1-[2-[4-Methoxy-2-[3-(4-methoxyphenyl)propoxy]phenyl]ethyl]imidazole (BioDeep_00000185268)

   

human metabolite blood metabolite


代谢物信息卡片


1-(2-{4-methoxy-2-[3-(4-methoxyphenyl)propoxy]phenyl}ethyl)-1H-imidazole

化学式: C22H26N2O3 (366.1943)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=C(C=C1)CCCOC2=C(C=CC(=C2)OC)CCN3C=CN=C3
InChI: InChI=1S/C22H26N2O3/c1-25-20-8-5-18(6-9-20)4-3-15-27-22-16-21(26-2)10-7-19(22)11-13-24-14-12-23-17-24/h5-10,12,14,16-17H,3-4,11,13,15H2,1-2H3



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mikio Marumo, Tomoyuki Nakano, Yuji Takeda, Kaoru Goto, Ichiro Wakabayashi. Inhibition of thrombin-induced Ca²⁺ influx in platelets by R59949, an inhibitor of diacylglycerol kinase. The Journal of pharmacy and pharmacology. 2012 Jun; 64(6):855-61. doi: 10.1111/j.2042-7158.2012.01485.x. [PMID: 22571264]
  • Maoquan Li, Chunhai Chen, Zhou Zhou, Shangcheng Xu, Zhengping Yu. A TRPC1-mediated increase in store-operated Ca2+ entry is required for the proliferation of adult hippocampal neural progenitor cells. Cell calcium. 2012 Jun; 51(6):486-96. doi: 10.1016/j.ceca.2012.04.014. [PMID: 22579301]
  • Paul E Wolkowicz, Jian Huang, Patrick K Umeda, Oleg F Sharifov, Edlue Tabengwa, Brian A Halloran, Ferdinand Urthaler, Hernan E Grenett. Pharmacological evidence for Orai channel activation as a source of cardiac abnormal automaticity. European journal of pharmacology. 2011 Oct; 668(1-2):208-16. doi: 10.1016/j.ejphar.2011.06.025. [PMID: 21745466]
  • Ningren Cui, Xiaoli Zhang, Jyothirmayee S Tadepalli, Lei Yu, Hongyu Gai, James Petit, Ravi T Pamulapati, Xin Jin, Chun Jiang. Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons. Journal of neurophysiology. 2011 Jun; 105(6):2791-801. doi: 10.1152/jn.00759.2010. [PMID: 21430274]
  • Paolo Ariano, Simona Dalmazzo, Grzegorz Owsianik, Bernd Nilius, Davide Lovisolo. TRPC channels are involved in calcium-dependent migration and proliferation in immortalized GnRH neurons. Cell calcium. 2011 Jun; 49(6):387-94. doi: 10.1016/j.ceca.2011.03.007. [PMID: 21511334]
  • Kay-Pong Yip, James S K Sham. Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct. American journal of physiology. Renal physiology. 2011 Feb; 300(2):F540-8. doi: 10.1152/ajprenal.00544.2009. [PMID: 21147839]
  • M Salomonsson, T H Braunstein, N-H Holstein-Rathlou, L J Jensen. Na+-independent, nifedipine-resistant rat afferent arteriolar Ca2+ responses to noradrenaline: possible role of TRPC channels. Acta physiologica (Oxford, England). 2010 Nov; 200(3):265-78. doi: 10.1111/j.1748-1716.2010.02141.x. [PMID: 20426773]
  • A Singh, M E Hildebrand, E Garcia, T P Snutch. The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. British journal of pharmacology. 2010 Jul; 160(6):1464-75. doi: 10.1111/j.1476-5381.2010.00786.x. [PMID: 20590636]
  • Kali Hicks, Roger G O'Neil, William S Dubinsky, Rachel C Brown. TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress. American journal of physiology. Cell physiology. 2010 Jun; 298(6):C1583-93. doi: 10.1152/ajpcell.00458.2009. [PMID: 20164382]
  • Yi-hua Sun, Yong-quan Li, Shan-li Feng, Bao-xin Li, Zhen-wei Pan, Chang-qing Xu, Ting-ting Li, Bao-feng Yang. Calcium-sensing receptor activation contributed to apoptosis stimulates TRPC6 channel in rat neonatal ventricular myocytes. Biochemical and biophysical research communications. 2010 Apr; 394(4):955-61. doi: 10.1016/j.bbrc.2010.03.096. [PMID: 20307499]
  • Kumiko Yamaoka, Akiko Yano, Kenji Kuroiwa, Kazushi Morimoto, Tomoaki Inazumi, Noriyuki Hatae, Hiroyuki Tabata, Eri Segi-Nishida, Satoshi Tanaka, Atsushi Ichikawa, Yukihiko Sugimoto. Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner. Biochemical and biophysical research communications. 2009 Nov; 389(4):678-82. doi: 10.1016/j.bbrc.2009.09.064. [PMID: 19769944]
  • Tanja Kirchberger, Christelle Moreau, Gerd K Wagner, Ralf Fliegert, Cornelia C Siebrands, Merle Nebel, Frederike Schmid, Angelika Harneit, Francesca Odoardi, Alexander Flügel, Barry V L Potter, Andreas H Guse. 8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist. The Biochemical journal. 2009 Jul; 422(1):139-49. doi: 10.1042/bj20082308. [PMID: 19492987]
  • Eva Schepers, Griet Glorieux, Annemieke Dhondt, Luc Leybaert, Raymond Vanholder. Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 May; 24(5):1429-35. doi: 10.1093/ndt/gfn670. [PMID: 19059932]
  • F Ardón, E Rodríguez-Miranda, C Beltrán, A Hernández-Cruz, A Darszon. Mitochondrial inhibitors activate influx of external Ca(2+) in sea urchin sperm. Biochimica et biophysica acta. 2009 Jan; 1787(1):15-24. doi: 10.1016/j.bbabio.2008.10.003. [PMID: 19000650]
  • Ian Daniels, Julie Turzanski, Andrew P Haynes. A requirement for calcium in the caspase-independent killing of Burkitt lymphoma cell lines by Rituximab. British journal of haematology. 2008 Jul; 142(3):394-403. doi: 10.1111/j.1365-2141.2008.07193.x. [PMID: 18544085]
  • Ronald M Lynch, Craig S Weber, Kevin D Nullmeyer, Edwin D W Moore, Richard J Paul. Clearance of store-released Ca2+ by the Na+-Ca2+ exchanger is diminished in aortic smooth muscle from Na+-K+-ATPase alpha 2-isoform gene-ablated mice. American journal of physiology. Heart and circulatory physiology. 2008 Mar; 294(3):H1407-16. doi: 10.1152/ajpheart.00855.2007. [PMID: 18192219]
  • Yichang Jia, Jian Zhou, Yilin Tai, Yizheng Wang. TRPC channels promote cerebellar granule neuron survival. Nature neuroscience. 2007 May; 10(5):559-67. doi: 10.1038/nn1870. [PMID: 17396124]
  • Octavio Pernas-Sueiras, Amparo Alfonso, Mercedes R Vieytes, Alberto Orfao, Luis Escribano, Sánchez-Jiménez Francisca, Luis M Botana. Calcium-pH crosstalks in the human mast cell line HMC-1: intracellular alkalinization activates calcium extrusion through the plasma membrane Ca2+-ATPase. Journal of cellular biochemistry. 2006 Dec; 99(5):1397-408. doi: 10.1002/jcb.21010. [PMID: 16817237]
  • Da-nian Nie, Song-mei Yin, Shuang-feng Xie. [Experimental study on anti-platelet effects of ginsenoside -2A in vitro]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2006 Jun; 26 Suppl(?):83-5. doi: NULL. [PMID: 17569356]
  • Mark E Hansen, Isaac N Pessah, Fumio Matsumura. Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells. Toxicology. 2006 Mar; 220(2-3):218-31. doi: 10.1016/j.tox.2006.01.006. [PMID: 16469423]
  • Nidhal Ben-Amor, Pedro C Redondo, Aghleb Bartegi, José A Pariente, Ginés M Salido, Juan A Rosado. A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets. The Journal of physiology. 2006 Jan; 570(Pt 2):309-23. doi: 10.1113/jphysiol.2005.100800. [PMID: 16308346]
  • Daoyan Liu, Alexandra Scholze, Zhiming Zhu, Reinhold Kreutz, Markus Wehland-von-Trebra, Walter Zidek, Martin Tepel. Increased transient receptor potential channel TRPC3 expression in spontaneously hypertensive rats. American journal of hypertension. 2005 Nov; 18(11):1503-7. doi: 10.1016/j.amjhyper.2005.05.033. [PMID: 16280289]
  • Shunichi Kajioka, Shinsuke Nakayama, Haruhiko Asano, Alison F Brading. Involvement of ryanodine receptors in muscarinic receptor-mediated membrane current oscillation in urinary bladder smooth muscle. American journal of physiology. Cell physiology. 2005 Jan; 288(1):C100-8. doi: 10.1152/ajpcell.00161.2004. [PMID: 15317662]
  • Alan Sabirsh, Jesper Bristulf, Christer Owman. Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2. European journal of pharmacology. 2004 Sep; 499(1-2):53-65. doi: 10.1016/j.ejphar.2004.07.060. [PMID: 15363951]
  • Ronald J Knox, Neil S Magoski, David Wing, Steven J Barbee, Leonard K Kaczmarek. Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia. Journal of neurobiology. 2004 Sep; 60(4):411-23. doi: 10.1002/neu.20029. [PMID: 15307146]
  • S V Mikhutkina, A B Salmina, A V Sychev, Yu A Uspenskaya, L V Trufanova, E I Taksanova, R Ya Olovyannikova. Blebbing of thymocyte plasma membrane and apoptosis are related to impairment of capacitance Ca2+ entry into cells. Bulletin of experimental biology and medicine. 2004 Jun; 137(6):551-5. doi: 10.1023/b:bebm.0000042709.57599.67. [PMID: 15455082]
  • Yi Pang, Pam Bounelis, John C Chatham, Richard B Marchase. Hexosamine pathway is responsible for inhibition by diabetes of phenylephrine-induced inotropy. Diabetes. 2004 Apr; 53(4):1074-81. doi: 10.2337/diabetes.53.4.1074. [PMID: 15047624]
  • Masahiro Matsubara, Shigehiro Masaki, Kenji Ohmori, Akira Karasawa, Kazuhide Hasegawa. Differential regulation of IL-4 expression and degranulation by anti-allergic olopatadine in rat basophilic leukemia (RBL-2H3) cells. Biochemical pharmacology. 2004 Apr; 67(7):1315-26. doi: 10.1016/j.bcp.2003.12.008. [PMID: 15013847]
  • Yaxiong Yang, Gregory A Kinney, William J Spain, John C S Breitner, David G Cook. Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. Journal of neurochemistry. 2004 Mar; 88(6):1361-72. doi: 10.1046/j.1471-4159.2003.02279.x. [PMID: 15009636]
  • C A Bertrand, H Danahay, C T Poll, C Laboisse, U Hopfer, R J Bridges. Niflumic acid inhibits ATP-stimulated exocytosis in a mucin-secreting epithelial cell line. American journal of physiology. Cell physiology. 2004 Feb; 286(2):C247-55. doi: 10.1152/ajpcell.00593.2002. [PMID: 14522823]
  • Mark E Boston, G Christopher Frech, Enrique Chacon-Cruz, E Stephen Buescher, David G Oelberg. Surfactant releases internal calcium stores in neutrophils by G protein-activated pathway. Experimental biology and medicine (Maywood, N.J.). 2004 Jan; 229(1):99-107. doi: 10.1177/153537020422900112. [PMID: 14709782]
  • Kazuhiko Seya, Ken-Ichi Furukawa, Satoshi Taniguchi, Genji Kodzuka, Yoshiteru Oshima, Masatake Niwa, Shigeru Motomura. Endothelium-dependent vasodilatory effect of vitisin C, a novel plant oligostilbene from Vitis plants (Vitaceae), in rabbit aorta. Clinical science (London, England : 1979). 2003 Jul; 105(1):73-9. doi: 10.1042/cs20020288. [PMID: 12605596]
  • Hyun-Sook Kim, Fumikazu Okajima, Dong-Soon Im. Analysis of vasopressin-induced Ca2+ increase in rat hepatocytes. Archives of pharmacal research. 2003 Jan; 26(1):64-9. doi: 10.1007/bf03179934. [PMID: 12568361]
  • Tsuneo Takenaka, Hiromichi Suzuki, Hirokazu Okada, Tsutomu Inoue, Yoshihiko Kanno, Yuri Ozawa, Koichi Hayashi, Takao Saruta. Transient receptor potential channels in rat renal microcirculation: actions of angiotensin II. Kidney international. 2002 Aug; 62(2):558-65. doi: 10.1046/j.1523-1755.2002.00484.x. [PMID: 12110018]
  • Alessandra Gamberucci, Emanuele Giurisato, Paola Pizzo, Maristella Tassi, Roberta Giunti, Deirdre Patricia McIntosh, Angelo Benedetti. Diacylglycerol activates the influx of extracellular cations in T-lymphocytes independently of intracellular calcium-store depletion and possibly involving endogenous TRP6 gene products. The Biochemical journal. 2002 May; 364(Pt 1):245-54. doi: 10.1042/bj3640245. [PMID: 11988098]
  • Antonio Riccio, Cesar Mattei, Rosemary E Kelsell, Andrew D Medhurst, Andrew R Calver, Andrew D Randall, John B Davis, Christopher D Benham, Menelas N Pangalos. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. The Journal of biological chemistry. 2002 Apr; 277(14):12302-9. doi: 10.1074/jbc.m112313200. [PMID: 11805119]
  • Karen E Smith, Chen Gu, Kent A Fagan, Biao Hu, Dermot M F Cooper. Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry. The Journal of biological chemistry. 2002 Feb; 277(8):6025-31. doi: 10.1074/jbc.m109615200. [PMID: 11744699]
  • Silke Jung, Rainer Strotmann, Günter Schultz, Tim D Plant. TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. American journal of physiology. Cell physiology. 2002 Feb; 282(2):C347-59. doi: 10.1152/ajpcell.00283.2001. [PMID: 11788346]
  • K Boels, G Glassmeier, D Herrmann, I B Riedel, W Hampe, I Kojima, J R Schwarz, H C Schaller. The neuropeptide head activator induces activation and translocation of the growth-factor-regulated Ca(2+)-permeable channel GRC. Journal of cell science. 2001 Oct; 114(Pt 20):3599-606. doi: 10.1242/jcs.114.20.3599. [PMID: 11707512]
  • K Dreja, A Bergdahl, P Hellstrand. Increased store-operated Ca2+ entry into contractile vascular smooth muscle following organ culture. Journal of vascular research. 2001 Jul; 38(4):324-31. doi: 10.1159/000051063. [PMID: 11455203]
  • C Kunzelmann-Marche, J M Freyssinet, M C Martínez. Regulation of phosphatidylserine transbilayer redistribution by store-operated Ca2+ entry: role of actin cytoskeleton. The Journal of biological chemistry. 2001 Feb; 276(7):5134-9. doi: 10.1074/jbc.m007924200. [PMID: 11076944]
  • V A Golovina, O Platoshyn, C L Bailey, J Wang, A Limsuwan, M Sweeney, L J Rubin, J X Yuan. Upregulated TRP and enhanced capacitative Ca(2+) entry in human pulmonary artery myocytes during proliferation. American journal of physiology. Heart and circulatory physiology. 2001 Feb; 280(2):H746-55. doi: 10.1152/ajpheart.2001.280.2.h746. [PMID: 11158974]
  • M C Martínez, J M Freyssinet. Deciphering the plasma membrane hallmarks of apoptotic cells: phosphatidylserine transverse redistribution and calcium entry. BMC cell biology. 2001; 2(?):20. doi: 10.1186/1471-2121-2-20. [PMID: 11701087]