1-[2-[4-Methoxy-2-[3-(4-methoxyphenyl)propoxy]phenyl]ethyl]imidazole (BioDeep_00000185268)
human metabolite blood metabolite
代谢物信息卡片
1-(2-{4-methoxy-2-[3-(4-methoxyphenyl)propoxy]phenyl}ethyl)-1H-imidazole
化学式: C22H26N2O3 (366.19433260000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=C(C=C1)CCCOC2=C(C=CC(=C2)OC)CCN3C=CN=C3
InChI: InChI=1S/C22H26N2O3/c1-25-20-8-5-18(6-9-20)4-3-15-27-22-16-21(26-2)10-7-19(22)11-13-24-14-12-23-17-24/h5-10,12,14,16-17H,3-4,11,13,15H2,1-2H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The Journal of pharmacy and pharmacology.
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Cell calcium.
2012 Jun; 51(6):486-96. doi:
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European journal of pharmacology.
2011 Oct; 668(1-2):208-16. doi:
10.1016/j.ejphar.2011.06.025. [PMID: 21745466] - Ningren Cui, Xiaoli Zhang, Jyothirmayee S Tadepalli, Lei Yu, Hongyu Gai, James Petit, Ravi T Pamulapati, Xin Jin, Chun Jiang. Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons.
Journal of neurophysiology.
2011 Jun; 105(6):2791-801. doi:
10.1152/jn.00759.2010. [PMID: 21430274] - Paolo Ariano, Simona Dalmazzo, Grzegorz Owsianik, Bernd Nilius, Davide Lovisolo. TRPC channels are involved in calcium-dependent migration and proliferation in immortalized GnRH neurons.
Cell calcium.
2011 Jun; 49(6):387-94. doi:
10.1016/j.ceca.2011.03.007. [PMID: 21511334] - Kay-Pong Yip, James S K Sham. Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct.
American journal of physiology. Renal physiology.
2011 Feb; 300(2):F540-8. doi:
10.1152/ajprenal.00544.2009. [PMID: 21147839] - M Salomonsson, T H Braunstein, N-H Holstein-Rathlou, L J Jensen. Na+-independent, nifedipine-resistant rat afferent arteriolar Ca2+ responses to noradrenaline: possible role of TRPC channels.
Acta physiologica (Oxford, England).
2010 Nov; 200(3):265-78. doi:
10.1111/j.1748-1716.2010.02141.x. [PMID: 20426773] - A Singh, M E Hildebrand, E Garcia, T P Snutch. The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels.
British journal of pharmacology.
2010 Jul; 160(6):1464-75. doi:
10.1111/j.1476-5381.2010.00786.x. [PMID: 20590636] - Kali Hicks, Roger G O'Neil, William S Dubinsky, Rachel C Brown. TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress.
American journal of physiology. Cell physiology.
2010 Jun; 298(6):C1583-93. doi:
10.1152/ajpcell.00458.2009. [PMID: 20164382] - Yi-hua Sun, Yong-quan Li, Shan-li Feng, Bao-xin Li, Zhen-wei Pan, Chang-qing Xu, Ting-ting Li, Bao-feng Yang. Calcium-sensing receptor activation contributed to apoptosis stimulates TRPC6 channel in rat neonatal ventricular myocytes.
Biochemical and biophysical research communications.
2010 Apr; 394(4):955-61. doi:
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Biochemical and biophysical research communications.
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The Biochemical journal.
2009 Jul; 422(1):139-49. doi:
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2009 May; 24(5):1429-35. doi:
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Biochimica et biophysica acta.
2009 Jan; 1787(1):15-24. doi:
10.1016/j.bbabio.2008.10.003. [PMID: 19000650] - Ian Daniels, Julie Turzanski, Andrew P Haynes. A requirement for calcium in the caspase-independent killing of Burkitt lymphoma cell lines by Rituximab.
British journal of haematology.
2008 Jul; 142(3):394-403. doi:
10.1111/j.1365-2141.2008.07193.x. [PMID: 18544085] - Ronald M Lynch, Craig S Weber, Kevin D Nullmeyer, Edwin D W Moore, Richard J Paul. Clearance of store-released Ca2+ by the Na+-Ca2+ exchanger is diminished in aortic smooth muscle from Na+-K+-ATPase alpha 2-isoform gene-ablated mice.
American journal of physiology. Heart and circulatory physiology.
2008 Mar; 294(3):H1407-16. doi:
10.1152/ajpheart.00855.2007. [PMID: 18192219] - Yichang Jia, Jian Zhou, Yilin Tai, Yizheng Wang. TRPC channels promote cerebellar granule neuron survival.
Nature neuroscience.
2007 May; 10(5):559-67. doi:
10.1038/nn1870. [PMID: 17396124] - Octavio Pernas-Sueiras, Amparo Alfonso, Mercedes R Vieytes, Alberto Orfao, Luis Escribano, Sánchez-Jiménez Francisca, Luis M Botana. Calcium-pH crosstalks in the human mast cell line HMC-1: intracellular alkalinization activates calcium extrusion through the plasma membrane Ca2+-ATPase.
Journal of cellular biochemistry.
2006 Dec; 99(5):1397-408. doi:
10.1002/jcb.21010. [PMID: 16817237] - Da-nian Nie, Song-mei Yin, Shuang-feng Xie. [Experimental study on anti-platelet effects of ginsenoside -2A in vitro].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2006 Jun; 26 Suppl(?):83-5. doi:
NULL. [PMID: 17569356] - Mark E Hansen, Isaac N Pessah, Fumio Matsumura. Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells.
Toxicology.
2006 Mar; 220(2-3):218-31. doi:
10.1016/j.tox.2006.01.006. [PMID: 16469423] - Nidhal Ben-Amor, Pedro C Redondo, Aghleb Bartegi, José A Pariente, Ginés M Salido, Juan A Rosado. A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets.
The Journal of physiology.
2006 Jan; 570(Pt 2):309-23. doi:
10.1113/jphysiol.2005.100800. [PMID: 16308346] - Daoyan Liu, Alexandra Scholze, Zhiming Zhu, Reinhold Kreutz, Markus Wehland-von-Trebra, Walter Zidek, Martin Tepel. Increased transient receptor potential channel TRPC3 expression in spontaneously hypertensive rats.
American journal of hypertension.
2005 Nov; 18(11):1503-7. doi:
10.1016/j.amjhyper.2005.05.033. [PMID: 16280289] - Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Alison F Brading. Involvement of ryanodine receptors in muscarinic receptor-mediated membrane current oscillation in urinary bladder smooth muscle.
American journal of physiology. Cell physiology.
2005 Jan; 288(1):C100-8. doi:
10.1152/ajpcell.00161.2004. [PMID: 15317662] - Alan Sabirsh, Jesper Bristulf, Christer Owman. Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2.
European journal of pharmacology.
2004 Sep; 499(1-2):53-65. doi:
10.1016/j.ejphar.2004.07.060. [PMID: 15363951] - Ronald J Knox, Neil S Magoski, David Wing, Steven J Barbee, Leonard K Kaczmarek. Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia.
Journal of neurobiology.
2004 Sep; 60(4):411-23. doi:
10.1002/neu.20029. [PMID: 15307146] - S V Mikhutkina, A B Salmina, A V Sychev, Yu A Uspenskaya, L V Trufanova, E I Taksanova, R Ya Olovyannikova. Blebbing of thymocyte plasma membrane and apoptosis are related to impairment of capacitance Ca2+ entry into cells.
Bulletin of experimental biology and medicine.
2004 Jun; 137(6):551-5. doi:
10.1023/b:bebm.0000042709.57599.67. [PMID: 15455082] - Yi Pang, Pam Bounelis, John C Chatham, Richard B Marchase. Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy.
Diabetes.
2004 Apr; 53(4):1074-81. doi:
10.2337/diabetes.53.4.1074. [PMID: 15047624] - Masahiro Matsubara, Shigehiro Masaki, Kenji Ohmori, Akira Karasawa, Kazuhide Hasegawa. Differential regulation of IL-4 expression and degranulation by anti-allergic olopatadine in rat basophilic leukemia (RBL-2H3) cells.
Biochemical pharmacology.
2004 Apr; 67(7):1315-26. doi:
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Journal of neurochemistry.
2004 Mar; 88(6):1361-72. doi:
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American journal of physiology. Cell physiology.
2004 Feb; 286(2):C247-55. doi:
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Experimental biology and medicine (Maywood, N.J.).
2004 Jan; 229(1):99-107. doi:
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2003 Jan; 26(1):64-9. doi:
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Kidney international.
2002 Aug; 62(2):558-65. doi:
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The Biochemical journal.
2002 May; 364(Pt 1):245-54. doi:
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The Journal of biological chemistry.
2002 Apr; 277(14):12302-9. doi:
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2002 Feb; 277(8):6025-31. doi:
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American journal of physiology. Cell physiology.
2002 Feb; 282(2):C347-59. doi:
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2001 Oct; 114(Pt 20):3599-606. doi:
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2001 Jul; 38(4):324-31. doi:
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2001 Feb; 276(7):5134-9. doi:
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American journal of physiology. Heart and circulatory physiology.
2001 Feb; 280(2):H746-55. doi:
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