N'-[(5-Formyl-3-hydroxy-2-methylpyridin-4-yl)methyl]pyridine-4-carbohydrazide (BioDeep_00000185397)
human metabolite blood metabolite
代谢物信息卡片
化学式: C14H14N4O3 (286.1066)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC=C(C(=C1O)CNNC(=O)C2=CC=NC=C2)C=O
InChI: InChI=1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-6,8,17,20H,7H2,1H3,(H,18,21)
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Armin Finkenstedt, Elisabeth Wolf, Elmar Höfner, Bethina Isasi Gasser, Sylvia Bösch, Rania Bakry, Marc Creus, Christian Kremser, Michael Schocke, Milan Theurl, Patrizia Moser, Melanie Schranz, Guenther Bonn, Werner Poewe, Wolfgang Vogel, Andreas R Janecke, Heinz Zoller. Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation.
Journal of hepatology.
2010 Dec; 53(6):1101-7. doi:
10.1016/j.jhep.2010.04.039. [PMID: 20801540] - Aneta Zabka, Justyna Teresa Polit, Janusz Maszewski. Inter- and intrachromosomal asynchrony of cell division cycle events in root meristem cells of Allium cepa: possible connection with gradient of cyclin B-like proteins.
Plant cell reports.
2010 Aug; 29(8):845-56. doi:
10.1007/s00299-010-0869-x. [PMID: 20490501] - Ján Stariat, Petra Kovaríková, Jirí Klimes, David B Lovejoy, Danuta S Kalinowski, Des R Richardson. HPLC methods for determination of two novel thiosemicarbazone anti-cancer drugs (N4mT and Dp44mT) in plasma and their application to in vitro plasma stability of these agents.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jan; 877(3):316-22. doi:
10.1016/j.jchromb.2008.11.044. [PMID: 19097949] - Petra Kovaríková, Zlata Mrkvicková, Jirí Klimes. Investigation of the stability of aromatic hydrazones in plasma and related biological material.
Journal of pharmaceutical and biomedical analysis.
2008 Jun; 47(2):360-70. doi:
10.1016/j.jpba.2008.01.011. [PMID: 18294799] - H Kaiserová, G J M den Hartog, T Simůnek, L Schröterová, E Kvasnicková, A Bast. Iron is not involved in oxidative stress-mediated cytotoxicity of doxorubicin and bleomycin.
British journal of pharmacology.
2006 Dec; 149(7):920-30. doi:
10.1038/sj.bjp.0706930. [PMID: 17031387] - T Simůnek, I Klimtová, J Kaplanová, M Sterba, Y Mazurová, M Adamcová, R Hrdina, V Gersl, P Ponka. Study of daunorubicin cardiotoxicity prevention with pyridoxal isonicotinoyl hydrazone in rabbits.
Pharmacological research.
2005 Mar; 51(3):223-31. doi:
10.1016/j.phrs.2004.08.005. [PMID: 15661572] - C S M Wong, J C Kwok, D R Richardson. PCTH: a novel orally active chelator of the aroylhydrazone class that induces iron excretion from mice.
Biochimica et biophysica acta.
2004 Dec; 1739(1):70-80. doi:
10.1016/j.bbadis.2004.09.001. [PMID: 15607119] - Joan L Buss, Jiri Neuzil, Prem Ponka. Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs.
Archives of biochemistry and biophysics.
2004 Jan; 421(1):1-9. doi:
10.1016/j.abb.2003.09.044. [PMID: 14678779] - Joan L Buss, Prem Ponka. Hydrolysis of pyridoxal isonicotinoyl hydrazone and its analogs.
Biochimica et biophysica acta.
2003 Jan; 1619(2):177-86. doi:
10.1016/s0304-4165(02)00478-6. [PMID: 12527114] - D Chan, T J Wilson, D Xu, H E Cowdery, E Sanij, P J Hertzog, I Kola. Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.
British journal of cancer.
2003 Jan; 88(1):137-45. doi:
10.1038/sj.bjc.6600669. [PMID: 12556973] - Joan L Buss, Emmanuele Arduini, Prem Ponka. Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron-chelator complexes.
Biochemical pharmacology.
2002 Dec; 64(12):1689-701. doi:
10.1016/s0006-2952(02)01426-0. [PMID: 12445858] - J L Buss, J Neuzil, P Ponka. The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues.
Biochemical Society transactions.
2002 Aug; 30(4):755-7. doi:
10.1042/bst0300755. [PMID: 12196187] - M Adamcová, J Machácková, V Gersl, V Pelouch, T Simůnek, I Klimtová, R Hrdina, P Ponka. Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits.
Physiological research.
2002; 51(5):443-8. doi:
NULL. [PMID: 12470196] - Des R Richardson. Therapeutic potential of iron chelators in cancer therapy.
Advances in experimental medicine and biology.
2002; 509(?):231-49. doi:
10.1007/978-1-4615-0593-8_12. [PMID: 12572997] - N C Santos, R F Castilho, A R Meinicke, M Hermes-Lima. The iron chelator pyridoxal isonicotinoyl hydrazone inhibits mitochondrial lipid peroxidation induced by Fe(II)-citrate.
European journal of pharmacology.
2001 Sep; 428(1):37-44. doi:
10.1016/s0014-2999(01)01291-2. [PMID: 11779035]
