7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-3,5-dienamide (BioDeep_00000185425)
human metabolite blood metabolite
代谢物信息卡片
N-Hydroxy7-[4-(dimethylamino)phenyl]-4,6-dimethyl-7-oxohepta-3,5-dienimidate
化学式: C17H22N2O3 (302.16303419999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C1=CC=C(C=C1)C(=O)C(C)=CC(C)=CCC(=O)NO
InChI: InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-9,11,22H,10H2,1-4H3,(H,18,20)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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BMC musculoskeletal disorders.
2010 Dec; 11(?):280. doi:
10.1186/1471-2474-11-280. [PMID: 21143861] - Vera L Costa, Rui Henrique, Stine A Danielsen, Sara Duarte-Pereira, Mette Eknaes, Rolf I Skotheim, Angelo Rodrigues, José S Magalhães, Jorge Oliveira, Ragnhild A Lothe, Manuel R Teixeira, Carmen Jerónimo, Guro E Lind. Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2010 Dec; 16(23):5842-51. doi:
10.1158/1078-0432.ccr-10-1312. [PMID: 20975101] - Enrique M Ocio, Jesús F San Miguel. The DAC system and associations with multiple myeloma.
Investigational new drugs.
2010 Dec; 28 Suppl 1(?):S28-35. doi:
10.1007/s10637-010-9589-x. [PMID: 21120582] - Attila Szanto, Balint L Balint, Zsuzsanna S Nagy, Endre Barta, Balazs Dezso, Attila Pap, Lajos Szeles, Szilard Poliska, Melinda Oros, Ronald M Evans, Yaacov Barak, John Schwabe, Laszlo Nagy. STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Immunity.
2010 Nov; 33(5):699-712. doi:
10.1016/j.immuni.2010.11.009. [PMID: 21093321] - Richard Bayles, Emma Baker, Nina Eikelis, Assam El-Osta, Gavin Lambert. Histone modifications regulate the norepinephrine transporter gene.
Cell cycle (Georgetown, Tex.).
2010 Nov; 9(22):4600-1. doi:
10.4161/cc.9.22.13888. [PMID: 21088495] - Jacky Y Suen, Brooke Gardiner, Sean Grimmond, David P Fairlie. Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells.
PloS one.
2010 Nov; 5(11):e13809. doi:
10.1371/journal.pone.0013809. [PMID: 21072196] - Ronald P Miller, Raghu K Tadagavadi, Ganesan Ramesh, William Brian Reeves. Mechanisms of Cisplatin nephrotoxicity.
Toxins.
2010 11; 2(11):2490-518. doi:
10.3390/toxins2112490. [PMID: 22069563] - Qiaoyi Liang, Jiayi Ding, Rongzhen Xu, Zefeng Xu, Shu Zheng. The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers.
International journal of cancer.
2010 Oct; 127(8):1833-43. doi:
10.1002/ijc.25213. [PMID: 20112338] - Masahiro Yoshikawa, Keiichi Hishikawa, Mana Idei, Toshiro Fujita. Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells.
European journal of pharmacology.
2010 Sep; 642(1-3):28-36. doi:
10.1016/j.ejphar.2010.05.055. [PMID: 20553909] - Fei Yang, Lu Zhang, Jun Li, Jing Huang, Ruoyu Wen, Lu Ma, Dongfeng Zhou, Lijia Li. Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize.
BMC plant biology.
2010 Aug; 10(?):178. doi:
10.1186/1471-2229-10-178. [PMID: 20718950] - Sam L Stephen, Katie Freestone, Sarah Dunn, Michael W Twigg, Shervanthi Homer-Vanniasinkam, John H Walker, Stephen B Wheatcroft, Sreenivasan Ponnambalam. Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease.
International journal of hypertension.
2010 Aug; 2010(?):646929. doi:
10.4061/2010/646929. [PMID: 20981357] - Huiying Duan, Jinling Luan, Qian Liu, Kazumi Yagasaki, Guoying Zhang. Suppression of human lung cancer cell growth and migration by berbamine.
Cytotechnology.
2010 Aug; 62(4):341-8. doi:
10.1007/s10616-009-9240-x. [PMID: 19967402] - Danielle M Robertson, Su-Inn Ho, H Dwight Cavanagh. C-terminal cleavage of DeltaNp63alpha is associated with TSA-induced apoptosis in immortalized corneal epithelial cells.
Investigative ophthalmology & visual science.
2010 Aug; 51(8):3977-85. doi:
10.1167/iovs.09-4919. [PMID: 20375332] - Sai Murali Krishna Pulukuri, Bharathi Gorantla, Venkata Ramesh Dasari, Christopher S Gondi, Jasti S Rao. Epigenetic upregulation of urokinase plasminogen activator promotes the tropism of mesenchymal stem cells for tumor cells.
Molecular cancer research : MCR.
2010 Aug; 8(8):1074-83. doi:
10.1158/1541-7786.mcr-09-0495. [PMID: 20663859] - Qian Zhang, Jianming Ying, Jisheng Li, Yichao Fan, Fan Fong Poon, Ka Man Ng, Qian Tao, Jie Jin. Aberrant promoter methylation of DLEC1, a critical 3p22 tumor suppressor for renal cell carcinoma, is associated with more advanced tumor stage.
The Journal of urology.
2010 Aug; 184(2):731-7. doi:
10.1016/j.juro.2010.03.108. [PMID: 20639048] - Li Zhang, Shengwei Jin, Changdong Wang, Rong Jiang, Jingyuan Wan. Histone deacetylase inhibitors attenuate acute lung injury during cecal ligation and puncture-induced polymicrobial sepsis.
World journal of surgery.
2010 Jul; 34(7):1676-83. doi:
10.1007/s00268-010-0493-5. [PMID: 20177680] - Giorgio Perrella, M Federica Consiglio, Riccardo Aiese-Cigliano, Gaetana Cremona, Eugenio Sanchez-Moran, Lucia Barra, Angela Errico, Ray A Bressan, F Christopher H Franklin, Clara Conicella. Histone hyperacetylation affects meiotic recombination and chromosome segregation in Arabidopsis.
The Plant journal : for cell and molecular biology.
2010 Jun; 62(5):796-806. doi:
10.1111/j.1365-313x.2010.04191.x. [PMID: 20230492] - Antonia P Popova, Paul D Bozyk, Adam M Goldsmith, Marisa J Linn, Jing Lei, J Kelley Bentley, Marc B Hershenson. Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells.
American journal of physiology. Lung cellular and molecular physiology.
2010 Jun; 298(6):L735-43. doi:
10.1152/ajplung.00347.2009. [PMID: 20190033] - Emma De Fabiani, Nico Mitro, Federica Gilardi, Andrea Galmozzi, Donatella Caruso, Maurizio Crestani. When food meets man: the contribution of epigenetics to health.
Nutrients.
2010 05; 2(5):551-71. doi:
10.3390/nu2050551. [PMID: 22254041] - Eric D de Groh, Lisa M Swanhart, Chiara Cianciolo Cosentino, Rachel L Jackson, Weixiang Dai, Carolyn A Kitchens, Billy W Day, Thomas E Smithgall, Neil A Hukriede. Inhibition of histone deacetylase expands the renal progenitor cell population.
Journal of the American Society of Nephrology : JASN.
2010 May; 21(5):794-802. doi:
10.1681/asn.2009080851. [PMID: 20378823] - Kyung Ju Lee, Kwang Youl Lee, You Mie Lee. Downregulation of a tumor suppressor RECK by hypoxia through recruitment of HDAC1 and HIF-1alpha to reverse HRE site in the promoter.
Biochimica et biophysica acta.
2010 May; 1803(5):608-16. doi:
10.1016/j.bbamcr.2010.01.004. [PMID: 20080132] - Yuan Lu, Jichan Nie, Xishi Liu, Yu Zheng, Sun-Wei Guo. Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice.
Human reproduction (Oxford, England).
2010 Apr; 25(4):1014-25. doi:
10.1093/humrep/dep472. [PMID: 20118114] - Sven Kroening, Emily Neubauer, Bernd Wullich, Jan Aten, Margarete Goppelt-Struebe. Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia.
American journal of physiology. Renal physiology.
2010 Mar; 298(3):F796-806. doi:
10.1152/ajprenal.00528.2009. [PMID: 20032117] - Leping Yang, Xingguo Tan, Zhulin Yang, Qinglong Li, Xiongying Miao. [Expression of RAD51 and MAX in pancreatic cancer rats].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2010 Feb; 35(2):146-51. doi:
10.3969/j.issn.1672-7347.2010.02.010. [PMID: 20197614] - Guie Dong, Jia Luo, Vijay Kumar, Zheng Dong. Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells.
American journal of physiology. Renal physiology.
2010 Feb; 298(2):F293-300. doi:
10.1152/ajprenal.00410.2009. [PMID: 19889954] - Kohji Hizume, Sumiko Araki, Kosuke Hata, Eloise Prieto, Tapas K Kundu, Kenichi Yoshikawa, Kunio Takeyasu. Nano-scale analyses of the chromatin decompaction induced by histone acetylation.
Archives of histology and cytology.
2010; 73(3):149-63. doi:
10.1679/aohc.73.149. [PMID: 22572182] - Herbert Rodrigues Goulart, Fernanda dos Santos Arthuso, Marcos Vinicius Nucci Capone, Taís Lima de Oliveira, Paolo Bartolini, Carlos Roberto Jorge Soares. Enhancement of human prolactin synthesis by sodium butyrate addition to serum-free CHO cell culture.
Journal of biomedicine & biotechnology.
2010; 2010(?):405872. doi:
10.1155/2010/405872. [PMID: 20625486] - Takeshi Marumo, Keiichi Hishikawa, Masahiro Yoshikawa, Junichi Hirahashi, Shoji Kawachi, Toshiro Fujita. Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury.
American journal of physiology. Renal physiology.
2010 Jan; 298(1):F133-41. doi:
10.1152/ajprenal.00400.2009. [PMID: 19906951] - Seungjeong Song, Sang Won Kang, Chulhee Choi. Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1.
Cardiovascular research.
2010 Jan; 85(1):241-9. doi:
10.1093/cvr/cvp263. [PMID: 19633316] - Tuncay Baubec, Huy Q Dinh, Ales Pecinka, Branislava Rakic, Wilfried Rozhon, Bonnie Wohlrab, Arndt von Haeseler, Ortrun Mittelsten Scheid. Cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic States in Arabidopsis.
The Plant cell.
2010 Jan; 22(1):34-47. doi:
10.1105/tpc.109.072819. [PMID: 20097869] - K E Giles, H Gowher, R Ghirlando, C Jin, G Felsenfeld. Chromatin boundaries, insulators, and long-range interactions in the nucleus.
Cold Spring Harbor symposia on quantitative biology.
2010; 75(?):79-85. doi:
10.1101/sqb.2010.75.006. [PMID: 21047907] - Salahuddin Ahmed. Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise.
Arthritis research & therapy.
2010; 12(2):208. doi:
10.1186/ar2982. [PMID: 20447316]