3,6-Dihydroxycyclohepta-2,4,6-trien-1-one (BioDeep_00000185284)
human metabolite blood metabolite
Metabolite Card
Formula: C7H6O3 (138.0317)
Chinese Names:
Spectrum Hits:
Top Source Mus musculus(blood) 100%
Molecular Structure
SMILES: C1=CC(=CC(=O)C=C1O)O
InChI: InChI=1S/C7H6O3/c8-5-1-2-6(9)4-7(10)3-5/h1-4,8-9H
Cross Reference
Classification Terms
Related Pathways
Reactome()
BioCyc()
PlantCyc()
Biological Process
related biological process reactions.
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 organism taxonomy source information
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| Sub-cellular location | Genes |
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Literature Reference
- Peter W Stacpoole. The dichloroacetate dilemma: environmental hazard versus therapeutic goldmine--both or neither?.
Environmental health perspectives.
2011 Feb; 119(2):155-8. doi:
10.1289/ehp.1002554. [PMID: 20920954] - Albert L Shroads, Xu Guo, Vaishali Dixit, Hui-Ping Liu, Margaret O James, Peter W Stacpoole. Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity.
The Journal of pharmacology and experimental therapeutics.
2008 Mar; 324(3):1163-71. doi:
10.1124/jpet.107.134593. [PMID: 18096758] - Jane C Caldwell, Nagalakshmi Keshava. Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesis.
Environmental health perspectives.
2006 Sep; 114(9):1457-63. doi:
10.1289/ehp.8692. [PMID: 16966105] - Melissa D Zolodz, Minghong Jia, Huiping Liu, George N Henderson, Peter W Stacpoole. A GC-MS/MS method for the quantitative analysis of low levels of the tyrosine metabolites maleylacetone, succinylacetone, and the tyrosine metabolism inhibitor dichloroacetate in biological fluids and tissues.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Jun; 837(1-2):125-32. doi:
10.1016/j.jchromb.2006.04.027. [PMID: 16713404] - Peter W Stacpoole, Douglas S Kerr, Carie Barnes, S Terri Bunch, Paul R Carney, Eileen M Fennell, Natalia M Felitsyn, Robin L Gilmore, Melvin Greer, George N Henderson, Alan D Hutson, Richard E Neiberger, Ralph G O'Brien, Leigh Ann Perkins, Ronald G Quisling, Albert L Shroads, Jonathan J Shuster, Janet H Silverstein, Douglas W Theriaque, Edward Valenstein. Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children.
Pediatrics.
2006 May; 117(5):1519-31. doi:
10.1542/peds.2005-1226. [PMID: 16651305] - Xu Guo, Vaishali Dixit, Huiping Liu, Albert L Shroads, George N Henderson, Margaret O James, Peter W Stacpoole. Inhibition and recovery of rat hepatic glutathione S-transferase zeta and alteration of tyrosine metabolism following dichloroacetate exposure and withdrawal.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Jan; 34(1):36-42. doi:
10.1124/dmd.105.003996. [PMID: 16199472] - Albert L Shroads, George N Henderson, Jang Cheung, Margaret O James, Peter W Stacpoole. Unified gas chromatographic-mass spectrometric method for quantitating tyrosine metabolites in urine and plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Sep; 808(2):153-61. doi:
10.1016/j.jchromb.2004.05.005. [PMID: 15261808] - Cindy E L Lim, Klaus I Matthaei, Anneke C Blackburn, Richard P Davis, Jane E Dahlstrom, Mark E Koina, M W Anders, Philip G Board. Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases.
The American journal of pathology.
2004 Aug; 165(2):679-93. doi:
10.1016/s0002-9440(10)63332-9. [PMID: 15277241] - Chandramohan V Ammini, Jose Fernandez-Canon, Albert L Shroads, Rachel Cornett, Jang Cheung, Margaret O James, George N Henderson, Markus Grompe, Peter W Stacpoole. Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents.
Biochemical pharmacology.
2003 Nov; 66(10):2029-38. doi:
10.1016/j.bcp.2003.07.002. [PMID: 14599561] - Hoffman B M Lantum, Judith Cornejo, Robert H Pierce, M W Anders. Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.
Toxicological sciences : an official journal of the Society of Toxicology.
2003 Jul; 74(1):192-202. doi:
10.1093/toxsci/kfg104. [PMID: 12730618] - Defu Chen, Yasuaki Kawarasaki, Hideo Nakano, Tsuneo Yamane. Cloning and in vitro and in vivo expression of plant glutathione S-transferase zeta class genes.
Journal of bioscience and bioengineering.
2003; 95(6):594-600. doi:
10.1016/s1389-1723(03)80168-8. [PMID: 16233463] - Hoffman B M Lantum, Raymond B Baggs, Daria M Krenitsky, Philip G Board, M W Anders. Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Jun; 30(6):616-25. doi:
10.1124/dmd.30.6.616. [PMID: 12019185]
