3-O-(2-Methoxyethyl) 5-O-(3-phenylprop-2-enyl) 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate (BioDeep_00000185274)
human metabolite blood metabolite
代谢物信息卡片
3-O-(2-Methoxyethyl) 5-O-(3-phenylprop-2-enyl) 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid
化学式: C27H28N2O7 (492.1896418)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COCCOC(=O)C1C(C2=CC(=CC=C2)[N+]([O-])=O)C(C(=O)OCC=CC2=CC=CC=C2)=C(C)N=C1C
InChI: InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,24-25H,14-16H2,1-3H3
描述信息
同义名列表
4 个代谢物同义名
3-O-(2-Methoxyethyl) 5-O-(3-phenylprop-2-enyl) 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid; 3-(2-Methoxyethyl) 5-(3-phenylprop-2-en-1-yl) 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid; 3-O-(2-Methoxyethyl) 5-O-(3-phenylprop-2-enyl) 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate; 3-(2-methoxyethyl) 5-(3-phenylprop-2-en-1-yl) 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
数据库引用编号
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Takeshi Soeki, Mitsuhiro Kitani, Kenya Kusunose, Shusuke Yagi, Yoshio Taketani, Kunihiko Koshiba, Tetsuzo Wakatsuki, Shunsuke Orino, Kazuhiro Kawano, Masataka Sata. Renoprotective and antioxidant effects of cilnidipine in hypertensive patients.
Hypertension research : official journal of the Japanese Society of Hypertension.
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Current pharmaceutical biotechnology.
2012 Jul; 13(9):1705-17. doi:
10.2174/138920112800958878. [PMID: 22039822] - Shizuka Aritomi, Tomoyuki Konda, Michihiro Yoshimura. L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action.
Heart and vessels.
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10.1007/s00380-011-0191-8. [PMID: 21989861] - Qi Guo, Takefumi Mori, Yue Jiang, Chunyan Hu, Yusuke Ohsaki, Yoshimi Yoneki, Takashi Nakamichi, Susumu Ogawa, Hiroshi Sato, Sadayoshi Ito. Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats.
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The Journal of international medical research.
2012; 40(4):1417-28. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Apr; 34(4):521-9. doi:
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The Journal of thoracic and cardiovascular surgery.
2011 Apr; 141(4):1063-9. doi:
10.1016/j.jtcvs.2010.01.048. [PMID: 20599230] - Yi-Jing Sheen, Wayne Huey-Herng Sheu. Metabolic syndrome and renal injury.
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Cardiovascular therapeutics.
2011 Feb; 29(1):46-53. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Feb; 34(2):193-201. doi:
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American journal of nephrology.
2011; 33(2):168-75. doi:
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Clinical and experimental hypertension (New York, N.Y. : 1993).
2011; 33(7):455-62. doi:
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Heart and vessels.
2010 Nov; 25(6):549-55. doi:
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Journal of hypertension.
2010 Oct; 28(10):2156-60. doi:
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PLoS computational biology.
2010 Sep; 6(9):e1000938. doi:
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Expert opinion on investigational drugs.
2010 Sep; 19(9):1027-37. doi:
10.1517/13543784.2010.505918. [PMID: 20649501] - Kanako Bokuda, Atsuhiro Ichihara, Mariyo Sakoda, Asako Mito, Kenichiro Kinouchi, Hiroshi Itoh. Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome.
Vascular health and risk management.
2010 Aug; 6(?):571-8. doi:
10.2147/vhrm.s11958. [PMID: 20730073] - Eiichiro Yamamoto, Keiichiro Kataoka, Yi-Fei Dong, Taishi Nakamura, Masaya Fukuda, Hisato Nako, Hisao Ogawa, Shokei Kim-Mitsuyama. Benidipine, a dihydropyridine L-type/T-type calcium channel blocker, affords additive benefits for prevention of cardiorenal injury in hypertensive rats.
Journal of hypertension.
2010 Jun; 28(6):1321-9. doi:
10.1097/hjh.0b013e3283388045. [PMID: 20224431] - Yu-Yan Fan, Masakazu Kohno, Daisuke Nakano, Hiroyuki Ohsaki, Hiroyuki Kobori, Diah Suwarni, Naro Ohashi, Hirofumi Hitomi, Katsuhiko Asanuma, Takahisa Noma, Yasuhiko Tomino, Toshiro Fujita, Akira Nishiyama. Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte.
Journal of hypertension.
2010 May; 28(5):1034-43. doi:
10.1097/hjh.0b013e328336ade3. [PMID: 20411599] - M Tanaka. The L/N-type calcium channel blocker, Cilnidipine, reduces heart rate and albuminuria in patients with type 2 diabetes.
The Journal of international medical research.
2010 Mar; 38(2):602-10. doi:
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Clinical calcium.
2010 Jan; 20(1):45-50. doi:
clica10014550. [PMID: 20048433] - Yoshikazu Miwa, Takuya Tsuchihashi, Yuko Ohta, Mitsuhiro Tominaga, Yuhei Kawano, Toshiyuki Sasaguri, Michio Ueno, Hiroaki Matsuoka. Antiproteinuric effect of cilnidipine in hypertensive Japanese treated with renin-angiotensin-system inhibitors - a multicenter, open, randomized trial using 24-hour urine collection.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2010; 32(6):400-5. doi:
10.3109/10641961003667914. [PMID: 20828221] - Koichi Hayashi, Koichiro Homma, Shu Wakino, Hirobumi Tokuyama, Naoki Sugano, Takao Saruta, Hiroshi Itoh. T-type Ca channel blockade as a determinant of kidney protection.
The Keio journal of medicine.
2010; 59(3):84-95. doi:
10.2302/kjm.59.84. [PMID: 20881449] - Takaaki Nakatsu, Shinji Toyonaga, Keiichi Mashima, Yoko Yuki, Aya Nishitani, Hiroko Ogawa, Toru Miyoshi, Satoshi Hirohata, Reishi Izumi, Shozo Kusachi. Effect of cilnidipine on normal to marginally elevated urine albumin-creatinine ratio in asymptomatic non-diabetic hypertensive patients: an exponential decay curve analysis.
Clinical drug investigation.
2010; 30(10):699-706. doi:
10.2165/11538510-000000000-00000. [PMID: 20701401] - A Takahara, Y Nakamura, H Wagatsuma, S Aritomi, A Nakayama, Y Satoh, Y Akie, A Sugiyama. Long-term blockade of L/N-type Ca(2+) channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart.
British journal of pharmacology.
2009 Nov; 158(5):1366-74. doi:
10.1111/j.1476-5381.2009.00407.x. [PMID: 19785655] - Yasuko Aota, Satoshi Morimoto, Takao Sakuma, Tatsuyori Morita, Fusakazu Jo, Nobuyuki Takahashi, Minoru Maehara, Koshi Ikeda, Satoshi Sawada, Toshiji Iwasaka. Efficacy of an L- and N-type calcium channel blocker in hypertensive patients with neurovascular compression of the rostral ventrolateral medulla.
Hypertension research : official journal of the Japanese Society of Hypertension.
2009 Aug; 32(8):700-5. doi:
10.1038/hr.2009.80. [PMID: 19521420] - Keiichi Hishikawa, Osamu Takase, Mana Idei, Toshiro Fujita, Toshiro Fujito. Comparison of antioxidant activity of cilnidipine and amlodipine.
Kidney international.
2009 Jul; 76(2):230-1. doi:
10.1038/ki.2009.146. [PMID: 19564858] - Tomoyuki Konda, Azusa Enomoto, Shizuka Aritomi, Kazumi Niinuma, Hajime Koganei, Tetsuya Ogawa, Kosaku Nitta. Different effects of L/N-type and L-type calcium channel blockers on the renin-angiotensin-aldosterone system in SHR/Izm.
American journal of nephrology.
2009; 30(2):155-61. doi:
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Arzneimittel-Forschung.
2009; 59(2):79-85. doi:
10.1055/s-0031-1296368. [PMID: 19338138] - Yuusuke Konno, Kenjiro Kimura. Vasodilatory effect of cilnidipine, an L-type and N-type calcium channel blocker, on rat kidney glomerular arterioles.
International heart journal.
2008 Nov; 49(6):723-32. doi:
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Kidney international.
2008 May; 73(9):1095; author reply 1095-6. doi:
10.1038/ki.2008.49. [PMID: 18414444] - Yoshihiro Uesawa, Kiminori Mohri. Relationship between lipophilicities of 1,4-dihydropyridine derivatives and pharmacokinetic interaction strengths with grapefruit juice.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2008 Jan; 128(1):117-22. doi:
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Kidney international.
2007 Dec; 72(12):1543-9. doi:
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Heart and vessels.
2007 Nov; 22(6):404-9. doi:
10.1007/s00380-007-0984-y. [PMID: 18043999] - Satoshi Morimoto, Yutaka Yano, Kei Maki, Toshiji Iwasaka. Renal and vascular protective effects of cilnidipine in patients with essential hypertension.
Journal of hypertension.
2007 Oct; 25(10):2178-83. doi:
10.1097/hjh.0b013e3282c2fa62. [PMID: 17885563] - Sota Hayashida, Takakazu Oka, Sadatoshi Tsuji. Cilnidipine lowered psychological stress-induced increase in blood pressure in a hypertensive man: a case report.
BioPsychoSocial medicine.
2007 Sep; 1(?):16. doi:
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Analytica chimica acta.
2007 Sep; 600(1-2):142-6. doi:
10.1016/j.aca.2006.11.072. [PMID: 17903476] - Tomomi Fujisawa, Hiroshi Ikegami, Shinsuke Noso, Yoshihisa Hiromine, Yumiko Kawabata, Masanori Nishino, Kazuaki Asano, Toshio Ogihara. Renoprotective effect of N-type Ca channel blockade in diabetic nephropathy.
Journal of diabetes and its complications.
2007 Jul; 21(4):252-7. doi:
10.1016/j.jdiacomp.2006.06.001. [PMID: 17616356] - Ramón C Hermida, Diana E Ayala, Carlos Calvo. Optimal timing for antihypertensive dosing: focus on valsartan.
Therapeutics and clinical risk management.
2007 Mar; 3(1):119-31. doi:
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Circulation research.
2007 Feb; 100(3):342-53. doi:
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Arzneimittel-Forschung.
2007; 57(8):526-31. doi:
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Kidney international.
2006 Jul; 70(1):151-6. doi:
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2006 May; 29(5):933-7. doi:
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Clinical and experimental hypertension (New York, N.Y. : 1993).
2005 Nov; 27(8):583-91. doi:
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Clinical drug investigation.
2005; 25(12):777-83. doi:
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Nephron. Physiology.
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Journal of pharmacological sciences.
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Internal medicine (Tokyo, Japan).
2004 Jul; 43(7):561-5. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Jun; 27(6):379-85. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
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Journal of hypertension.
2002 May; 20(5):993-1000. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2001 Nov; 24(6):679-84. doi:
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American journal of hypertension.
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Journal of cardiovascular pharmacology.
2001 Sep; 38(3):450-9. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2001 Jul; 24(4):377-83. doi:
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European journal of pharmacology.
2001 Feb; 413(1):117-20. doi:
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