3-Undec-1-enylbenzene-1,2,4,5-tetrol (BioDeep_00000185280)
human metabolite blood metabolite
代谢物信息卡片
3-(undec-1-en-1-yl)benzene-1,2,4,5-tetrol
化学式: C17H26O4 (294.1831)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCC=CC1=C(O)C(O)=CC(O)=C1O
InChI: InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h10-12,18-21H,2-9H2,1H3
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Rajnish Gupta, Anil K Sharma, Mahesh C Sharma, Radhey S Gupta. Antioxidant activity and protection of pancreatic β-cells by embelin in streptozotocin-induced diabetes.
Journal of diabetes.
2012 Sep; 4(3):248-56. doi:
10.1111/j.1753-0407.2012.00187.x. [PMID: 22252046] - Henriette Kauntz, Souad Bousserouel, Francine Gossé, Francis Raul. The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.
Apoptosis : an international journal on programmed cell death.
2012 Aug; 17(8):797-809. doi:
10.1007/s10495-012-0731-4. [PMID: 22555452] - Narayanaswamy Radhakrishnan, Arumugam Gnanamani, Nagarajan Rajendra Prasad, Asit Baran Mandal. Inhibition of UVB-induced oxidative damage and apoptotic biochemical changes in human lymphocytes by 2,5-dihydroxy-3-undecyl-1,4-benzoquinone (embelin).
International journal of radiation biology.
2012 Aug; 88(8):575-82. doi:
10.3109/09553002.2012.697644. [PMID: 22631448] - Yixian Huang, Jianqin Lu, Xiang Gao, Jiang Li, Wenchen Zhao, Ming Sun, Donna Beer Stolz, Raman Venkataramanan, Lisa Cencia Rohan, Song Li. PEG-derivatized embelin as a dual functional carrier for the delivery of paclitaxel.
Bioconjugate chemistry.
2012 Jul; 23(7):1443-51. doi:
10.1021/bc3000468. [PMID: 22681537] - Jennifer L Allensworth, Katherine M Aird, Amy J Aldrich, Ines Batinic-Haberle, Gayathri R Devi. XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells.
Molecular cancer therapeutics.
2012 Jul; 11(7):1518-27. doi:
10.1158/1535-7163.mct-11-0787. [PMID: 22508521] - Hemantkumar Somabhai Chaudhari, Uma Bhandari, Geetika Khanna. Preventive effect of embelin from embelia ribes on lipid metabolism and oxidative stress in high-fat diet-induced obesity in rats.
Planta medica.
2012 May; 78(7):651-7. doi:
10.1055/s-0031-1298379. [PMID: 22450777] - Premysl Landa, Zsofia Kutil, Veronika Temml, Anna Vuorinen, Jan Malik, Marcela Dvorakova, Petr Marsik, Ladislav Kokoska, Marie Pribylova, Daniela Schuster, Tomas Vanek. Redox and non-redox mechanism of in vitro cyclooxygenase inhibition by natural quinones.
Planta medica.
2012 Mar; 78(4):326-33. doi:
10.1055/s-0031-1280430. [PMID: 22174077] - B S Thippeswamy, P Nagakannan, B D Shivasharan, S Mahendran, V P Veerapur, S Badami. Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats.
Neurotoxicity research.
2011 Nov; 20(4):379-86. doi:
10.1007/s12640-011-9258-7. [PMID: 21751076] - Dennis D Raga, Glorina N Pocsidio, Annabelle A Herrera. Effects of the oral administration of nonpolar extract from Ardisia squamulosa Presl (Myrsinaceae) leaves on spermatogenesis in rats.
Pharmacognosy research.
2011 Oct; 3(4):260-5. doi:
10.4103/0974-8490.89747. [PMID: 22224050] - G Kalyan Kumar, R Dhamotharan, Nagaraj M Kulkarni, Mahamad Yunnus A Mahat, J Gunasekaran, Mohammad Ashfaque. Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice.
European journal of pharmacology.
2011 Jul; 662(1-3):63-9. doi:
10.1016/j.ejphar.2011.04.037. [PMID: 21549694] - Kalyan Kumar G, Dhamotharan R, Nagaraj M Kulkarni, Srinivasa Honnegowda, Murugesan S. Embelin ameliorates dextran sodium sulfate-induced colitis in mice.
International immunopharmacology.
2011 Jun; 11(6):724-31. doi:
10.1016/j.intimp.2011.01.022. [PMID: 21296695] - Soumya N Madhavan, Ranjith Arimboor, C Arumughan. RP-HPLC-DAD method for the estimation of embelin as marker in Embelia ribes and its polyherbal formulations.
Biomedical chromatography : BMC.
2011 May; 25(5):600-5. doi:
10.1002/bmc.1489. [PMID: 20687113] - Boreddy Shivanandappa Thippeswamy, Sekar Mahendran, Mahantesh I Biradar, Pooja Raj, Kamya Srivastava, Shrishailappa Badami, Veeresh Prabhakar Veerapur. Protective effect of embelin against acetic acid induced ulcerative colitis in rats.
European journal of pharmacology.
2011 Mar; 654(1):100-5. doi:
10.1016/j.ejphar.2010.12.012. [PMID: 21185828] - A K Pandey, Vijayalakshmi Ojha. Estimation of Embelin in Embelia tsjeriam-cottam Fruits by HPLC to Standardize Harvesting Time.
Indian journal of pharmaceutical sciences.
2011 Mar; 73(2):216-9. doi:
10.4103/0250-474x.91563. [PMID: 22303066] - S Mahendran, B S Thippeswamy, V P Veerapur, S Badami. Anticonvulsant activity of embelin isolated from Embelia ribes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Jan; 18(2-3):186-8. doi:
10.1016/j.phymed.2010.04.002. [PMID: 20605710] - Sekar Mahendran, Shrishailappa Badami, Subban Ravi, Boreddy Shivanandappa Thippeswamy, Veeresh Prabhakar Veerapur. Synthesis and evaluation of analgesic and anti-inflammatory activities of most active free radical scavenging derivatives of embelin-A structure-activity relationship.
Chemical & pharmaceutical bulletin.
2011; 59(8):913-9. doi:
10.1248/cpb.59.913. [PMID: 21804233] - Ipek Peşin Süntar, Ufuk Koca, Esra Küpeli Akkol, Demet Yılmazer, Murat Alper. Assessment of Wound Healing Activity of the Aqueous Extracts of Colutea cilicica Boiss. & Bal. Fruits and Leaves.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):758191. doi:
10.1093/ecam/nep190. [PMID: 19946024] - Simone Reuter, Sahdeo Prasad, Kanokkarn Phromnoi, Ramaswamy Kannappan, Vivek R Yadav, Bharat B Aggarwal. Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway.
Molecular cancer research : MCR.
2010 Oct; 8(10):1425-36. doi:
10.1158/1541-7786.mcr-10-0141. [PMID: 20826545] - Amanda M B Newell, Gad G Yousef, Mary Ann Lila, Marco Vinicio Ramírez-Mares, Elvira Gonzalez de Mejia. Comparative in vitro bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells.
Journal of ethnopharmacology.
2010 Aug; 130(3):536-44. doi:
10.1016/j.jep.2010.05.051. [PMID: 20561930] - Kevin K Schrader. Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus).
Toxins.
2010 07; 2(7):1676-89. doi:
10.3390/toxins2071676. [PMID: 22069655] - Marie-Hélène Teiten, Serge Eifes, Mario Dicato, Marc Diederich. Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment.
Toxins.
2010 01; 2(1):128-62. doi:
10.3390/toxins2010128. [PMID: 22069551] - Radhika Poojari, Sanjay Gupta, Girish Maru, Bharat Khade, Sanjay Bhagwat. Chemopreventive and hepatoprotective effects of embelin on N-nitrosodiethylamine and carbon tetrachloride induced preneoplasia and toxicity in rat liver.
Asian Pacific journal of cancer prevention : APJCP.
2010; 11(4):1015-20. doi:
. [PMID: 21133617] - Dharmendra Singh, Ruchi Singh, Pahup Singh, Radhey S Gupta. Effects of embelin on lipid peroxidation and free radical scavenging activity against liver damage in rats.
Basic & clinical pharmacology & toxicology.
2009 Oct; 105(4):243-8. doi:
10.1111/j.1742-7843.2009.00429.x. [PMID: 19496777] - Yan-ping Du, Jun-sheng Peng, Ai Sun, Zhi-hong Tang, Wen-hua Ling, Hui-lian Zhu. Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model.
BMC cancer.
2009 Jul; 9(?):261. doi:
10.1186/1471-2407-9-261. [PMID: 19642983] - Uma Bhandari, M Nazam Ansari, F Islam, C D Tripathi. The effect of aqueous extract of Embelia ribes Burm on serum homocysteine, lipids and oxidative enzymes in methionine induced hyperhomocysteinemia.
Indian journal of pharmacology.
2008 Aug; 40(4):152-7. doi:
10.4103/0253-7613.43161. [PMID: 20040948] - Ravi Joshi, J P Kamat, Tulsi Mukherjee. Free radical scavenging reactions and antioxidant activity of embelin: biochemical and pulse radiolytic studies.
Chemico-biological interactions.
2007 Apr; 167(2):125-34. doi:
10.1016/j.cbi.2007.02.004. [PMID: 17379198] - H M Kumara Swamy, V Krishna, K Shankarmurthy, B Abdul Rahiman, K L Mankani, K M Mahadevan, B G Harish, H Raja Naika. Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm.
Journal of ethnopharmacology.
2007 Feb; 109(3):529-34. doi:
10.1016/j.jep.2006.09.003. [PMID: 17034970] - Kwang Seok Ahn, Gautam Sethi, Bharat B Aggarwal. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products.
Molecular pharmacology.
2007 Jan; 71(1):209-19. doi:
10.1124/mol.106.028787. [PMID: 17028156] - Uma Bhandari, Neeti Jain, K K Pillai. Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes.
Experimental diabetes research.
2007; 2007(?):15803. doi:
10.1155/2007/15803. [PMID: 17641739] - Cheryl Lans, Nancy Turner, Gerhard Brauer, Grant Lourenco, Karla Georges. Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada.
Journal of ethnobiology and ethnomedicine.
2006 Aug; 2(?):31. doi:
10.1186/1746-4269-2-31. [PMID: 16893454] - Meenakshisundaram Sreepriya, Geetha Bali. Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Molecular and cellular biochemistry.
2006 Mar; 284(1-2):49-55. doi:
10.1007/s11010-005-9012-7. [PMID: 16477385] - Minjuan Xu, Jingrong Cui, Hongzheng Fu, Peter Proksch, Wenhan Lin, Min Li. Embelin derivatives and their anticancer activity through microtubule disassembly.
Planta medica.
2005 Oct; 71(10):944-8. doi:
10.1055/s-2005-871250. [PMID: 16254827] - M Sreepriya, Geetha Bali. Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Fitoterapia.
2005 Sep; 76(6):549-55. doi:
10.1016/j.fitote.2005.04.014. [PMID: 16009505] - E O Wango. Anti-fertility effects of embelin in female Sprague-Dawley rats may be due to suppression of ovarian function.
Acta biologica Hungarica.
2005; 56(1-2):1-9. doi:
10.1556/abiol.56.2005.1-2.1. [PMID: 15813209] - Zaneta Nikolovska-Coleska, Liang Xu, Zengjian Hu, York Tomita, Peng Li, Peter P Roller, Renxiao Wang, Xueliang Fang, Ribo Guo, Manchao Zhang, Marc E Lippman, Dajun Yang, Shaomeng Wang. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
Journal of medicinal chemistry.
2004 May; 47(10):2430-40. doi:
10.1021/jm030420+. [PMID: 15115387] - John B Githiori, Johan Höglund, Peter J Waller, R Leyden Baker. Evaluation of anthelmintic properties of extracts from some plants used as livestock dewormers by pastoralist and smallholder farmers in Kenya against Heligmosomoides polygyrus infections in mice.
Veterinary parasitology.
2003 Dec; 118(3-4):215-26. doi:
10.1016/j.vetpar.2003.10.006. [PMID: 14729169] - Gabriela Egly Feresin, Alejandro Tapia, Maximiliano Sortino, Susana Zacchino, Antonieta Rojas de Arias, Alba Inchausti, Gloria Yaluff, Jaime Rodriguez, Cristina Theoduloz, Guillermo Schmeda-Hirschmann. Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.
Journal of ethnopharmacology.
2003 Oct; 88(2-3):241-7. doi:
10.1016/s0378-8741(03)00258-7. [PMID: 12963150] - M Chitra, C S Shyamala Devi, E Sukumar. Antibacterial activity of embelin.
Fitoterapia.
2003 Jun; 74(4):401-3. doi:
10.1016/s0367-326x(03)00066-2. [PMID: 12781816] - Megumi Sumino, Toshikazu Sekine, Nijsiri Ruangrungsi, Kazuei Igarashi, Fumio Ikegami. Ardisiphenols and other antioxidant principles from the fruits of Ardisia colorata.
Chemical & pharmaceutical bulletin.
2002 Nov; 50(11):1484-7. doi:
10.1248/cpb.50.1484. [PMID: 12419914] - R Renuka, S Rajasekaran, G Radhakrishnan. Electrochemically synthesized polymer of the plant substance embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone).
Applied biochemistry and biotechnology.
2001 Oct; 96(1-3):83-92. doi:
10.1385/abab:96:1-3:083. [PMID: 11783903]
