(2R)-2-[[(2R)-2-[[(2S)-2-(Azepane-1-carbonylamino)-4-methylpentanoyl]amino]-3-(1-formylindol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid (BioDeep_00000185175)
human metabolite blood metabolite
代谢物信息卡片
化学式: C36H44N6O6 (656.3322164000001)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CC1=CN(C2=CC=CC=C21)C=O)C(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O)NC(=O)N5CCCCCC5
InChI: InChI=1S/C36H44N6O6/c1-23(2)17-29(40-36(48)41-15-9-3-4-10-16-41)33(44)38-30(19-25-21-42(22-43)32-14-8-6-12-27(25)32)34(45)39-31(35(46)47)18-24-20-37-28-13-7-5-11-26(24)28/h5-8,11-14,20-23,29-31,37H,3-4,9-10,15-19H2,1-2H3,(H,38,44)(H,39,45)(H,40,48)(H,46,47)
描述信息
同义名列表
8 个代谢物同义名
2-({2-[(2-{[(azepan-1-yl)(hydroxy)methylidene]amino}-1-hydroxy-4-methylpentylidene)amino]-3-(1-formyl-1H-indol-3-yl)-1-hydroxypropylidene}amino)-3-(1H-indol-3-yl)propanoate; (2R)-2-[[(2R)-2-[[(2S)-2-(Azepane-1-carbonylamino)-4-methylpentanoyl]amino]-3-(1-formylindol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid; (2R)-2-[[(2R)-2-[[(2S)-2-(Azepane-1-carbonylamino)-4-methylpentanoyl]amino]-3-(1-formylindol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoate; 2-(2-{2-[(azepane-1-carbonyl)amino]-4-methylpentanamido}-3-(1-formyl-1H-indol-3-yl)propanamido)-3-(1H-indol-3-yl)propanoic acid; 2-{2-[2-(azepane-1-carbonylamino)-4-methylpentanamido]-3-(1-formylindol-3-yl)propanamido}-3-(1H-indol-3-yl)propanoic acid; Hexahydroazepinocarbonyl-leucyl-tryptophyl(cho)-tryptophan; azepane-1-carbonyl-DL-Leu-DL-Trp(For)-DL-Trp-OH; Hexahydroazepinocarbonyl-leu-D-TRP(cho)-D-TRP
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sandra I Hope, Sabrina L Nabhen, Celeste Soria, Liliana G Bianciotti, Marcelo S Vatta. Endothelin-1 and -3 modulate the neuronal norepinephrine transporter through multiple signalling pathways in the rat posterior hypothalamus.
Neurochemistry international.
2010 Oct; 57(3):306-13. doi:
10.1016/j.neuint.2010.06.009. [PMID: 20600439] - Suyi Cao, Liang-Chao Wang, Herman Kwansa, Richard J Roman, David R Harder, Raymond C Koehler. Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 May; 296(5):R1412-8. doi:
10.1152/ajpregu.00003.2009. [PMID: 19261918] - Anjing Ren, Xiaohong Yan, Hong Lu, Jingsong Shi, Yuanjun Yin, Jie Bai, Wenjun Yuan, Li Lin. Antagonism of endothelin-1 inhibits hypoxia-induced apoptosis in cardiomyocytes.
Canadian journal of physiology and pharmacology.
2008 Aug; 86(8):536-40. doi:
10.1139/y08-051. [PMID: 18758501] - Christopher S Keator, David T Schreiber, Thomas A Hoagland, John A McCracken, Robert A Milvae. Intrauterine infusion of BQ-610, an endothelin type A receptor antagonist, delays luteolysis in dairy heifers.
Domestic animal endocrinology.
2008 May; 34(4):411-8. doi:
10.1016/j.domaniend.2007.11.002. [PMID: 18258406] - Matthew D Doerr, Madhusudan P Goravanahally, Justin D Rhinehart, E Keith Inskeep, Jorge A Flores. Effects of endothelin receptor type-A and type-B antagonists on prostaglandin F2alpha-induced luteolysis of the sheep corpus luteum.
Biology of reproduction.
2008 Apr; 78(4):688-96. doi:
10.1095/biolreprod.107.064105. [PMID: 18077801] - Alex A Pérez-Rivera, Gregory D Fink, James J Galligan. Vascular reactivity of mesenteric arteries and veins to endothelin-1 in a murine model of high blood pressure.
Vascular pharmacology.
2005 Jun; 43(1):1-10. doi:
10.1016/j.vph.2005.02.014. [PMID: 15975530] - Chi-Chang Juan, Yi-Wen Shen, Yueh Chien, Yen-Jie Lin, Shau-Feng Chang, Low-Tone Ho. Insulin infusion induces endothelin-1-dependent hypertension in rats.
American journal of physiology. Endocrinology and metabolism.
2004 Nov; 287(5):E948-54. doi:
10.1152/ajpendo.00536.2003. [PMID: 15226099] - Chia-Chyuan Liu, Zhih-Cherng Chen, Bor-Chih Cheng, Mao-Tsun Lin. Prior antagonism of endothelin-1A receptors alleviates circulatory shock and cerebral ischemia during rat heatstroke.
Journal of pharmacological sciences.
2004 Oct; 96(2):177-87. doi:
10.1254/jphs.fp0040203. [PMID: 15467261] - Bayram Cirak, Nejmi Kiymaz, Hasan Huseyin Ari, Serdar Ugras. The effects of endothelin antagonist BQ-610 on cerebral vascular wall following experimental subarachnoid hemorrhage and cerebral vasospasm.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society.
2004 Jun; 14(3):197-201. doi:
10.1007/s10286-004-0190-2. [PMID: 15241650] - A A Ajayi, G O Ogungbade, H C Hercule, A O Oyekan, L Mutembei. Alteration in endothelin receptor sub-type responsiveness and in the endothelin-TXA(2) mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats.
Diabetes research and clinical practice.
2004 Mar; 63(3):155-69. doi:
10.1016/j.diabres.2003.09.011. [PMID: 14757287] - Darshan K Bhangdia, Frederick A Gulmi, Shyan-Yih Chou, Unni M Mooppan, Hong Kim. Alterations of renal hemodynamics in unilateral ureteral obstruction mediated by activation of endothelin receptor subtypes.
The Journal of urology.
2003 Nov; 170(5):2057-62. doi:
10.1097/01.ju.0000081956.16457.67. [PMID: 14532853] - Benoit Boivin, Dominique Chevalier, Louis R Villeneuve, Eric Rousseau, Bruce G Allen. Functional endothelin receptors are present on nuclei in cardiac ventricular myocytes.
The Journal of biological chemistry.
2003 Aug; 278(31):29153-63. doi:
10.1074/jbc.m301738200. [PMID: 12756260] - Qiong Ye, Songcang Chen, David G Gardner. Endothelin inhibits NPR-A and stimulates eNOS gene expression in rat IMCD cells.
Hypertension (Dallas, Tex. : 1979).
2003 Mar; 41(3 Pt 2):675-81. doi:
10.1161/01.hyp.0000047204.72286.34. [PMID: 12623978] - Takayuki Kawakami, Hiromasa Mitsuhata, Jin Saitoh, Haruhiko Takeuchi, Naoki Hasome, Masahiro Hiruta, Yukari Horikawa, Norimasa Seo. Hypotension associated with systemic aggregated anaphylaxis is not attenuated by a selective endothelin-A receptor antagonist, BQ 610, in rabbits in vivo.
Journal of anesthesia.
2003; 17(1):22-9. doi:
10.1007/s005400300004. [PMID: 12908684] - Li Lin, Wen-Jun Yuan. Involvement of endothelin-1 in acute ischaemic arrhythmias in cats and rats.
Clinical science (London, England : 1979).
2002 Aug; 103 Suppl 48(?):228S-232S. doi:
10.1042/cs103s228s. [PMID: 12193092] - Martin E Beyer, Marcus Fischer, Tobias Hövelborn, Hans Martin Hoffmeister. ET(A) receptor blockade improves post-ischaemic functional recovery in 'hibernating' rat myocardium.
Clinical science (London, England : 1979).
2002 Aug; 103 Suppl 48(?):215S-218S. doi:
10.1042/cs103s215s. [PMID: 12193089] - Kazuhiro Takahashi, Kazuhito Totsune, Tomomi Kitamuro, Masahiko Sone, Osamu Murakami, Shigeki Shibahara. Three vasoactive peptides, endothelin-1, adrenomedullin and urotensin-II, in human tumour cell lines of different origin: expression and effects on proliferation.
Clinical science (London, England : 1979).
2002 Aug; 103 Suppl 48(?):35S-38S. doi:
10.1042/cs103s035s. [PMID: 12193050] - Xing-yi Zhang, Richard J B Francis, Cheuk-kwan Sun Ck, Antony M Wheatley. Endothelin receptor A blockade ameliorates hypothermic ischemia-reperfusion-related microhemodynamic disturbances during liver transplantation in the rat.
The Journal of surgical research.
2002 Feb; 102(2):63-70. doi:
10.1006/jsre.2001.6246. [PMID: 11796000] - R G Evans, A C Madden, J J Oliver, T V Lewis. Effects of ET(A) - and ET(B)-receptor antagonists on regional kidney blood flow, and responses to intravenous endothelin-1, in anaesthetized rabbits.
Journal of hypertension.
2001 Oct; 19(10):1789-99. doi:
10.1097/00004872-200110000-00013. [PMID: 11593099] - X X Li, M Bek, L D Asico, Z Yang, D K Grandy, D S Goldstein, M Rubinstein, G M Eisner, P A Jose. Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice.
Hypertension (Dallas, Tex. : 1979).
2001 Sep; 38(3):303-8. doi:
10.1161/01.hyp.38.3.303. [PMID: 11566895] - F T Hammad, G Davis, X Y Zhang, A M Wheatley. Endotelin ETA and ETB receptor antagonism during cold preservation in renal transplantation.
Transplantation.
2001 Mar; 71(5):619-27. doi:
10.1097/00007890-200103150-00007. [PMID: 11292290] - K Ishibashi, T Imamura, P M Sharma, S Ugi, J M Olefsky. The acute and chronic stimulatory effects of endothelin-1 on glucose transport are mediated by distinct pathways in 3T3-L1 adipocytes.
Endocrinology.
2000 Dec; 141(12):4623-8. doi:
10.1210/endo.141.12.7820. [PMID: 11108276] - R G Evans, A C Madden, E Cotterill. ET-receptor subtypes: roles in regional renal vascular actions of exogenous and endogenous endothelins in anesthetized rabbits.
Journal of cardiovascular pharmacology.
2000 May; 35(5):677-85. doi:
10.1097/00005344-200005000-00001. [PMID: 10813367] - Y Yokoyama, R Baveja, N Sonin, K Nakanishi, J X Zhang, M G Clemens. Altered endothelin receptor subtype expression in hepatic injury after ischemia/reperfusion.
Shock (Augusta, Ga.).
2000 Jan; 13(1):72-8. doi:
10.1097/00024382-200013010-00013. [PMID: 10638673] - F T Hammad, G Davis, X Zhang, A M Wheatley. The role of endothelin in early renal cortical reperfusionin renal transplantation.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.
2000; 32(6):380-8. doi:
10.1159/000052221. [PMID: 11182623] - C C Juan, V S Fang, Y P Hsu, Y J Huang, D B Hsia, P C Yu, C F Kwok, L T Ho. Overexpression of vascular endothelin-1 and endothelin-A receptors in a fructose-induced hypertensive rat model.
Journal of hypertension.
1998 Dec; 16(12 Pt 1):1775-82. doi:
10.1097/00004872-199816120-00010. [PMID: 9869011] - M Saito, K Nishi, Y Fukumoto, R M Weiss, J Latifpour. Characterization of endothelin receptors in streptozotocin-induced diabetic rat vas deferens.
Biochemical pharmacology.
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