4-Hydroxy-5-[3-[(1-methylcyclohexyl)methoxy]phenyl]-3H-1,3-thiazol-2-one (BioDeep_00000185303)
human metabolite blood metabolite
代谢物信息卡片
4-hydroxy-5-{3-[(1-methylcyclohexyl)methoxy]phenyl}-2,3-dihydro-1,3-thiazol-2-one
化学式: C17H21NO3S (319.1242)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 90%
分子结构信息
SMILES: CC1(CCCCC1)COC2=CC=CC(=C2)C3=C(NC(=O)S3)O
InChI: InChI=1S/C17H21NO3S/c1-17(8-3-2-4-9-17)11-21-13-7-5-6-12(10-13)14-15(19)18-16(20)22-14/h5-7,10,19H,2-4,8-9,11H2,1H3,(H,18,20)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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INOH(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Brian M Varisco, Namasivayam Ambalavanan, Jeffrey A Whitsett, James S Hagood. Thy-1 signals through PPARγ to promote lipofibroblast differentiation in the developing lung.
American journal of respiratory cell and molecular biology.
2012 Jun; 46(6):765-72. doi:
10.1165/rcmb.2011-0316oc. [PMID: 22268140] - Verena Paulitschke, Silke Gruber, Elisabeth Hofstätter, Verena Haudek-Prinz, Philipp Klepeisz, Nikolaus Schicher, Constanze Jonak, Peter Petzelbauer, Hubert Pehamberger, Christopher Gerner, Rainer Kunstfeld. Proteome analysis identified the PPARγ ligand 15d-PGJ2 as a novel drug inhibiting melanoma progression and interfering with tumor-stroma interaction.
PloS one.
2012; 7(9):e46103. doi:
10.1371/journal.pone.0046103. [PMID: 23049949] - Daisuke Yoshihara, Masanori Kugita, Tamio Yamaguchi, Harold M Aukema, Hiroki Kurahashi, Miwa Morita, Yoshiyuki Hiki, James P Calvet, Darren P Wallace, Takafumi Toyohara, Takaaki Abe, Shizuko Nagao. Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease.
PPAR research.
2012; 2012(?):695898. doi:
10.1155/2012/695898. [PMID: 22666229] - Jorge A López-Velázquez, Luis D Carrillo-Córdova, Norberto C Chávez-Tapia, Misael Uribe, Nahum Méndez-Sánchez. Nuclear receptors in nonalcoholic Fatty liver disease.
Journal of lipids.
2012; 2012(?):139875. doi:
10.1155/2012/139875. [PMID: 22187655] - Tamotsu Tsukahara. The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists.
PPAR research.
2012; 2012(?):362361. doi:
10.1155/2012/362361. [PMID: 22693486] - Eugenia Hovsepian, Federico Penas, Gerardo A Mirkin, Nora B Goren. Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy.
PPAR research.
2012; 2012(?):528435. doi:
10.1155/2012/528435. [PMID: 22448167] - Amrit Pal Singh, Amteshwar Jaggi Singh, Nirmal Singh. Pharmacological investigations of Punica granatum in glycerol-induced acute renal failure in rats.
Indian journal of pharmacology.
2011 Sep; 43(5):551-6. doi:
10.4103/0253-7613.84971. [PMID: 22021999] - Itsuo Murakami, Yukari Wakasa, Shinji Yamashita, Toshio Kurihara, Kota Zama, Naoyuki Kobayashi, Yukiko Mizutani, Susumu Mitsutake, Tatsuro Shigyo, Yasuyuki Igarashi. Phytoceramide and sphingoid bases derived from brewer's yeast Saccharomyces pastorianus activate peroxisome proliferator-activated receptors.
Lipids in health and disease.
2011 Aug; 10(?):150. doi:
10.1186/1476-511x-10-150. [PMID: 21861924] - P R Tuinman, M C Gerards, G Jongsma, A P Vlaar, L Boon, N P Juffermans. Lack of evidence of CD40 ligand involvement in transfusion-related acute lung injury.
Clinical and experimental immunology.
2011 Aug; 165(2):278-84. doi:
10.1111/j.1365-2249.2011.04422.x. [PMID: 21605114] - Tamas Varga, Zsolt Czimmerer, Laszlo Nagy. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
Biochimica et biophysica acta.
2011 Aug; 1812(8):1007-22. doi:
10.1016/j.bbadis.2011.02.014. [PMID: 21382489] - Zhi-Hong Yang, Hiroko Miyahara, Akimasa Hatanaka. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes.
Lipids in health and disease.
2011 Jul; 10(?):120. doi:
10.1186/1476-511x-10-120. [PMID: 21774832] - Zuzana Tobiasova, Lufeng Zhang, Tai Yi, Linfeng Qin, Thomas D Manes, Sanjay Kulkarni, Marc I Lorber, Frederick C Rodriguez, Je-Min Choi, George Tellides, Jordan S Pober, Ivana Kawikova, Alfred L M Bothwell. Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells.
Circulation.
2011 Jul; 124(2):196-205. doi:
10.1161/circulationaha.110.015396. [PMID: 21690493] - Alexandra Rogue, Carine Lambert, Rozenn Jossé, Sebastien Antherieu, Catherine Spire, Nancy Claude, André Guillouzo. Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in human hepatocytes.
PloS one.
2011 Apr; 6(4):e18816. doi:
10.1371/journal.pone.0018816. [PMID: 21533120] - Kei Nakajima, Tohru Nemoto, Toshitaka Muneyuki, Masafumi Kakei, Hiroshi Fuchigami, Hiromi Munakata. Low serum amylase in association with metabolic syndrome and diabetes: A community-based study.
Cardiovascular diabetology.
2011 Apr; 10(?):34. doi:
10.1186/1475-2840-10-34. [PMID: 21496338] - Jun-Jie Wang, Oi-Tong Mak. Induction of apoptosis by 15d-PGJ2 via ROS formation: an alternative pathway without PPARγ activation in non-small cell lung carcinoma A549 cells.
Prostaglandins & other lipid mediators.
2011 Apr; 94(3-4):104-11. doi:
10.1016/j.prostaglandins.2011.01.004. [PMID: 21396480] - Hong-ying Liu, Da-zhuo Shi, Jun-bo Ge. [Effect of ginsenoside Rb1 on immune maturation of human monocyte-derived dendritic cells induced by oxidized low-density lipoprotein].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2011 Mar; 31(3):350-4. doi:
NULL. [PMID: 21485077] - Olav A Christophersen, Anna Haug. Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology.
Lipids in health and disease.
2011 Jan; 10(?):16. doi:
10.1186/1476-511x-10-16. [PMID: 21247506] - Tzu-Hsuan Li, Chia-Chung Hou, Cicero Lee-Tian Chang, Wen-Chin Yang. Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):. doi:
10.1155/2011/128402. [PMID: 20924500] - William T Festuccia, Pierre-Gilles Blanchard, Yves Deshaies. Control of Brown Adipose Tissue Glucose and Lipid Metabolism by PPARγ.
Frontiers in endocrinology.
2011; 2(?):84. doi:
10.3389/fendo.2011.00084. [PMID: 22654830] - M-L Kruse, S Hopf-Jensen, C Timke, B Agricola, G Sparmann, A Schmid, B Sipos, A Arlt, H Schäfer. Differentiation potential of pancreatic fibroblastoid cells/stellate cells: effects of peroxisome proliferator-activated receptor gamma ligands.
International journal of cell biology.
2011; 2011(?):816791. doi:
10.1155/2011/816791. [PMID: 22007221] - Salvatore Salomone. Pleiotropic effects of glitazones: a double edge sword?.
Frontiers in pharmacology.
2011; 2(?):14. doi:
10.3389/fphar.2011.00014. [PMID: 21687509] - Prajna Mishra, Suresh K Paramasivam, Ramesh P Thylur, Ajay Rana, Basabi Rana. Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt.
Journal of molecular signaling.
2010 Dec; 5(?):20. doi:
10.1186/1750-2187-5-20. [PMID: 21144036] - Yiqin Du, Danny S Roh, Martha L Funderburgh, Mary M Mann, Kacey G Marra, J Peter Rubin, Xuan Li, James L Funderburgh. Adipose-derived stem cells differentiate to keratocytes in vitro.
Molecular vision.
2010 Dec; 16(?):2680-9. doi:
NULL. [PMID: 21179234] - Beatriz G Pérez-Nievas, Borja García-Bueno, José L M Madrigal, Juan C Leza. Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated.
Journal of neuroinflammation.
2010 Oct; 7(?):60. doi:
10.1186/1742-2094-7-60. [PMID: 20929574] - Masaki Wakutsu, Nobuyo Tsunoda, Sachiko Shiba, Etsuko Muraki, Keizo Kasono. Peroxisome proliferator-activated receptors (PPARs)-independent functions of fish oil on glucose and lipid metabolism in diet-induced obese mice.
Lipids in health and disease.
2010 Sep; 9(?):101. doi:
10.1186/1476-511x-9-101. [PMID: 20846400] - Paras K Mishra, Neetu Tyagi, Utpal Sen, Irving G Joshua, Suresh C Tyagi. Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempol.
Cardiovascular diabetology.
2010 Sep; 9(?):49. doi:
10.1186/1475-2840-9-49. [PMID: 20828387] - Jonathan Goldwasser, Pazit Y Cohen, Eric Yang, Patrick Balaguer, Martin L Yarmush, Yaakov Nahmias. Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha.
PloS one.
2010 Aug; 5(8):e12399. doi:
10.1371/journal.pone.0012399. [PMID: 20811644] - Wei Su, Aijun Sun, Danling Xu, Hongqi Zhang, Lin Yang, Lingyan Yuan, Jianguo Jia, Yunzeng Zou, Yiling Wu, Keqiang Wang, Junbo Ge. Tongxinluo inhibits oxidized low-density lipoprotein-induced maturation of human dendritic cells via activating peroxisome proliferator-activated receptor gamma pathway.
Journal of cardiovascular pharmacology.
2010 Aug; 56(2):177-83. doi:
10.1097/fjc.0b013e3181e5f0f8. [PMID: 20489656] - E Lord, E Bergeron, H Senta, H Park, N Faucheux. Effect of BMP-9 and its derived peptide on the differentiation of human white preadipocytes.
Growth factors (Chur, Switzerland).
2010 Jun; 28(3):149-56. doi:
10.3109/08977190903512610. [PMID: 20102315] - Sandrine Théoleyre, Stéphanie Mottier, Damien Masson, Marc G Denis. HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas.
Biochemical and biophysical research communications.
2010 Apr; 394(3):453-8. doi:
10.1016/j.bbrc.2009.11.163. [PMID: 19951697] - Teh Ban Hong, Anizah Rahumatullah, Thaneswary Yogarajah, Maimunah Ahmad, Khoo Boon Yin. Potential effects of chrysin on MDA-MB-231 cells.
International journal of molecular sciences.
2010 Mar; 11(3):1057-69. doi:
10.3390/ijms11031057. [PMID: 20479999] - J L Teeling, C Cunningham, T A Newman, V H Perry. The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1.
Brain, behavior, and immunity.
2010 Mar; 24(3):409-19. doi:
10.1016/j.bbi.2009.11.006. [PMID: 19931610] - Xiahui Tan, Hayat Dagher, Craig A Hutton, Jane E Bourke. Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells.
Respiratory research.
2010 Feb; 11(?):21. doi:
10.1186/1465-9921-11-21. [PMID: 20178607] - Justine Y Lau, Brian G Oliver, Lyn M Moir, Judith L Black, Janette K Burgess. Differential expression of peroxisome proliferator activated receptor gamma and cyclin D1 does not affect proliferation of asthma- and non-asthma-derived airway smooth muscle cells.
Respirology (Carlton, Vic.).
2010 Feb; 15(2):303-12. doi:
10.1111/j.1440-1843.2009.01683.x. [PMID: 20070588] - Basilia Zingarelli, Ranjit Chima, Michael O'Connor, Giovanna Piraino, Alvin Denenberg, Paul W Hake. Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock.
American journal of physiology. Gastrointestinal and liver physiology.
2010 Jan; 298(1):G133-41. doi:
10.1152/ajpgi.00262.2009. [PMID: 19926821] - Utpal Sen, Suresh C Tyagi. Homocysteine and Hypertension in Diabetes: Does PPARgamma Have a Regulatory Role?.
PPAR research.
2010; 2010(?):806538. doi:
10.1155/2010/806538. [PMID: 20613990] - Yuji Naito, Tomohisa Takagi, Toshikazu Yoshikawa. Gastrointestinal Cytoprotection by PPARγ Ligands.
PPAR research.
2010; 2010(?):. doi:
10.1155/2010/108632. [PMID: 20885923] - Yuhong Yang, Amy E Lovett-Racke, Michael K Racke. Regulation of Immune Responses and Autoimmune Encephalomyelitis by PPARs.
PPAR research.
2010; 2010(?):104705. doi:
10.1155/2010/104705. [PMID: 21234105] - Claire B Pollock, Olga Rodriguez, Philip L Martin, Chris Albanese, Xin Li, Levy Kopelovich, Robert I Glazer. Induction of metastatic gastric cancer by peroxisome proliferator-activated receptorδ activation.
PPAR research.
2010; 2010(?):571783. doi:
10.1155/2010/571783. [PMID: 21318167] - Farhat L Khanim, Rachel E Hayden, Jane Birtwistle, Alessia Lodi, Stefano Tiziani, Nicholas J Davies, Jon P Ride, Mark R Viant, Ulrich L Gunther, Joanne C Mountford, Heinrich Schrewe, Richard M Green, Jim A Murray, Mark T Drayson, Chris M Bunce. Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia.
PloS one.
2009 Dec; 4(12):e8147. doi:
10.1371/journal.pone.0008147. [PMID: 19997560] - K Y Chung, B J Johnson. Melengestrol acetate enhances adipogenic gene expression in cultured muscle-derived cells.
Journal of animal science.
2009 Dec; 87(12):3897-904. doi:
10.2527/jas.2008-1645. [PMID: 19684257] - B Chopra, N T Georgopoulos, A Nicholl, J Hinley, M B Oleksiewicz, J Southgate. Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels.
Cell proliferation.
2009 Oct; 42(5):688-700. doi:
10.1111/j.1365-2184.2009.00628.x. [PMID: 19614673] - Hyun Kook Cho, Hee Jeong Kong, Bo-Hye Nam, Woo-Jin Kim, Jae-Koo Noh, Jeong-Ho Lee, Young-Ok Kim, JaeHun Cheong. Molecular cloning and characterization of olive flounder (Paralichthys olivaceus) peroxisome proliferator-activated receptor gamma.
General and comparative endocrinology.
2009 Sep; 163(3):251-8. doi:
10.1016/j.ygcen.2009.04.018. [PMID: 19393656] - Kyeongjin Kim, Kook Hwan Kim, Eunsin Ha, Jin Young Park, Naoya Sakamoto, Jaehun Cheong. Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma.
FEBS letters.
2009 Sep; 583(17):2720-6. doi:
10.1016/j.febslet.2009.07.034. [PMID: 19631645] - Marijana Radonjic, Jorn R de Haan, Marjan J van Erk, Ko Willems van Dijk, Sjoerd A A van den Berg, Philip J de Groot, Michael Müller, Ben van Ommen. Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program.
PloS one.
2009 Aug; 4(8):e6646. doi:
10.1371/journal.pone.0006646. [PMID: 19680557] - Marianne Demerjian, Eung-Ho Choi, Mao-Qiang Man, Sandra Chang, Peter M Elias, Kenneth R Feingold. Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis.
Experimental dermatology.
2009 Jul; 18(7):643-9. doi:
10.1111/j.1600-0625.2009.00841.x. [PMID: 19236478] - Renata Grozovsky, Scott Ribich, Matthew L Rosene, Michelle A Mulcahey, Stephen A Huang, Mary Elizabeth Patti, Antonio C Bianco, Brian W Kim. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.
Endocrinology.
2009 Apr; 150(4):1976-83. doi:
10.1210/en.2008-0938. [PMID: 19036883] - Sophie S Y Chan, Lynette J Schedlich, Stephen M Twigg, Robert C Baxter. Inhibition of adipocyte differentiation by insulin-like growth factor-binding protein-3.
American journal of physiology. Endocrinology and metabolism.
2009 Apr; 296(4):E654-63. doi:
10.1152/ajpendo.90846.2008. [PMID: 19141684] - Chae Hwa Kwon, Ji Yeon Park, Thae Hyun Kim, Jae Suk Woo, Yong Keun Kim. Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca(2+) in opossum kidney cells.
Toxicology.
2009 Mar; 257(1-2):1-9. doi:
10.1016/j.tox.2008.11.019. [PMID: 19110029] - Xichun Zhang, Fahe Chen, Zhiyong Huang. Apoptosis induced by acrylamide is suppressed in a 21.5\% fat diet through caspase-3-independent pathway in mice testis.
Toxicology mechanisms and methods.
2009 Mar; 19(3):219-24. doi:
10.1080/15376510802499048. [PMID: 19750022] - Michiel E Stegenga, Sandrine Florquin, Alex F de Vos, Tom van der Poll. The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice.
Critical care medicine.
2009 Feb; 37(2):614-8. doi:
10.1097/ccm.0b013e31819599b6. [PMID: 19114898] - Melissa Runge-Morris, Thomas A Kocarek. Regulation of sulfotransferase and UDP-glucuronosyltransferase gene expression by the PPARs.
PPAR research.
2009; 2009(?):728941. doi:
10.1155/2009/728941. [PMID: 19680455] - Ulf Panzer, Gunther Zahner, Ulrike Wienberg, Oliver M Steinmetz, Anett Peters, Jan-Eric Turner, Hans-Joachim Paust, Gunter Wolf, Rolf A K Stahl, André Schneider. 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Dec; 23(12):3776-85. doi:
10.1093/ndt/gfn361. [PMID: 18596134] - Utpal Sen, Walter E Rodriguez, Neetu Tyagi, Munish Kumar, Soumi Kundu, Suresh C Tyagi. Ciglitazone, a PPARgamma agonist, ameliorates diabetic nephropathy in part through homocysteine clearance.
American journal of physiology. Endocrinology and metabolism.
2008 Nov; 295(5):E1205-12. doi:
10.1152/ajpendo.90534.2008. [PMID: 18780770] - Ranjit S Chima, Paul W Hake, Giovanna Piraino, Prajakta Mangeshkar, Alvin Denenberg, Basilia Zingarelli. Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock.
Critical care medicine.
2008 Oct; 36(10):2849-57. doi:
10.1097/ccm.0b013e318187810e. [PMID: 18828195] - Duygu Ozel Demiralp, Huseyin Aktas, Nejat Akar. The effect of plasminogen activator inhibitor-1 -675 4G/5G polymorphism on PAI-1 gene expression and adipocyte differentiation.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2008 Oct; 14(4):438-46. doi:
10.1177/1076029607305081. [PMID: 18160587] - Suzanne Zeitouni, Brian S Ford, Sean M Harris, Mandolin J Whitney, Carl A Gregory, Darwin J Prockop. Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs).
BMC biotechnology.
2008 Sep; 8(?):75. doi:
10.1186/1472-6750-8-75. [PMID: 18823563] - Walter E Rodriguez, Utpal Sen, Neetu Tyagi, Munish Kumar, Gene Carneal, Deep Aggrawal, Justin Newsome, Suresh C Tyagi. PPAR gamma agonist normalizes glomerular filtration rate, tissue levels of homocysteine, and attenuates endothelial-myocyte uncoupling in alloxan induced diabetic mice.
International journal of biological sciences.
2008 Aug; 4(4):236-44. doi:
10.7150/ijbs.4.236. [PMID: 18690293] - Chae Hwa Kwon, Chang Soo Yoon, Yong Keun Kim. Ciglitazone induces caspase-independent apoptosis via p38-dependent AIF nuclear translocation in renal epithelial cells.
Toxicology.
2008 Feb; 244(1):13-24. doi:
10.1016/j.tox.2007.10.019. [PMID: 18082925] - Keisuke Tachibana, Daisuke Yamasaki, Kenji Ishimoto, Takefumi Doi. The Role of PPARs in Cancer.
PPAR research.
2008; 2008(?):102737. doi:
10.1155/2008/102737. [PMID: 18584037] - Eva Kiss-Tóth, Tamás Roszer. PPARgamma in Kidney Physiology and Pathophysiology.
PPAR research.
2008; 2008(?):183108. doi:
10.1155/2008/183108. [PMID: 19283081] - Martin B Oleksiewicz, Jennifer Southgate, Lars Iversen, Frederikke L Egerod. Rat Urinary Bladder Carcinogenesis by Dual-Acting PPARalpha + gamma Agonists.
PPAR research.
2008; 2008(?):103167. doi:
10.1155/2008/103167. [PMID: 19197366] - Liliane Michalik, Walter Wahli. PPARs Mediate Lipid Signaling in Inflammation and Cancer.
PPAR research.
2008; 2008(?):134059. doi:
10.1155/2008/134059. [PMID: 19125181] - Yan J Jiang, Biao Lu, Peggy Kim, Gyorgy Paragh, Gerd Schmitz, Peter M Elias, Kenneth R Feingold. PPAR and LXR activators regulate ABCA12 expression in human keratinocytes.
The Journal of investigative dermatology.
2008 Jan; 128(1):104-9. doi:
10.1038/sj.jid.5700944. [PMID: 17611579] - Alexandra A Herzlich, Jingsheng Tuo, Chi-Chao Chan. Peroxisome proliferator-activated receptor and age-related macular degeneration.
PPAR research.
2008; 2008(?):389507. doi:
10.1155/2008/389507. [PMID: 18288287] - Terry Lichtor, Alessandra Spagnolo, Roberta P Glick, Douglas L Feinstein. PPAR-gamma Thiazolidinedione Agonists and Immunotherapy in the Treatment of Brain Tumors.
PPAR research.
2008; 2008(?):547470. doi:
10.1155/2008/547470. [PMID: 18509487] - Harrihar A Pershadsingh, David M Moore. PPARgamma Agonists: Potential as Therapeutics for Neovascular Retinopathies.
PPAR research.
2008; 2008(?):164273. doi:
10.1155/2008/164273. [PMID: 18509499] - Min-Chul Cho, Kyoung Lee, Sang-Gi Paik, Do-Young Yoon. Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders.
PPAR research.
2008; 2008(?):679137. doi:
10.1155/2008/679137. [PMID: 18566691] - Paul D Drew, Jihong Xu, Michael K Racke. PPAR-gamma: Therapeutic Potential for Multiple Sclerosis.
PPAR research.
2008; 2008(?):627463. doi:
10.1155/2008/627463. [PMID: 18604287] - Giuseppina Barrera, Cristina Toaldo, Stefania Pizzimenti, Angelo Cerbone, Piergiorgio Pettazzoni, Mario Umberto Dianzani, Carlo Ferretti. The Role of PPAR Ligands in Controlling Growth-Related Gene Expression and their Interaction with Lipoperoxidation Products.
PPAR research.
2008; 2008(?):524671. doi:
10.1155/2008/524671. [PMID: 18615196] - Shinji Kume, Takashi Uzu, Keiji Isshiki, Daisuke Koya. Peroxisome proliferator-activated receptors in diabetic nephropathy.
PPAR research.
2008; 2008(?):879523. doi:
10.1155/2008/879523. [PMID: 19277201] - Heath A Elrod, Shi-Yong Sun. PPARgamma and Apoptosis in Cancer.
PPAR research.
2008; 2008(?):704165. doi:
10.1155/2008/704165. [PMID: 18615184] - Jean-Yves Jouzeau, David Moulin, Meriem Koufany, Sylvie Sebillaud, Arnaud Bianchi, Patrick Netter. [Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists].
Journal de la Societe de biologie.
2008; 202(4):289-312. doi:
10.1051/jbio:2008034. [PMID: 19094928] - Woo Jae Kim, Joon Hyun Kim, Sung Key Jang. Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.
The EMBO journal.
2007 Dec; 26(24):5020-32. doi:
10.1038/sj.emboj.7601920. [PMID: 18034160] - Venkata R Narala, Rajesh Ranga, Monica R Smith, Aaron A Berlin, Theodore J Standiford, Nicholas W Lukacs, Raju C Reddy. Pioglitazone is as effective as dexamethasone in a cockroach allergen-induced murine model of asthma.
Respiratory research.
2007 Dec; 8(?):90. doi:
10.1186/1465-9921-8-90. [PMID: 18053220] - Sandra Brunelleschi, Claudio Bardelli, Angela Amoruso, Gabriele Gunella, Francesca Ieri, Annalisa Romani, Walter Malorni, Flavia Franconi. Minor polar compounds extra-virgin olive oil extract (MPC-OOE) inhibits NF-kappa B translocation in human monocyte/macrophages.
Pharmacological research.
2007 Dec; 56(6):542-9. doi:
10.1016/j.phrs.2007.10.001. [PMID: 17997324] - Corinne Pellieux, Christophe Montessuit, Irène Papageorgiou, René Lerch. Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes.
Pflugers Archiv : European journal of physiology.
2007 Dec; 455(3):443-54. doi:
10.1007/s00424-007-0297-0. [PMID: 17643263] - Yuh-Cheng Yang, Tsung-Chuan Ho, Show-Li Chen, Huei-Yi Lai, Ju-Yun Wu, Yeou-Ping Tsao. Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line.
BMC cancer.
2007 Nov; 7(?):216. doi:
10.1186/1471-2407-7-216. [PMID: 18021457] - Basilia Zingarelli, Paul W Hake, Prajakta Mangeshkar, Michael O'Connor, Timothy J Burroughs, Giovanna Piraino, Alvin Denenberg, Hector R Wong. Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt.
Shock (Augusta, Ga.).
2007 Nov; 28(5):554-63. doi:
10.1097/shk.0b013e31804f56b9. [PMID: 17589386] - Cai-Yan Zhao, Jun-Ying Zhou, Liu Yang, Ya-Dong Wang. [Molecular mechanism of ciglitazone inhibiting the expression of extracellular matrix in human hepatic stellate cells].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2007 Nov; 15(11):840-4. doi:
". [PMID: 18073068] - Masaaki Niino. Peroxisome proliferator-activated receptor agonists as potential therapeutic agents in multiple sclerosis.
Mini reviews in medicinal chemistry.
2007 Nov; 7(11):1129-35. doi:
10.2174/138955707782331687. [PMID: 18045216] - Sai Wang Seto, Tsz Yan Lam, George P H Leung, Alice L S Au, Sai Ming Ngai, Shun Wan Chan, Yiu Wa Kwan. Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice.
European journal of pharmacology.
2007 Oct; 572(1):40-8. doi:
10.1016/j.ejphar.2007.05.070. [PMID: 17603034] - Tzu-Hung Lin, Rong-Sen Yang, Chih-Hsin Tang, Chih-Peng Lin, Wen-Mei Fu. PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats.
Bone.
2007 Oct; 41(4):562-74. doi:
10.1016/j.bone.2007.06.017. [PMID: 17669705] - Gemma Olmos, Isabel Conde, Isabel Arenas, Luis Del Peso, Carmen Castellanos, Manuel O Landazuri, Javier Lucio-Cazana. Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism.
Cellular signalling.
2007 Oct; 19(10):2098-105. doi:
10.1016/j.cellsig.2007.06.004. [PMID: 17658243] - Patrizia Risé, Silvia Ghezzi, Romina Carissimi, Francesca Mastromauro, Anna Petroni, Claudio Galli. Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells.
European journal of pharmacology.
2007 Oct; 571(2-3):97-105. doi:
10.1016/j.ejphar.2007.06.021. [PMID: 17655842] - Héctor Giral, Ricardo Villa-Bellosta, Julia Catalán, Víctor Sorribas. Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines.
Toxicology in vitro : an international journal published in association with BIBRA.
2007 Sep; 21(6):1066-76. doi:
10.1016/j.tiv.2007.03.021. [PMID: 17521863] - Zivar Yousefipour, Hantz Hercule, Luan Truong, Adebayo Oyekan, Mohammad Newaz. Ciglitazone, a peroxisome proliferator-activated receptor gamma inducer, ameliorates renal preglomerular production and activity of angiotensin II and thromboxane A2 in glycerol-induced acute renal failure.
The Journal of pharmacology and experimental therapeutics.
2007 Aug; 322(2):461-8. doi:
10.1124/jpet.107.122473. [PMID: 17494862] - Roberto Scatena, Patrizia Bottoni, Giuseppe E Martorana, Federica Vincenzoni, Giorgia Botta, Paola Pastore, Bruno Giardina. Mitochondria, ciglitazone and liver: a neglected interaction in biochemical pharmacology.
European journal of pharmacology.
2007 Jul; 567(1-2):50-8. doi:
10.1016/j.ejphar.2007.04.017. [PMID: 17499714] - Cynthia Lee Richard, Jonathan Blay. Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner.
International journal of oncology.
2007 May; 30(5):1215-22. doi:
. [PMID: 17390024] - N K Singh, H S Chae, I H Hwang, Y M Yoo, C N Ahn, S H Lee, H J Lee, H J Park, H Y Chung. Transdifferentiation of porcine satellite cells to adipoblasts with ciglitizone.
Journal of animal science.
2007 May; 85(5):1126-35. doi:
10.2527/jas.2006-524. [PMID: 17178811] - Takehiko Maeda, Norikazu Kiguchi, Yohji Fukazawa, Akihiro Yamamoto, Masanobu Ozaki, Shiroh Kishioka. Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2007 May; 32(5):1133-40. doi:
10.1038/sj.npp.1301213. [PMID: 17019405] - S Mandard, R Stienstra, P Escher, N S Tan, I Kim, F J Gonzalez, W Wahli, B Desvergne, M Müller, S Kersten. Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.
Cellular and molecular life sciences : CMLS.
2007 May; 64(9):1145-57. doi:
10.1007/s00018-007-7006-1. [PMID: 17437057] - Marie-Paule Gonthier, Laurence Hoareau, Franck Festy, Isabel Matias, Marta Valenti, Sandrine Bès-Houtmann, Claude Rouch, Christine Robert-Da Silva, Serge Chesne, Christian Lefebvre d'Hellencourt, Maya Césari, Vincenzo Di Marzo, Régis Roche. Identification of endocannabinoids and related compounds in human fat cells.
Obesity (Silver Spring, Md.).
2007 Apr; 15(4):837-45. doi:
10.1038/oby.2007.581. [PMID: 17426318] - Sakiko Ohga, Kenichi Shikata, Kosuke Yozai, Shinichi Okada, Daisuke Ogawa, Hitomi Usui, Jun Wada, Yasushi Shikata, Hirofumi Makino. Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation.
American journal of physiology. Renal physiology.
2007 Apr; 292(4):F1141-50. doi:
10.1152/ajprenal.00288.2005. [PMID: 17190910] - Patricia Reyes-Martin, Matilde Alique, Trinidad Parra, Jaime Perez de Hornedo, Javier Lucio-Cazana. Cyclooxygenase-independent inhibition of H2O2-induced cell death by S-ketoprofen in renal cells.
Pharmacological research.
2007 Apr; 55(4):295-302. doi:
10.1016/j.phrs.2006.12.007. [PMID: 17291778] - Kris L Snow, Richard H Moseley. Effect of thiazolidinediones on bile acid transport in rat liver.
Life sciences.
2007 Jan; 80(8):732-40. doi:
10.1016/j.lfs.2006.11.001. [PMID: 17126857] - Xiang Fang, Joseph S Dillon, Shanming Hu, Shawn D Harmon, Jianrong Yao, Siddam Anjaiah, J R Falck, Arthur A Spector. 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma.
Prostaglandins & other lipid mediators.
2007 Jan; 82(1-4):175-84. doi:
10.1016/j.prostaglandins.2006.05.002. [PMID: 17164145] - Weiming Wang, Feng Liu, Nan Chen. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists attenuate the profibrotic response induced by TGF-beta1 in renal interstitial fibroblasts.
Mediators of inflammation.
2007; 2007(?):62641. doi:
10.1155/2007/62641. [PMID: 18274641] - Heather F Lakatos, Thomas H Thatcher, R Matthew Kottmann, Tatiana M Garcia, Richard P Phipps, Patricia J Sime. The Role of PPARs in Lung Fibrosis.
PPAR research.
2007; 2007(?):71323. doi:
10.1155/2007/71323. [PMID: 17710235]
