Zipeprol (BioDeep_00000185124)

   

human metabolite blood metabolite


代谢物信息卡片


1-(2-Methoxy-2-phenyl)ethyl- 4-(2-hydroxy-3-methoxy-3-phenyl)propylpiperazine

化学式: C23H32N2O3 (384.2412802)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 99.55%

分子结构信息

SMILES: COC(CN1CCN(CC(O)C(OC)C2=CC=CC=C2)CC1)C1=CC=CC=C1
InChI: InChI=1S/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3

描述信息

R - Respiratory system > R05 - Cough and cold preparations > R05D - Cough suppressants, excl. combinations with expectorants
C78273 - Agent Affecting Respiratory System > C66917 - Antitussive Agent
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents

同义名列表

8 个代谢物同义名

1-(2-Methoxy-2-phenyl)ethyl- 4-(2-hydroxy-3-methoxy-3-phenyl)propylpiperazine; 1-methoxy-3-[4-(2-methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-2-ol; Zipeprol dihydrochloride; Respilene; 3024 CERM; Zipeprol; Tusigen; Zo-tab



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Heesun Chung. Role of drug testing as an early warning programme: the experience of the Republic of Korea. Bulletin on narcotics. 2005; 57(1-2):231-48. doi: NULL. [PMID: 21338024]
  • S Athanaselis, A Dona, C Maravelias, A Koutselinis. Analysis and identification of zipeprol and its metabolites during drug abuse screening. Journal of analytical toxicology. 1996 Nov; 20(7):564-7. doi: 10.1093/jat/20.7.564. [PMID: 8934307]
  • P Kintz, F Flesch, A Jaeger, P Mangin. GC-MS procedure for the analysis of zipeprol. Journal of pharmaceutical and biomedical analysis. 1993 Apr; 11(4-5):335-8. doi: 10.1016/0731-7085(93)80025-v. [PMID: 8357869]
  • H Shin, J Park, D Lho, O Kim. Measurement of zipeprol in rat plasma by gas chromatography with nitrogen-phosphorus detection. Journal of chromatography. 1989 Sep; 493(2):398-401. doi: 10.1016/s0378-4347(00)82748-6. [PMID: 2584307]
  • J E De Larco, D A Pigott. Ectopic peptides released by a human melanoma cell line that modulate the transformed phenotype. Ciba Foundation symposium. 1985; 116(?):224-40. doi: 10.1002/9780470720974.ch14. [PMID: 3000706]
  • R Achari, A H Beckett. Buccal uptake, urinary excretion, and physicochemical properties of zipeprol and its N-dealkylated products. Biopharmaceutics & drug disposition. 1982 Jul; 3(3):203-9. doi: 10.1002/bdd.2510030303. [PMID: 7139061]
  • W Gielsdorf, P Toffel-Nadolny. [Biotransformation of zipeprol (Mirsol) in humans. Gas chromatographic/mass spectrometric studies, using ammonia as a selective reactant gas (author's transl)]. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1981 Jan; 19(1):25-30. doi: NULL. [PMID: 7205156]
  • A H Beckett, R Achari. Plasma concentrations and excretion of zipeprol in man under acidic urine conditions. The Journal of pharmacy and pharmacology. 1977 Oct; 29(10):589-92. doi: 10.1111/j.2042-7158.1977.tb11411.x. [PMID: 21236]
  • A H Beckett, R Achari. A note on the metabolism of Respilene in man. The Journal of pharmacy and pharmacology. 1977 Apr; 29(4):253. doi: 10.1111/j.2042-7158.1977.tb11304.x. [PMID: 17683]
  • J Ditzel. Oxygen transport impairment in diabetes. Diabetes. 1976; 25(2 SUPPL):832-8. doi: . [PMID: 9322]