4-Hydroxy-5-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl]methyl]-3H-1,3-thiazol-2-one (BioDeep_00000185302)
human metabolite blood metabolite
代谢物信息卡片
化学式: C23H20N2O4S (420.11437200000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(CCC(=O)C2=CC=C(CC3=C(O)NC(=O)S3)C=C2)N=C(O1)C1=CC=CC=C1
InChI: InChI=1S/C23H20N2O4S/c1-14-18(24-22(29-14)17-5-3-2-4-6-17)11-12-19(26)16-9-7-15(8-10-16)13-20-21(27)25-23(28)30-20/h2-10,27H,11-13H2,1H3,(H,25,28)
描述信息
同义名列表
3 个代谢物同义名
4-hydroxy-5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methyl)-2,3-dihydro-1,3-thiazol-2-one; 4-Hydroxy-5-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl]methyl]-3H-1,3-thiazol-2-one; 4-hydroxy-5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methyl)-3H-1,3-thiazol-2-one
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- V Pandit, R Gorantla, K Devi, Rs Pai, S Sarasija. Preparation and characterization of pioglitazone cyclodextrin inclusion complexes.
Journal of young pharmacists : JYP.
2011 Oct; 3(4):267-74. doi:
10.4103/0975-1483.90234. [PMID: 22224032] - Astrid Kamilla Stunes, Irene Westbroek, Reidar Fossmark, Rolf Kristian Berge, Janne Elin Reseland, Unni Syversen. Skeletal effects of the saturated 3-thia Fatty Acid tetradecylthioacetic Acid in rats.
PPAR research.
2011; 2011(?):436358. doi:
10.1155/2011/436358. [PMID: 22190907] - Marjolijn C E Bragt, Jogchum Plat, Marco Mensink, Patrick Schrauwen, Ronald P Mensink. Anti-inflammatory effect of rosiglitazone is not reflected in expression of NFkappaB-related genes in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus.
BMC endocrine disorders.
2009 Feb; 9(?):8. doi:
10.1186/1472-6823-9-8. [PMID: 19243600] - Peter J Little, Mandy L Ballinger, Narin Osman. Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis.
Vascular health and risk management.
2007; 3(1):117-24. doi:
". [PMID: 17583182] - M Li, L C Pan, H A Simmons, Y Li, D R Healy, B S Robinson, H Z Ke, T A Brown. Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice.
Bone.
2006 Oct; 39(4):796-806. doi:
10.1016/j.bone.2006.04.008. [PMID: 16759917] - Margarethe Hoenig, Duncan C Ferguson. Effect of darglitazone on glucose clearance and lipid metabolism in obese cats.
American journal of veterinary research.
2003 Nov; 64(11):1409-13. doi:
10.2460/ajvr.2003.64.1409. [PMID: 14620778] - Linda Granlund, Lene K Juvet, Jan I Pedersen, Hilde I Nebb. Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator.
Journal of lipid research.
2003 Aug; 44(8):1441-52. doi:
10.1194/jlr.m300120-jlr200. [PMID: 12754280] - Michael D Aleo, Gregg R Lundeen, David K Blackwell, Ward M Smith, Gerald L Coleman, Stanley W Stadnicki, William M Kluwe. Mechanism and implications of brown adipose tissue proliferation in rats and monkeys treated with the thiazolidinedione darglitazone, a potent peroxisome proliferator-activated receptor-gamma agonist.
The Journal of pharmacology and experimental therapeutics.
2003 Jun; 305(3):1173-82. doi:
10.1124/jpet.102.042648. [PMID: 12626651] - L Svensson, G Camejo, A Cabré, J-C Vallvé, J Pedreño, K Norén, O Wiklund, L M Hultén. Fatty acids modulate the effect of darglitazone on macrophage CD36 expression.
European journal of clinical investigation.
2003 Jun; 33(6):464-71. doi:
10.1046/j.1365-2362.2003.01181.x. [PMID: 12795642] - Lene K Juvet, Sissel M Andresen, Gertrud U Schuster, Knut Tomas Dalen, Kari Anne R Tobin, Kristin Hollung, Fred Haugen, Severina Jacinto, Stine M Ulven, Krister Bamberg, Jan-Ake Gustafsson, Hilde I Nebb. On the role of liver X receptors in lipid accumulation in adipocytes.
Molecular endocrinology (Baltimore, Md.).
2003 Feb; 17(2):172-82. doi:
10.1210/me.2001-0210. [PMID: 12554745] - N D Oakes, P G Thalén, S M Jacinto, B Ljung. Thiazolidinediones increase plasma-adipose tissue FFA exchange capacity and enhance insulin-mediated control of systemic FFA availability.
Diabetes.
2001 May; 50(5):1158-65. doi:
10.2337/diabetes.50.5.1158. [PMID: 11334421]