(8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1-carbonitrile (BioDeep_00000185230)
human metabolite blood metabolite
代谢物信息卡片
(8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-1-carbonitrile
化学式: C22H31NO2 (341.2354666)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)C1CCC2C1(CCC3C2CC=C4C3(C(CC(C4)O)C#N)C)C
InChI: InChI=1S/C22H31NO2/c1-13(24)18-6-7-19-17-5-4-14-10-16(25)11-15(12-23)22(14,3)20(17)8-9-21(18,19)2/h4,15-20,25H,5-11H2,1-3H3
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代谢反应
0 个相关的代谢反应过程信息。
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Terrilyn A Richardson, Curtis D Klaassen. Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2010 Aug; 116(2):413-21. doi:
10.1093/toxsci/kfq125. [PMID: 20421340] - Masaaki Miyata, Masahiro Nomoto, Fumiaki Sotodate, Tomohiro Mizuki, Wataru Hori, Miho Nagayasu, Shinya Yokokawa, Shin-ichi Ninomiya, Yasushi Yamazoe. Possible protective role of pregnenolone-16 alpha-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis.
European journal of pharmacology.
2010 Jun; 636(1-3):145-54. doi:
10.1016/j.ejphar.2010.03.022. [PMID: 20359477] - Ming-Jie Liu, Yuki Takahashi, Taira Wada, Jinhan He, Jie Gao, Yanan Tian, Song Li, Wen Xie. The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.
Molecular pharmacology.
2009 Sep; 76(3):604-11. doi:
10.1124/mol.109.057455. [PMID: 19542321] - Huey-Mei Shaw, Wan-Hsuan Chen. Effects of pregnenolone-16alpha-carbonitrile on vitamin E status and protein levels of antioxidant enzymes in male rats fed a vitamin E-supplemented diet.
Redox report : communications in free radical research.
2009; 14(2):61-8. doi:
10.1179/135100009x392494. [PMID: 19389273] - Björn Bauer, Anika M S Hartz, Jonathan R Lucking, Xiaodong Yang, Gary M Pollack, David S Miller. Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2008 Jun; 28(6):1222-34. doi:
10.1038/jcbfm.2008.16. [PMID: 18349876] - Tomoji Maeda, Masanobu Oyabu, Takafumi Yotsumoto, Ryunosuke Higashi, Kiyoshi Nagata, Yasushi Yamazoe, Ikumi Tamai. Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Sep; 35(9):1580-6. doi:
10.1124/dmd.107.015842. [PMID: 17553914] - Yi-Jen Li, Huey-Mei Shaw. Pregnenolone and dexamethasone, modulators of cytochrome P450-3A, not increase but reduce urinary alpha-CEHC excretion in rats.
BioFactors (Oxford, England).
2007; 31(1):67-76. doi:
10.1002/biof.5520310107. [PMID: 18806310] - Sayeepriyadarshini Anakk, Wendong Huang, Jeffrey L Staudinger, Kheng Tan, Timothy J Cole, David D Moore, Henry W Strobel. Gender dictates the nuclear receptor-mediated regulation of CYP3A44.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Jan; 35(1):36-42. doi:
10.1124/dmd.106.011270. [PMID: 17020958] - Xingguo Cheng, Curtis D Klaassen. Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Nov; 34(11):1863-7. doi:
10.1124/dmd.106.010520. [PMID: 16928788] - Martin Wagner, Emina Halilbasic, Hanns-Ulrich Marschall, Gernot Zollner, Peter Fickert, Cord Langner, Kurt Zatloukal, Helmut Denk, Michael Trauner. CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice.
Hepatology (Baltimore, Md.).
2005 Aug; 42(2):420-30. doi:
10.1002/hep.20784. [PMID: 15986414] - Nichole R Vansell, Jagan R Muppidi, Sultan M Habeebu, Curtis D Klaassen. Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB).
Toxicological sciences : an official journal of the Society of Toxicology.
2004 Sep; 81(1):50-9. doi:
10.1093/toxsci/kfh197. [PMID: 15201439] - Tracy C DeLozier, Cheng-Chung Tsao, Sherry J Coulter, Julie Foley, J Alyce Bradbury, Darryl C Zeldin, Joyce A Goldstein. CYP2C44, a new murine CYP2C that metabolizes arachidonic acid to unique stereospecific products.
The Journal of pharmacology and experimental therapeutics.
2004 Sep; 310(3):845-54. doi:
10.1124/jpet.104.067819. [PMID: 15084647] - Björn Bauer, Anika M S Hartz, Gert Fricker, David S Miller. Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier.
Molecular pharmacology.
2004 Sep; 66(3):413-9. doi:
NULL. [PMID: 15322232] - Christopher J Matheny, Rabia Y Ali, Xiaodong Yang, Gary M Pollack. Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues.
Drug metabolism and disposition: the biological fate of chemicals.
2004 Sep; 32(9):1008-14. doi:
". [PMID: 15319343] - S Anakk, A Kalsotra, Y Kikuta, W Huang, J Zhang, J L Staudinger, D D Moore, H W Strobel. CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11.
The pharmacogenomics journal.
2004; 4(2):91-101. doi:
10.1038/sj.tpj.6500222. [PMID: 14770174] - Alan Hood, Marcia L Allen, YaPing Liu, Jie Liu, Curtis D Klaassen. Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers.
Toxicology and applied pharmacology.
2003 Apr; 188(1):6-13. doi:
10.1016/s0041-008x(02)00071-6. [PMID: 12668117] - David R Johnson, Curtis D Klaassen. Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction.
Toxicology and applied pharmacology.
2002 Apr; 180(1):56-63. doi:
10.1006/taap.2002.9375. [PMID: 11922777] - Nichole R Vansell, Curtis D Klaassen. Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites.
Toxicological sciences : an official journal of the Society of Toxicology.
2002 Feb; 65(2):184-91. doi:
10.1093/toxsci/65.2.184. [PMID: 11812922] - N R Vansell, C D Klaassen. Increased biliary excretion of thyroxine by microsomal enzyme inducers.
Toxicology and applied pharmacology.
2001 Nov; 176(3):187-94. doi:
10.1006/taap.2001.9278. [PMID: 11714251] - K Jarukamjorn, T Sakuma, M Yamamoto, A Ohara, N Nemoto. Sex-associated expression of mouse hepatic and renal CYP2B enzymes by glucocorticoid hormones.
Biochemical pharmacology.
2001 Jul; 62(2):161-9. doi:
10.1016/s0006-2952(01)00656-6. [PMID: 11389874] - L C Rausch-Derra, D P Hartley, P J Meier, C D Klaassen. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2.
Hepatology (Baltimore, Md.).
2001 Jun; 33(6):1469-78. doi:
10.1053/jhep.2001.25088. [PMID: 11391536] - C D Klaassen, A M Hood. Effects of microsomal enzyme inducers on thyroid follicular cell proliferation and thyroid hormone metabolism.
Toxicologic pathology.
2001 Jan; 29(1):34-40. doi:
10.1080/019262301301418838. [PMID: 11215682]
