5-Hydroxy-3-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-1H-imidazol-2-one (BioDeep_00000185380)
human metabolite blood metabolite
代谢物信息卡片
4-hydroxy-1-({[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)-2,3-dihydro-1H-imidazol-2-one
化学式: C14H10N4O5 (314.065117)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: OC1=CN(N=CC2=CC=C(O2)C2=CC=C(C=C2)[N+]([O-])=O)C(=O)N1
InChI: InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-8,19H,(H,16,20)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Mutation research.
2005 Oct; 586(2):124-37. doi:
10.1016/j.mrgentox.2005.06.001. [PMID: 16099703] - Lan Hu, Richard B Raybourne, Dennis J Kopecko. Ca2+ release from host intracellular stores and related signal transduction during Campylobacter jejuni 81-176 internalization into human intestinal cells.
Microbiology (Reading, England).
2005 Sep; 151(Pt 9):3097-3105. doi:
10.1099/mic.0.27866-0. [PMID: 16151220] - Guido Mannaioni, Roberto Baronti, Flavio Moroni. Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome.
Therapeutics and clinical risk management.
2005 Sep; 1(3):225-30. doi:
NULL. [PMID: 18360563] - Tokuaki Murakawa, Ichiro Sakai, Akitomo Matsuki. [Central hyperthermia suspected of malignant hyperthermia in a patient undergoing radical neck clipping for cerebral aneurysm].
Masui. The Japanese journal of anesthesiology.
2005 Jan; 54(1):49-53. doi:
. [PMID: 15717469] - Alan Sabirsh, Jesper Bristulf, Christer Owman. Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2.
European journal of pharmacology.
2004 Sep; 499(1-2):53-65. doi:
10.1016/j.ejphar.2004.07.060. [PMID: 15363951] - Kazi Mirazul Hoque, Subhrajit Saha, Dyuti Datta Gupta, Manoj K Chakrabarti. Role of nitric oxide in NAG-ST induced store-operated calcium entry in rat intestinal epithelial cells.
Toxicology.
2004 Sep; 201(1-3):95-103. doi:
10.1016/j.tox.2004.04.006. [PMID: 15297024] - Mehmet Emin Büyükokuroğlu, Seyithan Taysi, Mustafa Buyukavci, Ebubekir Bakan. Prevention of acute adriamycin cardiotoxicity by dantrolene in rats.
Human & experimental toxicology.
2004 May; 23(5):251-6. doi:
10.1191/0960327104ht443oa. [PMID: 15222403] - Forrest L Smith, Scott J LeBlanc, Richard Carter. Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice.
European journal of pain (London, England).
2004 Apr; 8(2):153-61. doi:
10.1016/s1090-3801(03)00089-2. [PMID: 14987625] - Erica C McKenzie, Stephanie J Valberg, Sandra M Godden, Carrie J Finno, Michael J Murphy. Effect of oral administration of dantrolene sodium on serum creatine kinase activity after exercise in horses with recurrent exertional rhabdomyolysis.
American journal of veterinary research.
2004 Jan; 65(1):74-9. doi:
10.2460/ajvr.2004.65.74. [PMID: 14719706] - M Martínez-Sánchez, F Striggow, U H Schröder, S Kahlert, K G Reymann, G Reiser. Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures.
Neuroscience.
2004; 128(4):729-40. doi:
10.1016/j.neuroscience.2004.06.074. [PMID: 15464281] - J G T Edwards, J R Newtont, P H L Ramzan, R C Pilsworth, M C Shepherd. The efficacy of dantrolene sodium in controlling exertional rhabdomyolysis in the Thoroughbred racehorse.
Equine veterinary journal.
2003 Nov; 35(7):707-11. doi:
10.2746/042516403775696221. [PMID: 14649364] - Shigetoshi Mieno, Kunio Asada, Hitoshi Horimoto, Shinjiro Sasaki. Neuroleptic malignant syndrome following cardiac surgery: successful treatment with dantrolene.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2003 Sep; 24(3):458-60. doi:
10.1016/s1010-7940(03)00332-4. [PMID: 12965323] - Kenji Shigematsu, Shinjiro Shono, Koichi Tanigawa, Keiko Mukaida, Kiyoshi Katori, Takamitsu Hamada, Kazuo Higa. [Malignant hyperthermia during emergency craniotomy: a case report].
Masui. The Japanese journal of anesthesiology.
2003 Jul; 52(7):773-6. doi:
NULL. [PMID: 12910983] - Mehmet Emin Büyükokuroğlu, Seyithan Taysi, Mehmet Koç, Nuri Bakan. Dantrolene protects erythrocytes against oxidative stress during whole-body irradiation in rats.
Cell biochemistry and function.
2003 Jun; 21(2):127-31. doi:
10.1002/cbf.1008. [PMID: 12736901] - Seong G Kim, Zhan-Guo Gao, Kelly A Soltysiak, Tong-Shin Chang, Chaya Brodie, Kenneth A Jacobson. P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis.
Cellular and molecular neurobiology.
2003 Jun; 23(3):401-18. doi:
10.1023/a:1023696806609. [PMID: 12825835] - O Kunitz, A Ince, R Kuhlen, R Rossaint. [Hyperpyrexia and rhabdomyolysis after ecstasy (MDMA) intoxication].
Der Anaesthesist.
2003 Jun; 52(6):511-5. doi:
10.1007/s00101-003-0474-2. [PMID: 12835872] - Masahiko Atsumi, Yuko Chimoto, Shogo Nishikawa, Haruyuki Mineta, Yoshikuni Nakasaka, Kazuhiro Nishimoto, Hisashi Tanaka, Masataka Kitaguchi. [Head retraction reflex-like movements with severe bulbar symptoms in a patient with stiff-person syndrome].
Rinsho shinkeigaku = Clinical neurology.
2003 Jun; 43(6):322-6. doi:
NULL. [PMID: 14503349] - Yoshikuni Mizuno, Hideki Takubo, Eiiji Mizuta, Sadako Kuno. Malignant syndrome in Parkinson's disease: concept and review of the literature.
Parkinsonism & related disorders.
2003 Apr; 9 Suppl 1(?):S3-9. doi:
10.1016/s1353-8020(02)00125-6. [PMID: 12735909] - Hideki Takubo, Toshihide Harada, Takao Hashimoto, Yutaka Inaba, Ichiro Kanazawa, Sadako Kuno, Yoshikuni Mizuno, Eiji Mizuta, Miho Murata, Toshiharu Nagatsu, Shigenobu Nakamura, Nobuo Yanagisawa, Hirotaro Narabayashi. A collaborative study on the malignant syndrome in Parkinson's disease and related disorders.
Parkinsonism & related disorders.
2003 Apr; 9 Suppl 1(?):S31-41. doi:
10.1016/s1353-8020(02)00122-0. [PMID: 12735913] - Francesca Ceccarelli, Maria C Scavuzzo, Laura Giusti, Gianni Bigini, Barbara Costa, Vittoria Carnicelli, Riccardo Zucchi, Antonio Lucacchini, Maria R Mazzoni. ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells.
Biochemical pharmacology.
2003 Mar; 65(5):783-93. doi:
10.1016/s0006-2952(02)01624-6. [PMID: 12628492] - Lorelei B Silverman-Gavrila, Roger R Lew. An IP3-activated Ca2+ channel regulates fungal tip growth.
Journal of cell science.
2002 Dec; 115(Pt 24):5013-25. doi:
10.1242/jcs.00180. [PMID: 12432087] - Angel Cedazo-Minguez, Bogdan O Popescu, Maria Ankarcrona, Takeshi Nishimura, Richard F Cowburn. The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations.
The Journal of biological chemistry.
2002 Sep; 277(39):36646-55. doi:
10.1074/jbc.m112117200. [PMID: 12121968] - Mariusz Swiader, Kinga K Borowicz, Jacek Porebiak, Zdzisław Kleinrok, Stanisław J Czuczwar. Influence of agents affecting voltage-dependent calcium channels and dantrolene on the anticonvulsant action of the AMPA/kainate receptor antagonist LY 300164 in mice.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2002 Aug; 12(4):311-9. doi:
10.1016/s0924-977x(02)00045-7. [PMID: 12126870] - Mehmet Emin Büyükokuroğlu, Seyithan Taysi, Fevzi Polat, Fatma Göçer. Mechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats.
Pharmacological research.
2002 May; 45(5):421-5. doi:
10.1006/phrs.2002.0951. [PMID: 12123631] - Mini P Sajan, Gautam Bandyopadhyay, Yoshinori Kanoh, Mary L Standaert, Michael J Quon, Brent C Reed, Ivan Dikic, Robert V Farese. Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D.
The Biochemical journal.
2002 Mar; 362(Pt 3):665-74. doi:
10.1042/0264-6021:3620665. [PMID: 11879194] - Seong Gon Kim, Gnana Ravi, Carsten Hoffmann, Yun Jin Jung, Min Kim, Aishe Chen, Kenneth A Jacobson. p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA.
Biochemical pharmacology.
2002 Mar; 63(5):871-80. doi:
10.1016/s0006-2952(02)00839-0. [PMID: 11911839] - Luca Raiteri, Sara Stigliani, Luca Zedda, Maurizio Raiteri, Giambattista Bonanno. Multiple mechanisms of transmitter release evoked by 'pathologically' elevated extracellular [K+]: involvement of transporter reversal and mitochondrial calcium.
Journal of neurochemistry.
2002 Feb; 80(4):706-14. doi:
10.1046/j.0022-3042.2001.00750.x. [PMID: 11841577] - Masakazu Kawajiri, Yasumasa Ohyagi, Hirokazu Furuya, Takehisa Araki, Naohide Inoue, Shigemitsu Esaki, Takeshi Yamada, Junichi Kira. [A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam].
Rinsho shinkeigaku = Clinical neurology.
2002 Feb; 42(2):136-9. doi:
NULL. [PMID: 12424963] - Kayser Caglar, Mehmet Emin Orhan, Bulent Gulec, Izzet Yavuz, Mujdat Yenicesu, Erdal Guzeldemir, Abdulgaffar Vural. Severe rhabdomyolysis due to malignant hyperthermia during renal transplantation procedure can cause delayed graft function.
American journal of nephrology.
2002 Jan; 22(1):81-3. doi:
10.1159/000046678. [PMID: 11919407] - Dagmara Reingardiene. [Neuroleptic malignant syndrome].
Medicina (Kaunas, Lithuania).
2002; 38(1):1-5. doi:
NULL. [PMID: 12474710] - M E Büyükokuroğlu, I GülçIn, M Oktay, O I Küfrevioğlu. In vitro antioxidant properties of dantrolene sodium.
Pharmacological research.
2001 Dec; 44(6):491-4. doi:
10.1006/phrs.2001.0890. [PMID: 11735355] - N J Linford, Y Yang, D G Cook, D M Dorsa. Neuronal apoptosis resulting from high doses of the isoflavone genistein: role for calcium and p42/44 mitogen-activated protein kinase.
The Journal of pharmacology and experimental therapeutics.
2001 Oct; 299(1):67-75. doi:
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