, Chantal Barin-Le Guellec. A Machine Learning Approach to Estimate the Glomerular Filtration Rate in Intensive Care Unit Patients Based on Plasma Iohexol Concentrations and Covariates. Clinical pharmacokinetics. 2021 02; 60(2):223-233. doi: 10.1007/s40262-020-00927-6. [PMID: 32794122]
  • Yan Chen, Leila R Zelnick, Andrew N Hoofnagle, Catherine K Yeung, Laura M Shireman, Brian Phillips, Calder C Brauchla, Ian de Boer, Linda Manahan, Susan R Heckbert, Jonathan Himmelfarb, Bryan R Kestenbaum. Prediction of Kidney Drug Clearance: A Comparison of Tubular Secretory Clearance and Glomerular Filtration Rate. Journal of the American Society of Nephrology : JASN. 2021 02; 32(2):459-468. doi: 10.1681/asn.2020060833. [PMID: 33239392]
  • Thanh Minh Dang, Trinh Van Le, Huy Quang Do, Van Thuan Nguyen, Ai Xuan Le Holterman, Loan Tung Thi Dang, Nhan Chinh Lu Phan, Phuc Van Pham, Son Nghia Hoang, Long Thanh Le, Gabriele Grassi, Nhung Hai Truong. Optimization of the isolation procedure and culturing conditions for hepatic stellate cells obtained from mouse. Bioscience reports. 2021 01; 41(1):. doi: 10.1042/bsr20202514. [PMID: 33350435]
  • Marlon Perera, Joseph Ischia, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel. Zinc Preconditioning Provides Cytoprotection following Iodinated Contrast Media Exposure in In Vitro Models. Contrast media & molecular imaging. 2021; 2021(?):6686803. doi: 10.1155/2021/6686803. [PMID: 33679268]
  • G Ma, D Han, S Dang, N Yu, Q Yang, C Yang, C Jin, Y Dou. Replacing true unenhanced imaging in renal carcinoma with virtual unenhanced images in dual-energy spectral CT: a feasibility study. Clinical radiology. 2021 01; 76(1):81.e21-81.e27. doi: 10.1016/j.crad.2020.08.026. [PMID: 32993881]
  • Chandrashekar Annamalai, Rohit Seth, Pragasam Viswanathan. Ferrotoxicity and Its Amelioration by Calcitriol in Cultured Renal Cells. Analytical cellular pathology (Amsterdam). 2021; 2021(?):6634429. doi: 10.1155/2021/6634429. [PMID: 33680716]
  • Dandong Fang, Yongbin Wang, Ziyue Zhang, Donghai Yang, Daqian Gu, Bo He, Xiaoqun Zhang, Duofen He, HongYong Wang, Pedro A Jose, Yu Han, Chunyu Zeng. Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation. Oxidative medicine and cellular longevity. 2021; 2021(?):2999296. doi: 10.1155/2021/2999296. [PMID: 34712381]
  • Guanzhong Chen, Bowen Liu, Shiqun Chen, Huanqiang Li, Jin Liu, Ziling Mai, Enzhao Chen, Chunyun Zhou, Guoli Sun, Zhaodong Guo, Li Lei, Shanyi Huang, Liyao Zhang, Min Li, Ning Tan, Hong Li, Yulin Liao, Jia Liu, Jiyan Chen, Yong Liu. Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles. International journal of biological sciences. 2021; 17(3):882-896. doi: 10.7150/ijbs.45294. [PMID: 33767596]
  • Yohan Jeong, Heejun Shin, Kun Na. Facile Hydrothermal Synthesis of an Iodine-Doped Computed Tomography Contrast Agent Using Insoluble Triiodobenzene. ACS biomaterials science & engineering. 2020 12; 6(12):6961-6970. doi: 10.1021/acsbiomaterials.0c01131. [PMID: 33320597]
  • Carissa Vinovskis, Lu-Ping Li, Pottumarthi Prasad, Kalie Tommerdahl, Laura Pyle, Robert G Nelson, Meda E Pavkov, Daniel van Raalte, Marian Rewers, Marlon Pragnell, Farid H Mahmud, David Z Cherney, Richard J Johnson, Kristen J Nadeau, Petter Bjornstad. Relative Hypoxia and Early Diabetic Kidney Disease in Type 1 Diabetes. Diabetes. 2020 12; 69(12):2700-2708. doi: 10.2337/db20-0457. [PMID: 32737116]
  • Fréderic Sangla, Pierre Emmanuel Marti, Thomas Verissimo, Jérôme Pugin, Sophie de Seigneux, David Legouis. Measured and Estimated Glomerular Filtration Rate in the ICU: A Prospective Study. Critical care medicine. 2020 12; 48(12):e1232-e1241. doi: 10.1097/ccm.0000000000004650. [PMID: 33044285]
  • Daqian Gu, Yu Shi, Zhengfan Gong, Tianyang Xia, Hongmei Ren, Duofen He, Jian Yang, Yu Han, Chunyu Zeng. AdipoRon, an adiponectin receptor agonist, protects contrast-induced nephropathy by suppressing oxidative stress and inflammation via activation of the AMPK pathway. Clinical and experimental nephrology. 2020 Nov; 24(11):989-998. doi: 10.1007/s10157-020-01944-2. [PMID: 32734507]
  • Chao Liu, Yun-Hui Hu, Yu Han, Yong-Bin Wang, Yan Zhang, Xiao-Qun Zhang, Duo-Fen He, Hong-Mei Ren, Yu-Kai Liu, Hong-Yong Wang, Tao Tan, Pei-Hui Lin, Hai-Chang Li, Brad H Rovin, Jian-Jie Ma, Chun-Yu Zeng. MG53 protects against contrast-induced acute kidney injury by reducing cell membrane damage and apoptosis. Acta pharmacologica Sinica. 2020 Nov; 41(11):1457-1464. doi: 10.1038/s41401-020-0420-8. [PMID: 32424239]
  • Anand Joshi, Jianxia Guo, Julianne L Holleran, Brian Kiesel, Sarah Taylor, Susan Christner, Robert A Parise, Brian M Miller, S Percy Ivy, Edward Chu, Raman Venkataramanan, Jan H Beumer. Evaluation of the pharmacokinetic drug-drug interaction potential of iohexol, a renal filtration marker. Cancer chemotherapy and pharmacology. 2020 10; 86(4):535-545. doi: 10.1007/s00280-020-04145-6. [PMID: 32948918]
  • Jun Xu, Liang Ma, Ping Fu. MicroRNA-30c attenuates contrast-induced acute kidney injury by suppressing NLRP3 inflammasome. International immunopharmacology. 2020 Oct; 87(?):106457. doi: 10.1016/j.intimp.2020.106457. [PMID: 32682254]
  • Julianne L Holleran, Robert A Parise, Jianxia Guo, Brian F Kiesel, Sarah E Taylor, S Percy Ivy, Edward Chu, Jan H Beumer. Quantitation of iohexol, a glomerular filtration marker, in human plasma by LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2020 Sep; 189(?):113464. doi: 10.1016/j.jpba.2020.113464. [PMID: 32659569]
  • Alain Viguier, Louis Delamarre, Julien Duplantier, Jean-Marc Olivot, Fabrice Bonneville. Acute ischemic stroke complicating common carotid artery thrombosis during a severe COVID-19 infection. Journal of neuroradiology = Journal de neuroradiologie. 2020 Sep; 47(5):393-394. doi: 10.1016/j.neurad.2020.04.003. [PMID: 32389423]
  • Soufiane El Assri, Hicham Sam, Ayoub El Assri, Yassamine Bentata, Ennouamane Saalaoui, Chaymae Rochdi, El-Houcine Sebbar, Mohammed Choukri. Iohexol assay for direct determination of glomerular filtration rate: optimization and development of an HPLC-UV method for measurement in serum and urine. Clinica chimica acta; international journal of clinical chemistry. 2020 Sep; 508(?):115-121. doi: 10.1016/j.cca.2020.04.038. [PMID: 32416172]
  • Remi Beunders, Roger van Groenendael, Guus P Leijte, Matthijs Kox, Peter Pickkers. Proenkephalin Compared to Conventional Methods to Assess Kidney Function in Critically Ill Sepsis Patients. Shock (Augusta, Ga.). 2020 09; 54(3):308-314. doi: 10.1097/shk.0000000000001510. [PMID: 31977957]
  • Ji-Jun Fu, Jun-Jie Guo, Ai-Ping Qin, Xi-Yong Yu, Qiang Zhang, Xue-Ping Lei, Yu-Gang Huang, Ming-Yue Chen, Jie-Xia Li, Yu Zhang, Jing-Ping Liu, Yuan-Ye Dang, Dan Wu, Xiao-Ya Zhao, Zhong-Xiao Lin, Yin-Lei Lin, Song-Pei Li, Ling-Yan Zhang. Bismuth chelate as a contrast agent for X-ray computed tomography. Journal of nanobiotechnology. 2020 Aug; 18(1):110. doi: 10.1186/s12951-020-00669-4. [PMID: 32762751]
  • Bjørn O Eriksen, Elke Schaeffner, Toralf Melsom, Natalie Ebert, Markus van der Giet, Vilmundur Gudnason, Olafur S Indridasson, Amy B Karger, Andrew S Levey, Mirjam Schuchardt, Liv K Sørensen, Runolfur Palsson. Comparability of Plasma Iohexol Clearance Across Population-Based Cohorts. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2020 07; 76(1):54-62. doi: 10.1053/j.ajkd.2019.10.008. [PMID: 31879216]
  • Na Duan, Xiao Chen, Yanyun Yin, Zhongqiu Wang, Rong Chen. Comparison between magnetic resonance hysterosalpingography and conventional hysterosalpingography: direct visualization of the fallopian tubes using a novel MRI contrast agent mixture. Acta radiologica (Stockholm, Sweden : 1987). 2020 Jul; 61(7):1001-1007. doi: 10.1177/0284185119883712. [PMID: 31684746]
  • Jasper Stevens, Mireille A Wessels, Jan Roggeveld, Remco A Koster, Claire Cj Dekkers, Maaike K van Gelder, Ron T Gansevoort, Hiddo Jl Heerspink, Daan J Touw. UHPLC-MS/MS method for iohexol determination in human EDTA and lithium-heparin plasma, human urine and in goat- and pig EDTA plasma. Bioanalysis. 2020 Jul; 12(14):981-990. doi: 10.4155/bio-2020-0122. [PMID: 32697606]
  • Zhiqiang Wang, Hongxu Liu, Heng Meng, Duo Zhang. Application of diffusion tensor imaging and blood oxygenation level-dependent magnetic resonance imaging to assess bilateral renal function induced by Iohexol in rabbits. BMC nephrology. 2020 06; 21(1):210. doi: 10.1186/s12882-020-01857-y. [PMID: 32493274]
  • Andreu F Costa, Kris Peet, Mohamed Abdolell. Dosing Iodinated Contrast Media According to Lean Versus Total Body Weight at Abdominal CT: A Stratified Randomized Controlled Trial. Academic radiology. 2020 06; 27(6):833-840. doi: 10.1016/j.acra.2019.07.014. [PMID: 31439467]
  • Vincent Schweinsberg, Stefan Eckelt, Anna Marta Schulz, Marcel Arlt, Marc Schumann, Markus van der Giet, Rudolf Tauber, Torsten Binscheck-Domaß, Peggy Kießling. Enhanced specificity due to method specific limits for relative ion intensities in a high-performance liquid chromatography - tandem mass spectrometry method for iohexol in human serum. Clinical chemistry and laboratory medicine. 2020 04; 58(5):709-718. doi: 10.1515/cclm-2019-1001. [PMID: 32069224]
  • Dinesh Manoharan, Arjunlokesh Netaji, Chandan J Das, Sanjay Sharma. Iodine Parameters in Triple-Bolus Dual-Energy CT Correlate With Perfusion CT Biomarkers of Angiogenesis in Renal Cell Carcinoma. AJR. American journal of roentgenology. 2020 04; 214(4):808-816. doi: 10.2214/ajr.19.21969. [PMID: 32069083]
  • Carlo Briguori, Carmen D'Amore, Francesca De Micco, Nicola Signore, Giovanni Esposito, Giovanni Napolitano, Amelia Focaccio. Renal insufficiency following contrast media administration trial III: Urine flow rate-guided versus left-ventricular end-diastolic pressure-guided hydration in high-risk patients for contrast-induced acute kidney injury. Rationale and design. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2020 04; 95(5):895-903. doi: 10.1002/ccd.28386. [PMID: 31282129]
  • Camille Riff, Joevin Besombes, Philippe Gatault, Christelle Barbet, Matthias Büchler, Hélène Blasco, Jean-Michel Halimi, Chantal Barin-Le Guellec, Isabelle Benz-de Bretagne. Assessment of the glomerular filtration rate (GFR) in kidney transplant recipients using Bayesian estimation of the iohexol clearance. Clinical chemistry and laboratory medicine. 2020 03; 58(4):577-587. doi: 10.1515/cclm-2019-0904. [PMID: 31926067]
  • Jesse C Seegmiller, Natalie Ebert. Measuring glomerular filtration rate with iohexol plasma disappearance: blood collection duration is essential for accurate glomerular filtration rate determinations. Kidney international. 2020 03; 97(3):616. doi: 10.1016/j.kint.2019.11.034. [PMID: 32087892]
  • Jiao Bai, Jing Dong, Jian Shu, Yang Xu, Wenfei Ding, Jing Chen. Experimental studies on computed tomographic peritoneography. Peritoneal and residual renal function tolerance to iodinated contrast media injected into the peritoneal cavity. Seminars in dialysis. 2020 03; 33(2):163-169. doi: 10.1111/sdi.12867. [PMID: 32163640]
  • Sunita Seshia, Ryan M Dickinson. What is your diagnosis? Urine from a dog. Veterinary clinical pathology. 2020 Mar; 49(1):167-169. doi: 10.1111/vcp.12813. [PMID: 31997378]
  • Fei Chen, Jingchao Lu, Xiuchun Yang, Bing Xiao, Huiqiang Chen, Weina Pei, Yaqiong Jin, Mengxiao Wang, Yue Li, Jie Zhang, Fan Liu, Guoqiang Gu, Wei Cui. Acetylbritannilactone attenuates contrast-induced acute kidney injury through its anti-pyroptosis effects. Bioscience reports. 2020 02; 40(2):. doi: 10.1042/bsr20193253. [PMID: 31998952]
  • Jeng-Jong Shieh, I Rochelle Riley, Thomas E Rogers, Lung-Fa Kao, Richard B Dorshow. Characterization of MB-102, a New Fluorescent Tracer Agent for Point-of-Care Renal Function Monitoring. Journal of pharmaceutical sciences. 2020 02; 109(2):1191-1198. doi: 10.1016/j.xphs.2019.11.002. [PMID: 31715178]
  • Zhenchao Tang, Dexin Yu, Tianjiao Ni, Tongtong Zhao, Ye Jin, Enqing Dong. Quantitative Analysis of Multiphase Contrast-Enhanced CT Images: A Pilot Study of Preoperative Prediction of Fat-Poor Angiomyolipoma and Renal Cell Carcinoma. AJR. American journal of roentgenology. 2020 02; 214(2):370-382. doi: 10.2214/ajr.19.21625. [PMID: 31799870]
  • Robert Kalyesubula, June Fabian, Wisdom Nakanga, Robert Newton, Billy Ssebunnya, Josephine Prynn, Jaya George, Alisha N Wade, Janet Seeley, Dorothea Nitsch, Christian Hansen, Moffat Nyirenda, Liam Smeeth, Saraladevi Naicker, Amelia C Crampin, Laurie A Tomlinson. How to estimate glomerular filtration rate in sub-Saharan Africa: design and methods of the African Research into Kidney Diseases (ARK) study. BMC nephrology. 2020 01; 21(1):20. doi: 10.1186/s12882-020-1688-0. [PMID: 31941441]
  • V A Gerova, D A Svinarov, R V Nakov, S G Stoynov, L T Tankova, V N Nakov. Intestinal barrier dysfunction in liver cirrhosis assessed by iohexol test. European review for medical and pharmacological sciences. 2020 01; 24(1):315-322. doi: 10.26355/eurrev_202001_19928. [PMID: 31957845]
  • Myles McKenna, Ludovic Pelligand, Jonathan Elliott, Daniel Cotter, Rosanne Jepson. Relationship between serum iohexol clearance, serum SDMA concentration, and serum creatinine concentration in non-azotemic dogs. Journal of veterinary internal medicine. 2020 Jan; 34(1):186-194. doi: 10.1111/jvim.15659. [PMID: 31725186]
  • Elke Gasthuys, Andrés Montesinos, Nele Caekebeke, Mathias Devreese, Siegrid De Baere, Maria Ardiaca, Dominique Paepe, Siska Croubels, Gunther Antonissen. Comparative physiology of glomerular filtration rate by plasma clearance of exogenous creatinine and exo-iohexol in six different avian species. Scientific reports. 2019 12; 9(1):19699. doi: 10.1038/s41598-019-56096-5. [PMID: 31873143]
  • Heng-Huei Lin, Tzong-Shyuan Lee, Shing-Jong Lin, Yi-Chen Yeh, Tse-Min Lu, Chiao-Po Hsu. DDAH-2 alleviates contrast medium iopromide-induced acute kidney injury through nitric oxide synthase. Clinical science (London, England : 1979). 2019 12; 133(23):2361-2378. doi: 10.1042/cs20190455. [PMID: 31763675]
  • Violeta Stojkovic, Pierre Delanaye, Gregory Collard, Nunzio Ferrante, Caroline Le Goff, Laurence Lutteri, Etienne Cavalier. Estimated glomerular filtration rate using a point of care measure of creatinine in patients with iohexol determinate GFR. Clinica chimica acta; international journal of clinical chemistry. 2019 Dec; 499(?):123-127. doi: 10.1016/j.cca.2019.08.032. [PMID: 31479650]
  • Keum-Jin Yang, Jeong Ho Kim, Yoon Kyung Chang, Cheol Whee Park, Suk Young Kim, Yu Ah Hong. Inhibition of xanthine oxidoreductase protects against contrast-induced renal tubular injury by activating adenosine monophosphate-activated protein kinase. Free radical biology & medicine. 2019 12; 145(?):209-220. doi: 10.1016/j.freeradbiomed.2019.09.027. [PMID: 31560952]
  • William K Diprose, Luke J Sutherland, Michael T M Wang, P Alan Barber. Contrast-Associated Acute Kidney Injury in Endovascular Thrombectomy Patients With and Without Baseline Renal Impairment. Stroke. 2019 12; 50(12):3527-3531. doi: 10.1161/strokeaha.119.026738. [PMID: 31587663]
  • Thomas E Kalogirou, Soultana Meditskou, Sotiria Davidopoulou, Ioannis Savvas, Apostolos G Pitoulias, Georgios A Pitoulias. Investigating the Possible Protective Role of Direct Intra-arterial Administration of Mannitol and N-Acetylcysteine and Per Os Administration of Simvastatin Against Contrast-Induced Nephropathy: An Experimental Study in a Rabbit Model. Cardiovascular and interventional radiology. 2019 Dec; 42(12):1777-1785. doi: 10.1007/s00270-019-02304-8. [PMID: 31392490]
  • Ilaria Lippi, Francesca Bonelli, Valentina Meucci, Valentina Vitale, Micaela Sgorbini. Estimation of glomerular filtration rate by plasma clearance of iohexol in healthy horses of various ages. Journal of veterinary internal medicine. 2019 11; 33(6):2765-2769. doi: 10.1111/jvim.15642. [PMID: 31663649]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • C Robert, Y Gandon, B Peyronnet, S Gauthier, C Aubé, A Paisant. Utility of enhanced CT for patients with suspected uncomplicated renal colic and no acute findings on non-enhanced CT. Clinical radiology. 2019 Oct; 74(10):813.e11-813.e18. doi: 10.1016/j.crad.2019.06.007. [PMID: 31300208]
  • Amy Staples, Craig Wong, George J Schwartz. Iohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods: response to comments from Dr. Luis-Lima. Pediatric nephrology (Berlin, Germany). 2019 09; 34(9):1631. doi: 10.1007/s00467-019-04286-8. [PMID: 31203494]
  • Sergio Luis Lima, Flavio Gaspari, Fabiola Carrara, Esteban Porrini. Response to 'Iohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods'. Pediatric nephrology (Berlin, Germany). 2019 09; 34(9):1629-1630. doi: 10.1007/s00467-019-04285-9. [PMID: 31203493]
  • Andrew J Einstein, Jeffrey H Newhouse. Differences in Nephrotoxicity between Modes of Iodinated Contrast Material Administration in Patients Suspected of Having Coronary Artery Disease. Radiology. 2019 Sep; 292(3):673-675. doi: 10.1148/radiol.2019191163. [PMID: 31268825]
  • Kun Liu, Ling-Yun Zhou, Dai-Yang Li, Wen-Jing Cheng, Wen-Jun Yin, Can Hu, Yue-Liang Xie, Jiang-Lin Wang, Shan-Ru Zuo, Lin-Hua Chen, Ge Zhou, Xiao-Cong Zuo. A novel rat model of contrast-induced nephropathy based on dehydration. Journal of pharmacological sciences. 2019 Sep; 141(1):49-55. doi: 10.1016/j.jphs.2019.09.003. [PMID: 31611174]
  • Paola Pocar, Paola Scarpa, Anna Berrini, Petra Cagnardi, Rita Rizzi, Vitaliano Borromeo. Diagnostic potential of simplified methods for measuring glomerular filtration rate to detect chronic kidney disease in dogs. Journal of veterinary internal medicine. 2019 Sep; 33(5):2105-2116. doi: 10.1111/jvim.15573. [PMID: 31444986]
  • Bo Ravn, Claire Rimes-Stigare, Max Bell, Magnus Hansson, Lars-Olof Hansson, Claes-Roland Martling, Anders Larsson, Johan Mårtensson. Creatinine versus cystatin C based glomerular filtration rate in critically ill patients. Journal of critical care. 2019 08; 52(?):136-140. doi: 10.1016/j.jcrc.2019.04.007. [PMID: 31039451]
  • Charlotte Salmon Gandonnière, Julie Helms, Olivier Le Tilly, Isabelle Benz-de Bretagne, Anne Bretagnol, Laetitia Bodet-Contentin, Emmanuelle Mercier, Jean-Michel Halimi, Dalila Benzékri-Lefèvre, Ferhat Meziani, Chantal Barin-Le Guellec, Stephan Ehrmann. Glomerular Hyper- and Hypofiltration During Acute Circulatory Failure: Iohexol-Based Gold-Standard Descriptive Study. Critical care medicine. 2019 08; 47(8):e623-e629. doi: 10.1097/ccm.0000000000003804. [PMID: 31306257]
  • Laurence Chardon, Laurence Dubourg, Chantal Barin-Le Guellec, Francis Guinard, Thierry Hannedouche, Jean-Michel Halimi, Christophe Mariat. [Measurement of glomerular filtration rate using a reference method]. Annales de biologie clinique. 2019 08; 77(4):371-374. doi: 10.1684/abc.2019.1455. [PMID: 31418697]